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1. 发明授权

US07252685B2 Fusion implant and method of making same 失效
标题翻译：融合种植体及其制作方法
公开(公告)号：US07252685B2
公开(公告)日：2007-08-07
申请号：US10455760
申请日：2003-06-05
申请人： James J. Bindseil , William F. McKay , Cary R. Reeves , T. Andrew Simonton , Eddie F. Ray
发明人： James J. Bindseil , William F. McKay , Cary R. Reeves , T. Andrew Simonton , Eddie F. Ray
IPC分类号： A61F2/28 , A61F2/44 , A61B17/56 , A61K6/083
CPC分类号： A61F2/4455 , A61F2/28 , A61F2/2846 , A61F2002/2817 , A61F2002/2835 , A61F2002/30057 , A61F2002/30062 , A61F2002/30224 , A61F2002/30235 , A61F2002/30245 , A61F2002/30261 , A61F2002/30293 , A61F2002/30448 , A61F2002/30451 , A61F2002/30461 , A61F2002/30464 , A61F2002/30472 , A61F2002/30588 , A61F2002/30604 , A61F2002/30622 , A61F2002/30772 , A61F2002/30971 , A61F2002/4495 , A61F2002/4649 , A61F2210/0004 , A61F2220/0041 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0069 , A61F2230/0071 , A61F2230/0082 , A61F2230/0091 , A61F2310/00011 , A61F2310/00161 , A61F2310/00179 , A61F2310/00359
摘要： The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises at least one structural member combined with at least one flexible planar member to retain the at least one structural member to form the implant.
摘要翻译：本发明提供一种用于融合相邻骨结构的植入物。植入物包括与至少一个柔性平面构件组合的至少一个结构构件，以保持至少一个结构构件以形成植入物。

2. 发明授权

US07351262B2 Bone implants and methods of making same 有权
标题翻译：骨植入物及其制作方法
公开(公告)号：US07351262B2
公开(公告)日：2008-04-01
申请号：US10455771
申请日：2003-06-05
申请人： James J. Bindseil , T. Andrew Simonton , Cary R. Reeves , William F. McKay , Eddie F. Ray
发明人： James J. Bindseil , T. Andrew Simonton , Cary R. Reeves , William F. McKay , Eddie F. Ray
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/70 , A61F2/28 , A61F2/2846 , A61F2002/2817 , A61F2002/2835 , A61F2002/30057 , A61F2002/30224 , A61F2002/30242 , A61F2002/30261 , A61F2002/30289 , A61F2002/30291 , A61F2002/30448 , A61F2002/30449 , A61F2002/30461 , A61F2002/30462 , A61F2002/30472 , A61F2002/30604 , A61F2002/30622 , A61F2002/30784 , A61F2002/30971 , A61F2002/4415 , A61F2220/0041 , A61F2220/005 , A61F2220/0075 , A61F2230/0069 , A61F2230/0071 , A61F2230/0082 , A61F2230/0091 , A61F2310/00359
摘要： The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of pieces of bone and a flexible mechanism including one or more flexible, elongate, biocompatible connectors interconnecting the pieces of bone.
摘要翻译：本发明提供一种用于融合相邻骨结构的植入物。植入物包括多个骨块和柔性机构，该柔性机构包括互连骨块的一个或多个柔性细长的生物相容的连接件。

3. 发明授权

US07537617B2 Bone strip implants and method of making same 有权
标题翻译：骨带植入物及其制作方法
公开(公告)号：US07537617B2
公开(公告)日：2009-05-26
申请号：US10455770
申请日：2003-06-05
申请人： James J. Bindsell , T. Andrew Simonton , Cary R. Reeves , William F. McKay , Eddie F. Ray
发明人： James J. Bindsell , T. Andrew Simonton , Cary R. Reeves , William F. McKay , Eddie F. Ray
IPC分类号： A61F2/44
CPC分类号： A61F2/4455 , A61B17/68 , A61B17/80 , A61B17/82 , A61B17/842 , A61B17/86 , A61F2/28 , A61F2/2875 , A61F2/30767 , A61F2002/2817 , A61F2002/30014 , A61F2002/30018 , A61F2002/30057 , A61F2002/30059 , A61F2002/30136 , A61F2002/30261 , A61F2002/30293 , A61F2002/30324 , A61F2002/30448 , A61F2002/30449 , A61F2002/30461 , A61F2002/30462 , A61F2002/30492 , A61F2002/30622 , A61F2002/30914 , A61F2002/30915 , A61F2002/30971 , A61F2002/4649 , A61F2220/0025 , A61F2220/005 , A61F2220/0075 , A61F2230/0004 , A61F2230/0082 , A61F2230/0091 , A61F2250/0018 , A61F2250/0029 , A61F2250/0036 , A61F2310/00365 , A61L27/3608 , A61L27/365 , A61L27/3683 , A61L2430/02
摘要： The present invention provides an implant for use in fusing adjacent bony structures. The implant comprises a plurality of bone pieces formed into at least one load bearing layer.
摘要翻译：本发明提供一种用于融合相邻骨结构的植入物。植入物包括形成至少一个承载层的多个骨块。

