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1. 发明授权

US5665869A Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin 失效
标题翻译：从原卟啉IX含血红蛋白溶液中快速除去原卟啉的方法
公开(公告)号：US5665869A
公开(公告)日：1997-09-09
申请号：US153071
申请日：1993-11-15
申请人： James R. Ryland , Maura-Ann H. Matthews , Ulrich P. Ernst , Daniel E. Houk , David W. Traylor , Lee R. Williams
发明人： James R. Ryland , Maura-Ann H. Matthews , Ulrich P. Ernst , Daniel E. Houk , David W. Traylor , Lee R. Williams
IPC分类号： C12P21/02 , A61K38/16 , A61P7/08 , C07K1/16 , C07K14/805 , C12R1/19 , A23J1/00
CPC分类号： C07K14/805
摘要： The present invention relates to a method for the production of a substantially protoporphyrin IX free hemoglobin solution comprising: rapidly heating a crude protoporphyrin IX-containing hemoglobin solution for a relatively short time and at a relatively high temperature to reduce protoporphyrin IX-containing hemoglobin to insignificant levels in said protoporphyrin IX-containing hemoglobin solution.
摘要翻译：本发明涉及一种生产基本上原卟啉IX游离血红蛋白溶液的方法，包括：将较短的原卟啉Ⅸ的血红蛋白溶液快速加热相对较短的时间并在较高的温度下将原卟啉IX的血红蛋白减少到不显着所述原卟啉IX含血红蛋白溶液中的水平。

2. 发明授权

US5840851A Purification of hemoglobin 失效
标题翻译：血红蛋白的纯化
公开(公告)号：US5840851A
公开(公告)日：1998-11-24
申请号：US438511
申请日：1995-05-10
申请人： J. Jeffrey Plomer , James R. Ryland , Maura-Ann H. Matthews , David W. Traylor , Erin E. Milne , Steven L. Durfee , Antony J. Mathews , Justinian O. Neway
发明人： J. Jeffrey Plomer , James R. Ryland , Maura-Ann H. Matthews , David W. Traylor , Erin E. Milne , Steven L. Durfee , Antony J. Mathews , Justinian O. Neway
IPC分类号： A61K38/00 , C07K14/805 , C07K1/22 , C07K1/18
CPC分类号： C07K14/805 , A61K38/00
摘要： The present invention generally relates to methods for purifying hemoglobin solutions and to hemoglobin solutions obtained by the methods. In one aspect, such methods include removing contaminants in crude hemoglobin-containing lysates with heat treatment. In a further aspect, the present invention provides methods for producing substantially purified hemoglobin solutions using immobilized metal affinity chromatography, optionally following by anion exchange chromatography.
摘要翻译：本发明一般涉及通过该方法获得的血红蛋白溶液和血红蛋白溶液的纯化方法。在一个方面，这些方法包括通过热处理去除含粗血红蛋白的裂解物中的污染物。在另一方面，本发明提供了使用固定化金属亲和层析，任选地通过阴离子交换色谱法生产基本纯化的血红蛋白溶液的方法。

3. 发明申请

US20160096559A1 RETRACTABLE FAIRING FOR REDUCING AERODYNAMIC DRAG AT THE REAR END OF A COMMERICAL MOTOR VEHICLE 有权
标题翻译：商业车辆后端减少航空拖车的可回收公平
公开(公告)号：US20160096559A1
公开(公告)日：2016-04-07
申请号：US14872883
申请日：2015-10-01
申请人： David W. Traylor
发明人： David W. Traylor
IPC分类号： B62D35/00
CPC分类号： B62D35/001 , B62D35/007
摘要： A retractable fairing for reducing aerodynamic drag at a rear end of a commercial motor vehicle (CMV) may comprise a streamlining element having a medial plane and an airflow surface for streamlining air flow. A suspension frame may have an element end for hingedly supporting the streamlining element at approximately the medial plane and may have a trailer end for hingedly mounting the suspension frame to approximately an outer vertical corner of the rear end and may include a trailer hinge allowing the streamlining element to move in a horizontal plane into a folded position adjacent to the rear end. A pair of streamlining elements of complementary shape may be each mounted by a suspension frame to respective left and right halves of the rear end and placed in the folded position, the medial planes of each element facing one another and the streamlining elements collectively forming the retractable fairing.
摘要翻译：用于减小商业机动车辆（CMV）的后端处的气动阻力的可伸缩整流罩可以包括具有中间平面和用于精简空气流的气流表面的精简元件。悬挂框架可以具有用于在大致中间平面处铰接地支撑流线型元件的元件端，并且可以具有用于将悬挂框架铰接地安装到后端的大致外部垂直角部的拖车端，并且可以包括拖车铰链，允许流线型元件在水平平面中移动到与后端相邻的折叠位置。互补形状的一对精简元件可以各自由悬挂框架安装到后端的相应的左半部和右半部并且被放置在折叠位置，每个元件的内侧面彼此相对，并且流线元件共同地形成可缩回整流罩

4. 发明授权

US09688319B2 Retractable fairing for reducing aerodynamic drag at the rear end of a commerical motor vehicle 有权
公开(公告)号：US09688319B2
公开(公告)日：2017-06-27
申请号：US14872883
申请日：2015-10-01
申请人： David W. Traylor
发明人： David W. Traylor
IPC分类号： B62D35/00
CPC分类号： B62D35/001 , B62D35/007
摘要： A retractable fairing for reducing aerodynamic drag at a rear end of a commercial motor vehicle (CMV) may comprise a streamlining element having a medial plane and an airflow surface for streamlining air flow. A suspension frame may have an element end for hingedly supporting the streamlining element at approximately the medial plane and may have a trailer end for hingedly mounting the suspension frame to approximately an outer vertical corner of the rear end and may include a trailer hinge allowing the streamlining element to move in a horizontal plane into a folded position adjacent to the rear end. A pair of streamlining elements of complementary shape may be each mounted by a suspension frame to respective left and right halves of the rear end and placed in the folded position, the medial planes of each element facing one another and the streamlining elements collectively forming the retractable fairing.

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