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    • 5. 发明授权
    • Zeolite compositions
    • 沸石组合物
    • US5252345A
    • 1993-10-12
    • US649417
    • 1991-02-01
    • Patrick C. HuJames S. StatonKarl E. Wiegand
    • Patrick C. HuJames S. StatonKarl E. Wiegand
    • A61K33/06
    • A61K33/06
    • A composition containing a zeolite and an acid suitable for use in increasing bone strength in an animal having a bone strength less than desired and/or for use in treating, preventing or delaying the onset of a bone disorder such as osteoporosis, osteochondrosis, or dyschondroplasia. A preferred zeolite is zeolite A. Preferred acids are illustrated by citric, fumaric and aspartic acids. The presence of such acids in the composition enhances the breakdown (i.e. decomposition) of the zeolite thereby making it more efficacious for increasing bone strength or combating bone disease. Preferably, the compositions contain from about 35 to about 65 weight percent of the acid; the remainder being the zeolite Such compositions can be admixed with other materials such as excipients used in the preparation of unit dosage forms.
    • 含有沸石和酸的组合物,其适用于增加骨骼强度低于所需的动物骨骼强度和/或用于治疗,预防或延迟骨病,如骨质疏松症,骨软骨病或软骨发育不良的发作 。 优选的沸石是沸石A.优选的酸由柠檬酸,富马酸和天冬氨酸说明。 组合物中这种酸的存在增强了沸石的分解(即分解),从而使其更有效地增加骨强度或抵抗骨疾病。 优选地,组合物含有约35至约65重量%的酸; 其余的是沸石。这些组合物可以与其它材料混合,例如用于制备单位剂型的赋形剂。