4. 发明申请

US20120310348A1 BONE GRAFTS 审中-公开
标题翻译：骨头
公开(公告)号：US20120310348A1
公开(公告)日：2012-12-06
申请号：US13153697
申请日：2011-06-06
申请人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
发明人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
IPC分类号： A61F2/44
CPC分类号： A61F2/30767 , A61B2017/0256 , A61B2090/034 , A61F2/30724 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30075 , A61F2002/30112 , A61F2002/30136 , A61F2002/30153 , A61F2002/30187 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/30772 , A61F2002/30774 , A61F2002/30787 , A61F2002/30797 , A61F2002/30813 , A61F2002/30836 , A61F2002/30841 , A61F2002/30848 , A61F2002/3085 , A61F2002/30866 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/448 , A61F2002/4623 , A61F2002/4627 , A61F2002/4628 , A61F2002/4649 , A61F2310/00161 , A61F2310/00293 , A61F2310/00365 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L27/3608 , A61L27/54 , A61L2300/414 , A61L2430/38
摘要： Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a hone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
摘要翻译：提供脊柱间隔件20用于运动段的融合。间隔件包括具有壁22的承载构件21，该壁22的尺寸设置成用于接合在相邻椎骨之间的空间中，以维持空间和有效量的成骨组合物以刺激骨诱导。成骨组合物包括药学上可接受的载体中基本上纯的成骨因子。在一个实施方案中，承载构件包括浸渍在成骨组合物中的橡胶接枝。在另一个实施方案中，成骨组合物30包装在限定在移植物中的腔室25内。涵盖骨移植物的任何合适构型，包括骨榫，D形间隔物和皮质环。

5. 发明授权

US07981156B2 Bone grafts 有权
标题翻译：骨移植
公开(公告)号：US07981156B2
公开(公告)日：2011-07-19
申请号：US10781058
申请日：2004-02-18
申请人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
发明人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
IPC分类号： A61F2/44 , A61F2/28
CPC分类号： A61F2/30767 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2090/034 , A61F2/28 , A61F2/30724 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30075 , A61F2002/30112 , A61F2002/30136 , A61F2002/30153 , A61F2002/30187 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/30772 , A61F2002/30774 , A61F2002/30787 , A61F2002/30797 , A61F2002/30813 , A61F2002/30836 , A61F2002/30841 , A61F2002/30848 , A61F2002/3085 , A61F2002/30866 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/448 , A61F2002/4623 , A61F2002/4627 , A61F2002/4628 , A61F2002/4649 , A61F2210/0004 , A61F2210/0061 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2310/00161 , A61F2310/00293 , A61F2310/00365 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L27/10 , A61L27/12 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/54 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2300/252 , A61L2300/414 , A61L2300/802 , A61L2430/38 , Y10S606/907 , Y10S606/908 , Y10S606/909 , Y10S606/91 , A61L27/227
摘要： Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
摘要翻译：提供脊柱间隔件20用于运动段的融合。间隔件包括具有壁22的承载构件21，该壁22的尺寸设置成用于接合在相邻椎骨之间的空间中，以维持空间和有效量的成骨组合物以刺激骨诱导。成骨组合物包括药学上可接受的载体中基本上纯的成骨因子。在一个实施例中，承载构件包括浸渍在成骨组合物中的骨移植物。在另一个实施方案中，成骨组合物30被包装在限定在移植物中的腔室25内。涵盖骨移植物的任何合适构型，包括骨榫，D形间隔物和皮质环。

