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1. 发明申请

US20090170768A1 WATER-SOLUBLE CARBON NANOTUBE COMPOSITIONS FOR DRUG DELIVERY AND MEDICINAL APPLICATIONS 有权
标题翻译：用于药物递送和药物应用的可溶性碳纳米管组合物
公开(公告)号：US20090170768A1
公开(公告)日：2009-07-02
申请号：US12245438
申请日：2008-10-03
申请人： James M. Tour , Valerie C. Moore , S. Ward Casscella , Jeffrey N. Myers , Zvonimir L. Milas , Kathy A. Mason , Luka Milas , Brandl Katherine Price , Jared L. Hudson , Jodie L. Conyers, JR. , Rebecca L. Lucente-Schultz , Ashley Leonard , Dmitry V. Kosynkin
发明人： James M. Tour , Valerie C. Moore , S. Ward Casscella , Jeffrey N. Myers , Zvonimir L. Milas , Kathy A. Mason , Luka Milas , Brandl Katherine Price , Jared L. Hudson , Jodie L. Conyers, JR. , Rebecca L. Lucente-Schultz , Ashley Leonard , Dmitry V. Kosynkin
IPC分类号： A61K38/18 , A61K31/337 , A61K47/04
CPC分类号： A61K31/337 , A61K38/1808 , A61K47/60 , A61K47/6925 , A61K47/6929 , B82Y5/00
摘要： Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
摘要翻译：本文提供了包含多个官能化碳纳米管和至少一种有效载荷分子的组合物。在一些实施方案中，组合物可溶于水和PBS。在某些实施方案中，有效载荷分子不溶于水。描述了制备组合物和施用组合物的方法。还描述了利用官能化碳纳米管的紫杉醇的延长释放制剂。

2. 发明授权

US08784866B2 Water-soluble carbon nanotube compositions for drug delivery and medicinal applications 有权
标题翻译：用于药物输送和药物应用的水溶性碳纳米管组合物
公开(公告)号：US08784866B2
公开(公告)日：2014-07-22
申请号：US12245438
申请日：2008-10-03
申请人： James M. Tour , Rebecca Lucente-Schultz , Ashley Leonard , Dmitry V. Kosynkin , Brandi Katherine Price , Jared L. Hudson , Jodie L. Conyers, Jr. , Valerie C. Moore , S. Ward Casscells , Jeffrey N. Myers , Zvonimir L. Milas , Kathy A. Mason , Luka Milas
发明人： James M. Tour , Rebecca Lucente-Schultz , Ashley Leonard , Dmitry V. Kosynkin , Brandi Katherine Price , Jared L. Hudson , Jodie L. Conyers, Jr. , Valerie C. Moore , S. Ward Casscells , Jeffrey N. Myers , Zvonimir L. Milas , Kathy A. Mason , Luka Milas
IPC分类号： A61F2/00
CPC分类号： A61K31/337 , A61K38/1808 , A61K47/60 , A61K47/6925 , A61K47/6929 , B82Y5/00
摘要： Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
摘要翻译：本文提供了包含多个官能化碳纳米管和至少一种有效载荷分子的组合物。在一些实施方案中，组合物可溶于水和PBS。在某些实施方案中，有效载荷分子不溶于水。描述了制备组合物和施用组合物的方法。还描述了利用官能化碳纳米管的紫杉醇的延长释放制剂。

3. 发明申请

US20100197783A1 Radiation Protection Using Single Wall Carbon Nanotube Derivatives 审中-公开
标题翻译：使用单壁碳纳米管衍生物的辐射防护
公开(公告)号：US20100197783A1
公开(公告)日：2010-08-05
申请号：US12593585
申请日：2008-03-26
申请人： James M. Tour , Meng Lu , Rebecca Lucente-Schultz , Ashley Leonard , Condell Dewayne Doyle , Dmitry V. Kosynkin , Brandi Katherine Price
发明人： James M. Tour , Meng Lu , Rebecca Lucente-Schultz , Ashley Leonard , Condell Dewayne Doyle , Dmitry V. Kosynkin , Brandi Katherine Price
IPC分类号： A61K31/215 , A61P43/00 , C07C229/00
CPC分类号： A61K9/0092 , A61K8/19 , A61K47/60 , A61K47/6925 , A61K2800/413 , A61Q17/04 , B82Y5/00 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B2202/02 , C01B2202/04 , C01B2202/06
摘要： A method of reducing side effects of damage in a human subject exposed to radiation includes administering to the human subject carbon nanotubes in a pharmaceutically acceptable carrier after or prior to exposure to radiation. A composition for reducing radical damage includes a carbon nanotube which is functionalized (1) for substantial water solubility and (2) with a radical trapping agent appended to the carbon nanotube forming a radical scavenger-carbon nanotube conjugate.
摘要翻译：在暴露于辐射的人类受试者中减少损伤的副作用的方法包括在暴露于辐射之后或暴露于辐射之前向人受试者在药学上可接受的载体中施用碳纳米管。用于还原自由基损伤的组合物包括官能化（1）用于大量水溶性的碳纳米管和（2）附着到形成自由基清除剂 - 碳纳米管缀合物的碳纳米管上的自由基捕获剂。

4. 发明申请

US20120142111A1 NANOMATERIAL-CONTAINING SIGNALING COMPOSITIONS FOR ASSAY OF FLOWING LIQUID STREAMS AND GEOLOGICAL FORMATIONS AND METHODS FOR USE THEREOF 审中-公开
标题翻译：用于流动液体流动和地质形态测定的含纳米信号的组合物及其使用方法
公开(公告)号：US20120142111A1
公开(公告)日：2012-06-07
申请号：US13378440
申请日：2010-06-11
申请人： James M. Tour , Dmitry Kosynkin , Michael Wong , Mason Tomson , Jacob Berlin , Ashley Leonard , Jay Lomeda , Wei Lu , Jie yu , Lunliang Zhang , Amy Kan
发明人： James M. Tour , Dmitry Kosynkin , Michael Wong , Mason Tomson , Jacob Berlin , Ashley Leonard , Jay Lomeda , Wei Lu , Jie yu , Lunliang Zhang , Amy Kan
IPC分类号： G01N21/64 , C07D303/32 , C07D263/52 , G01N33/00 , C09K11/06 , G01N21/29 , C07C63/33 , B82Y15/00
CPC分类号： B82Y30/00 , E21B47/1015 , Y10T428/2982 , Y10T436/13
摘要： Compositions containing a transporter component and a signaling component and a method for using said compositions for analyzing porous media and flowing liquid streams, specifically for measuring pressure, temperature, relative abundance of water, pH, redox potential and electrolyte concentration. Analytes may include petroleum or other hydrophobic media, sulfur-containing compounds. The transporter component includes an amphiphilic nanomatenal and a plurality of solubilizing groups covalently bonded to the transporter component. The signaling component includes a plurality of reporter molecules associated with the transporter component. Said reporter molecules may be releasable from the transporter component upon exposure to at least one analyte. The reporter molecules may be non-covalently associated with the transporter component, or the reporter molecules are covalently bonded to the transporter component. Furthermore, said compositions and methods may be used to actively enhance oil recovery and for remediation of pollutants.
摘要翻译：含有转运体组分和信号传导组分的组合物以及使用所述组合物分析多孔介质和流动液体流的方法，特别是用于测量压力，温度，相对丰度的水，pH，氧化还原电势和电解质浓度。分析物可以包括石油或其它疏水介质，含硫化合物。转运体组分包括两亲纳米级和多个与转运蛋白成分共价结合的增溶基团。信号组件包括与转运蛋白组分相关的多个报道分子。所述报告分子在暴露于至少一种分析物时可以与转运蛋白成分一起释放。报道分子可能与转运蛋白成分非共价结合，或报道分子共价键合到转运蛋白成分。此外，所述组合物和方法可用于主动地增强油回收和污染物的修复。

5. 发明授权

US09572834B2 Use of carbon nanomaterials with antioxidant properties to treat oxidative stress 有权
标题翻译：使用具有抗氧化性能的碳纳米材料来治疗氧化应激
公开(公告)号：US09572834B2
公开(公告)日：2017-02-21
申请号：US14114007
申请日：2012-04-26
申请人： James M. Tour , Jacob Berlin , Daniela Marcano , Ashley Leonard , Thomas A. Kent , Robia G. Pautler , Brittany Bitner , Taeko Inoue
发明人： James M. Tour , Jacob Berlin , Daniela Marcano , Ashley Leonard , Thomas A. Kent , Robia G. Pautler , Brittany Bitner , Taeko Inoue
IPC分类号： A61K31/335 , A61K9/00 , A61K38/00 , A61K47/00 , A61K33/44 , B82Y5/00 , A61K45/06 , A61K47/48 , A61K31/713
CPC分类号： A61K33/44 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K47/60 , A61K47/6925 , B82Y5/00 , A61K2300/00
摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.
摘要翻译：在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳黑色，氧化炭黑，亲水性碳簇及其组合。在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

