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1. 发明授权

US07332125B2 System and method for processing blood 失效
标题翻译：血液处理系统及方法
公开(公告)号：US07332125B2
公开(公告)日：2008-02-19
申请号：US10462373
申请日：2003-06-16
申请人： James P. Cianci , Thomas D. Headley , Edward T. Powers
发明人： James P. Cianci , Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/00 , A61M37/00
CPC分类号： B04B5/0428 , A61M1/0009 , A61M1/0011 , A61M1/0218 , A61M1/3633 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M5/1483 , A61M2205/331 , B04B5/0442
摘要： A system for filtering and processing blood that is simple to implement and that reduces the need for human intervention. The system may be used to collect red blood cells (RBCs). For such a system, a disposable set may be provided with an inlet port, an RBC container, a centrifuge rotor having a variable total volume, and a filter, along with tubing connecting the port, the container, the rotor and the filter. The filter is located in tubing between the inlet port and the rotor. A control unit is also provided and includes a spinner in which the rotor may be held, a flow-control arrangement for controlling flow among the various components of the disposable set, and an electronic controller. The whole blood is directed by the flow-control arrangement from the inlet through the filter to the rotor. The rotor includes an elastic diaphragm, and the control unit's flow-control arrangement includes a pump or other device for applying a positive and negative pressure to the rotor's elastic diaphragm. The spinner rotates the rotor so as to separate the whole blood into plasma and RBCs. Preferably, the plasma is urged out of the rotor first and returned to the donor, while the rotor is still being spun. After the plasma has been removed from the rotor, the RBCs are urged from the rotor to an RBC container. In preferred embodiments, the filter is a white blood cell filter, so that white blood cells are filtered from the blood before it reaches the rotor.
摘要翻译：用于过滤和处理血液的系统，其易于实施并且减少对人类干预的需要。该系统可用于收集红细胞（RBC）。对于这种系统，一次性组件可以设置有连接端口，容器，转子和过滤器的管道的入口端口，RBC容器，具有可变总体积的离心机转子和过滤器。过滤器位于入口和转子之间的管道中。还提供了控制单元，并且包括可以保持转子的旋转器，用于控制一次性组件的各个部件之间的流动的流量控制装置和电子控制器。整个血液由流量控制装置从入口通过过滤器引导到转子。转子包括弹性隔膜，并且控制单元的流量控制装置包括用于向转子的弹性隔膜施加正负压的泵或其它装置。旋转器旋转转子，以将全血分离成血浆和红细胞。优选地，当转子仍在旋转时，等离子体首先被推出转子并返回到供体。等离子体从转子中取出后，将RBC从转子推到RBC容器。在优选实施例中，过滤器是白细胞过滤器，使得在血液到达转子之前将白细胞从血液中过滤。

2. 发明授权

US6074335A Rotor with elastic diaphragm defining a liquid separating chamber of varying volume 失效
公开(公告)号：US6074335A
公开(公告)日：2000-06-13
申请号：US800087
申请日：1997-02-12
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M5/148 , B04B5/04 , B04B11/00
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate, located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes, wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves in the boundary wall may be used as the outlet-control structure.

3. 发明授权

US6099491A Fluid separation system 失效
标题翻译：流体分离系统
公开(公告)号：US6099491A
公开(公告)日：2000-08-08
申请号：US843218
申请日：1997-04-14
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M5/148 , B04B5/04 , A61M37/00 , B01D37/00 , B04B11/00 , B04B15/00
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system for separating a fluid having heavier and lighter components. The system includes a rotor having a rigid mounting member and an elastic diaphragm attached to the mounting member, the diaphragm defining a chamber. The system also includes a chuck for holding the rigid mounting member of the rotor and for spinning the rotor around an axis. The pressure of a control fluid, preferably a control gas, disposed adjacent the rotor's diaphragm is varied in order to control the volume of the rotor. Pressurizing the control gas causes fluid to flow out of the rotor; applying a vacuum to the diaphragm draws fluid into the rotor.
摘要翻译：用于分离具有较重和较轻组分的流体的系统。该系统包括具有刚性安装构件和附接到安装构件的弹性膜片的转子，隔膜限定室。该系统还包括用于保持转子的刚性安装构件并用于围绕轴线旋转转子的卡盘。改变设置在转子隔膜附近的控制流体（优选控制气体）的压力，以便控制转子的体积。加压控制气体导致流体流出转子; 向隔膜施加真空将流体吸入转子。

