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    • 7. 发明申请
    • Thin-film ultrasonic probe having a flexible membrane
    • 具有柔性膜的薄膜超声波探头
    • US20070175282A1
    • 2007-08-02
    • US11345905
    • 2006-02-02
    • Barry FetzerJames KennedyThomas Riechers
    • Barry FetzerJames KennedyThomas Riechers
    • G01H11/00G01N29/00G01R33/20
    • G01N29/28B33Y80/00G01N29/223G01N29/24G01N2291/101
    • An ultrasonic probe for examining an item. The probe includes a body having a contact surface adapted for contacting the item when being examined and an ultrasonic transducer attached to the body and spaced from the contact surface. The probe further includes a spacer positioned in the body between the transducer and the contact surface for spacing the transducer from the item when being examined. The spacer includes a coupling surface facing the item when being examined and a transducer surface facing the transducer. The probe also includes a fluid outlet positioned adjacent the coupling surface of the spacer for delivering coupling fluid to the coupling surface as a film so that the coupling fluid tends to maintain contact with the spacer due to surface tension after the fluid is delivered through the outlet.
    • 用于检查物品的超声波探头。 探针包括具有接触表面的本体,该接触表面适于在检查时接触物品,以及附接到身体并与接触表面间隔开的超声波换能器。 探头还包括位于换能器和接触表面之间的主体中的间隔件,用于在检测时将换能器与物品间隔开。 间隔件包括当检查时面向物品的联接表面和面向换能器的换能器表面。 探针还包括邻近间隔件的联接表面定位的流体出口,用于将耦合流体作为膜输送到耦合表面,使得耦合流体趋向于在流体通过出口输送流体之后由于表面张力而保持与间隔物的接触 。
    • 8. 发明申请
    • SLC1A1 marker for anxiety disorder
    • SLC1A1焦虑症标志物
    • US20070099224A1
    • 2007-05-03
    • US11591244
    • 2006-10-31
    • Paul ArnoldMargaret RichterJames Kennedy
    • Paul ArnoldMargaret RichterJames Kennedy
    • C12Q1/68
    • C12Q1/6883C12Q2600/136C12Q2600/156C12Q2600/158C12Q2600/172
    • The present invention provides methods for diagnosing or identifying susceptibility of a subject to an anxiety or mood disorder. One method involves testing a sample obtained from the subject for the presence of a polymorphism in Intron 10 of the SLC1A1 gene. The presence of allele G or allele A of the A/G polymorphism rs301434 indicates that the patient is susceptible to an anxiety disorder. An alternate method involves testing a sample obtained from the subject for the presence of a polymorphism in the 3′ untranslated region of the SLC1A1 gene. The presence of allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to an anxiety disorder. Furthermore, a method is provided that involves testing a sample obtained from the subject for the presence of a haplotype in the SLC1A1 gene, wherein the combined presence allele G of the A/G polymorphism rs301434 and allele C of C/G polymorphism rs3087879 indicates that the patient is susceptible to a mood disorder.
    • 本发明提供用于诊断或鉴定受试者对焦虑或情绪障碍的易感性的方法。 一种方法包括测试从受试者获得的样品在SLC1A1基因的内含子10中存在多态性。 A / G多态性rs301434等位基因G或等位基因A的存在表明患者易患焦虑症。 一种替代方法包括测试从受试者获得的样品在SLC1A1基因的3'非翻译区中存在多态性。 C / G多态性rs3087879等位基因C的存在表明患者易患焦虑症。 此外,提供了一种方法,其包括测试从受试者获得的样品中SLC1A1基因中单体型的存在,其中A / G多态性rs301434的组合存在等位基因G和C / G多态性rs3087879的等位基因C表明 患者容易发生心境障碍。