专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09701740B2 Cell-penetrating anti-DNA antibodies and uses thereof inhibit DNA repair 有权
公开(公告)号：US09701740B2
公开(公告)日：2017-07-11
申请号：US14009327
申请日：2012-04-02
申请人： James E. Hansen , Peter M. Glazer , Richard H. Weisbart , Robert N. Nishimura , Grace Chan
发明人： James E. Hansen , Peter M. Glazer , Richard H. Weisbart , Robert N. Nishimura , Grace Chan
IPC分类号： C07K16/18 , A61K39/00 , A61K39/395 , C07K16/44 , A61K31/704 , A61K45/06 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/7068 , A61K33/24
CPC分类号： C07K16/18 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.

2. 发明申请

US20140050723A1 Cell-Penetrating Anti-DNA Antibodies and Uses Thereof Inhibit DNA Repair 有权
标题翻译：细胞穿透抗DNA抗体及其用途抑制DNA修复
公开(公告)号：US20140050723A1
公开(公告)日：2014-02-20
申请号：US14009327
申请日：2012-04-02
申请人： James E. Hansen , Peter M. Glazer , Richard H. Weisbart , Robert N. Nishimura , Grace Chan
发明人： James E. Hansen , Peter M. Glazer , Richard H. Weisbart , Robert N. Nishimura , Grace Chan
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K31/337 , A61K31/475 , A61K31/513 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/44 , C07K2317/622 , C07K2317/73 , C07K2317/77 , A61K2300/00
摘要： Antibodies that penetrate cell nuclei and inhibit DNA repair or interfere with DNA metabolism are provided for treatment of cancer (both directly and by sensitizing cancer cells to DNA-damaging treatments) or inhibiting or preventing viral infection, proliferation or metabolism. The method involves treating cells with a composition containing cell-penetrating anti-DNA antibodies or derivatives thereof, alone or in combination with treatment that induces DNA damage such as DNA-damaging chemotherapy or radiation. The impact of the cell-penetrating anti-DNA antibodies or derivatives thereof is potentiated in cancer cells that are deficient in DNA repair, and the cell-penetrating anti-DNA antibodies or derivatives thereof are synthetically lethal to cancer cells with DNA repair deficiencies.
摘要翻译：提供穿透细胞核并抑制DNA修复或干扰DNA代谢的抗体用于治疗癌症（直接和通过致敏癌细胞对DNA损伤性治疗）或抑制或预防病毒感染，增殖或代谢。该方法包括用包含细胞穿透性抗DNA抗体或其衍生物的组合物单独或与诱导DNA损伤如DNA损伤性化学疗法或辐射的治疗组合处理细胞。细胞穿透性抗DNA抗体或其衍生物的影响在DNA修复缺陷的癌细胞中被增强，并且细胞穿透抗DNA抗体或其衍生物对具有DNA修复缺陷的癌细胞是合成致死的。

3. 发明授权

US06442812B1 Method of manufacturing a piezoelectric torque sensor 失效
标题翻译：制造压电扭矩传感器的方法
公开(公告)号：US06442812B1
公开(公告)日：2002-09-03
申请号：US09517828
申请日：2000-03-02
申请人： John A. Kovacich , Wayne S. Kaboord , Fred J. Begale , Robert R. Brzycki , Birger Pahl , James E. Hansen
发明人： John A. Kovacich , Wayne S. Kaboord , Fred J. Begale , Robert R. Brzycki , Birger Pahl , James E. Hansen
IPC分类号： H04R1700
CPC分类号： G01L1/162 , G01L1/16 , G01L3/10 , Y10T29/42 , Y10T29/49103 , Y10T29/49146 , Y10T29/49171 , Y10T29/49766
摘要： A method of manufacturing a piezoelectric torque transducer is provided, comprising the steps of (a) forming a prepared area on a surface of a torsion member adapted to be strained by an applied torque; (b) providing a piezoelectric element having an axis of maximum strain sensitivity and disposing first and second electrodes on opposite faces of the element, respectively, and attaching an electrical lead to each electrode; (c) connecting electrical leads to the electrodes; and (d) disposing the element on the prepared area and orienting the axis of maximum strain sensitivity on the member and securing the element to the prepared area with a material selected from a group consisting of (i) adhesive material and (ii) potting material. The step of disposing the piezoelectric element includes configuring the piezoelectric element in a plate-shaped configuration and disposing a resilient annular member on each opposite face of the plate-shaped element and overlaying each of the annular members with a protective cover.
摘要翻译：提供一种制造压电扭矩传感器的方法，包括以下步骤：（a）在适于被施加的扭矩应变的扭转部件的表面上形成准备区域; （b）提供具有最大应变灵敏度轴的压电元件，并分别在元件的相对面上设置第一和第二电极，并将电导线附接到每个电极; （c）将电引线连接到电极; 和（d）将该元件放置在准备的区域上并将该最大应变敏感度轴定向在该构件上并用选自以下的材料将元件固定到准备区域：（i）粘合剂材料和（ii）灌封材料。设置压电元件的步骤包括将压电元件构造成板状构造，并且在板状元件的每个相对面上设置弹性环形构件，并用保护盖覆盖每个环形构件。

4. 发明授权

US6130488A Switching filter producing a low impedance control input on a high impedance input line for discriminating false control signals 失效
标题翻译：开关滤波器在高阻抗输入线路上产生低阻抗控制输入，用于识别假控制信号
公开(公告)号：US6130488A
公开(公告)日：2000-10-10
申请号：US969989
申请日：1997-11-13
申请人： James E. Hansen , Michael R. Scharnick , Thomas A. