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1. 发明授权

US4784638A Angled hole ventricular catheter and method of making same 失效
标题翻译：角孔心室导管及其制作方法
公开(公告)号：US4784638A
公开(公告)日：1988-11-15
申请号：US98097
申请日：1987-09-17
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
IPC分类号： A61M25/00 , A61M31/00
CPC分类号： A61M25/0015 , A61M25/007
摘要： A catheter for placement into the ventricular system of the brain of a subject comprising a flexible elongated body having a wall thickness sufficient to contain and transport fluid therein and having a forward end and tip for insertion into the ventricular system of the brain of a subject; and a plurality of spaced apertures located in the forward end of the body spaced from the tip, each of the apertures extending through the wall thickness at an angle such that a portion of the wall thickness is visible when viewing the aperture perpendicular to the longitudinal axis of the body, thereby to minimize abrasion of brain tissue upon insertion of the catheter and to prevent choroid plexus and ependymal tissue from growing into the catheter apertures, thereby providing improved flow of fluid into or from said ventricular system. Also, methods of using and apparatus for making such catheters are disclosed herein.
摘要翻译：一种用于放置到受试者的脑的心室系统中的导管，包括具有足以容纳和输送流体的壁厚的柔性细长主体，并且具有用于插入受试者脑部的心室系统的前端和尖端; 以及多个间隔开的孔，位于主体的与尖端间隔开的前端中，每个孔以一定角度延伸穿过壁厚，使得当观察垂直于纵向轴线的孔时壁厚的一部分是可见的从而在插入导管时最小化脑组织的磨损并且防止脉络丛和室管膜组织生长到导管孔中，由此提供流体进入或离开所述心室系统的改善的流动。此外，本文公开了使用方法和制造这种导管的装置。

2. 发明授权

US4998938A Removable skull mounted work platform and method of assembling same 失效
标题翻译：可移动颅骨安装工作平台及其组装方法
公开(公告)号：US4998938A
公开(公告)日：1991-03-12
申请号：US204451
申请日：1988-06-09
申请人： Jamshid B. G. Ghajar , Fathali G. Ghadjar , Robert J. Hariri
发明人： Jamshid B. G. Ghajar , Fathali G. Ghadjar , Robert J. Hariri
IPC分类号： A61B17/34 , A61B19/00
CPC分类号： A61B90/11 , A61B2017/3484 , A61B2017/3492
摘要： A device for facilitating the insertion of an instrument such as a surgical or observational tool into a patient's cranial cavity through a previously formed aperture in the cranium. The device comprises a guide with an open elongated tubular member having a first and a second end, wherein at least a portion of the tubular member at the first and thereof is configured and adapted for passage through the aperture. An outer surface portion of the open tubular member is configured for engagement with a separate locking apparatus for securing the device to the cranial surface. The device further comprises a flanged tip on the first end of the tubular member for stabilizing it within the aperture. An alignment stand configured for the passage therethrough of at least a portion of the device is seated upon the cranium directly above the aperture. The guide is inserted therethrough and into the cranial cavity. Subsequently, an elongated tubular member is inserted into the guide, which spreads the flanged tips therof, thus creating an interference fit between the flanges and the inner surface of the cranium. A locking ring, positioned upon the guide above the alignment stand, is utilized to secure the device against the cranium by screwing the ring in the direction of the stand. A method for assembling the device within a burr hole previously prepared in the patient's cranium is additionally disclosed.
摘要翻译：一种便于将诸如手术或观察工具的器械通过颅骨中先前形成的孔插入患者颅腔中的装置。该装置包括具有开口的细长管状构件的引导件，该构件具有第一和第二端，其中在第一和第二端处的管状构件的至少一部分构造并适于通过孔。开口管状构件的外表面部分构造成用于与单独的锁定装置接合，用于将装置固定到颅面。该装置还包括在管状构件的第一端上的凸缘尖端，用于使其在孔内稳定。配置用于穿过其中至少一部分装置的对准支架直接位于颅骨上方的正上方。引导件插入其中并进入颅腔。随后，将细长的管状构件插入引导件中，该引导件扩大了带凸缘的尖端，从而在凸缘和颅骨的内表面之间形成过盈配合。位于定位架上方的引导件上的锁定环用于通过沿着支架的方向拧紧环来将装置固定在颅骨上。另外公开了一种将装置组装在预先制备在患者头颅中的钻孔内的方法。

