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1. 发明授权

US5515847A Self-emission noninvasive infrared spectrophotometer 失效
标题翻译：自发式无创红外分光光度计
公开(公告)号：US5515847A
公开(公告)日：1996-05-14
申请号：US247311
申请日：1994-05-23
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Bernhard B. Sterling
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Bernhard B. Sterling
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1455 , G01N21/35
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/6826 , G01N21/35 , G01N21/3581
摘要： A method and apparatus for monitoring glucose, ethyl alcohol and other blood constituents in a noninvasive manner. The measurements are made by monitoring infrared absorption of the desired blood constituent in the long infrared wavelength range where the blood constituent has a strong and distinguishable absorption spectrum. The long wavelength infrared energy emitted by the person as heat is monitored and the infrared absorption of particular constituents in the blood (such as glucose or blood alcohol) is measured at characteristic infrared absorption wavelengths for those constituents. The measurements are preferably synchronized with systole and diastole of the cardiac cycle so that the signal contribution caused by veins and tissues (which do not pulse) may be cancelled when a ratio of the detected signals is taken. The concentration of the blood constituents are then determined in accordance with a polynomial equation.
摘要翻译：一种以非侵入性方式监测葡萄糖，乙醇和其他血液成分的方法和装置。通过监测血液成分具有强烈且可区分的吸收光谱的长红外波长范围内的所需血液成分的红外吸收来进行测量。监测由人发射的长波长红外能量作为热，并且对于那些成分在特征红外吸收波长处测量血液中特定成分（如葡萄糖或血液酒精）的红外吸收。所述测量优选与心动周期的收缩和心律舒张同步，使得当检测到的信号的比率被采取时，可以消除由静脉和组织引起的信号贡献（其不脉冲）。然后根据多项式方程确定血液成分的浓度。

2. 发明授权

US06095986A Disposable anti-fog airway adapter 失效
标题翻译：一次性防雾气道适配器
公开(公告)号：US06095986A
公开(公告)日：2000-08-01
申请号：US123232
申请日：1998-07-28
申请人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
发明人： James R. Braig , Daniel S. Goldberger , Roger O. Herrera , Mark L. Yelderman
IPC分类号： A61B5/097 , A61B5/08
CPC分类号： A61B5/097
摘要： A disposable anti-fog airway adapter for use with a mainstream respiratory gas analyzer which provides a measurement of a patient's inhaled and exhaled gases. The airway adapter includes windows that are constructed of a thin, low heat capacity plastic that rapidly equilibrates to the temperature of the warm moist gases in the patient breathing circuit. In addition, the inside of the windows is also coated with an anti-fog surfactant either by laminating an anti-fog film with the window plastic prior to attaching the window to the airway adapter body or by first attaching the window to the airway adapter body and then applying the surfactant to the airway adapter after the window film is bonded in place so that the surfactant coats the entire inside of the adapter. The surfactant functions to increase the critical wetting tension of the surface it covers so that water on the window spreads into a uniform thin layer which does not absorb very much infrared energy and thus does not significantly reduce the signal strength. "Instant on" operation is accomplished because no heater and the like is necessary to warm up the windows to maintain them at an elevated temperature to prevent fogging. Numerous techniques are also provided for adhering the windows to the airway adapter body so that a substantially airtight seal may be obtained.
摘要翻译：用于主流呼吸气体分析仪的一次性防雾气道适配器，其提供对患者的吸入和呼出气体的测量。气道适配器包括由能够快速平衡到患者呼吸回路中的温湿润气体的温度的薄的低热容塑料构成的窗户。此外，窗户的内部还通过在将窗口附接到气道适配器主体之前层叠防雾膜与窗户塑料，或者通过首先将窗口附接到气道适配器本体上来涂覆防雾表面活性剂然后在将窗膜粘合就位后将表面活性剂施用于气道适配器，使得表面活性剂涂覆在适配器的整个内部。表面活性剂用于增加其覆盖的表面的临界润湿张力，使得窗户上的水扩散到不吸收非常多的红外能量的均匀薄层，因此不显着降低信号强度。实现“即时打开”操作，因为不需要加热器等来预热窗户以将其保持在高温以防止起雾。还提供了许多技术用于将窗口粘附到气道适配器主体，使得可以获得基本上气密的密封。