6. 发明申请

US20140120081A1 USE OF CARBON NANOMATERIALS WITH ANTIOXIDANT PROPERTIES TO TREAT OXIDATIVE STRESS 有权
标题翻译：使用碳纳米微粒与抗氧化性能来处理氧化应激
公开(公告)号：US20140120081A1
公开(公告)日：2014-05-01
申请号：US14114007
申请日：2012-04-26
申请人： James M. Tour , Jacob Berlin , Daniela Marcano , Ashley Leonard , Thomas A. Kent , Robia G. Pautler , Brittany Bitner , Taeko Inoue
发明人： James M. Tour , Jacob Berlin , Daniela Marcano , Ashley Leonard , Thomas A. Kent , Robia G. Pautler , Brittany Bitner , Taeko Inoue
IPC分类号： A61K33/44 , A61K45/06 , A61K47/48
CPC分类号： A61K33/44 , A61K9/0019 , A61K31/713 , A61K45/06 , A61K47/60 , A61K47/6925 , B82Y5/00 , A61K2300/00
摘要： In some embodiments, the present invention provides methods of treating oxidative stress in a subject by administering a therapeutic composition to the subject. In some embodiments, the therapeutic composition comprises a carbon nanomaterial with anti-oxidant activity. In some embodiments, the anti-oxidant activity of the carbon nanomaterial corresponds to ORAC values between about 200 to about 15,000. In some embodiments, the administered carbon nanomaterials include at least one of single-walled nanotubes, double-walled nanotubes, triple-walled nanotubes, multi-walled nanotubes, ultra-short nanotubes, graphene, graphene nanoribbons, graphite, graphite oxide nanoribbons, carbon black, oxidized carbon black, hydrophilic carbon clusters, and combinations thereof. In some embodiments, the carbon nanomaterial is an ultra-short single-walled nanotube that is functionalized with a plurality of solubilizing groups. In some embodiments, the carbon nanomaterial is a polyethylene glycol functionalized hydrophilic carbon cluster (PEG-HCC). In some embodiments, the administered therapeutic compositions of the present invention may also include an active agent or targeting agent associated with the carbon nanomaterial. Additional embodiments of the present invention pertain to the aforementioned carbon nanomaterial compositions for treating oxidative stress.
摘要翻译：在一些实施方案中，本发明提供了通过向受试者施用治疗组合物来治疗受试者的氧化应激的方法。在一些实施方案中，治疗组合物包含具有抗氧化活性的碳纳米材料。在一些实施方案中，碳纳米材料的抗氧化活性对应于约200至约15,000之间的ORAC值。在一些实施方案中，所施用的碳纳米材料包括单壁纳米管，双壁纳米管，三壁纳米管，多壁纳米管，超短纳米管，石墨烯，石墨烯纳米带，石墨，氧化石墨纳米带，碳黑色，氧化炭黑，亲水性碳簇及其组合。在一些实施方案中，碳纳米材料是用多个增溶基团官能化的超短单壁纳米管。在一些实施方案中，碳纳米材料是聚乙二醇官能化的亲水性碳簇（PEG-HCC）。在一些实施方案中，本发明施用的治疗组合物还可以包括与碳纳米材料相关的活性剂或靶向剂。本发明的另外的实施方案涉及上述用于治疗氧化应激的碳纳米材料组合物。

7. 发明申请

US20130200299A1 THERMALLY CONDUCTIVE NANOCOMPOSITION AND METHOD OF MAKING THE SAME 有权
标题翻译：导热纳米材料及其制备方法
公开(公告)号：US20130200299A1
公开(公告)日：2013-08-08
申请号：US13364515
申请日：2012-02-02
申请人： Oleg A. Mazyar , Ashley Leonard , Joshua C. Falkner
发明人： Oleg A. Mazyar , Ashley Leonard , Joshua C. Falkner
IPC分类号： C09K5/00 , F28D15/00 , B23K9/235
CPC分类号： C09K5/14 , B26D7/08 , B62D7/08 , C09K5/10 , E21B43/128 , F16J15/02 , Y10T83/041
摘要： A nanocomposite fluid includes a fluid medium; and a nanoparticle composition comprising nanoparticles which are electrically insulating and thermally conductive. A method of making the nanocomposite fluid includes forming boron nitride nanoparticles; dispersing the boron nitride nanoparticles in a solvent; combining the boron nitride nanoparticles and a fluid medium; and removing the solvent.
摘要翻译：纳米复合流体包括流体介质; 以及包含电绝缘和导热的纳米颗粒的纳米颗粒组合物。制备纳米复合流体的方法包括形成氮化硼纳米颗粒; 将氮化硼纳米颗粒分散在溶剂中; 组合氮化硼纳米颗粒和流体介质; 并除去溶剂。