4. 发明授权

US06039711A System for liquid separation 有权
标题翻译：液体分离系统
公开(公告)号：US06039711A
公开(公告)日：2000-03-21
申请号：US197066
申请日：1998-11-20
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M5/148 , B04B5/04 , A61M37/00 , B04B11/00
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate, located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes, wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves in the boundary wall may be used as the outlet-control structure.
摘要翻译：用于在一定体积范围内收集和离心生物流体的转子。转子包括限定可变体积处理室的至少一部分的弹性不可渗透隔膜，其中流体被离心。转子包括刚性安装构件，隔膜安装在该刚性安装构件上，并由卡盘保持和旋转。优选地，该刚性安装构件包括与弹性隔膜一起限定腔室的边界壁。边界壁可以是基本上无孔的圆形壁，其延伸到处理室的周边，但限定一个开口，优选地在旋转轴线附近，允许导管或导管穿过其中，以便与处理室流体连通。转子可以包括用于控制液体流出腔室进入管道的单独结构。在一个优选实施例中，该出口控制结构是位于处理室内并安装在刚性边界壁附近的穿孔的，基本上刚性的壁或板。在替代实施例中，用于控制从处理室到管道的流动的出口控制结构可以包括至少一个管或优选地一组管，其中每个管提供腔室和导管之间的流体连通。在一个优选实施例中，边界壁中的槽可以用作出口控制结构。

5. 发明授权

US5733253A Fluid separation system 失效
公开(公告)号：US5733253A
公开(公告)日：1998-03-31
申请号：US322601
申请日：1994-10-13
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M5/148 , B04B5/04 , A61M37/00 , B04B11/00
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A system for separating a fluid having heavier and lighter components. The system includes a rotor having a rigid mounting member and an elastic diaphragm attached to the mounting member, the diaphragm defining a chamber. The system also includes a chuck for holding the rigid mounting member of the rotor and for spinning the rotor around an axis. The pressure of a control fluid, preferably a control gas, disposed adjacent the rotor's diaphragm is varied in order to control the volume of the rotor. Pressurizing the control gas causes fluid to flow out of the rotor; applying a vacuum to the diaphragm draws fluid into the rotor.

6. 发明授权

US07452322B2 Rotor with elastic diaphragm for liquid-separation system 有权
标题翻译：用于液体分离系统的带有弹性隔膜的转子
公开(公告)号：US07452322B2
公开(公告)日：2008-11-18
申请号：US10339165
申请日：2003-01-09
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： B04B11/00
CPC分类号： B04B5/0428 , A61M1/0009 , A61M1/0011 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M5/1483 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , B04B5/0442
摘要： A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate, located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes, wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves in the boundary wall may be used as the outlet-control structure.
摘要翻译：用于在一定体积范围内收集和离心生物流体的转子。转子包括限定可变体积处理室的至少一部分的弹性不可渗透隔膜，其中流体被离心。转子包括刚性安装构件，隔膜安装在该刚性安装构件上，并由卡盘保持和旋转。优选地，该刚性安装构件包括与弹性隔膜一起限定腔室的边界壁。边界壁可以是基本上无孔的圆形壁，其延伸到处理室的周边，但限定一个开口，优选地在旋转轴线附近，允许导管或导管穿过其中，以便与处理室流体连通。转子可以包括用于控制液体流出腔室进入管道的单独结构。在一个优选实施例中，该出口控制结构是位于处理室内并安装在刚性边界壁附近的穿孔的，基本上刚性的壁或板。在替代实施例中，用于控制从处理室到管道的流动的出口控制结构可以包括至少一个管或优选地一组管，其中每个管提供腔室和导管之间的流体连通。在一个优选实施例中，边界壁中的槽可以用作出口控制结构。