3. 发明授权

US5296706A Shutterless mainstream discriminating anesthetic agent analyzer 失效
标题翻译：快门主流鉴别麻醉剂分析仪
公开(公告)号：US5296706A
公开(公告)日：1994-03-22
申请号：US985793
申请日：1992-12-02
申请人： James R. Braig , Daniel S. Goldberger , Mark L. Yelderman , Roger O. Herrera
发明人： James R. Braig , Daniel S. Goldberger , Mark L. Yelderman , Roger O. Herrera
IPC分类号： G01J5/06 , G01J5/12 , G01N21/31 , G01N21/35 , G01J5/2
CPC分类号： G01N21/3581 , G01N21/3504 , G01J2005/066 , G01J5/12 , G01N2021/3129 , G01N2021/3166
摘要： An anesthetic agent analyzer having six or more independent analytical channels, where each channel comprises a first thermopile which receives incident infrared radiation and a second thermopile behind the first thermopile which is blocked from the incident infrared radiation and thus serves as a reference for detecting ambient temperature variations. The first and second thermopiles are connected in a "parallel opposed" fashion so that the effects of ambient temperature variations automatically cancel and the detectors may be readily configured in a detector package. The anesthetic agent analyzer of the invention is designed for use with a wideband infrared radiation source so that anesthetic agents having characteristic absorption bands in the far infrared wavelength range (6-15 microns) may be more readily detected and discriminated. When implemented in a mainstream configuration, a disposable airway adapter with windows formed of polypropylene or some other suitable window material which minimally attenuates the infrared energy at the wavelengths of interest is also used. The concentrations of the discriminated anesthetic agent gases are then calculated using a second order polynomial equation having cross product terms. By connecting the first and second thermopiles in a back to back configuration, the detector device of the invention permits twice as many independent analytical channels to be provided in the same substrate area, with the resultant reduction in ambient temperature gradients.
摘要翻译：具有六个或更多个独立分析通道的麻醉剂分析器，其中每个通道包括接收入射的红外辐射的第一热电堆和第一热电堆后面的第二热电堆，其被阻挡入射的红外辐射，因此用作检测环境温度的参考变化。第一和第二热电堆以“平行相对”的方式连接，使得环境温度变化的影响自动消除，并且检测器可以容易地配置在检测器封装中。本发明的麻醉剂分析仪被设计用于宽带红外辐射源，从而可以更容易地检测和鉴别具有远红外波长范围（6-15微米）特征吸收带的麻醉剂。当以主流配置实施时，还使用具有由聚丙烯形成的窗口的一次性气道适配器或一些其它合适的窗口材料，其最小程度地衰减感兴趣的波长处的红外能量。然后使用具有交叉乘积项的二阶多项式方程来计算鉴别的麻醉剂气体的浓度。通过以背靠背的形式连接第一和第二热电堆，本发明的检测器装置允许在同一衬底区域中提供两倍的独立分析通道，从而降低环境温度梯度。

4. 发明授权

US06959211B2 Device for capturing thermal spectra from tissue 失效
标题翻译：用于从组织中捕获热谱的装置
公开(公告)号：US06959211B2
公开(公告)日：2005-10-25
申请号：US10213730
申请日：2002-08-06
申请人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
发明人： Peter Rule , James R. Braig , Daniel S. Goldberger , Julian M. Cortella , Heidi M. Smith , Roger O. Herrera , Kenneth G. Witte , Philip C. Hartstein , Mark D. Agostino
IPC分类号： A61B5/00 , G01N21/01 , G01N21/03 , G01N21/35
CPC分类号： A61B5/01 , A61B5/061 , A61B5/14532 , A61B5/6824 , G01J3/0286 , G01J3/0291 , G01N21/01 , G01N21/35 , G01N2021/0389 , G01N2201/021 , G01N2201/0245
摘要： A device and method are provided for use with a noninvasive optical measurement system, such as a thermal gradient spectrometer, for improved determination of analyte concentrations within living tissue. In one embodiment, a wearable window is secured to a patient's forearm thereby isolating a measurement site on the patient's skin for determination of blood glucose levels. The wearable window effectively replaces a window of the spectrometer, and thus forms an interface between the patient's skin and a thermal mass window of the spectrometer. When the spectrometer must be temporarily removed from the patient's skin, such as to allow the patient mobility, the wearable window is left secured to the forearm so as to maintain a consistent measurement site on the skin. When the spectrometer is later reattached to the patient, the wearable window will again form an interface between the spectrometer and the same location of skin as before.
摘要翻译：提供了一种用于无创光学测量系统（例如热梯度光谱仪）的装置和方法，用于改善活体组织内分析物浓度的测定。在一个实施例中，可佩戴的窗户被固定到患者的前臂，从而隔离患者皮肤上的测量部位以确定血糖水平。穿戴式窗户有效地代替了光谱仪的窗口，从而形成了患者皮肤与光谱仪的热质量窗口之间的界面。当光谱仪必须临时从患者皮肤上移除时，例如允许患者移动，则将可佩戴的窗口固定在前臂上，以便在皮肤上保持一致的测量部位。当光谱仪后来重新连接到患者身上时，穿戴式窗户将再次形成光谱仪与以前相同的皮肤位置之间的界面。

