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1. 发明申请

US20050066588A1 Folding modular structure 失效
公开(公告)号：US20050066588A1
公开(公告)日：2005-03-31
申请号：US10675665
申请日：2003-09-30
申请人： James Stapleton , William Canfield
发明人： James Stapleton , William Canfield
IPC分类号： E04B1/344 , E04H3/00 , E04H5/00 , E04H6/00 , E04H9/00 , E04H14/00
CPC分类号： E04B1/3445
摘要： A folding modular structure is described. The structure typically includes a top panel, which is ultimately the roof deck. Two side panels, a front and a rear panel are connected to the top panel by pivoting mechanisms so that the side, front and rear panels can fold open to create the modular structure. Spacer panels are connected between three of the four total side, front and rear panels. The spacer panels are necessary to provide clearance so that each of the panels can be folded onto the other already folded panels. In the folded configuration, shipping many more modular structures to final destinations is possible.

2. 发明授权

US07917873B1 System and method for verification of integrated circuit design 有权
标题翻译：集成电路设计验证的系统和方法
公开(公告)号：US07917873B1
公开(公告)日：2011-03-29
申请号：US12029683
申请日：2008-02-12
申请人： William Canfield , Khalil Shalish
发明人： William Canfield , Khalil Shalish
IPC分类号： G06F17/50
CPC分类号： G01R31/318314
摘要： Embodiments of the methods and systems of the present invention may provide improved methods for the verification of an integrated circuit where a verification project for an integrated circuit may be created by selecting a set of intent units corresponding to the integrated circuit design from a library of intent units and linking these intent units to the integrated circuit design. Specifically, in one embodiment each of these intent units may comprise a corresponding code component and text component such that from the set of intent units selected and configured based on the integrated circuit design a verification plan can be generated from the text components of the corresponding intent units while a testbench can be generated from the code components of the corresponding intent units. This testbench can then be used to generate a model for testing the integrated circuit design.
摘要翻译：本发明的方法和系统的实施例可以提供用于验证集成电路的改进方法，其中可以通过从意图库中选择与集成电路设计相对应的一组意图单元来创建用于集成电路的验证项目并将这些意图单元与集成电路设计联系起来。具体地，在一个实施例中，这些意图单元中的每一个可以包括对应的代码组件和文本组件，使得从基于集成电路设计选择和配置的意图单元集合可以从相应意图的文本组件生成验证计划单元，同时可以从相应的意图单元的代码组件生成测试平台。然后，该测试台可用于生成用于测试集成电路设计的模型。

3. 发明申请

US20140186326A1 MODIFIED ACID ALPHA GLUCOSIDASE WITH ACCELERATED PROCESSING 审中-公开
标题翻译：具有加速加工的改性酸性阿尔法糖皮质激素
公开(公告)号：US20140186326A1
公开(公告)日：2014-07-03
申请号：US14113360
申请日：2012-04-20
申请人： William Canfield , Mariko Kudo , Rodney Moreland
发明人： William Canfield , Mariko Kudo , Rodney Moreland
IPC分类号： C12N9/26
CPC分类号： C12N9/2408 , A61K38/00 , C07K2319/74 , C12Y302/0102
摘要： A modified human acid alpha-glucosidase polypeptide is provided, as well as methods of making and using modified human acid alpha-glucosidase to treat glycogen storage disorders.
摘要翻译：提供了修饰的人酸性α-葡糖苷酶多肽，以及制备和使用改性的人酸性α-糖苷酶来治疗糖原储存障碍的方法。

4. 发明申请

US20060073498A1 GlcNAc phosphotransferase of the lysosomal targeting pathway 有权
公开(公告)号：US20060073498A1
公开(公告)日：2006-04-06
申请号：US11199233
申请日：2005-08-09
申请人： William Canfield
发明人： William Canfield
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/08 , C07K16/40
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/1223 , C12N9/16 , C12Y301/04045
摘要： The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.

5. 发明授权

US07135322B2 Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase 有权
标题翻译：表达前N-乙酰葡糖胺-1-磷酸二酯α-N-乙酰葡糖苷酶的细胞中溶酶体水解酶的表达
公开(公告)号：US07135322B2
公开(公告)日：2006-11-14
申请号：US10901216
申请日：2004-07-29
申请人： William Canfield , Stuart Kornfeld
发明人： William Canfield , Stuart Kornfeld
IPC分类号： C23N9/14 , C23N9/24
CPC分类号： C12N9/16 , C12N9/2428 , C12P21/005 , C12Y302/01003
摘要： The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiesterαN-acetyl glucosimanidase (phosphodiester α-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.
摘要翻译：本发明提供了在弗林蛋白水解酶缺陷的哺乳动物细胞中制备原N-乙酰氨基葡萄糖-1-磷酸二酯基N-乙酰葡糖胺酶（磷酸二酯α-GlcNAcase）的方法和制备具有N-乙酰葡糖胺-1-磷酸的溶酶体副溶出酶的方法，磷酸盐。

