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1. 发明申请

US20050155231A1 Bevel and depth of cut detent system 有权
标题翻译：斜角和深度切割制动系统
公开(公告)号：US20050155231A1
公开(公告)日：2005-07-21
申请号：US10898853
申请日：2004-07-26
申请人： James Hartmann , Ralf Bocka , Joseph Wascow
发明人： James Hartmann , Ralf Bocka , Joseph Wascow
IPC分类号： B27B9/02
CPC分类号： B27B9/02 , Y10T403/32377 , Y10T403/32541 , Y10T403/599 , Y10T403/606
摘要： A circular saw assembly of the type that includes a motor housing, a handle coupled to the motor housing, a generally circular saw blade disposed within a blade housing at a first end of the motor housing, and a foot member through which the blade extends for guiding the saw assembly along a work surface, where the circular saw assembly including a depth of cut locking system and an angle of cut locking system. The depth of cut locking system includes an arcuate bracket with an arcuate slot, and an engagement member extends through the slot and is operatively connected to the motor housing and slideable in the arcuate slot. The angle of cut locking system includes a bracket having an arcuate slot and an engagement member movable in the slot and configured to the bracket. A biasing member is provided to bias the engagement member, and at least one detent recess is provided to retain the engagement member therein.
摘要翻译：一种圆锯组件，其包括马达壳体，与马达壳体连接的手柄，在马达壳体的第一端处设置在叶片壳体内的大致圆形锯片，以及叶片延伸穿过其的脚构件沿着工作表面引导锯组件，其中圆锯组件包括切割深度的锁定系统和切割角度的锁定系统。切割锁定系统的深度包括具有弧形槽的弓形支架，并且接合构件延伸穿过狭槽并且可操作地连接到马达壳体并且可在弓形槽中滑动。切割锁定系统的角度包括具有弧形槽的支架和可在槽中移动并配置到支架的接合构件。提供偏置构件以偏置接合构件，并且设置至少一个制动凹部以将接合构件保持在其中。

2. 发明申请

US20050155232A1 Universal locking lever 有权
标题翻译：通用锁定杆
公开(公告)号：US20050155232A1
公开(公告)日：2005-07-21
申请号：US10898875
申请日：2004-07-26
申请人： Ralf Bocka , James Hartmann , Joseph Wascow
发明人： Ralf Bocka , James Hartmann , Joseph Wascow
IPC分类号： B27B9/02
CPC分类号： B27B9/02 , Y10T74/20624
摘要： A repositionable operating lever including a lever body having a handle and a generally hollow cylindrical housing, an inner end portion of which has a multi-faced wall configured to engage a multi-faced head portion of an adjusting member, an adjusting member positioned in the cylindrical housing and having a multi-faced head portion engaging the multi-faced wall of the inner end portion, a generally cylindrical end piece configured to fit within an outer end portion of the cylindrical housing, a biasing member having a inner end and a outer end, and wherein the lever body is capable of being moved in the outer direction relative to the adjusting member by manipulation overcoming the biasing force whereby the multi-faced head portion and the multi-faced wall disengage from one another, permitting relative rotation of the lever body and the adjusting member to reposition the lever body on the adjusting member.
摘要翻译：一种可重新定位的操作杆，包括具有把手的杠杆主体和大致中空的圆柱形壳体，其内端部具有配置为接合调节构件的多面头部的多面壁，圆柱形壳体，并且具有接合内端部的多面壁的多面头部，大致圆柱形的端部件，构造成装配在圆柱形壳体的外端部内;偏置构件，其具有内端和外侧并且其中所述杆体能够通过克服所述偏压力的操作而相对于所述调节构件在外部方向上移动，由此所述多面部头部和所述多面壁彼此脱离，允许所述杆体相对旋转，杠杆体和调节构件，以将杆体重新定位在调节构件上。