5. 发明授权

US5247185A Regulated infrared source 失效
标题翻译：调节红外源
公开(公告)号：US5247185A
公开(公告)日：1993-09-21
申请号：US782990
申请日：1991-10-28
申请人： Roger O. Herrera , James R. Braig , Daniel S. Goldberger
发明人： Roger O. Herrera , James R. Braig , Daniel S. Goldberger
IPC分类号： G01J5/02 , G01J3/10 , G01J5/00 , G01N21/01 , G01N21/35 , G05D23/24 , H05B3/46
CPC分类号： G05D23/24 , G01J3/108 , H05B3/46 , G01N21/3504 , G01N2201/069
摘要： An infrared source which provides a miniature, highly stable and efficient source of infrared energy for use with infrared detectors and the like. The infrared source of the invention incorporates a platinum resistance temperature detector (RTD) which is integrated with the heater element to provide a means of electronic servo control of the heater temperature. The heater element and the RTD are tightly coupled thermally to provide accurate, continuous tracking and control of the heater temperature. The infrared source design provides excellent infrared energy output with less than one watt input power to the heater.
摘要翻译：提供用于红外探测器等的微型，高度稳定和高效的红外能量源的红外源。本发明的红外光源包括与加热器元件集成的铂电阻温度检测器（RTD），以提供加热器温度的电子伺服控制装置。加热器元件和RTD紧密耦合，以提供对加热器温度的精确，连续的跟踪和控制。红外源设计为加热器提供了不到一瓦特输入功率的出色的红外能量输出。

6. 发明授权

US07593108B2 Method of determining analyte concentration in a sample using infrared transmission data 有权
标题翻译：使用红外线传输数据确定样品中分析物浓度的方法
公开(公告)号：US07593108B2
公开(公告)日：2009-09-22
申请号：US11841878
申请日：2007-08-20
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philip C. Hartstein , Robert D. Gaffney
IPC分类号： G01N33/48 , G01N21/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

7. 发明授权

US06580934B1 Method and apparatus for determining analyte concentration using phase and magnitude detection of a radiation transfer function 失效
标题翻译：使用辐射传递函数的相位和幅度检测来确定分析物浓度的方法和装置
公开(公告)号：US06580934B1
公开(公告)日：2003-06-17
申请号：US09538164
申请日：2000-03-30
申请人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trembino , Richard A. King , Casper W. Barnes
发明人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trembino , Richard A. King , Casper W. Barnes
IPC分类号： A61B500
CPC分类号： A61B5/0059 , G01N21/35
摘要： A method and apparatus of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. The modulation of the temperature gradient is controlled by a surface temperature modulation. A transfer function is determined that relates the surface temperature modulation to the modulation of the measured infrared radiation. Reference and analytical signals are detected. In the presence of the selected analyte, phase and magnitude differences in the transfer function are detected. These phase and magnitude differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample.
摘要翻译：描述了测定试样的分析物浓度的方法和装置。在测试样品中引入温度梯度，红外辐射检测器测量所选分析物的吸收峰和参考波长的辐射。温度梯度的调制由表面温度调制控制。确定将表面温度调制与所测量的红外辐射的调制相关联的传递函数。检测参考和分析信号。在所选分析物的存在下，检测到传递函数中的相位和幅度差异。测量，相关和处理与分析物浓度关系的这些相位和幅度差异，以确定测试样品中的分析物浓度。