3. 发明授权

US4821716A Method and apparatus for perpendicular perforation of the cranium 失效
标题翻译：颅骨垂直穿孔的方法和装置
公开(公告)号：US4821716A
公开(公告)日：1989-04-18
申请号：US93426
申请日：1987-09-04
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
IPC分类号： A61B17/16 , A61B19/00
CPC分类号： A61B17/1695 , A61B90/11
摘要： An apparatus and method for drilling an orifice in a human cranium at an angle of substantially 90.degree. to a plane defined by a tangent to the surface of the cranium at the orifice. The apparatus comprises a first tubular guide for directing a drill at the proper angle, the first guide being supported upon the cranium by a plurality of leg members. The invention further comprises a hand-operated twist drill device, configured for insertion into the tubular guide. A second guide, of reduced diameter relative to the first tubular guide is insertable into the first guide upon completion of the burr hole to facilitate entry of a catheter into the ventricular portion of the patient's brain. The method of the invention comprises positioning the first drill guide upon the patient's cranium, inserting the twist drill therein so as to prepare a burr hole extending at an angle of substantially 90.degree. to a plane tangential to the surface, replacing the drill with a catheter guide insertable within the drill guide and inserting a catheter through the second guide, through the burr hole and into a ventricular portion of the patient's brain.
摘要翻译：一种用于在人类头颅中以与孔口表面的切线限定的平面大致90度的角度钻孔的装置和方法。该装置包括用于以适当角度引导钻头的第一管状引导件，第一引导件由多个腿部构件支撑在颅骨上。本发明还包括一种手动麻花钻装置，其构造成用于插入管状引导件中。相对于第一管状引导件直径减小的第二引导件在毛刺孔完成时可插入到第一引导件中，以便于将导管进入患者大脑的心室部分。本发明的方法包括将第一钻子引导件定位在患者的颅骨上，将麻花钻插入其中，以便制备一个与表面相切的平面以大致90度的角度延伸的钻孔，用导管引导件可插入到钻孔引导器内并将导管穿过第二引导件穿过钻孔并进入患者大脑的心室部分。

4. 发明授权

US4931056A Catheter guide apparatus for perpendicular insertion into a cranium orifice 失效
标题翻译：导管引导装置，用于垂直插入头颅孔
公开(公告)号：US4931056A
公开(公告)日：1990-06-05
申请号：US261063
申请日：1988-10-24
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
IPC分类号： A61B17/16 , A61B19/00
CPC分类号： A61B17/1695 , A61B90/11
摘要： An apparatus and method for drilling an orifice in a human cranium at an angle of substantially 90.degree. to a plane defined by a tangent to the surface of the cranium at the orifice. The apparatus comprises a first tubular guide for directing a drill at the proper angle, the first guide being suppored upon the cranium by a plurality of leg members. The invention further comprises a hand-operated twist drill device, configured for insertion into the tubular guide. A second guide, of reduced diameter relative to the first tubular guide is insertable into the first guide upon completion of the burr hole to facilitate entry of a catheter into the ventricular portion of the patient's brain. The method of the invention comprises positioning the first drill guide upon the patient's cranium, inserting the twist drill therein so as to prepare a burr hole extending at an angle of substantially 90.degree. to a plane tangential to the surface, replacing the drill with a catheter guide insertable within the drill guide and inserting a catheter through the second guide, through the burr hole and into a ventricular portion of the patient's brain.
摘要翻译：一种用于在人类头颅中以与孔口表面的切线限定的平面大致90度的角度钻孔的装置和方法。该装置包括用于以适当角度引导钻头的第一管状引导件，第一引导件由多个腿部构件支撑在颅骨上。本发明还包括一种手动麻花钻装置，其构造成用于插入管状引导件中。相对于第一管状引导件直径减小的第二引导件在毛刺孔完成时可插入到第一引导件中，以便于将导管进入患者大脑的心室部分。本发明的方法包括将第一钻子引导件定位在患者的颅骨上，将麻花钻插入其中，以便制备一个与表面相切的平面以大致90度的角度延伸的钻孔，用导管引导件可插入到钻孔引导器内并将导管穿过第二引导件穿过钻孔并进入患者大脑的心室部分。

