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1. 发明申请

US20070254837A1 Treatment for Necrotizing Enterocolitis 审中-公开
标题翻译：治疗坏死性小肠结肠炎
公开(公告)号：US20070254837A1
公开(公告)日：2007-11-01
申请号：US10596565
申请日：2004-12-16
申请人： James Hardin , Andre Buret
发明人： James Hardin , Andre Buret
IPC分类号： A61K38/18 , A61K31/04 , A61K31/195 , A61K31/198 , A61P1/00 , A61K31/295 , A61K31/34
CPC分类号： A61K31/04 , A61K31/195 , A61K31/198 , A61K31/295 , A61K31/34 , A61K38/1808 , A61K2300/00
摘要： The invention provides compositions and methods for the treatment of necrotizing enterocolitis (NEC). A treatment of epidermal growth factor (EGF) receptor agonist and L-arginine, a bioequivalent thereof, or NO-donor showed efficacy against NEC. The invention also provides kits, unit doses and uses comprising epidermal growth factor (EGF) receptor agonist and L-arginine, a bioequivalent thereof, or NO-donor for the treatment of NEC.
摘要翻译：本发明提供了用于治疗坏死性小肠结肠炎（NEC）的组合物和方法。表皮生长因子（EGF）受体激动剂和L-精氨酸（其生物等效物）或NO供体的治疗显示出对NEC的功效。本发明还提供包含表皮生长因子（EGF）受体激动剂和L-精氨酸（其生物等效物）或用于治疗NEC的NO供体的试剂盒，单位剂量和用途。

2. 发明申请

US20060014684A1 Novel uses of EGF 审中-公开
标题翻译： EGF的新用途
公开(公告)号：US20060014684A1
公开(公告)日：2006-01-19
申请号：US11009490
申请日：2004-12-10
申请人： Andre Buret , D. Gall , Merle Olson , James Hardin
发明人： Andre Buret , D. Gall , Merle Olson , James Hardin
IPC分类号： A61K38/18
CPC分类号： A61K38/1808 , A61K38/1841
摘要： This invention relates to treating or preventing pathogenic infections with an epidermal growth factor (EGF). EGF is capable of inhibiting pathogenic colonization of pathogens in a variety of tissue or cell types. Since pathogenic colonization is essential for pathogenic infection, EGF can be used as an effective preventive and therapeutic agent for pathogenic infections, particularly in the urogenital tract. A method of increasing weight gain in an animal by administering epidermal growth factor is also described.
摘要翻译：本发明涉及用表皮生长因子（EGF）治疗或预防病原体感染。 EGF能够抑制各种组织或细胞类型的病原体的致病性定植。由于致病性定植对致病性感染至关重要，因此EGF可用作致病感染的有效预防和治疗剂，特别是在泌尿生殖道中。还描述了通过施用表皮生长因子来增加动物体重增加的方法。

3. 发明申请

US20060166358A1 Biofilm incubation 审中-公开
标题翻译：生物膜孵育
公开(公告)号：US20060166358A1
公开(公告)日：2006-07-27
申请号：US11305428
申请日：2005-12-15
申请人： Howard Ceri , Merle Olson , Douglas Morck , Ronald Read , Andre Buret
发明人： Howard Ceri , Merle Olson , Douglas Morck , Ronald Read , Andre Buret
IPC分类号： C12M3/00
CPC分类号： C12M27/16 , C12M23/12 , C12M23/20 , C12M23/38 , C12M23/48
摘要： Biofilm forming organisms are incubated to form a biofilm on projections by providing a flow of liquid growth medium across projections, the direction of the flow of liquid being repeatedly changed, and an assay made of the resulting biofilm. Biofilm forming organisms are incubated to form a biofilm on projections arranged in rows, with several projections in each row, while providing a flow of liquid growth medium across each row of projections, and an assay made of the resulting biofilm. Sensitivity of the biofilm to antimicrobial reagent may be determined by treating the projections with antimicrobial reagent before carrying out the assay, by treating each row of projections with a different antimicrobial reagent, and each of the projections in a row with a different concentration of antimicrobial reagent.
摘要翻译：将生物膜形成生物体孵育以在突起上形成生物膜，通过提供液体生长培养基跨过突起的流动，液体的流动方向被重复改变，以及由所得生物膜制成的测定。将生物膜形成生物体孵育以在排列成排的突起上形成生物膜，每行中具有若干突起，同时在每排突起处提供液体生长介质流，以及由所得生物膜制成的测定。生物膜对抗微生物试剂的敏感性可以通过在进行测定之前用抗微生物剂处理突出物，通过用不同的抗微生物试剂处理每一排突起，并且将每个突起以不同浓度的抗微生物剂。

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