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1. 发明授权

US4522828A Therapeutic agents 失效
公开(公告)号：US4522828A
公开(公告)日：1985-06-11
申请号：US365285
申请日：1982-04-05
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

2. 发明授权

US4746680A Therapeutic agents 失效
标题翻译：治疗剂
公开(公告)号：US4746680A
公开(公告)日：1988-05-24
申请号：US725206
申请日：1985-04-19
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
摘要翻译：式I的化合物其中R 1为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-7环烷基，环烷基烷基或任选取代的苯基; R2是H或C1-3烷基; R 3和/或R 4是H，甲酰基，C 1-3烷基，C 3-6烯基，C 3-6炔基，C 3-7环烷基或R 3和R 4与氮原子一起形成杂环体系; R 5和/或R 6是H，卤素，CF 3，C 1-3烷基，C 1-3烷氧基，C 1-3烷硫基或R 5和R 6与它们所连接的碳原子一起形成第二苯环，治疗抑郁症。公开了制备式I化合物的药物组合物和方法。

3. 发明授权

US4814352A Therapeutic agents 失效
标题翻译：治疗剂
公开(公告)号：US4814352A
公开(公告)日：1989-03-21
申请号：US44604
申请日：1987-05-01
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
摘要翻译：式I的化合物其中R 1为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-7环烷基，环烷基烷基或任选取代的苯基; R2是H或C1-3烷基; R 3和/或R 4是H，甲酰基，C 1-3烷基，C 3-6烯基，C 3-6炔基，C 3-7环烷基或R 3和R 4与氮原子一起形成杂环体系; R 5和/或R 6是H，卤素，CF 3，C 1-3烷基，C 1-3烷氧基，C 1-3烷硫基或R 5和R 6与它们所连接的碳原子一起形成第二苯环，治疗抑郁症。公开了制备式I化合物的药物组合物和方法。

4. 发明授权

US4767790A Therapeutic agents 失效
标题翻译：治疗剂
公开(公告)号：US4767790A
公开(公告)日：1988-08-30
申请号：US725129
申请日：1985-04-19
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmshurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185 , C07C87/50
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic acitivity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
摘要翻译：式I的化合物其中R 1为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-7环烷基，环烷基烷基或任选取代的苯基; R2是H或C1-3烷基; R 3和/或R 4是H，甲酰基，C 1-3烷基，C 3-6烯基，C 3-6炔基，C 3-7环烷基或R 3和R 4与氮原子一起形成杂环体系; R 5和/或R 6是H，卤素，CF 3，C 1-3烷基，C 1-3烷氧基，C 1-3烷硫基或R 5和R 6与它们所连接的碳原子一起形成第二苯环，表明在治疗抑郁症。公开了用于制备式I化合物的药物组合物和方法。

5. 发明授权

US4443449A Arylcyclobutylalkylamines and anti-depression composition and methods using same 失效
标题翻译：芳基丁基烷基胺和抗抑郁组合物及其使用方法
公开(公告)号：US4443449A
公开(公告)日：1984-04-17
申请号：US365287
申请日：1982-04-05
申请人： James E. Jeffery , Eric C. Wilmshurst
发明人： James E. Jeffery , Eric C. Wilmshurst
IPC分类号： A61K31/13 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/44 , C07C57/46 , C07C61/40 , C07D211/70 , C07D295/073 , C07D295/185 , A61K31/135 , C07C87/28
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/44 , C07C57/46 , C07C61/40 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is H or C.sub.1-3 alkyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, or C.sub.1-3 alkyl (with the proviso that R.sub.5 and R.sub.6 cannot both be H or methyl) or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring and R.sub.7 and/or R.sub.8 are H or C.sub.1-3 alkyl show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.
摘要翻译：其中R 1是H或C 1-3烷基的式I化合物 R2是H或C1-3烷基; R 3和/或R 4是H，C 1-3烷基，C 3-6烯基，C 3-6炔基，C 3-7环烷基或R 3和R 4与氮原子一起形成杂环体系; R 5和/或R 6是H，卤素，CF 3或C 1-3烷基（条件是R 5和R 6不能都是H或甲基）或R 5和R 6与它们所连接的碳原子一起形成第二个苯 R 7和/或R 8为H或C 1-3烷基表示治疗抑郁症的治疗活性。公开了制备式I化合物的药物组合物和方法。

