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1. 发明授权

US08524490B2 Fully automated portable DNA detection system 有权
标题翻译：全自动便携式DNA检测系统
公开(公告)号：US08524490B2
公开(公告)日：2013-09-03
申请号：US12561092
申请日：2009-09-16
申请人： James H. Lipscomb , Peter Blacklin , Michael Keating , Robert Bernstine , Richard Raffauf, Jr.
发明人： James H. Lipscomb , Richard Raffauf, Sr. , Peter Blacklin , Michael Keating , Robert Bernstine
IPC分类号： C12M1/00 , C12M1/36 , C12M1/38
CPC分类号： B01L7/5255 , B01L7/52 , B01L9/065 , B01L2200/10 , B01L2200/147 , B01L2300/027 , B01L2300/0838 , B01L2300/1827 , B01L2300/1883
摘要： Provided herein is a portable thermocycler, comprising: (i) a case; (ii) a rotary plate in the case; (iii) a plurality of heating blocks arranged in a geometric pattern disposed on the rotary plate; and (iv) at least one vessel adapted to move and contact at least two of the plurality of heating blocks; wherein each of the heating blocks comprises a heating plate maintained at a set temperature over a thermally insulating material; wherein the geometric pattern comprises a number of center heating blocks arranged in a shape defining a polygon and a number of outside heating blocks disposed around the periphery of the rotary plate; and wherein the rotary plate includes a plurality of rotating wheels adapted to rotate at least one of the vessels into contact with each of the heating blocks.
摘要翻译：本文提供的便携式热循环仪包括：（i）壳体; （ii）壳体中的旋转板; （iii）以设置在所述旋转板上的几何图案布置的多个加热块; 和（iv）适于移动和接触多个加热块中的至少两个的至少一个容器; 其中每个所述加热块包括在绝热材料上保持在设定温度的加热板; 其中所述几何图形包括多个中心加热块，所述多个中心加热块以限定多边形的形状和围绕所述旋转板周边设置的多个外部加热块布置; 并且其中所述旋转板包括多个旋转轮，其适于使所述容器中的至少一个与所述加热块接触。

2. 发明申请

US20100136632A1 FULLY AUTOMATED PORTABLE DNA DETECTION SYSTEM 有权
标题翻译：全自动便携式DNA检测系统
公开(公告)号：US20100136632A1
公开(公告)日：2010-06-03
申请号：US12561092
申请日：2009-09-16
申请人： James H. LIPSCOMB , Richard Raffauf, SR. , Peter Blacklin , Michael Keating , Robert Bernstine , Richard Raffauf, JR.
发明人： James H. LIPSCOMB , Richard Raffauf, SR. , Peter Blacklin , Michael Keating , Robert Bernstine , Richard Raffauf, JR.
IPC分类号： C12P19/34 , C12M1/00 , H01R43/00
CPC分类号： B01L7/5255 , B01L7/52 , B01L9/065 , B01L2200/10 , B01L2200/147 , B01L2300/027 , B01L2300/0838 , B01L2300/1827 , B01L2300/1883
摘要： Provided herein is a portable thermocycler, comprising: (i) a case; (ii) a rotary plate in the case; (iii) a plurality of heating blocks arranged in a geometric pattern disposed on the rotary plate; and (iv) at least one vessel adapted to move and contact at least two of the plurality of heating blocks; wherein each of the heating blocks comprises a heating plate maintained at a set temperature over a thermally insulating material; wherein the geometric pattern comprises a number of center heating blocks arranged in a shape defining a polygon and a number of outside heating blocks disposed around the periphery of the rotary plate; and wherein the rotary plate includes a plurality of rotating wheels adapted to rotate at least one of the vessels into contact with each of the heating blocks.
摘要翻译：本文提供的便携式热循环仪包括：（i）壳体; （ii）壳体中的旋转板; （iii）以设置在所述旋转板上的几何图案布置的多个加热块; 和（iv）适于移动和接触多个加热块中的至少两个的至少一个容器; 其中每个所述加热块包括在绝热材料上保持在设定温度的加热板; 其中所述几何图案包括多个中心加热块，所述多个中心加热块以限定多边形的形状和围绕所述旋转板周边设置的多个外部加热块布置; 并且其中所述旋转板包括多个旋转轮，其适于使所述容器中的至少一个与所述加热块接触。