5. 发明授权

US5207681A Drill guide apparatus for perpendicular perforation of the cranium 失效
标题翻译：用于颅骨垂直穿孔的钻孔引导装置
公开(公告)号：US5207681A
公开(公告)日：1993-05-04
申请号：US424034
申请日：1989-10-19
申请人： Fathali G. Ghadjar , Jamshid B. G. Ghajar , Robert J. Hariri
发明人： Fathali G. Ghadjar , Jamshid B. G. Ghajar , Robert J. Hariri
IPC分类号： A61B17/16
CPC分类号： A61B17/1695
摘要： An apparatus and method for drilling an orifice in a human cranium at an angle of substantially 90.degree. to a plane defined by a tangent to the surface of the cranium at the orifice. The apparatus comprises a ring structure adapted to guide and support a drill, the ring structure comprising a retaining member configured for engagement with a flexible member such as a spring and a sleeve member configured for insertion within the retaining member and operatively associated therewith to form a support assembly. The support assembly is capable of a restricted degree of vertical, slideable movement within a tubular member. The apparatus further comprises a tubular member, adjacent and external to the ring structure, adapted to guide and support the support assembly; a flexible member adjacent the support assembly for restricting vertical movement thereby within the tube; and support structure, the support structure being adapted to rest unsecured upon the cranium. The method of the invention comprises positioning the drill guide upon the patient's cranium such that the support structure, the tubular member and the support assembly are related to each other and to the cranium so as to guide the drill through the cranium in a direction perpendicular to a plane defined by a tangent to the surface of the cranium at the orifice and drilling through said cranium until the tip of the drill bit passes therethrough and stops rotation rapidly once it has penetrated the surface.
摘要翻译：一种用于在人类头颅中以与孔口表面的切线限定的平面大致90度的角度钻孔的装置和方法。该装置包括适于引导和支撑钻头的环形结构，所述环形结构包括构造成与诸如弹簧的柔性构件接合的保持构件和构造成用于插入保持构件中并与其可操作地相关联的套筒构件，以形成支撑装配。支撑组件能够在管状构件内具有受限度的垂直的，可滑动的运动。该装置还包括与环形结构相邻并在外部的管状构件，其适于引导和支撑支撑组件; 邻近所述支撑组件的柔性构件，用于限制所述管内的垂直运动; 和支撑结构，所述支撑结构适于不安定在所述颅骨上。本发明的方法包括将钻子引导件定位在患者的颅骨上，使得支撑结构，管状构件和支撑组件彼此相关并且与颅骨相关联，以便将钻头沿垂直于颅骨的方向引导颅骨由颅骨表面在孔口处切线定义的平面，并且穿过所述颅骨钻孔直到钻头的尖端通过，并且一旦其穿透表面就迅速停止旋转。

6. 发明授权

US5180387A Angled hole ventricular catheter with non-circular bore 失效
标题翻译：角孔心室导管与非圆孔
公开(公告)号：US5180387A
公开(公告)日：1993-01-19
申请号：US266451
申请日：1988-11-02
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali G. Ghadjar
IPC分类号： A61M25/00
CPC分类号： A61M25/001 , A61M25/0015 , A61M25/007 , A61M2025/0008
摘要： A catheter for placement into the ventricular system of the brain or any other member or cavity of the body of a subject comprising a flexible elongated body having a non-circular bore, a wall thickness sufficient to contain and transport fluid therein, a forward end and tip for insertion into the ventricular system of the brain of a subject, and a plurality of spaced apertures located in the forward end of the body spaced from the tip. The apertures are configured and positioned to minimize abrasion of brain tissue upon insertion of the catheter and to prevent tissue from growing into the catheter apertures, thereby providing improved flow of fluid into or from said ventricular system. The non-circular bore, preferably triangular, provides increased structural integrity and increased effective flow through the catheter compared to those having a circular bore. Also methods of using such catheters are disclosed herein.
摘要翻译：一种用于放置在脑或脑部体内的任何其他构件或空腔的导管，其包括具有非圆形孔的柔性细长体，足以容纳和输送流体的壁厚，前端和用于插入到受试者的脑的心室系统中的尖端以及位于与顶端间隔开的主体的前端中的多个间隔开的孔。孔被构造和定位成最小化插入导管时脑组织的磨损并防止组织生长到导管孔中，由此提供流体进入或离开所述心室系统的改善的流动。与具有圆形孔的那些相比，非圆形孔，优选为三角形，提供增加的结构完整性和增加的通过导管的有效流动。本文还公开了使用这种导管的方法。