3. 发明公开

US20230172956A1 COMBINATORIAL THERAPY FOR USE IN INDUCING IMMUNOGENIC CELL DEATH IN CANCER CELLS 审中-公开
公开(公告)号：US20230172956A1
公开(公告)日：2023-06-08
申请号：US18075621
申请日：2022-12-06
申请人： James Hartmann , Patricia Keating , Youssef Motii
发明人： James Hartmann , Patricia Keating , Youssef Motii
IPC分类号： A61K31/7004 , A61K31/519 , A61K31/352 , A61K45/06
CPC分类号： A61K31/7004 , A61K31/519 , A61K31/352 , A61K45/06
摘要： The invention is based on the discovery that combination therapy with 2-deoxyglucose, methotrexate, and wogonin provides a synergistic therapeutic effect in selectively killing cancer cells. Advantageously, the disclosed combinatorial therapy does not adversely affect normal, healthy cells. Although the individual compounds have been previously used in cancer treatment, the cited combination has been surprisingly found to selectively kill cancer cells, while not adversely affecting normal, healthy cells, especially those of the immune system. Further, the combination of the compounds produces a synergistic effect, with increased killing of cancer cells compared to each compound alone. Importantly, the combination caused the dying cancer cells to release three key markers of immunogenic cell death: HMGB1, ATP and calreticulin. Immunogenic cell death attracts and activates immune cells against cancers.

4. 发明申请

US20060036186A1 Automated impedance measurement of an implantable medical device 有权
标题翻译：可植入医疗器械的自动阻抗测量
公开(公告)号：US20060036186A1
公开(公告)日：2006-02-16
申请号：US11253391
申请日：2005-10-19
申请人： Steven Goetz , Jordan Barnhorst , James Hartmann
发明人： Steven Goetz , Jordan Barnhorst , James Hartmann
IPC分类号： A61B5/05
CPC分类号： A61N1/08 , A61N2001/083
摘要： Aspects of the present invention relate to automatic impedance measurements between one or more electrodes in a set of electrodes that may be associated with a lead of an implanted device. A voltage measurement that is associated with a stimulation pulse between the two electrodes may be made. The voltage measurement may be used to determine the impedance between the two electrodes. The impedance measurement may be made for each possible pair of electrodes in the set of electrodes. The impedance measurements may be displayed to a clinician on a user interface.
摘要翻译：本发明的方面涉及可以与植入装置的引线相关联的一组电极中的一个或多个电极之间的自动阻抗测量。可以进行与两个电极之间的刺激脉冲相关联的电压测量。电压测量可用于确定两个电极之间的阻抗。可以对该组电极中的每对可能的电极进行阻抗测量。阻抗测量可以在用户界面上向临床医生显示。

5. 发明申请

US20050004628A1 Amplitude ramping of waveforms generated by an implantable medical device 有权
标题翻译：由可植入医疗设备产生的波形的幅度斜坡
公开(公告)号：US20050004628A1
公开(公告)日：2005-01-06
申请号：US10099438
申请日：2002-03-15
申请人： Steven Goetz , Jordan Barnhorst , James Hartmann
发明人： Steven Goetz , Jordan Barnhorst , James Hartmann
IPC分类号： A61N1/372 , A61N1/18
CPC分类号： A61N1/37252 , A61N1/37247
摘要： The present invention automates the adjustment of an amplitude of stimulated pulses that are generated by an implanted device. Apparatus comprises a processor that communicates with the implanted device over a communications channel through a communications module. The apparatus enables the clinician to select a pair of electrodes that is contained on a lead of the implanted device. Corresponding to each iteration of the process, the processor sends a command to the implanted device in order to increment the amplitude of the stimulation pulse between the selected electrodes. Each iteration of the process corresponds to the apparatus incrementing the current value by a predetermined incremental value that can be selected by the clinician. When the current value of the amplitude equals the target value, the process is halted. Additionally, the clinician can halt process during the execution of the process by instructing the apparatus.
摘要翻译：本发明使由植入装置产生的受激脉冲的幅度自动化。装置包括通过通信模块通过通信信道与植入装置进行通信的处理器。该装置使得临床医生能够选择包含在植入装置的引线上的一对电极。对应于过程的每个迭代，处理器向植入装置发送命令，以便增加所选择的电极之间的刺激脉冲的幅度。过程的每次迭代对应于将当前值递增预定增量值的装置，该预定增量值可由临床医生选择。当幅度的当前值等于目标值时，过程停止。此外，临床医生可以通过指示该装置在执行过程期间停止处理。

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