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1. 发明授权

US07620441B2 Method and device for improved ECG triggering 有权
标题翻译：改善ECG触发的方法和装置
公开(公告)号：US07620441B2
公开(公告)日：2009-11-17
申请号：US11455263
申请日：2006-06-16
申请人： Jan Boese , Johann Seissl
发明人： Jan Boese , Johann Seissl
IPC分类号： A61B5/0452 , A61B5/05
CPC分类号： A61B5/0245 , A61B5/02405 , A61B5/7285 , A61B6/032 , A61B6/541 , A61B8/543
摘要： The invention relates to a method and a device for improved imaging by means of ECG triggering. A first trigger time A and a second trigger time B, as well as a threshold value for the heart rate variability is determined with the method according to the invention. The heart rate variability is subsequently calculated. Trigger time A is used as long as the threshold value is exceeded. Trigger time B is used when the threshold value is reached or exceeded.
摘要翻译：本发明涉及通过ECG触发来改进成像的方法和装置。使用根据本发明的方法确定第一触发时间A和第二触发时间B以及心率变异性的阈值。随后计算心率变异性。只要超过阈值，就使用触发时间A. 达到或超过阈值时使用触发时间B。

2. 发明申请

US20060287594A1 Method and device for improved ECG triggering 有权
公开(公告)号：US20060287594A1
公开(公告)日：2006-12-21
申请号：US11455263
申请日：2006-06-16
申请人： Jan Boese , Johann Seissl
发明人： Jan Boese , Johann Seissl
IPC分类号： A61B5/05
CPC分类号： A61B5/0245 , A61B5/02405 , A61B5/7285 , A61B6/032 , A61B6/541 , A61B8/543
摘要： The invention relates to a method and a device for improved imaging by means of ECG triggering. A first trigger time A and a second trigger time B, as well as a threshold value for the heart rate variability is determined with the method according to the invention. The heart rate variability is subsequently calculated. Trigger time A is used as long as the threshold value is exceeded. Trigger time B is used when the threshold value is reached or exceeded.

3. 发明授权

US10719986B2 Method and system for virtual percutaneous valve implantation 有权
公开(公告)号：US10719986B2
公开(公告)日：2020-07-21
申请号：US12975714
申请日：2010-12-22
申请人： Dominik Zaeuner , Razvan Ioan Ionasec , Bogdan Georgescu , Yefeng Zheng , Dorin Comaniciu , Ingmar Voigt , Jan Boese
发明人： Dominik Zaeuner , Razvan Ioan Ionasec , Bogdan Georgescu , Yefeng Zheng , Dorin Comaniciu , Ingmar Voigt , Jan Boese
IPC分类号： G06T17/00 , G06T19/00 , G16H50/50 , G06F19/00
摘要： A method and system for virtual percutaneous valve implantation is disclosed. A patient-specific anatomical model of a heart valve is estimated based on 3D cardiac medical image data and an implant model representing a valve implant is virtually deployed into the patient-specific anatomical model of the heart valve. A library of implant models, each modeling geometrical properties of a corresponding valve implant, is maintained. The implant models maintained in the library are virtually deployed into the patient specific anatomical model of the heart valve to select an implant type and size and deployment location and orientation for percutaneous valve implantation.