7. 发明授权

US4970926A Apparatus for making angled hole ventricular catheter 失效
标题翻译：用于制作斜孔心室导管的装置
公开(公告)号：US4970926A
公开(公告)日：1990-11-20
申请号：US227397
申请日：1988-08-02
申请人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali Ghahremani-Ghadjar
发明人： Jamshid B. G. Ghajar , Robert J. Hariri , Fathali Ghahremani-Ghadjar
IPC分类号： A61M25/00
CPC分类号： A61M25/0015 , A61M25/007 , Y10T83/0596 , Y10T83/7673 , Y10T83/8831 , Y10T83/8857 , Y10T83/889 , Y10T83/944
摘要： An apparatus for making a hollow elongated member having a plurality of apertures therein comprising: a first component for supporting a hollow elongated member in a predetermined position and orientation for formation of a plurality of apertures therein; and a second component for forming a plurality of apertures at a predetermined position and orientation and of a predetermmined dimension thereof in the hollow elongated member; the second component being guidably received within the first component for alignment therewith. Alternatively, the apparatus includes an insert comprising rod means for forming a plurality of apertures of a predetermined size; and means for forming and supporting the hollow bore of the elongated member. The rod means is positioned at a predetermined orientation with respect to the bore forming means so that the hollow elongated member receives a plurality of apertures therein at a predetermined position, orientation and dimension. This embodiment includes a molding assembly comprising means for forming and supporting a hollow elongated member by substantially completely surrounding the member; a plurality of apertures located in the forming means for guidably receiving the rod means therein to properly orient the insert within a forming means; and means for introducing a polymerizable liquid into the molding assembly so as to form the catheter by polymerization of the liquid therein.
摘要翻译：一种用于制造具有多个孔的中空细长构件的装置，包括：用于将中空细长构件支撑在用于在其中形成多个孔的预定位置和取向的第一部件; 以及用于在所述中空细长构件中以预定位置和方向以及预定尺寸形成多个孔的第二部件; 所述第二部件被可引导地接纳在所述第一部件内用于与其对准。或者，该装置包括插入件，其包括用于形成预定尺寸的多个孔的杆装置; 以及用于形成和支撑细长构件的中空孔的装置。杆装置相对于孔形成装置定位在预定取向，使得中空细长构件在预定位置，取向和尺寸处容纳多个孔。该实施例包括一个模制组件，其包括用于通过基本上完全围绕该构件形成和支撑中空细长构件的装置; 位于所述成形装置中的多个孔，用于在其中引导地容纳所述杆装置，以将所述插入件适当地定位在成形装置内; 以及用于将可聚合液体引入到模制组件中以通过其中的液体聚合形成导管的装置。

8. 发明授权

US4875482A Flexible grasping device 失效
标题翻译：柔性抓握装置
公开(公告)号：US4875482A
公开(公告)日：1989-10-24
申请号：US209434
申请日：1988-06-21
申请人： Robert J. Hariri , Jamshid B. G. Ghajar , Fathali Ghahremani-Ghadjar
发明人： Robert J. Hariri , Jamshid B. G. Ghajar , Fathali Ghahremani-Ghadjar
IPC分类号： A61B17/42
CPC分类号： A61B17/42
摘要： A device is disclosed comprising a stretchable cylindrical net-like structure and at least one guide ring for partial placement over a fetus. The cylindrical net-like structure is formed such that as force is applied along its longitudinal axis, the length of the cylindrical structure is increased while the diameter of such cylindrical structure is decreased. The guide ring is expandable for passage therethrough of the fetal head and has an at rest diameter between that of the fetal neck and the fetal head.
摘要翻译：公开了一种装置，其包括可伸缩的圆柱形网状结构和用于部分放置在胎儿上的至少一个引导环。圆柱形网状结构形成为当沿着其纵向轴线施加力时，圆柱形结构的长度增加，而这种圆柱形结构的直径减小。引导环可扩张以通过胎头部，并且具有在胎儿颈部和胎儿头部之间的静止直径。

