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    • 5. 发明申请
    • Implantable prosthetic devices containing timed release therapeutic agents
    • 含有定时释放治疗剂的可植入假体装置
    • US20050260247A1
    • 2005-11-24
    • US11135256
    • 2005-05-23
    • James RalphStephen Tatar
    • James RalphStephen Tatar
    • A61K9/22A61M31/00A61F2/00
    • A61L31/16A61K9/0024A61L31/145A61L31/148A61L2300/604A61M31/002
    • Bioabsorbable drug delivery devices including modular drug delivery devices having shapes and sizes adapted to be inserted within a recess on the surface of an implantable prosthesis are disclosed. The devices may be attached to one another to create custom drug delivery devices having controllable drug release characteristics that depend on the composition of individual modules comprising the device. The modules may be cylinders, disks, tiles or tubes comprised of a bioabsorbable polymer and a therapeutic agent. The therapeutic agent(s) may be homogeneously distributed throughout the polymeric body of the device or contained within a cavity within a module comprising the device, or both. The device(s) may be threaded or attached to a prosthesis by a biodegradable adhesive. The modular devices may also be formed into tapered plugs for insertion into a mating receptacle. In another embodiment, the drug delivery device may be inserted within a mesh bag that may be attached to a soft tissue as, for example, by sutures, for localized controlled dispensation of a therapeutic agent.
    • 公开了生物可吸收药物递送装置,其包括具有适于插入在可植入假体的表面上的凹部内的形状和尺寸的模块化药物递送装置。 装置可以彼此附接以产生具有可控药物释放特性的定制药物递送装置,其取决于包括该装置的各个模块的组成。 模块可以是由生物可吸收聚合物和治疗剂组成的圆柱体,盘,瓦或管。 治疗剂可以均匀地分布在整个装置的聚合体中,或者包含在包含该装置的模块或两者中的空腔内。 该装置可以通过可生物降解的粘合剂被螺纹连接到假体上。 模块化装置也可以形成为用于插入配合插座的锥形塞子。 在另一个实施方案中,药物递送装置可以插入网袋中,网袋可以例如通过缝线连接到软组织,用于治疗剂的局部受控分配。