8. 发明授权

US6161028A Method for determining analyte concentration using periodic temperature modulation and phase detection 失效
公开(公告)号：US6161028A
公开(公告)日：2000-12-12
申请号：US267121
申请日：1999-03-10
申请人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trebino , Richard A. King , Casper W. Barnes
发明人： James R. Braig , Charles E. Kramer , Bernhard B. Sterling , Daniel S. Goldberger , Peng Zheng , Arthur M. Shulenberger , Rick Trebino , Richard A. King , Casper W. Barnes
IPC分类号： A61B5/00 , G01N21/35
CPC分类号： A61B5/0059 , G01N21/35
摘要： A method of determining the analyte concentration of a test sample is described. A temperature gradient is introduced in the test sample and infrared radiation detectors measure radiation at selected analyte absorbance peak and reference wavelengths. Reference and analytical signals are detected. In the presence of the selected analyte, parameter differences between reference and analytical signals are detectable. These parameter differences, having a relationship to analyte concentration, are measured, correlated, and processed to determine analyte concentration in the test sample. Accuracy is enhanced by inducing a periodically modulated temperature gradient in the test sample. The analytical and reference signals may be measured continuously and the parameter difference integrated over the measurement period to determine analyte concentration.

9. 发明申请

US20080212071A1 METHOD OF DETERMINING ANALYTE CONCENTRATION IN A SAMPLE USING INFRARED TRANSMISSION DATA 有权
标题翻译：使用红外传输数据确定样品中分析物浓度的方法
公开(公告)号：US20080212071A1
公开(公告)日：2008-09-04
申请号：US11841878
申请日：2007-08-20
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philp C. Hartstein , Robert D. Gaffney
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Philp C. Hartstein , Robert D. Gaffney
IPC分类号： G01N21/00
CPC分类号： A61B5/14546 , A61B5/14532 , G01N21/03 , G01N21/314 , G01N21/35
摘要： A method determines an analyte concentration in a sample. The sample includes the analyte and a substance. The method includes providing absorption data of the sample. The method further includes providing reference absorption data of the substance. The method further includes calculating a substance contribution of the absorption data. The method further includes subtracting the substance contribution from the absorption data, thereby providing corrected absorption data substantially free of a contribution from the substance.
摘要翻译：一种方法确定样品中的分析物浓度。样品包括分析物和物质。该方法包括提供样品的吸收数据。该方法还包括提供该物质的参考吸收数据。该方法还包括计算吸收数据的物质贡献。该方法还包括从吸收数据中减去物质贡献，由此提供基本上不含该物质贡献的校正吸收数据。

10. 发明授权

US07096124B2 Method of determining an analyte concentration in a sample from an absorption spectrum 失效
标题翻译：从吸收光谱确定样品中分析物浓度的方法
公开(公告)号：US07096124B2
公开(公告)日：2006-08-22
申请号：US11062110
申请日：2005-02-18
申请人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
发明人： Bernhard B. Sterling , James R. Braig , Daniel S. Goldberger , Kenneth G. Witte
IPC分类号： G06F19/00
CPC分类号： A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B2562/0295 , G01N21/274 , G01N21/314 , G01N21/35 , G01N27/3271
摘要： A method determines an analyte concentration in a sample including the analyte and a substance. The method includes providing an absorption spectrum of the sample. The absorption spectrum has an absorption baseline. The method further includes shifting the absorption spectrum so that the absorption baseline approximately equals a selected absorption value in a selected absorption wavelength range. The method further includes subtracting a substance contribution from the absorption spectrum. Thus, the method provides a corrected absorption spectrum substantially free of a contribution from the substance.
摘要翻译：一种方法确定包含分析物和物质的样品中的分析物浓度。该方法包括提供样品的吸收光谱。吸收光谱具有吸收基线。该方法还包括移动吸收光谱，使得吸收基线大约等于所选吸收波长范围内的选定吸收值。该方法还包括从吸收光谱中减去物质贡献。因此，该方法提供基本上不含该物质的贡献的校正吸收光谱。

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