3. 发明申请

US20060058383A1 Propyl 3-bromo-2-oxopropionate and derivatives as novel anticancer agents 审中-公开
标题翻译： 3-溴-2-氧代丙酸丙酯及其衍生物作为新型抗癌剂
公开(公告)号：US20060058383A1
公开(公告)日：2006-03-16
申请号：US11192281
申请日：2005-07-28
申请人： Peng Huang , Michael Keating , Ruihau Xu
发明人： Peng Huang , Michael Keating , Ruihau Xu
IPC分类号： A61K31/22 , A61K31/19
CPC分类号： A61K31/22 , A61K31/19
摘要： The present invention is directed to compositions that inhibit glycolysis, perferentially in cancer. Specifically, the anticancer compositions comprise 3-halo-2-oxopropionate and its derivatives, such as ester derivatives. However, in specific embodiments, the anticancer composition is sodium 3-halo-2-oxopropionate, such as sodium 3-bromo-2-oxopropionate and a stabilizing agent, such as carbonic acid. In particular embodiments, the compositions of the present invention further comprise a metabolic intermediate for normal cells to utilize in a pathway for an alternate energy source, thereby providing protection to normal cells. In other embodiments, the 3-halo-2-oxopropionate or its ester derivative is used in combination with an additional cancer therapy, such as radiation and/or a drug.
摘要翻译：本发明涉及在癌症中抑制糖酵解的组合物。具体地，抗癌组合物包含3-卤代-2-氧代丙酸酯及其衍生物，例如酯衍生物。然而，在具体实施方案中，抗癌组合物是3-卤代-2-氧代丙酸钠，如3-溴-2-氧代丙酸钠和稳定剂如碳酸。在具体实施方案中，本发明的组合物进一步包含正常细胞的代谢中间体，以用于替代能量源的途径，由此为正常细胞提供保护。在其它实施方案中，3-卤代-2-氧代丙酸酯或其酯衍生物与额外的癌症治疗如辐射和/或药物组合使用。

4. 发明申请

US20060001920A1 Portable electronic device 失效
标题翻译：便携式电子设备
公开(公告)号：US20060001920A1
公开(公告)日：2006-01-05
申请号：US10884594
申请日：2004-07-03
申请人： Mario Moreno , Robert Cichielo , Michael Keating
发明人： Mario Moreno , Robert Cichielo , Michael Keating
IPC分类号： H04N1/04
CPC分类号： H04N1/00 , H04N2201/0081 , H04N2201/0082 , H04N2201/0093 , H04N2201/0096
摘要： A lightweight, battery operated, portable, personal electronic device capable of faxing, scanning, printing and copying media as a standalone device or in cooperation with other electronic devices including PCs, mobile telephones, PDAs, etc. is provided. The device automatically detects the presence of fax-capable devices and reconfigures the software for compatibility with the fax-capable device eliminating the need for user programming. The device's ergonomic design, intrinsic physical stability, and same side paper feeds and user interface provide use in work areas having limited space. The device includes unidirectional, independent pathways for original and recording media such that paper jams are minimized. Portability is maximized through innovative power management software and hardware.
摘要翻译：提供了一种轻巧的，电池供电的便携式个人电子设备，其能够传真，扫描，打印和复制作为独立设备的媒体或与包括PC，移动电话，PDA等其他电子设备的协作。该设备自动检测是否有传真功能的设备，并重新配置该软件以兼容具有传真功能的设备，从而无需用户编程。该设备的人体工程学设计，固有的物理稳定性以及相同的侧面进纸和用户界面可在具有有限空间的工作区域中使用。该装置包括用于原始和记录介质的单向独立通路，使卡纸最小化。通过创新的电源管理软件和硬件，可移植性最大化。