6. 发明授权

US06371988B1 Bone grafts 有权
标题翻译：骨移植
公开(公告)号：US06371988B1
公开(公告)日：2002-04-16
申请号：US09484354
申请日：2000-01-18
申请人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
发明人： John Pafford , Lawrence M. Boyd , William F. McKay , Eddie F. Ray, III , James E. Van Hoeck
IPC分类号： A61F228
CPC分类号： A61F2/30767 , A61B17/1671 , A61B17/1757 , A61B2017/0256 , A61B2090/034 , A61F2/28 , A61F2/30724 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2/468 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30004 , A61F2002/30057 , A61F2002/30062 , A61F2002/30075 , A61F2002/30112 , A61F2002/30136 , A61F2002/30153 , A61F2002/30187 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30271 , A61F2002/30677 , A61F2002/30772 , A61F2002/30774 , A61F2002/30787 , A61F2002/30797 , A61F2002/30813 , A61F2002/30836 , A61F2002/30841 , A61F2002/30848 , A61F2002/3085 , A61F2002/30866 , A61F2002/30879 , A61F2002/30892 , A61F2002/30904 , A61F2002/3092 , A61F2002/30929 , A61F2002/4475 , A61F2002/448 , A61F2002/4623 , A61F2002/4627 , A61F2002/4628 , A61F2002/4649 , A61F2210/0004 , A61F2210/0061 , A61F2230/0004 , A61F2230/0019 , A61F2230/0034 , A61F2230/0069 , A61F2230/0082 , A61F2250/0014 , A61F2310/00161 , A61F2310/00293 , A61F2310/00365 , A61F2310/00491 , A61F2310/00544 , A61F2310/00796 , A61L27/10 , A61L27/12 , A61L27/16 , A61L27/18 , A61L27/24 , A61L27/54 , A61L31/024 , A61L31/026 , A61L31/044 , A61L31/047 , A61L31/048 , A61L31/06 , A61L2300/252 , A61L2300/414 , A61L2300/802 , A61L2430/38 , Y10S606/907 , Y10S606/908 , Y10S606/909 , Y10S606/91 , A61L27/227
摘要： Spinal spacers 20 are provided for fusion of a motion segment. The spacers include a load bearing member 21 having a wall 22 sized for engagement within a space between adjacent vertebrae to maintain the space and an effective amount of an osteogenic composition to stimulate osteoinduction. The osteogenic composition includes a substantially pure osteogenic factor in a pharmaceutically acceptable carrier. In one embodiment the load bearing member includes a bone graft impregnated in an osteogenic composition. In another embodiment, the osteogenic composition 30 is packed within a chamber 25 defined in the graft. Any suitable configuration of a bone graft is contemplated, including bone dowels, D-shaped spacers and cortical rings.
摘要翻译：提供脊柱间隔件20用于运动段的融合。间隔件包括具有壁22的承载构件21，该壁22的尺寸设置成用于接合在相邻椎骨之间的空间中，以维持空间和有效量的成骨组合物以刺激骨诱导。成骨组合物包括药学上可接受的载体中基本上纯的成骨因子。在一个实施例中，承载构件包括浸渍在成骨组合物中的骨移植物。在另一个实施方案中，成骨组合物30被包装在限定在移植物中的腔室25内。涵盖骨移植物的任何合适构型，包括骨榫，D形间隔物和皮质环。

7. 发明授权

US09616153B2 Rigid bone graft substitute 有权
公开(公告)号：US09616153B2
公开(公告)日：2017-04-11
申请号：US12104564
申请日：2008-04-17
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61F2/28 , A61L27/56 , A61L27/40 , A61L27/54 , A61F2/30
CPC分类号： A61L27/56 , A61F2/2803 , A61F2002/2817 , A61F2002/30062 , A61F2002/3092 , A61F2002/3096 , A61F2210/0004 , A61F2310/00293 , A61F2310/00365 , A61L27/40 , A61L27/54 , A61L2300/414 , A61L2430/02
摘要： A bone graft substitute includes a porous matrix at least partially covered by a reinforcing outer layer. The porous matrix may be a collagen-ceramic composite, and the reinforcing outer layer may be formed from highly cross-linked collagen. The implant may also include one or more reinforcement ribs, which may be made from calcium phosphate or dense collagen. In addition, the bone graft substitute preferably includes an effective amount of a bioactive agent, such as BMP-2, rhBMP-2, or functional fragments thereof. The bioactive agent is preferably disposed within the porous matrix.