6. 发明授权

US06800472B2 Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester &agr;-N-acetyl glucosimanidase 有权
标题翻译：表达前N-乙酰葡糖胺-1-磷酸二酯α-N-乙酰葡糖苷酶的细胞中溶酶体水解酶的表达
公开(公告)号：US06800472B2
公开(公告)日：2004-10-05
申请号：US10023894
申请日：2001-12-21
申请人： William Canfield , Stuart Kornfeld
发明人： William Canfield , Stuart Kornfeld
IPC分类号： C12N914
CPC分类号： C12N9/16 , C12N9/2428 , C12P21/005 , C12Y302/01003
摘要： The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester &agr; N-acetyl glucosimanidase (phosphodiester &agr;-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal hydrolases having an N-acetylglucosamine-1-phosphate.
摘要翻译：本发明提供了在弗林蛋白水解酶缺陷的哺乳动物细胞中产生前N-乙酰葡糖胺-1-磷酸二酯α-N-乙酰葡糖苷酶（磷酸二酯α-GlcNAcase）的方法和制备具有N-乙酰氨基葡糖苷酶的溶酶体水解酶的方法， 1-磷酸盐。

7. 发明申请

US20050003486A1 Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester alpha-N-acetyl glucosimanidase 有权
标题翻译：表达前N-乙酰葡糖胺-1-磷酸二酯α-N-乙酰葡糖苷酶的细胞中溶酶体水解酶的表达
公开(公告)号：US20050003486A1
公开(公告)日：2005-01-06
申请号：US10901216
申请日：2004-07-29
申请人： William Canfield , Stuart Kornfeld
发明人： William Canfield , Stuart Kornfeld
IPC分类号： C12N9/16 , C12N9/24 , C12P21/00 , C12N9/36 , C07H21/04 , C12N9/14
CPC分类号： C12N9/16 , C12N9/2428 , C12P21/005 , C12Y302/01003
摘要： The present invention provides methods of producing a pro-N-acetylglucosamine-1-phosphodiester α N-acetyl glucosimanidase (phosphodiester α-GlcNAcase), in mammalian cells deficient in the furin proteolytic enzyme and methods of making lysosomal bydrolases having an N-acetylglucosamine-1-phosphate.
摘要翻译：本发明提供了在弗林蛋白水解酶缺陷的哺乳动物细胞中制备前N-乙酰葡糖胺-1-磷酸二酯α-N-乙酰葡糖苷酶（磷酸二酯α-GlcNAcase）的方法和制备具有N-乙酰葡糖胺 - 1-磷酸盐。

8. 发明申请

US20050170449A1 Soluble GlcNAc phosphotransferase 审中-公开
公开(公告)号：US20050170449A1
公开(公告)日：2005-08-04
申请号：US11045114
申请日：2005-01-31
申请人： William Canfield , Mariko Kudo
发明人： William Canfield , Mariko Kudo
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/18 , C12N9/44 , C12N9/78 , C12P21/00 , C12P21/02 , C12P21/06 , C07K14/47 , C12N9/14
CPC分类号： C12N9/12 , A61K38/00 , C12P21/005 , C12P21/02
摘要： The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same.

9. 发明授权

US06905856B2 Soluble GlcNAc phosphotransferase 有权
标题翻译：可溶性GlcNAc磷酸转移酶
公开(公告)号：US06905856B2
公开(公告)日：2005-06-14
申请号：US10023888
申请日：2001-12-21
申请人： William Canfield , Mariko Kudo
发明人： William Canfield , Mariko Kudo
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/16 , C12N9/18 , C12N9/44 , C12N9/78 , C12P21/00 , C12P21/02 , C07H21/04 , C12N9/14 , C12P21/06
CPC分类号： C12N9/12 , A61K38/00 , C12P21/005 , C12P21/02
摘要： The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same.
摘要翻译：本发明涉及一种可溶性GlcNAc磷酸转移酶，其制备方法和使其磷酸化的方法。

10. 发明申请

US20050089869A1 GlcNac phosphotransferase of the lysosomal targeting pathway 有权
标题翻译： GlcNac磷酸转移酶的溶酶体靶向途径
公开(公告)号：US20050089869A1
公开(公告)日：2005-04-28
申请号：US10657280
申请日：2003-09-09
申请人： William Canfield
发明人： William Canfield
IPC分类号： C12N15/09 , A61K38/00 , A61K38/46 , A61P43/00 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/10 , C12N9/12 , C12N9/14 , C12N9/16 , C12N9/24 , C12N9/26 , C12Q1/68 , C07H21/04
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/1223 , C12N9/16 , C12Y301/04045
摘要： The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme.
摘要翻译：本发明提供了溶酶体靶向途径酶GlcNAc-磷酸转移酶的核苷酸和氨基序列，其生产方法和纯化该酶的方法。

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