6. 发明授权

US4806570A Therapeutic agents 失效
公开(公告)号：US4806570A
公开(公告)日：1989-02-21
申请号：US812730
申请日：1985-12-23
申请人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmhurst
发明人： James E. Jeffery , Antonin Kozlik , Eric C. Wilmhurst
IPC分类号： C07D295/06 , A01N33/02 , A61K31/135 , A61K31/16 , A61K31/165 , A61K31/40 , A61K31/435 , A61K31/495 , A61P25/24 , A61P25/26 , C07C29/147 , C07C33/50 , C07C45/00 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07C67/00 , C07C209/00 , C07C209/28 , C07C209/40 , C07C209/48 , C07C209/52 , C07C209/56 , C07C209/58 , C07C211/25 , C07C211/26 , C07C213/00 , C07C217/74 , C07C231/00 , C07C231/02 , C07C231/08 , C07C231/10 , C07C231/12 , C07C233/03 , C07C233/05 , C07C233/13 , C07C233/18 , C07C313/00 , C07C323/32 , C07D207/06 , C07D211/70 , C07D295/073 , C07D295/185
CPC分类号： C07D295/185 , C07C255/00 , C07C29/147 , C07C33/50 , C07C45/004 , C07C45/42 , C07C45/44 , C07C49/237 , C07C49/567 , C07C57/46 , C07C61/40 , C07D207/06 , C07D211/70 , C07D295/073 , C07C2101/04
摘要： Compounds of formula I ##STR1## in which R.sub.1 is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-7 cycloalkyl, cycloalkylalkyl or optionally substituted phenyl; R.sub.2 is H or C.sub.1-3 alkyl; R.sub.3 and/or R.sub.4 are H, formyl, C.sub.1-3 alkyl, C.sub.3-6 alkenyl, C.sub.3-6 alkynyl, C.sub.3-7 cycloalkyl or R.sub.3 and R.sub.4 together with the nitrogen atom form a heterocyclic ring system; R.sub.5 and/or R.sub.6 are H, halo, CF.sub.3, C.sub.1-3 alkyl, C.sub.1-3 alkoxy, C.sub.1-3 alkylthio or R.sub.5 and R.sub.6 together with the carbon atoms to which they are attached form a second benzene ring show therapeutic activity in the treatment of depression. Pharmaceutical compositions and processes for preparing compounds of formula I are disclosed.

