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    • 4. 发明申请
    • Screening Methods and Transgenic Animals for the Treatment of Beta-Globin Related Disease and Conditions
    • 用于治疗β-球蛋白相关疾病和病症的筛选方法和转基因动物
    • US20080008651A1
    • 2008-01-10
    • US11754197
    • 2007-05-25
    • James Engel
    • James Engel
    • A61K49/00A61P7/00G01N33/53
    • C12Q1/6883C12Q2600/158G01N33/5044G01N33/6875
    • The orphan nuclear receptors TR2 and TR4 together constitute the DNA binding core of the 540 kDa DRED complex, a putative repressor of the human embryonic ε- and fetal γ-globin genes. Here the functional consequences of TR2 and TR4 germ line loss of function were examined, transgenic gain of function and dominant negative gain of function on human and murine β-type globin gene expression throughout development. ε-globin transcription responded in a manner consistent with the hypothesis that TR2/TR4 is a constitutive erythroid ε-globin repressor. In contrast, parallel experiments show that TR2/TR4 is a definitive stage-selective γ-globin repressor. This developmental stage-specific, gene-selective repression of the ε- and γ-globin genes by TR2/TR4 establishes, when considered in concert with the competition hypothesis, a coherent molecular rationale for hemoglobin switching (temporally specific, sequential activation of all the β-type globin genes) during vertebrate development.
    • 孤儿核受体TR2和TR4一起构成540kDa DRED复合物的DNA结合核心,该复合物是人类胚胎和胎儿γ-珠蛋白基因的推定阻遏物。 在此研究TR2和TR4生殖系丧失功能的功能后果,在整个发展过程中检测了转基因人类和鼠类β型球蛋白基因表达功能的功能增强和显性负增益。 ε-珠蛋白转录以与TR2 / TR4是组成型红细胞ε-珠蛋白阻遏物的假设一致的方式进行应答。 相比之下,平行实验显示TR2 / TR4是确定性的阶段选择性γ-球蛋白阻遏物。 TR2 / TR4对ε-和γ-珠蛋白基因的这种发育阶段特异性基因选择性抑制,当与竞争假说一致时,建立了血红蛋白切换的连贯分子理论(时间特异性,顺序激活所有 β型球蛋白基因)。
    • 6. 发明申请
    • Variable Sigma Adjust Methodology For Static Timing
    • 静态时序的可变Sigma调整方法
    • US20070089078A1
    • 2007-04-19
    • US11560500
    • 2006-11-16
    • James EngelJerry Hayes
    • James EngelJerry Hayes
    • G06F17/50G06F9/45
    • G06F17/5031G06F17/5045
    • The invention presents a method of accommodating for across chip line variation (ACLV) and/or changing static timing of an integrated circuit design. The invention first establishes a circuit design having initial timing requirements and an initial voltage supply and also establishes a relationship between gate timing variations caused by voltage supply changes and gate timing variations caused by manufacturing processing changes. Then, according to the customer's orders that change the initial timing requirements to revised timing requirements, the invention changes the initial voltage supply to a revised voltage supply to accommodate the revised timing requirements (and ACLV if desired) based on the relationship between voltage limits and transistor delay. This process of changing the initial voltage supply does not alter the circuit design.
    • 本发明提出了一种适应跨芯片线路变化(ACLV)和/或改变集成电路设计的静态定时的方法。 本发明首先建立了具有初始定时要求和初始电压供应的电路设计,并且还建立由电压供应变化引起的门定时变化与由制造处理变化引起的门时序变化之间的关系。 然后,根据客户的订单,将初始时间要求改变为修订的时序要求,本发明将初始电压供应改变为修正的电源,以适应修订的时序要求(如果需要,则根据需要进行ACLV),基于电压限制和 晶体管延迟。 改变初始电压源的这个过程不会改变电路设计。
    • 7. 发明申请
    • NOTCH-FINDING MECHANISM AND METHOD OF USING THE SAME
    • 发现机制及其使用方法
    • US20070063092A1
    • 2007-03-22
    • US11533605
    • 2006-09-20
    • Thomas ZevinJames Engel
    • Thomas ZevinJames Engel
    • B65H16/06
    • B65H16/06B65H19/126B65H75/185B65H75/30B65H2301/41369B65H2801/12B65H2801/36
    • One embodiment of the invention is a notch finding mechanism that at least partially supports and drives a core carrying printer media. The notch finding mechanism includes a notch finding spring and a plurality of support posts that extend from a support disk. The notch finding spring includes a plurality of fingers constructed of a flexible sheet material, and the fingers are positioned circumferentially and adjacent each other to define a plurality of spaces between the fingers. In addition, the fingers are biased radially outwardly, and each of the fingers has a free end that has a width that is approximately matched to a width of a notch in an end of the core. The bias of one of the fingers urges the free end of the finger into the notch aligned with the finger when the core is placed over the fingers and is rotated a small amount.
    • 本发明的一个实施例是一种缺口查找机构,其至少部分地支撑和驱动携带携带的打印机介质的核心。 缺口查找机构包括切口弹簧和从支撑盘延伸的多个支撑柱。 缺口查找弹簧包括由柔性片材构成的多个指状物,并且指状物周向地定位并且彼此相邻以在指状物之间限定多个空间。 此外,手指被径向向外偏置,并且每个指状物具有自由端,该自由端具有与芯的端部中的凹口的宽度近似匹配的宽度。 当芯部放置在手指上方并且旋转少量时,其中一个指状物的偏压促使手指的自由端进入与手指对准的凹口中。
    • 8. 发明申请
    • VARIABLE SIGMA ADJUST METHODOLOGY FOR STATIC TIMING
    • 用于静态定时的可变SIGMA调整方法
    • US20060026544A1
    • 2006-02-02
    • US10710734
    • 2004-07-30
    • James EngelJerry Hayes
    • James EngelJerry Hayes
    • G06F17/50
    • G06F17/5031G06F17/5045
    • The invention presents a method of accommodating for across chip line variation (ACLV) and/or changing static timing of an integrated circuit design. The invention first establishes a circuit design having initial timing requirements and an initial voltage supply and also establishes a relationship between gate timing variations caused by voltage supply changes and gate timing variations caused by manufacturing processing changes. Then, according to the customer's orders that change the initial timing requirements to revised timing requirements, the invention changes the initial voltage supply to a revised voltage supply to accommodate the revised timing requirements (and ACLV if desired) based on the relationship between voltage limits and transistor delay. This process of changing the initial voltage supply does not alter the circuit design.
    • 本发明提出了一种适应跨芯片线路变化(ACLV)和/或改变集成电路设计的静态定时的方法。 本发明首先建立了具有初始定时要求和初始电压供应的电路设计,并且还建立由电压供应变化引起的门定时变化与由制造处理变化引起的门时序变化之间的关系。 然后,根据客户的订单,将初始时间要求改变为修订的时序要求,本发明将初始电压供应改变为修正的电源,以适应修订的时序要求(如果需要,则根据需要进行ACLV),基于电压限制和 晶体管延迟。 改变初始电压源的这个过程不会改变电路设计。