4. 发明授权

US09014423B2 Method and system for catheter tracking in fluoroscopic images using adaptive discriminant learning and measurement fusion 有权
标题翻译：使用自适应判别学习和测量融合的荧光镜图像中导管跟踪的方法和系统
公开(公告)号：US09014423B2
公开(公告)日：2015-04-21
申请号：US13412882
申请日：2012-03-06
申请人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
发明人： Peng Wang , Yefeng Zheng , Matthias John , Jan Boese , Gareth Funka-Lea , Dorin Comaniciu
IPC分类号： G06K9/00 , A61B6/00 , A61B6/12 , G06T7/20
CPC分类号： A61B6/487 , A61B6/12 , A61B6/503 , G06T7/246 , G06T2207/10016 , G06T2207/10064 , G06T2207/20076 , G06T2207/20081 , G06T2207/30021 , G06T2207/30048
摘要： A method and system for adaptive discriminant learning and measurement fusion for image based catheter tracking is disclosed. An adaptive discriminant model is trained online based on a tracked object, such as a pigtail catheter tip, in at least one previous frame of a fluoroscopic image sequence. The object is tracked in the current frame of the fluoroscopic image sequence based at least on the adaptive discriminant model trained online. The object may be tracked in the current frame based on a fusion of three types of measurement models including the adaptive discriminant model trained online, an object detection model trained offline, and an online appearance model.
摘要翻译：公开了一种用于基于图像的导管跟踪的自适应判别学习和测量融合的方法和系统。在荧光镜像图像序列的至少一个先前帧中，基于跟踪对象（例如尾纤导管尖端）在线训练自适应判别模型。至少基于在线训练的自适应判别模型，在透视图像序列的当前帧中跟踪对象。基于三种类型的测量模型的融合，可以在当前帧中跟踪对象，包括在线训练的自适应判别模型，离线训练的对象检测模型和在线外观模型。

5. 发明授权

US08428319B2 Automatic measurement of morphometric and motion parameters of the coronary tree from a rotational X-ray sequence 有权
标题翻译：从旋转X射线序列自动测量冠状动脉树的形态和运动参数
公开(公告)号：US08428319B2
公开(公告)日：2013-04-23
申请号：US12764225
申请日：2010-04-21
申请人： Yanghai Tsin , Klaus J. Kirchberg , Günter Lauritsch , Chenyang Xu , Jan Boese , Rui Liao
发明人： Yanghai Tsin , Klaus J. Kirchberg , Günter Lauritsch , Chenyang Xu , Jan Boese , Rui Liao
IPC分类号： G06K9/00
CPC分类号： G06T7/251 , G06T7/60 , G06T7/62 , G06T2207/10116 , G06T2207/30101 , G06T2207/30172
摘要： Automatic measurement of morphometric and motion parameters of a coronary target includes extracting reference frames from input data of a coronary target at different phases of a cardiac cycle, extracting a three-dimensional centerline model for each phase of the cardiac cycle based on the references frames and projection matrices of the coronary target, tracking a motion of the coronary target through the phases based on the three-dimensional centerline models, and determining a measurement of morphologic and motion parameters of the coronary target based on the motion.
摘要翻译：自动测量冠状动脉靶标的形态测量和运动参数包括：在心脏周期的不同阶段从冠状动脉靶的输入数据提取参考帧，基于参考帧提取心动周期的每个相位的三维中心线模型，以及冠状动脉靶的投影矩阵，基于三维中心线模型跟踪通过相位的冠状动脉靶的运动，以及基于运动确定冠状动脉靶标的形态和运动参数的测量。

6. 发明授权

US08428221B2 Medical x-ray acquisition system 有权
标题翻译：医疗x射线采集系统
公开(公告)号：US08428221B2
公开(公告)日：2013-04-23
申请号：US12893189
申请日：2010-09-29
申请人： Jan Boese , Michael Maschke
发明人： Jan Boese , Michael Maschke
IPC分类号： H01J35/06 , H05G1/02
CPC分类号： H01J35/065 , A61B6/4007 , A61B6/4028 , A61B6/4441 , A61B6/4458 , A61B6/4464 , A61B6/548 , H01J2235/068
摘要： A medical x-ray acquisition system has an x-ray source and an x-ray detector, the x-ray source having at least one field emission radiator with at least one field emission cathode. The field emission cathode can be formed by a nanostructured material with carbon nanotubes.
摘要翻译：医用x射线摄取系统具有x射线源和x射线检测器，该x射线源具有至少一个具有至少一个场发射阴极的场发射辐射器。场发射阴极可以由具有碳纳米管的纳米结构材料形成。

