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1. 发明授权

US5607925A Treatment of carcinoma by administration of 2'-halomethylidenyl-2'-deoxynucleosides 失效
标题翻译：通过给予2'-卤代亚甲基-2'-脱氧核苷治疗癌症
公开(公告)号：US5607925A
公开(公告)日：1997-03-04
申请号：US333017
申请日：1994-11-01
申请人： Donald P. Matthews , Alan J. Bitonti , Michael L. Edwards , James R. McCarthy
发明人： Donald P. Matthews , Alan J. Bitonti , Michael L. Edwards , James R. McCarthy
IPC分类号： C07H19/06 , C07H19/16 , A61K31/70
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

2. 发明授权

US5616702A 2-'-ethenylidene cytidine, uridine and guanosine derivatives 失效
标题翻译： 2-乙烯基胞苷，尿苷和鸟苷衍生物
公开(公告)号：US5616702A
公开(公告)日：1997-04-01
申请号：US362366
申请日：1994-12-22
申请人： Michael L. Edwards , Donald P. Matthews , James R. McCarthy
发明人： Michael L. Edwards , Donald P. Matthews , James R. McCarthy
IPC分类号： C07H19/06 , C07H19/073 , C07H19/16 , C07H19/173 , C07H19/73
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

3. 发明授权

US5378693A 2'-halomethylidene cytidine, uridine and guanosine compounds and their pharmaceutical compositions 失效
标题翻译： 2'-卤代亚甲基胞苷，尿苷和鸟苷化合物及其药物组合物
公开(公告)号：US5378693A
公开(公告)日：1995-01-03
申请号：US113505
申请日：1993-08-27
申请人： James R. McCarthy , Michael L. Edwards , Donald P. Matthews
发明人： James R. McCarthy , Michael L. Edwards , Donald P. Matthews
IPC分类号： A61K31/513 , A61K31/519 , A61K31/522 , A61K31/7072 , A61K31/7076 , C07D473/04 , C07D473/18 , C07D487/02 , C07H19/06 , C07H19/16 , C07H19/073 , C07H19/173
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

4. 发明授权

US5977325A 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives 失效
标题翻译： 2'-亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物
公开(公告)号：US5977325A
公开(公告)日：1999-11-02
申请号：US89839
申请日：1998-06-03
申请人： James R. McCarthy , Michael L. Edwards , Donald P. Matthews
发明人： James R. McCarthy , Michael L. Edwards , Donald P. Matthews
IPC分类号： C07H19/06 , C07H19/073 , C07H19/16 , C07H19/173
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

5. 发明授权

US5792841A 2'-halomethylidene, 2'-ethenylidene and 2'-ethynl cytidine, uridine and guanosine derivatives 失效
标题翻译： 2'-亚甲基亚甲基，2'-亚乙基和2'-炔炔基胞苷，尿苷和鸟苷衍生物
公开(公告)号：US5792841A
公开(公告)日：1998-08-11
申请号：US744652
申请日：1996-11-06
申请人： Michael L. Edwards , Donald P. Matthews
发明人： Michael L. Edwards , Donald P. Matthews
IPC分类号： C07H19/06 , C07H19/073 , C07H19/16 , C07H19/173 , C07D473/30 , C07D239/47 , C07D239/52 , C07D473/40
CPC分类号： C07H19/06 , C07H19/16
摘要： This invention relates to certain novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives, and compositions thereof, which are useful in the treatment of patients afflicted with neoplastic or viral disease states.
摘要翻译：本发明涉及某些新的2'-卤代亚甲基，2'-亚乙基和2'-乙炔基胞苷，尿苷和鸟苷衍生物及其组合物，其可用于治疗患有肿瘤或病毒疾病状态的患者。

6. 发明授权

US5011859A Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase 失效
标题翻译：角鲨烯的二氟和四氟类似物作为角鲨烯环氧酶的抑制剂
公开(公告)号：US5011859A
公开(公告)日：1991-04-30
申请号：US502203
申请日：1990-03-30
申请人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
发明人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
IPC分类号： A61K31/035 , A61K31/045 , A61P3/06 , A61P9/10 , A61P43/00 , C07C21/215 , C07C33/42
CPC分类号： C07C21/215
摘要： This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.

