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1. 发明申请

US20140005213A1 TRIAZOLOPYRIDINE COMPOUNDS AS PIM KINASE INHIBITORS 有权
标题翻译：三唑啉化合物作为PIM激酶抑制剂
公开(公告)号：US20140005213A1
公开(公告)日：2014-01-02
申请号：US14001657
申请日：2012-02-24
申请人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
发明人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
IPC分类号： C07D471/04 , C07D491/048 , C07D487/10 , C07D487/04
CPC分类号： C07D471/04 , C07D401/06 , C07D487/04 , C07D487/10 , C07D491/048 , C07D519/00
摘要： Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要翻译： R 1，R 2，R 3，R 4和R 10具有本说明书中给出的含义的式I化合物是可用于治疗由PIM-1和/或PIM-2和/或PIM-2介导的疾病的受体酪氨酸抑制剂， 3激酶。

2. 发明授权

US08889704B2 Triazolopyridine compounds as PIM kinase inhibitors 有权
标题翻译：三唑并吡啶化合物作为PIM激酶抑制剂
公开(公告)号：US08889704B2
公开(公告)日：2014-11-18
申请号：US14001657
申请日：2012-02-24
申请人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
发明人： James F. Blake , Robert Kirk Delisle , Lisa A. De Meese , James M. Graham , Yvan Le Huerou , Michael Lyon , John E. Robinson , Eli M. Wallace , Bin Wang , Rui Xu
IPC分类号： C07D471/04 , C07D487/04 , C07D487/10 , C07D491/048 , C07D401/06 , C07D519/00
CPC分类号： C07D471/04 , C07D401/06 , C07D487/04 , C07D487/10 , C07D491/048 , C07D519/00
摘要： Compounds of Formula I: in which R1, R2, R3, R4 and R10 have the meanings given in the specification, are receptor tyrosine inhibitors useful in the treatment of diseases mediated by PIM-1 and/or PIM-2 and/or PIM-3 kinases.
摘要翻译： R 1，R 2，R 3，R 4和R 10具有本说明书中给出的含义的式I化合物是可用于治疗由PIM-1和/或PIM-2和/或PIM-2介导的疾病的受体酪氨酸抑制剂， 3激酶。

3. 发明授权

US08618097B2 Pyrimidyl cyclopentanes as AKT protein kinase inhibitors 有权
标题翻译：嘧啶环戊烷作为AKT蛋白激酶抑制剂
公开(公告)号：US08618097B2
公开(公告)日：2013-12-31
申请号：US12667848
申请日：2008-07-03
申请人： Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
发明人： Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
IPC分类号： A61K31/5377 , A61K31/496 , C07D413/14 , C07D239/70 , A61P25/28 , A61P35/00 , A61P29/00 , A61P9/00
CPC分类号： C07D403/12 , C07D401/12
摘要： The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供式（I）化合物，其包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

4. 发明申请

US20110015204A1 PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS 有权
标题翻译：作为AKT蛋白激酶抑制剂的PYRIMIDYL CYCLOPENTANES
公开(公告)号：US20110015204A1
公开(公告)日：2011-01-20
申请号：US12667848
申请日：2008-07-03
申请人： Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
发明人： Josef Bencsik , James F. Blake , James M. Graham , Martin F. Hentemann , Nicholas C. Kallan , Ian S. Mitchell , Stephen T. Schlachter , Keith L. Spencer , Dengming Xiao , Rui Xu , Mike Welch , Jun Liang , Brian S. Safina
IPC分类号： A61K31/497 , C07D239/70 , A61P35/00
CPC分类号： C07D403/12 , C07D401/12
摘要： The present invention provides compounds of Formula (I), including tautomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.
摘要翻译：本发明提供式（I）化合物，其包括互变异构体，拆分的对映异构体，非对映异构体，溶剂合物，代谢物，盐和药学上可接受的前药。还提供了使用本发明化合物作为AKT蛋白激酶抑制剂和治疗过度增殖性疾病如癌症的方法。