7. 发明授权

US4795448A Suction collection system 失效
标题翻译：抽吸系统
公开(公告)号：US4795448A
公开(公告)日：1989-01-03
申请号：US139461
申请日：1987-12-30
申请人： Gary R. Stacey , Wesley H. Verkaart , Thomas D. Headley , Edward T. Powers
发明人： Gary R. Stacey , Wesley H. Verkaart , Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0017 , A61M1/0031 , A61M1/0033 , A61M2205/21 , A61M2205/7536 , A61M2205/8206
摘要： A suction collection system particularly suitable for drawing fluids from a patient area and storing the fluids for later use or disposal, which is operable in any orientation of the device, thereby providing a field operable system which may be transported in battlefield conditions. The portable suction system consists of a cylindrical evacuating chamber with a top sealing cap. A suction port on the sealing cap is connected to the fluid collection bag, which consists of a laminar flexible plastic bag having an air permeable, liquid impermeable patch or portion through which air may pass for purposes of providing a vacuum suction, yet the collected fluids will remain in the bag. The suction power is provided by a vacuum pump which is electronically regulated by periodically energizing and de-energizing the pump to conserve power supply energy.
摘要翻译：一种特别适用于从患者区域抽取流体并储存流体供以后使用或处理的抽吸收集系统，其可在装置的任何方向上操作，从而提供可在战场条件下运输的现场可操作系统。便携式抽吸系统由具有顶部密封盖的圆柱形抽空室组成。密封盖上的吸入口连接到流体收集袋，该流体收集袋由具有透气的液体不可渗透的贴片或部分的层状柔性塑料袋组成，空气可通过该部分以提供真空吸力，而收集的流体将留在包里。抽吸功率由真空泵提供，该真空泵通过周期性地给泵泵浦和断电以节省电力能量而进行电子调节。

8. 发明授权

US06602179B1 Rotor with elastic diaphragm defining a liquid separating chamber of varying volume 有权
标题翻译：转子具有弹性隔膜，限定了不同体积的液体分离室
公开(公告)号：US06602179B1
公开(公告)日：2003-08-05
申请号：US09592601
申请日：2000-06-12
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： B04B1100
CPC分类号： B04B5/0428 , A61M1/0009 , A61M1/0011 , A61M1/3692 , A61M1/3693 , A61M1/3696 , A61M1/3698 , A61M5/1483 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , B04B5/0442
摘要： A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate, located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes, wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves in the boundary wall may be used as the outlet-control structure.
摘要翻译：用于在一定体积范围内收集和离心生物流体的转子。转子包括限定可变体积处理室的至少一部分的弹性不可渗透隔膜，其中流体被离心。转子包括刚性安装构件，隔膜安装在该刚性安装构件上，并由卡盘保持和旋转。优选地，该刚性安装构件包括与弹性隔膜一起限定腔室的边界壁。边界壁可以是基本上无孔的圆形壁，其延伸到处理室的周边，但限定一个开口，优选地在旋转轴线附近，允许导管或导管穿过其中，以便与处理室流体连通。转子可以包括用于控制液体流出腔室进入管道的单独结构。在一个优选实施例中，该出口控制结构是位于处理室内并安装在刚性边界壁附近的穿孔的，基本上刚性的壁或板。在替代实施例中，用于控制从处理室到管道的流动的出口控制结构可以包括至少一个管或优选地一组管，其中每个管提供腔室和导管之间的流体连通。在一个优选实施例中，边界壁中的槽可以用作出口控制结构。