8. 发明授权

US09163212B2 Osteogenic cell delivery matrix 有权
标题翻译：成骨细胞递送基质
公开(公告)号：US09163212B2
公开(公告)日：2015-10-20
申请号：US12692940
申请日：2010-01-25
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61K9/14 , A61K33/42 , A61K47/02 , A61K35/12 , A61P19/00 , C12N5/00 , A61L27/42 , A61L27/56
CPC分类号： A61L27/44 , A61L27/365 , A61L27/3834 , A61L27/3847 , A61L27/425 , A61L27/54 , A61L27/56 , A61L2300/102 , A61L2300/112 , A61L2300/412 , A61L2300/64 , A61L2430/02 , C12N5/0068 , C12N2533/14
摘要： Compositions and methods for augmenting bone formation by administering isolated human mesenchymal stem cells (hMSCs) within a matrix provided. By adding calcium and/or phosphate ions to the matrix, one may foster greater bone regeneration.
摘要翻译：通过在提供的基质内施用分离的人间充质干细胞（hMSCs）来增加骨形成的组合物和方法。通过向基质中加入钙和/或磷酸根离子，可以促进更大的骨再生。

9. 发明授权

US09161903B2 Flowable composition that hardens on delivery to a target tissue site beneath the skin 有权
标题翻译：可流动的组合物在皮肤递送至目标组织部位时变硬
公开(公告)号：US09161903B2
公开(公告)日：2015-10-20
申请号：US12262705
申请日：2008-10-31
申请人： Susan J. Drapeau , William F. McKay , Nelson Scarborough
发明人： Susan J. Drapeau , William F. McKay , Nelson Scarborough
IPC分类号： A61K51/00 , A61K9/00 , A61K9/14 , A61K47/34
CPC分类号： A61K9/0024 , A61K9/0085 , A61K9/16 , A61K31/573 , A61K47/10 , A61K47/34 , A61K51/1213
摘要： Flowable compositions and methods are provided for delivering a therapeutic agent at or near a target tissue site beneath the skin of a patient, the flowable composition comprising (i) a solvent and (ii) an effective amount of the therapeutic agent, the flowable composition being capable of hardening to form a drug depot at a physiological temperature or as solvent contacts bodily fluid at or near the target tissue site, wherein the drug depot is capable of releasing the therapeutic agent over a period of at least one day and the target tissue site comprises at least one muscle, ligament, tendon, cartilage, spinal disc, spinal foraminal space near the spinal nerve root, facet or synovial joint, or spinal canal. In some embodiments, an implantable drug depot for delivering a therapeutic agent is provided, the implantable drug depot comprising (i) a chamber; and (ii) a flowable composition comprising an effective amount of a therapeutic agent disposed within the chamber of the drug depot, the flowable composition capable of hardening when the drug depot is delivered at or near the target tissue site.
摘要翻译：提供可流动的组合物和方法用于在患者皮肤下方的靶组织部位处或附近递送治疗剂，所述可流动组合物包含（i）溶剂和（ii）有效量的治疗剂，所述可流动组合物为能够在生理温度下硬化形成药物贮库，或者作为溶剂与目标组织部位处或附近的体液接触，其中药物贮库能够在至少一天的时间内释放治疗剂，并且靶组织部位包括至少一个肌肉，韧带，肌腱，软骨，脊椎盘，脊神经根附近的脊椎孔隙空间，小面或滑膜关节或椎管。在一些实施方案中，提供了用于递送治疗剂的可植入药物贮库，所述可植入药物贮库包括（i）室; 和（ii）可流动组合物，其包含设置在所述药物贮库的所述室内的有效量的治疗剂，所述可流动组合物能够在所述药物贮库在所述靶组织部位处或附近递送时硬化。

10. 发明授权

US09107983B2 Osteoconductive matrices comprising statins 有权
标题翻译：包含他汀类的骨诱导性基质
公开(公告)号：US09107983B2
公开(公告)日：2015-08-18
申请号：US12913237
申请日：2010-10-27
申请人： William F. McKay
发明人： William F. McKay
IPC分类号： A61L27/44 , A61L27/54 , A61K9/00 , A61K35/32
CPC分类号： A61L27/446 , A61L27/54 , A61L2300/412 , A61L2430/02
摘要： Osteoconductive matrices and methods are provided that have one or more statins disposed therein. The matrices may be injected into a fracture site. The osteoconductive matrices provided allow for sustain release of the statin and facilitate bone formation and repair of the fracture site.
摘要翻译：提供具有一个或多个他汀类药物的骨诱导性基质和方法。可将基质注入骨折部位。提供的骨传导性基质允许他汀类维生素的释放并促进骨形成部位的骨形成和修复。

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