5. 发明申请

US20050004044A1 Use of orsaponin [3beta, 16beta, 17 alpha-trihydroxycholost-5-en-22-one 16-0-(2-0-4-methoxybenzoyl-beta-D-xylopyranosyl)-(1->3)-(2-0-acetyl-alpha-L-arabinopyranoside)] or OSW-1 and its derivatives for cancer therapeutics 审中-公开
标题翻译：使用orsaponin [3β，16beta，17α-三羟基磷酸酯-5-烯-22-酮16-0-（2-0-4-甲氧基苯甲酰基-β-D-吡喃木糖基） - （1-> 3） - （2- O-乙酰-α-L-阿拉伯糖苷）]或OSW-1及其衍生物用于癌症治疗
公开(公告)号：US20050004044A1
公开(公告)日：2005-01-06
申请号：US10819479
申请日：2004-04-07
申请人： Peng Huang , Michael Keating , Zhendong Jin
发明人： Peng Huang , Michael Keating , Zhendong Jin
IPC分类号： A01N45/00 , A61K20060101 , A61K31/56 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704
CPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/704
摘要： The present invention concerns methods for treating pancreatic cancers, leukemias, colon cancers, malignant gliomas and other brain tumors, and ovarian cancers which comprise providing to an individual compositions comprising an orsaponin such as OSW-1 or its derivatives such as 17-deoxyorsaponin. Various therapeutically useful derivatives of orsaponins are also described.
摘要翻译：本发明涉及用于治疗胰腺癌，白血病，结肠癌，恶性胶质瘤和其他脑肿瘤的卵巢癌和卵巢癌的方法，所述卵巢癌包括提供包含诸如OSW-1或其衍生物例如17-脱氧肌糖蛋白的牡蛎素的个体组合物。还描述了orapapin的各种治疗上有用的衍生物。

6. 外观设计

USD456754S1 Vehicle gauge 失效
公开(公告)号：USD456754S1
公开(公告)日：2002-05-07
申请号：US29144420
申请日：2001-07-03
申请人： Michael Keating
设计人： Michael Keating

7. 发明申请

US20090048504A1 Medical electrode systems and methods 审中-公开
公开(公告)号：US20090048504A1
公开(公告)日：2009-02-19
申请号：US11893815
申请日：2007-08-17
申请人： Rafael V. Andino , Christopher Brooks , Michael Keating , Courtney Morgan , Donald Van Royen
发明人： Rafael V. Andino , Christopher Brooks , Michael Keating , Courtney Morgan , Donald Van Royen
IPC分类号： A61B5/04
CPC分类号： A61N1/0468 , A61B5/445 , A61B2562/043 , A61N1/0472 , A61N1/0476 , A61N1/0492 , A61N1/0496 , A61N1/205
摘要： Systems, methods, and devices are provided for creating and applying electrodes and electrode systems to a wound or skin. An electrode may be applied as a single electrode strip using a dispenser. An electrode may also be cut to size from a single sheet of electrode. Additionally, an electrode may be formed from a plurality of electrode segments which may be connected together. Electrodes can also be incorporated as part of drainage tubes. A medical electrode kit may be provided that includes multiple electrode segments and connectors, multiple electrodes, and multiple control modules. In addition, electrodes or electrode systems may be provided with a color scoring chart. An electrode system may be configured to interface with a selected body part. Electrode systems may include sensors and electrodes configured for application to areas outside of a wound or the skin intended to be treated.

8. 发明申请

US20060073527A1 Using plasma proteomic pattern for diagnosis, classification, prediction of response to therapy and clinical behavior, stratification of therapy, and monitoring disease in hematologic malignancies 有权
公开(公告)号：US20060073527A1
公开(公告)日：2006-04-06
申请号：US11110374
申请日：2005-04-20
申请人： Maher Albitar , Elihu Estey , Hagop Kantarjian , Francis Giles , Michael Keating
发明人： Maher Albitar , Elihu Estey , Hagop Kantarjian , Francis Giles , Michael Keating
IPC分类号： G01N33/574 , G01N33/00
CPC分类号： G01N33/6851 , G01N33/57426 , G01N33/6803 , G01N33/6848 , G01N2800/52 , Y10T436/24 , Y10T436/25 , Y10T436/25625
摘要： The present invention demonstrates that the diagnosis and prediction of clinical behavior in patients with hematologic malignancies, such as leukemia, can be accomplished by analysis of proteins present in a plasma sample. Thus, in particular embodiments the present invention uses plasma to create a diagnostic or prognostic protein profile of a hematologic malignancy comprising collecting plasma samples from a population of patients with hematologic malignancies; generating protein spectra from the plasma samples with or without fractionation; comparing the protein spectra with clinical data; and identifying protein markers in the plasma samples that correlate with the clinical data. Protein markers identified by this approach can then be used to create a protein profile that can be used to diagnose the hematologic malignancy or determine the prognosis of the hematologic malignancy. Potentially these specific proteins can be identified and targeted in the therapy of these malignancies.

9. 发明申请

US20060152770A1 Gravure printing 审中-公开
标题翻译：凹版印刷
公开(公告)号：US20060152770A1
公开(公告)日：2006-07-13
申请号：US10521374
申请日：2003-02-20
申请人： Michael Keating
发明人： Michael Keating
IPC分类号： B41C1/04
CPC分类号： B41C1/045 , B44B3/061
摘要： The invention relates to a method of engraving a plurality of gravure cells in a surface, the method comprising the steps of; (a) mounting an engraving stylus comprising a stylus body inwardly tapering to the stylus tip, in an engraving head; (b) effecting penetration of the engraving stylus into the surface to a desired depth to produce a cell; (c) effecting partial withdrawal of the engraving stylus from the cell; (d) effecting relative movement between the stylus and the surface such that the partially withdrawn stylus effects engraving of a channel of shallower depth than the cell in the surface and having a channel width of at least 40% of the width of the previous cell engraved in the method; and (e) effecting further penetration of the engraving stylus into the surface to a desired depth, and effecting relative movement between the stylus and surface to produce a cell. The invention further relates to novel gravure engraving styli, comprising triangular prism, triangular prismoid or planar quadrilateral shaped tips.
摘要翻译：本发明涉及一种在表面上雕刻多个凹版印刷电池的方法，该方法包括以下步骤：（a）在雕刻头中安装包括向内逐渐变细的触控笔体的雕刻笔，（b）使雕刻触针进入表面到期望的深度以产生电池; （c）将雕刻笔从电池部分退出; （d）实现触针与表面之间的相对运动，使得部分抽出的触控笔实现比表面中的单元更浅深度的沟道的雕刻，并且具有至少刻有上一个单元的宽度的至少40％的沟道宽度在方法中; 和（e）进一步将雕刻触针进入表面到期望的深度，并且实现触针和表面之间的相对运动以产生电池。本发明还涉及新型凹版雕刻笔，其包括三角棱镜，三棱柱形或平面四边形形状的尖端。

10. 发明申请

US20050251234A1 Systems and methods for RF-induced hyperthermia using biological cells and nanoparticles as RF enhancer carriers 审中-公开
标题翻译：使用生物细胞和纳米颗粒作为RF增强载体的RF诱导的热疗的系统和方法
公开(公告)号：US20050251234A1
公开(公告)日：2005-11-10
申请号：US11050481
申请日：2005-02-03
申请人： John Kanzius , William Steinbrink , Robert McDonald , Michael Keating
发明人： John Kanzius , William Steinbrink , Robert McDonald , Michael Keating
IPC分类号： A61B18/14 , A61F2/00 , A61N1/40
CPC分类号： A61K41/0052 , A61N1/403 , A61N1/406 , A61N5/1001 , B82Y5/00
摘要： A method of inducing hyperthermia in at least a portion of a target area—e.g., a tumor or a portion of a tumor or targeted cancerous cells—is provided. Targeted RF absorption enhancers, e.g., tumor infiltrating lymphocytes (TILs) containing RF absorbing particles, are introduced into a patient. These targeted RF absorption enhancers will target certain cells in the target areas and enhance the effect of a hyperthermia generating RF signal directed toward the target area. The targeted RF absorption enhancers may, in a manner of speaking, add one or more RF absorption frequencies to cells in the target area, which will permit a hyperthermia generating RF signal at that frequency or frequencies to heat the targeted cells.
摘要翻译：提供了在目标区域的至少一部分（例如肿瘤或肿瘤部分或靶向癌细胞）中诱导高热的方法。靶向RF吸收增强剂，例如含有RF吸收颗粒的肿瘤浸润淋巴细胞（TIL）被引入患者体内。这些靶向RF吸收增强剂将靶向目标区域中的某些细胞并且增强产生针对靶区域的RF热信号产生的热疗效果。靶向RF吸收增强剂可以以说话的方式将一个或多个RF吸收频率添加到目标区域中的细胞，这将允许产生以该频率或频率的RF信号以加热靶细胞的热疗。

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