7. 发明申请

US20120296202A1 Method and System for Registration of Ultrasound and Physiological Models to X-ray Fluoroscopic Images 有权
标题翻译：超声和生理模型注射X射线荧光镜图像的方法和系统
公开(公告)号：US20120296202A1
公开(公告)日：2012-11-22
申请号：US13475048
申请日：2012-05-18
申请人： Peter Mountney , Markus Kaiser , Ingmar Voigt , Matthias John , Razvan Ioan Ionasec , Jan Boese , Dorin Comaniciu
发明人： Peter Mountney , Markus Kaiser , Ingmar Voigt , Matthias John , Razvan Ioan Ionasec , Jan Boese , Dorin Comaniciu
IPC分类号： A61B6/02 , A61B8/12
CPC分类号： A61B6/12 , A61B6/4417 , A61B6/4441 , A61B6/487 , A61B6/503 , A61B6/5247 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/4245 , A61B8/4416 , A61B8/5261
摘要： A method and system for registering ultrasound images and physiological models to x-ray fluoroscopy images is disclosed. A fluoroscopic image and an ultrasound image, such as a Transesophageal Echocardiography (TEE) image, are received. A 2D location of an ultrasound probe is detected in the fluoroscopic image. A 3D pose of the ultrasound probe is estimated based on the detected 2D location of the ultrasound probe in the fluoroscopic image. The ultrasound image is mapped to a 3D coordinate system of a fluoroscopic image acquisition device used to acquire the fluoroscopic image based on the estimated 3D pose of the ultrasound probe. The ultrasound image can then be projected into the fluoroscopic image using a projection matrix associated with the fluoroscopic image. A patient specific physiological model can be detected in the ultrasound image and projected into the fluoroscopic image.
摘要翻译：公开了一种用于将超声图像和生理模型记录到X射线透视图像的方法和系统。接收透视图像和超声图像，如经食道超声心动图（TEE）图像。在透视图像中检测超声探头的2D位置。基于在荧光镜图像中检测到的超声波探头的2D位置来估计超声探头的3D姿态。超声图像被映射到用于根据超声探头的估计3D姿势获取荧光镜图像的荧光镜图像采集装置的3D坐标系。然后可以使用与透视图像相关联的投影矩阵将超声图像投影到透视图像中。可以在超声图像中检测患者特异性生理模型并将其投影到透视图像中。

8. 发明申请

US20120123250A1 Method and System for Pigtail Catheter Motion Prediction 有权
标题翻译：猪尾导管运动预测方法与系统
公开(公告)号：US20120123250A1
公开(公告)日：2012-05-17
申请号：US13297373
申请日：2011-11-16
申请人： Yu Pang , Yefeng Zheng , Matthias John , Jan Boese , Dorin Comaniciu
发明人： Yu Pang , Yefeng Zheng , Matthias John , Jan Boese , Dorin Comaniciu
IPC分类号： A61B6/00
CPC分类号： A61B6/487 , A61B6/12 , A61B6/5264 , G06T7/246 , G06T7/277 , G06T2207/10121 , G06T2207/30021
摘要： A method and system for autoregressive model based pigtail catheter motion prediction in a fluoroscopic image sequence is disclosed. Parameters of an autoregressive model are estimated based on observed pigtail catheter tip positions in a plurality of previous frames of a fluoroscopic image sequence. A pigtail catheter tip position in a current frame of the fluoroscopic image sequence is predicted using the fitted autoregressive model. The predicted pigtail catheter tip position can be used to constrain pigtail catheter tip detection in the current frame. The predicted pigtail catheter tip position may also be used to predict abnormal motion in the fluoroscopic image sequence.
摘要翻译：公开了一种在透视图像序列中基于自回归模型的尾纤导管运动预测的方法和系统。基于在透视图像序列的多个先前帧中的观察到的尾纤导管尖端位置来估计自回归模型的参数。使用拟合的自回归模型预测荧光镜图像序列的当前帧中的尾纤导管尖端位置。预测的猪尾导管尖端位置可用于限制当前帧中的尾纤导管尖端检测。预测的猪尾导管尖端位置也可以用于预测荧光镜像图像序列中的异常运动。

