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1. 发明申请

US20090191147A1 Use of Interleukin-11 to Prevent Immune-Mediated Cytotoxicity 审中-公开
标题翻译：使用白细胞介素-11来预防免疫介导的细胞毒性
公开(公告)号：US20090191147A1
公开(公告)日：2009-07-30
申请号：US12199590
申请日：2008-08-27
申请人： James Keith , Joseph M. Carroll , Jordan S. Pober
发明人： James Keith , Joseph M. Carroll , Jordan S. Pober
IPC分类号： A61K38/20 , A61P37/02
CPC分类号： A61K38/2073 , Y10S514/885
摘要： The use of interleukin-11 to prevent, to ameliorate, and to treat an immune-mediated disease in a mammal in need of such treatment is disclosed.
摘要翻译：公开了使用白细胞介素-11来预防，改善和治疗需要这种治疗的哺乳动物中的免疫介导的疾病。

2. 发明授权

US06953777B2 Use of interleukin-11 to prevent immune-mediated cytotoxicity 有权
标题翻译：使用白细胞介素-11来预防免疫介导的细胞毒性
公开(公告)号：US06953777B2
公开(公告)日：2005-10-11
申请号：US09521696
申请日：2000-03-09
申请人： James Keith , Joseph M. Carroll , Jordan S. Pober
发明人： James Keith , Joseph M. Carroll , Jordan S. Pober
IPC分类号： A61K38/20 , A61K38/00 , A61K38/21
CPC分类号： A61K38/2073 , Y10S514/885
摘要： The use of interleukin-11 to prevent, to ameliorate, and to treat an immune-mediated disease in a mammal in need of such treatment is disclosed.
摘要翻译：公开了在需要这种治疗的哺乳动物中使用白细胞介素-11来预防，改善和治疗免疫介导的疾病。

3. 发明授权

US6001651A Antisense modulation of LFA-3 失效
标题翻译： LFA-3的反义调制
公开(公告)号：US6001651A
公开(公告)日：1999-12-14
申请号：US45106
申请日：1998-03-20
申请人： C. Frank Bennett , Thomas P. Condon , Shin Cheng Flournoy , Jordan S. Pober , Weillie Ma
发明人： C. Frank Bennett , Thomas P. Condon , Shin Cheng Flournoy , Jordan S. Pober , Weillie Ma
IPC分类号： C12N15/09 , A61K31/711 , A61K38/00 , A61K39/00 , A61K48/00 , A61P1/00 , A61P19/02 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/06 , C07H21/04 , C12N15/113 , C12P19/34 , C12Q1/68 , C12N15/85 , C12N15/11 , C12P21/04
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/3181 , C12N2310/321 , C12N2310/322 , C12N2310/334 , C12N2310/341 , C12N2310/346
摘要： Compositions and methods for the treatment and diagnosis of diseases or disorders amenable to treatment through modulation of expression of a nucleic acid encoding a lymphocyte function associated antigen 3 (LFA-3; also known as CD58) protein are provided.
摘要翻译：提供了用于治疗和诊断易于通过调节编码淋巴细胞功能相关抗原3（LFA-3;也称为CD58）蛋白的核酸的表达进行治疗的疾病或病症的组合物和方法。

4. 发明授权

US5602305A Immunodeficient animal model for studying T cell-mediated immune 失效
标题翻译：用于研究T细胞介导免疫的免疫缺陷型动物模型
公开(公告)号：US5602305A
公开(公告)日：1997-02-11
申请号：US220900
申请日：1994-03-31
申请人： Jordan S. Pober , Christopher C. W. Hughes , Allan G. Murray , Philip W. Askenase , Peter Petzelbauer
发明人： Jordan S. Pober , Christopher C. W. Hughes , Allan G. Murray , Philip W. Askenase , Peter Petzelbauer
IPC分类号： A01K67/027 , A61K49/00 , C02N15/00
CPC分类号： A61K49/0008 , A01K67/0271
摘要： The present invention describes a novel immunodeficient rodent model comprising an organ graft, such as a human skin graft, said graft containing microvessels lined by endothelial cells, human T lymphocytes and, optionally, at least one agent capable of substantially depleting the rodent's Natural Killer cells. The human T lymphocytes are engrafted and circulating in the animal's blood, enabling interaction with the endothelial cells which can be allogenic to the donor for the skin graft. The immunodeficient rodent used can be a SCID mouse. Preferably, the endothelial cells are provided by grafting said human skin with an intact dermal superficial vascular plexus. This immunodeficient rodent can be used as a model for studying inflammatory human immune responses of the engrafted T lymphocytes to foreign antigen as well as for studying human allograft rejection, e.g. human microvessel destruction and the T cell-endothelial cell in vivo interactions associated with a human allograft rejection.
摘要翻译：本发明描述了一种新型免疫缺陷型啮齿动物模型，其包括器官移植物，例如人皮肤移植物，所述移植物含有由内皮细胞排列的微血管，人T淋巴细胞和任选地至少一种能够消灭啮齿动物的天然杀伤细胞。人T淋巴细胞被植入并在动物的血液中循环，使得能够与内皮细胞相互作用，所述内皮细胞可以与皮肤移植物的供体同种异体。使用的免疫缺陷型啮齿类动物可以是SCID小鼠。优选地，通过用完整的真皮浅表血管丛移植所述人皮肤来提供内皮细胞。该免疫缺陷型啮齿类动物可用作研究移植的T淋巴细胞对外源抗原的炎症性人免疫应答以及研究人类同种异体移植排斥反应的模型。人类微血管破坏和与人类同种异体移植排斥相关的T细胞 - 内皮细胞体内相互作用。

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