9. 发明授权

US5885239A Method for collecting red blood cells 失效
标题翻译：收集红细胞的方法
公开(公告)号：US5885239A
公开(公告)日：1999-03-23
申请号：US800086
申请日：1997-02-12
申请人： Thomas D. Headley , Edward T. Powers
发明人： Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M5/148 , B04B5/04 , A61M37/00 , B04B9/10
CPC分类号： B04B5/0428 , A61M1/3693 , A61M1/3696 , A61M1/3698 , B04B5/0442 , A61M1/0009 , A61M1/0011 , A61M2205/3306 , A61M2205/331 , A61M2205/3393 , A61M5/1483
摘要： A rotor for collecting and centrifuging biological fluids in a range of volumes. The rotor includes an elastic impermeable diaphragm which defines at least a portion of a variable-volume processing chamber, where the fluid is centrifuged. The rotor includes a rigid mounting member, to which the diaphragm is mounted and which is held and spun by a chuck. Preferably, this rigid mounting member includes a boundary wall which together with the elastic diaphragm defines the chamber. The boundary wall may be a substantially imperforate circular wall which extends to the periphery of the processing chamber but defining one opening, preferably near the axis of rotation, permitting a conduit or conduits to pass therethrough so as to be in fluid communication with the processing chamber. The rotor may include a separate structure for controlling the flow of liquid out of the chamber into the conduit. In a preferred embodiment, this outlet-control structure is a perforate, substantially rigid wall or plate, located within the processing chamber and mounted adjacent the rigid boundary wall. In an alternative embodiment, the outlet-control structure for controlling flow from the processing chamber to the conduit may include at least one tube or preferably a set of tubes, wherein each tube provides fluid communication between the chamber and the conduit. In one preferred embodiment, grooves in the boundary wall may be used as the outlet-control structure.
摘要翻译：用于在一定体积范围内收集和离心生物流体的转子。转子包括限定可变体积处理室的至少一部分的弹性不可渗透隔膜，其中流体被离心。转子包括刚性安装构件，隔膜安装在该刚性安装构件上，并由卡盘保持和旋转。优选地，该刚性安装构件包括与弹性隔膜一起限定腔室的边界壁。边界壁可以是基本上无孔的圆形壁，其延伸到处理室的周边，但限定一个开口，优选地在旋转轴线附近，允许导管或导管穿过其中，以便与处理室流体连通。转子可以包括用于控制液体流出腔室进入管道的单独结构。在一个优选实施例中，该出口控制结构是位于处理室内并安装在刚性边界壁附近的穿孔的，基本上刚性的壁或板。在替代实施例中，用于控制从处理室到管道的流动的出口控制结构可以包括至少一个管或优选地一组管，其中每个管提供腔室和导管之间的流体连通。在一个优选实施例中，边界壁中的槽可以用作出口控制结构。

10. 发明授权

US4740202A Suction collection device 失效
标题翻译：抽吸装置
公开(公告)号：US4740202A
公开(公告)日：1988-04-26
申请号：US894731
申请日：1986-08-08
申请人： Gary R. Stacey , Wesley H. Verkaart , Thomas D. Headley , Edward T. Powers
发明人： Gary R. Stacey , Wesley H. Verkaart , Thomas D. Headley , Edward T. Powers
IPC分类号： A61M1/00
CPC分类号： A61M1/0001 , A61M1/0017 , A61M1/0031 , A61M1/0033 , A61M2205/21 , A61M2205/7536 , A61M2205/8206
摘要： A suction collection system particularly suitable for drawing fluids from a patient area and storing the fluids for later use or disposal, which is operable in any orientation of the device, thereby providing a field operable system which may be transported in battlefield conditions. The portable suction system consists of a cylindrical evacuating chamber with a top sealing cap. A suction port on the sealing cap is connected to the fluid collection bag, which consists of a laminar flexible plastic bag having an air permeable, liquid impermeable patch or portion through which air may pass for purposes of providing a vacuum suction, yet the collected fluids will remain in the bag. The suction power is provided by a vacuum pump which is electronically regulated by periodically energizing and de-energizing the pump to conserve power supply energy.
摘要翻译：一种特别适用于从患者区域抽取流体并储存流体供以后使用或处理的抽吸收集系统，其可在装置的任何方向上操作，从而提供可在战场条件下运输的现场可操作系统。便携式抽吸系统由具有顶部密封盖的圆柱形抽空室组成。密封盖上的吸入口连接到流体收集袋，该流体收集袋由具有透气的液体不可渗透的贴片或部分的层状柔性塑料袋组成，空气可通过该部分以提供真空吸力，而收集的流体将留在包里。抽吸功率由真空泵提供，该真空泵通过周期性地给泵泵浦和断电以节省电力能量而进行电子调节。

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