9. 发明授权

US08050483B2 Method for image registration processes and X-ray angiography system 有权
标题翻译：图像配准过程和X射线血管造影系统的方法
公开(公告)号：US08050483B2
公开(公告)日：2011-11-01
申请号：US12070484
申请日：2008-02-19
申请人： Jan Boese , Jörn Justiz , Andreas Meyer , Marcus Pfister
发明人： Jan Boese , Jörn Justiz , Andreas Meyer , Marcus Pfister
IPC分类号： G06K9/00
CPC分类号： G06T7/38 , A61B2090/364 , G06T2207/10072 , G06T2207/10081 , G06T2207/10088 , G06T2207/30004 , G06T2207/30012 , G06T2207/30048
摘要： Registration of preoperatively acquired MRI images of soft parts to intraoperatively acquired X-ray images of soft parts is not possible. The invention shows a way of nevertheless using such preoperatively acquired images for superimposition with 2D projections of the soft parts, taking an indirect route via 3D/3D registration of images of the spinal column. For this purpose, 3D image data sets of the spinal column must be obtained separately on the one hand using MRI and on the other using the X-ray imaging system so that the 3D/3D registration produces a mapping rule which then also applies to the preoperatively acquired images of the soft part if the soft part images and the spinal images are acquired without intervening change in the patient position in the MRI scanner.
摘要翻译：将软件部分术前获取的MRI图像注册到软组件的术中获得的X射线图像是不可能的。本发明示出了一种使用这种预先获取的图像与软部件的2D投影叠加的方式，通过经脊柱的图像的3D / 3D对准进行间接路线。为此，必须使用MRI单独获得脊柱的3D图像数据集，另一方面必须使用X射线成像系统获得脊柱的3D图像数据集，使得3D / 3D注册产生映射规则，其然后也适用于如果获取软部分图像和脊柱图像而不在MRI扫描仪中的患者位置的中间改变，则在术前获取软部分的图像。

10. 发明授权

US08023616B2 Method and apparatus for setting a dynamically adjustable position of an imaging system 有权
标题翻译：用于设置成像系统的动态可调位置的方法和装置
公开(公告)号：US08023616B2
公开(公告)日：2011-09-20
申请号：US12501539
申请日：2009-07-13
申请人： Jan Boese
发明人： Jan Boese
IPC分类号： G01N23/00 , H05G1/62
CPC分类号： A61B6/504 , A61B6/4441
摘要： The invention relates to a method and an apparatus for setting a dynamically adjustable position of an imaging system for providing an optimum view onto a moving object during a medical intervention. A time-resolved at least three-dimensional data record of the moving object is generated. A position of the imaging system for each period of time is determined from the time-resolved data record from which the optimum view onto a structure of interest of the moving object is produced and automatically setting a calculated position of the imaging system in real-time so that the optimum view onto the structure of interest can be shown at any time. Optionally prior to determining the position of the imaging system, a structure of interest of the moving object can be segmented with this structure being segmented for each period of time from the time-resolved data record.
摘要翻译：本发明涉及一种用于设置成像系统的动态可调节位置以在医疗介入期间向运动物体提供最佳视野的方法和装置。生成移动对象的时间分辨的至少三维数据记录。从时间分辨数据记录确定成像系统的每个时间段的位置，从该时间分辨数据记录生成关于移动物体的感兴趣结构的最佳视图，并且自动地将计算出的成像系统的位置实时地设置从而可以随时显示关注结构的最佳视图。可选择地，在确定成像系统的位置之前，可以将该结构从时间分辨数据记录分割为每段时间段来分割移动对象的感兴趣结构。

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