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1. 发明授权

US07645737B2 Drug delivery system comprising an RGD-enriched gelatine 有权
标题翻译：药物递送系统包含富含RGD的明胶
公开(公告)号：US07645737B2
公开(公告)日：2010-01-12
申请号：US11770197
申请日：2007-06-28
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

2. 发明授权

US08080515B2 Method for prevention of platelet aggregation employing and RGD-enriched gelatine-like protein 有权
标题翻译：防止使用富含RGD的明胶样蛋白的血小板聚集的方法
公开(公告)号：US08080515B2
公开(公告)日：2011-12-20
申请号：US12494450
申请日：2009-06-30
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

3. 发明授权

US07671016B2 RGD-enriched gelatine-like proteins with enhanced cell binding 有权
标题翻译：具有增强的细胞结合的RGD富集的明胶样蛋白质
公开(公告)号：US07671016B2
公开(公告)日：2010-03-02
申请号：US11770271
申请日：2007-06-28
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

4. 发明授权

US07670839B2 Process for coating cell-culture support 失效
标题翻译：涂覆细胞培养支持的方法
公开(公告)号：US07670839B2
公开(公告)日：2010-03-02
申请号：US10540167
申请日：2003-12-23
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C12N5/00 , C07K14/00
CPC分类号： C12N5/0075 , C07K14/78 , C12N2533/54
摘要： The invention relates to a support for culturing cells, in particular to microcarriers coated with gelatine or gelatine-like proteins. Such microcarriers serve as support for culturing anchorage dependent cells. In particular the invention relates to a process for the preparation of a cell culture support comprising the step of coating a microcarrier bead with gelatine or gelatine-like protein, said gelatine or gelatine-like protein having a molecular weight of about 40 kDa to about 200 kDa.
摘要翻译：本发明涉及培养细胞的载体，特别涉及用明胶或明胶样蛋白包被的微载体。这种微载体用作培养依赖于锚定细胞的载体。特别地，本发明涉及一种制备细胞培养支持物的方法，其包括用明胶或明胶样蛋白包被微载体珠的步骤，所述明胶或明胶样蛋白具有约40kDa至约200的分子量 kDa。

5. 发明授权

US07598347B2 RGD-enriched gelatines 有权
标题翻译：富含RGD的明胶
公开(公告)号：US07598347B2
公开(公告)日：2009-10-06
申请号：US11770019
申请日：2007-06-28
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

6. 发明授权

US07560427B2 RGD-enriched gelatine-like proteins with enhanced cell binding 有权
标题翻译：具有增强的细胞结合的RGD富集的明胶样蛋白质
公开(公告)号：US07560427B2
公开(公告)日：2009-07-14
申请号：US11770256
申请日：2007-06-28
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

7. 发明授权

US07517954B2 RGD-enriched gelatine-like proteins with enhanced cell binding 有权
标题翻译：具有增强的细胞结合的RGD富集的明胶样蛋白质
公开(公告)号：US07517954B2
公开(公告)日：2009-04-14
申请号：US10550786
申请日：2004-03-26
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚定依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

8. 发明授权

US08138139B2 Use of RGD-enriched gelatine-like proteins for inhibition of cancer metastasis 有权
标题翻译：使用RGD富集的明胶样蛋白抑制癌症转移
公开(公告)号：US08138139B2
公开(公告)日：2012-03-20
申请号：US12504838
申请日：2009-07-17
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

9. 发明授权

US07579314B2 Use of RGD-enriched gelatine-like proteins for inhibition of cancer metastasis 有权
标题翻译：使用RGD富集的明胶样蛋白抑制癌症转移
公开(公告)号：US07579314B2
公开(公告)日：2009-08-25
申请号：US11770215
申请日：2007-06-28
申请人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
发明人： Jan Bastiaan Bouwstra , Andries Johannes Jozef Van Es , Yuzo Toda
IPC分类号： C07K14/00
CPC分类号： A61K9/5078 , A61K9/1658 , A61K47/42 , C07K14/78 , C12N5/0075 , C12N2533/30 , C12N2533/54
摘要： The invention concerns a cell support comprising an RGD-enriched gelatine that has a more even distribution of RGD sequences than occurring in a natural gelatine and with a minimum level of RGD sequences. More precise the percentage of RGD sequences related to the total number of amino acids is at least 0.4 and if the RGD-enriched gelatine comprises 350 amino acids or more, each stretch of 350 amino acids contains at least one RGD motif. Preferably the RGD-enriched gelatines are prepared by recombinant technology, and have a sequence that is derived from a human gelatine or collagen amino acid sequence. The invention also relates to RGD-enriched gelatines that are used for attachment to integrins. In particular The RGD-enriched gelatines of the invention are suitable for coating a cell culture support for growing anchor-dependant cell types. Further, the RGD-enriched gelatines of the invention may find use in medical applications, in particular as a coating on implant or transplant material or as a component of drug delivery systems.
摘要翻译：本发明涉及包含富含RGD的明胶的细胞支持物，其具有比在天然明胶中发生的RGD序列更均匀的分布并具有最低水平的RGD序列。更准确地说，与氨基酸总数相关的RGD序列的百分比至少为0.4，并且如果RGD富集的明胶包含350个氨基酸或更多个，则每个拉伸的350个氨基酸含有至少一个RGD基序。优选地，通过重组技术制备富含RGD的明胶，并且具有源自人明胶或胶原氨基酸序列的序列。本发明还涉及用于与整联蛋白连接的RGD富集的明胶。特别地，本发明的RGD富集的明胶适用于涂覆细胞培养支持物，用于生长锚依赖细胞类型。此外，本发明的富含RGD的明胶可用于医学应用，特别是作为植入物或移植材料上的涂层或药物递送系统的组分。

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