9. 发明授权

US09149569B2 Treatment of diseases or disorders using placental stem cells 有权
标题翻译：使用胎盘干细胞治疗疾病或病症
公开(公告)号：US09149569B2
公开(公告)日：2015-10-06
申请号：US13108871
申请日：2011-05-16
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： C12N5/071 , A61M1/02 , C12N5/073 , C12N5/0775 , A61K35/12 , A61K48/00
CPC分类号： C12N5/0605 , A01N1/021 , A61K35/12 , A61K35/50 , A61K48/00 , A61K2035/124 , A61M1/02 , A61M2202/0462 , A61M2210/1458 , A61M2210/1466 , C12M29/10 , C12M47/04 , C12N5/0603 , C12N5/0647 , C12N5/0668 , C12N2509/00 , C12N2510/02 , C12N2533/90
摘要： The present invention provides a method of extracting and recovering embryonic-like stem cells, including, but not limited to pluripotent or multipotent stem cells, from an exsanguinated human placenta. A placenta is treated to remove residual umbilical cord blood by perfusing an exsanguinated placenta, preferably with an anticoagulant solution, to flush out residual cells. The residual cells and perfusion liquid from the exsanguinated placenta are collected, and the embryonic-like stem cells are separated from the residual cells and perfusion liquid. The invention also provides a method of utilizing the isolated and perfused placenta as a bioreactor in which to propagate endogenous cells, including, but not limited to, embryonic-like stem cells. The invention also provides methods for propagation of exogenous cells in a placental bioreactor and collecting the propagated exogenous cells and bioactive molecules therefrom.
摘要翻译：本发明提供了从放血的人胎盘中提取和回收胚胎样干细胞（包括但不限于多潜能或多能干细胞）的方法。通过灌注放血的胎盘，优选用抗凝血剂溶液来处理胎盘以除去残留的脐带血，以冲洗残留的细胞。收集来自放血胎盘的残留细胞和灌注液，从残留细胞和灌注液中分离胚胎样干细胞。本发明还提供了利用分离和灌注的胎盘作为其中传播内源性细胞的生物反应器的方法，其包括但不限于胚胎样干细胞。本发明还提供了用于在胎盘生物反应器中繁殖外源细胞并从其收集繁殖的外源细胞和生物活性分子的方法。

10. 发明申请

US20150239949A1 GENETICALLY MODIFIED MICROORGANISMS 审中-公开
标题翻译：遗传修饰微生物
公开(公告)号：US20150239949A1
公开(公告)日：2015-08-27
申请号：US14557415
申请日：2014-12-01
申请人： Robert J. Hariri
发明人： Robert J. Hariri
IPC分类号： C07K14/495 , A23L1/305
CPC分类号： A61K38/1703 , A23L33/14 , A23L33/17 , A23L33/195 , A23V2002/00 , A23V2200/316 , C07K14/4703 , C07K14/495 , C12C2200/05 , A23V2250/546
摘要： Embodiments of the present invention are generally related to genetically modified microorganisms. More specifically, embodiments of the present invention relate to genetically modified microorganisms having the avian follistatin genome engineered therein to create a microorganism strain having the enhanced properties of follistatin. In accordance with one embodiment of the present invention, a method of treating an individual with a muscle degenerative disease comprises administering an effective amount of avian follistatin, wherein the avian follistatin is derived from a genetically modified microorganism.
摘要翻译：本发明的实施方案通常涉及转基因微生物。更具体地，本发明的实施方案涉及在其中改造的禽类卵泡抑素基因组的遗传修饰的微生物，以产生具有增强的卵泡抑素特性的微生物菌株。根据本发明的一个实施方案，治疗患有肌肉退行性疾病的个体的方法包括施用有效量的禽卵泡抑素，其中禽卵泡抑素衍生自遗传修饰的微生物。

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