7. 发明授权

US4833143A Antidepressant amines 失效
标题翻译：抗抑郁胺
公开(公告)号：US4833143A
公开(公告)日：1989-05-23
申请号：US536670
申请日：1983-09-28
申请人： Bernard J. Armitage , John R. Housley , James E. Jeffery , David N. Johnston
发明人： Bernard J. Armitage , John R. Housley , James E. Jeffery , David N. Johnston
IPC分类号： C07D257/02 , A61K31/135 , A61K31/34 , A61K31/381 , A61K31/385 , A61K31/40 , A61K31/415 , A61K31/4164 , A61K31/425 , A61K31/44 , A61K31/4425 , A61P25/24 , A61P25/26 , C07D207/09 , C07D207/12 , C07D207/335 , C07D213/38 , C07D231/12 , C07D233/54 , C07D233/61 , C07D233/64 , C07D235/14 , C07D249/08 , C07D257/04 , C07D277/28 , C07D295/13 , C07D295/15 , C07D307/14 , C07D307/34 , C07D307/52 , C07D333/20 , C07D333/22 , C07D339/08 , C07D401/12 , C07D409/12 , C07D521/00
CPC分类号： C07D231/12 , C07C255/00 , C07D207/09 , C07D207/12 , C07D213/38 , C07D233/56 , C07D233/64 , C07D249/08 , C07D257/04 , C07D277/28 , C07D295/13 , C07D295/15 , C07D307/14 , C07D307/52 , C07D333/20 , C07D333/22 , C07D339/08 , C07D401/12 , C07D409/12
摘要： Compounds of formula I ##STR1## in which R.sub.1 is a heterocyclic ring containing one or more heteroatoms selected from N, O and S;in which R.sub.2 is H, a straight or branched chain alkyl group containing 1 to 4 carbon atoms, an alkenyl group containing 3 to 6 carbon atoms, an alkynyl group containing 3 to 6 carbon atoms or a cycloalkyl group containing 3 to 7 carbon atoms;in which R.sub.3, is H, a straight chain alkyl group containing 1 to 3 carbon atoms or a formyl groupin which R.sub.4, R.sub.5 and R.sub.6 which may be the same or different, are H, halo, trifluoromethyl, hydroxy, an alkyl group containing 1 to 3 carbon atoms, an alkoxy group containing 1 to 3 carbon atoms, phenyl or R.sub.4 and R.sub.5, together with the carbon atoms to which they are attached, form an optionally substituted second benzene ring;and their pharmaceutically acceptable salts have utility in the treatment of depression. Pharmaceutical compositions and processes for the preparation of compounds of formula I are disclosed.
摘要翻译：式I的化合物其中R 1是含有一个或多个选自N，O和S的杂原子的杂环; 其中R 2为H，含有1至4个碳原子的直链或支链烷基，含3至6个碳原子的烯基，含有3至6个碳原子的炔基或含3至7个碳原子的环烷基; 其中R3为H，含有1至3个碳原子的直链烷基或甲酰基，其中可以相同或不同的R 4，R 5和R 6为H，卤素，三氟甲基，羟基，含有 1至3个碳原子，含有1至3个碳原子的烷氧基，苯基或R4和R5与它们所连接的碳原子一起形成任选取代的第二苯环; 其药学上可接受的盐可用于治疗抑郁症。公开了用于制备式I化合物的药物组合物和方法。

8. 发明授权

US5068440A Process for the manufacture of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate 失效
标题翻译：制备N，N-二甲基-1-（1-（4-氯苯基）环己基）-3-甲基丁基氯化氢单一盐酸盐的方法
公开(公告)号：US5068440A
公开(公告)日：1991-11-26
申请号：US467471
申请日：1990-01-19
申请人： James E. Jeffery , Derek Whybrow
发明人： James E. Jeffery , Derek Whybrow
IPC分类号： A61K31/135 , A61K31/12 , A61K31/13 , A61P25/24 , A61P25/26 , C07C20060101 , C07C67/00 , C07C209/00 , C07C211/00 , C07C211/01 , C07C211/17 , C07C211/26 , C07C211/27 , C07C211/29 , C07C211/33
CPC分类号： C07C211/29 , C07B2200/13 , C07C2101/04
摘要： A process for the preparation of N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate, a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.

9. 发明授权

US4929629A Therapeutic compound 失效
标题翻译：治疗化合物
公开(公告)号：US4929629A
公开(公告)日：1990-05-29
申请号：US342638
申请日：1989-04-19
申请人： James E. Jeffery
发明人： James E. Jeffery
IPC分类号： A61K31/135 , A61K31/12 , A61K31/13 , A61P25/24 , A61P25/26 , C07C20060101 , C07C67/00 , C07C209/00 , C07C211/00 , C07C211/01 , C07C211/17 , C07C211/26 , C07C211/27 , C07C211/29 , C07C211/33
CPC分类号： C07C211/29 , C07B2200/13 , C07C2101/04
摘要： N,N-Dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride monohydrate is a non-hygroscopic material which can be used as a pharmaceutical in the treatment of depression.
摘要翻译： N，N-二甲基-1- [1-（4-氯苯基）环丁基] -3-甲基丁胺盐酸盐一水合物是可用作治疗抑郁症药物的非吸湿性材料。