8. 发明申请

US20120032543A1 OIL COMPOSITION COMPRISING FUNCTIONALIZED NANOPARTICLES 审中-公开
标题翻译：包含官能化纳米粒子的油组合物
公开(公告)号：US20120032543A1
公开(公告)日：2012-02-09
申请号：US13021137
申请日：2011-02-04
申请人： Soma Chakraborty , Ashley Leonard , Gaurav Agrawal , Ketankumar K. Sheth
发明人： Soma Chakraborty , Ashley Leonard , Gaurav Agrawal , Ketankumar K. Sheth
IPC分类号： C10M169/04 , H02K7/08 , B82Y99/00
CPC分类号： B82Y30/00 , C10M125/02 , C10M171/06 , C10M2201/041 , C10M2201/0413 , C10M2201/061 , C10M2201/0613 , C10M2201/062 , C10M2201/0623 , C10M2201/065 , C10M2201/0653 , C10M2201/066 , C10M2201/0663 , C10M2201/105 , C10M2201/1053 , C10M2201/14 , C10M2219/044 , C10N2220/082 , C10N2220/084 , C10N2230/02 , C10N2230/06 , C10N2230/58 , C10N2230/60 , C10N2240/20 , C10N2240/201 , C10N2250/12 , H02K5/132 , H02K5/161 , H02K9/19 , H02K2201/03 , H02K2205/12
摘要： An improved oil composition is disclosed. The oil composition includes a base oil comprising a hydrocarbon, the base oil having a base thermal conductivity. The oil composition also includes a first additive comprising a plurality of derivatized first additive nanoparticles dispersed within the base oil to form a modified oil having a modified thermal conductivity, wherein the modified thermal conductivity is greater than the base thermal conductivity. Alternately, an improved oil composition includes a base oil comprising a hydrocarbon and a first additive comprising a plurality of derivatized first additive nanoparticles dispersed within the base oil to form a modified oil comprising a stabilized suspension of the derivatized first additive nanoparticles in the base oil.
摘要翻译：公开了改进的油组合物。油组合物包括基础油，其包含烃，所述基础油具有基础导热性。油组合物还包括第一添加剂，其包含分散在基础油中的多个衍生化的第一添加剂纳米颗粒，以形成具有改进的导热性的改性油，其中改性的导热率大于基底热导率。或者，改进的油组合物包括包含烃的基础油和包含分散在基础油内的多个衍生的第一添加剂纳米颗粒的第一添加剂，以形成包含衍生的第一添加剂纳米颗粒在基础油中的稳定悬浮液的改性油。

9. 发明授权

US08840803B2 Thermally conductive nanocomposition and method of making the same 有权
标题翻译：导热纳米组合及其制备方法
公开(公告)号：US08840803B2
公开(公告)日：2014-09-23
申请号：US13364515
申请日：2012-02-02
申请人： Oleg A. Mazyar , Ashley Leonard , Joshua C. Falkner
发明人： Oleg A. Mazyar , Ashley Leonard , Joshua C. Falkner
IPC分类号： C09K5/10 , B26D7/08
CPC分类号： C09K5/14 , B26D7/08 , B62D7/08 , C09K5/10 , E21B43/128 , F16J15/02 , Y10T83/041
摘要： A nanocomposite fluid includes a fluid medium; and a nanoparticle composition comprising nanoparticles which are electrically insulating and thermally conductive. A method of making the nanocomposite fluid includes forming boron nitride nanoparticles; dispersing the boron nitride nanoparticles in a solvent; combining the boron nitride nanoparticles and a fluid medium; and removing the solvent.
摘要翻译：纳米复合流体包括流体介质; 以及包含电绝缘和导热的纳米颗粒的纳米颗粒组合物。制备纳米复合流体的方法包括形成氮化硼纳米颗粒; 将氮化硼纳米颗粒分散在溶剂中; 组合氮化硼纳米颗粒和流体介质; 并除去溶剂。

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