5. 发明授权

US4838005A Stairway apparatus and method of manufacture 失效
标题翻译：楼梯装置及制造方法
公开(公告)号：US4838005A
公开(公告)日：1989-06-13
申请号：US929826
申请日：1986-11-13
申请人： James M. Graham , Edward F. Schaack
发明人： James M. Graham , Edward F. Schaack
IPC分类号： E04F11/025 , E04F11/112
CPC分类号： E04F11/025 , E04F11/112
摘要： Stair apparatus and method of manufacture, wherein the stair apparatus has concrete tread pads and landings which are poured and set during manufacture so that pouring and setting of the concrete does not have to be done in the field, thereby saving much labor and time. The method includes a unique step of clamping the step elements between the stringer elements so that the step elements are firmly held in proper position during welding thereof to the stringer elements. The landings are supported in a novel manner in a stairwell, and the stair assemblies are supported between the landings.
摘要翻译：楼梯装置和制造方法，其中，楼梯装置具有在制造过程中倾倒和固定的混凝土踏板和平台，使得混凝土的浇注和固定不必在现场进行，从而节省了大量劳力和时间。该方法包括在纵梁元件之间夹紧台阶元件的独特步骤，使得台阶元件在将其焊接到纵梁元件期间牢固地保持在适当的位置。楼梯在楼梯间以新颖的方式得到支持，楼梯组件在着陆之间得到支撑。

6. 发明授权

US07101886B2 Phenylalkyl and pyridylalkyl piperazine derivatives 失效
标题翻译：苯基烷基和吡啶基烷基哌嗪衍生物
公开(公告)号：US07101886B2
公开(公告)日：2006-09-05
申请号：US10703333
申请日：2003-11-07
申请人： Stephen Sung Yong Cho , Jamie Marie Singer , James M. Graham , Tracy Fay Gregory , Harry Ralph Howard, Jr. , Sham Shridhar Nikam , Michael Anthony Walters
发明人： Stephen Sung Yong Cho , Jamie Marie Singer , James M. Graham , Tracy Fay Gregory , Harry Ralph Howard, Jr. , Sham Shridhar Nikam , Michael Anthony Walters
IPC分类号： A61K31/496 , C07D417/04 , C07D417/14
CPC分类号： C07D231/56 , C07D275/04 , C07D275/06 , C07D417/12
摘要： This invention relates to compounds of the formula 1 wherein R1, R3, R4, X1, and X2 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
摘要翻译：本发明涉及式1化合物，其中R 1，R 3，R 4，X 1，和X 2定义如说明书中所述，含有它们的药物组合物及其在治疗中枢神经系统和其它疾病中的用途。

7. 发明授权

US4893442A Stairway apparatus and method of manufacture 失效
标题翻译：楼梯装置及制造方法
公开(公告)号：US4893442A
公开(公告)日：1990-01-16
申请号：US275970
申请日：1988-12-28
申请人： James M. Graham , Edward F. Schaack
发明人： James M. Graham , Edward F. Schaack
IPC分类号： E04F11/025 , E04F11/112
CPC分类号： E04F11/025 , E04F11/112
摘要： Stair apparatus and method of manufacture, wherein the stair apparatus has concrete tread pads and landings which are poured and set during manufacture so that pouring and setting of the concrete does not have to be done in the field, thereby saving much labor and time. The method includes a unique step of clamping the step elements between the stringer elements so that the step elements are firmly held in proper position during welding thereof to the stringer elements. The landings are supported in a novel manner in a stairwell, and the stair assemblies are supported between the landings.
摘要翻译：楼梯装置和制造方法，其中，楼梯装置具有在制造过程中倾倒和固定的混凝土踏板和平台，使得混凝土的浇注和固定不必在现场进行，从而节省了大量劳力和时间。该方法包括在纵梁元件之间夹紧台阶元件的独特步骤，使得台阶元件在将其焊接到纵梁元件期间牢固地保持在适当的位置。楼梯在楼梯间以新颖的方式得到支持，楼梯组件在着陆之间得到支撑。