10. 发明授权

US5580866A Therapeutic 1,4-thiazepines 失效
标题翻译：治疗性1,4-硫氮杂
公开(公告)号：US5580866A
公开(公告)日：1996-12-03
申请号：US424464
申请日：1995-05-03
申请人： John R. Housley , James E. Jeffery , Kenneth J. Nichol , Bruce J. Sargent
发明人： John R. Housley , James E. Jeffery , Kenneth J. Nichol , Bruce J. Sargent
IPC分类号： A61K31/55 , A61K31/554 , A61P25/08 , C07D281/10
CPC分类号： C07D281/10
摘要： Compounds of formula I ##STR1## in which n=0, 1 or 2;R.sub.1, R.sub.2, R.sub.6 and R.sub.7 independently represent H or alkyl (optionally substituted by one or more halo);R.sub.3 and R.sub.4 independently represent H or alkyl or together represent a group of formula .dbd.NR.sub.12 where R.sub.12 represents H, hydroxy, alkyl, phenyl or alkoxy; each alkyl, phenyl and alkoxy being optionally substituted with one or more halo;R.sub.5 represents: (a) H, (b) alkyl, (c) a group of formula --COR.sub.13 in which R.sub.13 is H, alkyl or phenyl, when R.sub.3 and R.sub.4 represent H or alkyl (optionally substituted with one or more halo), or (d) a group of formula --S(O).sub.p R.sub.14 in which p=1 or 2 and R.sub.14 is alkyl or phenyl, when R.sub.3 and R.sub.4 represent H or alkyl (optionally substituted with one or more halo); each alkyl and phenyl optionally substituted with one or more halo;and R.sub.8 to R.sub.11 independently represent H, halo, cyano, nitro, alkyl alkoxy, alkanoyl, carboxy, alkanoyloxy, carbamoyl (optionally substituted with alkyl or sulphamoyl (optionally substituted with alkyl of 1 to 4 carbon atoms); each alkyl, alkoxy, alkanoyl or alkanoyloxy optionally substituted with one or more halo;have utility in the treatment of seizures and/or neurological disorders such as epilepsy and/or as neuroprotective agents to protect against conditions such as stroke.
摘要翻译： PCT No.PCT / EP93 / 03123 Sec。 371日期：1995年5月3日 102（e）日期1995年5月3日PCT提交1993年11月6日PCT公布。第WO94 / 11360号公报日期：1994年5月26日公式I I的化合物，其中n = 0,1或2; R1，R2，R6和R7独立地表示H或烷基（任选被一个或多个卤素取代）; R3和R4独立地表示H或烷基或一起代表式= NR12的基团，其中R12表示H，羟基，烷基，苯基或烷氧基; 每个烷基，苯基和烷氧基任选被一个或多个卤素取代; R 5表示：（a）H，（b）烷基，（c）R 3为H，烷基或苯基的式-COR 13基团，当R 3和R 4表示H或烷基（任选被一个或多个卤素取代时）或（d）当R 3和R 4表示H或烷基（任选被一个或多个卤素取代）时，其中p = 1或2且R 14为烷基或苯基的式-S（O）pR 14基团; 每个烷基和任选被一个或多个卤素取代的苯基; 并且R 8至R 11独立地表示H，卤素，氰基，硝基，烷基烷氧基，烷酰基，羧基，烷酰氧基，氨基甲酰基（任选被烷基或氨磺酰基（任选被1至4个碳原子的烷基取代）取代;各烷基，烷氧基，烷酰基或任选被一个或多个卤素取代的烷酰氧基;可用于治疗癫痫发作和/或神经障碍，例如癫痫和/或作为神经保护剂以防止诸如中风的病症。

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