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1. 发明授权

US08889635B2 Dendrimer conjugates 有权
标题翻译：树枝状结合物
公开(公告)号：US08889635B2
公开(公告)日：2014-11-18
申请号：US12570977
申请日：2009-09-30
申请人： James R. Baker, Jr. , Xue-min Cheng , Abraham F. L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
发明人： James R. Baker, Jr. , Xue-min Cheng , Abraham F. L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
IPC分类号： A61K31/5513 , A61K31/485 , A61K31/5377 , C07D489/02 , A61K47/48
CPC分类号： A61K47/483 , A61K31/485 , A61K47/595
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

2. 发明申请

US20120277376A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20120277376A1
公开(公告)日：2012-11-01
申请号：US13547929
申请日：2012-07-12
申请人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： C08G69/48
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

3. 发明申请

US20100160299A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20100160299A1
公开(公告)日：2010-06-24
申请号：US12570977
申请日：2009-09-30
申请人： James R. Baker, JR. , Xue-min Cheng , Abraham F.L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
发明人： James R. Baker, JR. , Xue-min Cheng , Abraham F.L. Van Der Spek , Baohua Mark Huang , Thommey P. Thomas
IPC分类号： A61K31/5513 , C07D489/02 , A61K31/485 , C07D243/24 , C07D413/06 , A61K31/5377
CPC分类号： A61K47/483 , A61K31/485 , A61K47/595
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

4. 发明授权

US08445528B2 Dendrimer conjugates 有权
公开(公告)号：US08445528B2
公开(公告)日：2013-05-21
申请号：US13547929
申请日：2012-07-12
申请人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： A61K31/403 , A61K31/485 , C07D209/12 , C07D471/04
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.

5. 发明授权

US08252834B2 Dendrimer conjugates 有权
标题翻译：树枝状结合物
公开(公告)号：US08252834B2
公开(公告)日：2012-08-28
申请号：US12403179
申请日：2009-03-12
申请人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, Jr. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： A61K31/403 , A61K31/485 , C07D209/12 , C07D471/04
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

6. 发明申请

US20090287005A1 DENDRIMER CONJUGATES 有权
标题翻译： DENDRIMER联合
公开(公告)号：US20090287005A1
公开(公告)日：2009-11-19
申请号：US12403179
申请日：2009-03-12
申请人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
发明人： James R. Baker, JR. , Xue-min Cheng , Thommey P. Thomas , Baohua Mark Huang
IPC分类号： C07D305/08
CPC分类号： C07D305/08
摘要： The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
摘要翻译：本发明涉及新的治疗和诊断树枝状大分子。特别地，本发明涉及树枝状大分子 - 连接体缀合物，其合成方法，包含缀合物的组合物，以及利用缀合物的系统和方法（例如，在诊断和/或治疗设置（例如，用于递送治疗，成像和/或靶向剂（例如，在疾病（例如癌症）诊断和/或治疗，疼痛治疗等中））。因此，本发明的树枝状大分子 - 接头缀合物还可包含一种或多种用于靶向，成像，感测和/或提供治疗或诊断材料和/或监测治疗反应的组分。

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