8. 发明授权

US5331554A Method and apparatus for semantic pattern matching for text retrieval 失效
标题翻译：用于文本检索的语义模式匹配的方法和装置
公开(公告)号：US5331554A
公开(公告)日：1994-07-19
申请号：US988729
申请日：1992-12-10
申请人： James M. Graham
发明人： James M. Graham
IPC分类号： G06F17/30 , G06F15/38
CPC分类号： G06F17/30908 , G06F17/30259 , G06F17/30625 , G06F17/30643 , G06F17/30672 , G06F17/30684 , G06F17/30722 , Y10S707/99935
摘要： A method and apparatus utilizing automated semantic pattern recognition whereby a user of a manual enters a query regarding information in the text of the manual and the invention displays the locations in which information responsive to the query is located. The present invention includes a computer that stores a data structure representing the natural language text of a manual, the structure being a tree structure having nodes, wherein each node represents information from associated locations of the text. The nodes at higher levels of the tree represent general categories of information. Nodes at succeedingly lower levels of the tree represent succeedingly more specific categorical subsets of the general categories of information represented at the higher levels by ancestors of the lower level nodes. The query is formatted into a query data structure that is similar in format to the node structure representing the text. The query data structure is compared to each node in the tree. If the degree of similarity between the query and the node exceeds a predetermined threshold value after taking into account the degree of similarity between the ancestors of the node and the query, then the locations associated with the node are displayed on a video monitor as locations containing information responsive to the query.
摘要翻译：一种使用自动语义模式识别的方法和装置，其中手册的用户输入关于手册的文本中的信息的查询，并且本发明显示响应于该查询的信息所在的位置。本发明包括存储表示手册的自然语言文本的数据结构的计算机，该结构是具有节点的树结构，其中每个节点表示来自文本的关联位置的信息。树的较高级别的节点表示信息的一般类别。在树的后续较低级别的节点代表由较低级节点的祖先在较高级别表示的一般信息类别的更具体的分类子集。该查询格式化为与表示文本的节点结构格式相似的查询数据结构。将查询数据结构与树中的每个节点进行比较。如果在考虑到节点的祖先与查询之间的相似度之后，查询和节点之间的相似度超过预定阈值，则与节点相关联的位置被显示在视频监视器上，作为包含响应查询的信息。

9. 发明授权

US4712092A Parallel encoded piezoelectric keyboard switch and array 失效
标题翻译：并行编码压电键盘开关和阵列
公开(公告)号：US4712092A
公开(公告)日：1987-12-08
申请号：US563525
申请日：1983-12-20
申请人： Austin Boldridge, Jr. , Scott Buell , James M. Graham
发明人： Austin Boldridge, Jr. , Scott Buell , James M. Graham
IPC分类号： H01H13/70 , H01L41/113 , H03K17/96 , H03M11/22 , G06F3/02
CPC分类号： H03M11/22 , H01H13/70 , H03K17/9643 , H03K2217/96027
摘要： A keyboard switch includes a plurality of spaced piezoelectric transducers secured to a common strike plate which is selectively impacted to actuate all of the transducers in response to switch actuation. The switch includes a snap action spring member carrying an impact member which impacts the strike plate as the spring member snaps to its actuated state when the switch is depressed . The spring member causes the impact member to maintain a compressive force against the strike plate, maintaining the transducers actuated while the key remains depressed and for a short interval after the key is released. An array of such switches on a keyboard is disposed over a plurality of parallel data lines which electrically contact one or more transducers at each switch in accordance with a switch indentification code. The parallel binary number appearing on the lines is received by processing circuitry which identifies each depressed key by its code. By maintaining compressive forces on the transducers, the system facilitates character processing and generation of certain specialized character functions.
摘要翻译：键盘开关包括固定到公共撞击板的多个间隔开的压电换能器，其被选择性地撞击以响应于开关致动来致动所有换能器。该开关包括一个卡扣动作弹簧构件，该弹簧构件承受冲击构件，当冲击开关被按压时，该冲击构件随着弹簧构件卡入其致动状态而撞击冲击板。弹簧构件使冲击构件保持抵抗撞击板的压缩力，当钥匙保持按压时，保持换能器的作用并且在钥匙被释放之后的短时间间隔内。键盘上的这种开关的阵列设置在多个并行数据线上，该数据线根据开关识别码在每个开关处电接触一个或多个换能器。出现在行上的并行二进制数由通过其代码识别每个按下的键的处理电路接收。通过保持换能器上的压缩力，系统便于字符处理和产生某些专门的字符功能。

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