7. 发明授权

US4996308A Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group 失效
标题翻译：具有5'-羟甲基不饱和取代基的衍生物
公开(公告)号：US4996308A
公开(公告)日：1991-02-26
申请号：US173782
申请日：1988-03-25
申请人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
发明人： Michael L. Edwards , James R. McCarthy , Nellikunja J. Prakash
IPC分类号： A61K31/505 , A61K31/52 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7076 , A61P35/00 , C07D473/00 , C07D473/16 , C07D473/34 , C07D473/40 , C07D487/04 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
CPC分类号： C07D473/00 , C07H19/04 , C07H19/052 , C07H19/056 , C07H19/06 , C07H19/16
摘要： This invention relates to certain acetylenic, cyano and allenic aristeromycin/adenosine derivatives which are useful in inhibiting AdoMet-dependent transmethylation and in the treatment of patients afflicted with neoplastic or viral disease states.

8. 发明授权

US5157166A Process for the preparation of di-fluro analogs of squalene 失效
标题翻译：制备角鲨烯二氟类似物的方法
公开(公告)号：US5157166A
公开(公告)日：1992-10-20
申请号：US844356
申请日：1992-03-02
申请人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
发明人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
IPC分类号： C07C21/215
CPC分类号： C07C21/215
摘要： This invention relates to a process for making di-fluoro analogs of squalene.
摘要翻译：本发明涉及一种制备角鲨烯的二氟类似物的方法。

9. 发明授权

US5064864A Di- and tetra-fluoro analogs of squalene as inhibitors of squalene epoxidase 失效
标题翻译：角鲨烯的二氟和四氟类似物作为角鲨烯环氧酶的抑制剂
公开(公告)号：US5064864A
公开(公告)日：1991-11-12
申请号：US626507
申请日：1990-12-12
申请人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
发明人： Esa T. Jarvi , Michael L. Edwards , James R. McCarthy
IPC分类号： C07C21/215
CPC分类号： C07C21/215
摘要： This invention relates to certain novel di- and tetra-fluoro analogs of squalene and to their methods of use in lowering plasma cholesterol and in inhibiting squalene epoxidase in patients in need thereof.
摘要翻译：本发明涉及角鲨烯的某些新颖的二 - 和四 - 氟类似物及其在降低血浆胆固醇和抑制需要的患者中角鲨烯环氧酶的用途。

10. 发明申请

US20130024336A1 Systems and Methods for Providing Controls for Aggregated Weather-Based Work 有权
标题翻译：提供总体天气工作控制系统和方法
公开(公告)号：US20130024336A1
公开(公告)日：2013-01-24
申请号：US13187364
申请日：2011-07-20
申请人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
发明人： Raymond P. Jones, JR. , Gregory G. Gonzales , Michael L. Edwards , Douglas S., II Haymore
IPC分类号： G06Q10/00 , G06F17/00
CPC分类号： G06Q30/0202 , G06Q30/06 , G06Q50/188
摘要： Systems, methods, non-transitory computer-readable media storing computer program instructions for causing a computer device to implement methods, and the like utilize weather information from one or a variety of locations to estimate costs for providing weather-dependent work, and to provide financial controls for weather-dependent work allegedly performed. One method includes utilizing historical weather information relating to performance of weather-dependent work at a work location to generate an estimate of an anticipated frequency with which weather-dependent work will be necessary, utilizing information to estimate an anticipated cost per incident for performing weather-dependent work at the selected work location, and using such information at a plurality of locations to generate an aggregate bid for performing weather-dependent work at the locations. Weather information is also used to audit weather-dependent work allegedly performed at the work locations to provide financial controls to the aggregated weather-dependent work in compliance with law and regulation.
摘要翻译：存储用于使计算机设备实现方法的计算机程序指令的系统，方法，非暂时计算机可读介质等利用来自一个或多个位置的天气信息来估计用于提供与天气有关的工作的成本，并提供涉及天气依赖的工作的财务控制。一种方法包括利用与在工作场所执行天气依赖性工作相关的历史天气信息来产生对于天气依赖性工作将是必要的预期频率的估计，利用信息来估计每个事件的预期成本，并且在多个位置处使用这些信息来生成用于在该位置执行与天气有关的工作的总出价。天气信息也用于审计据称在工作地点执行的天气依赖工作，以便根据法律和法规为天气依赖的工作提供财务控制。

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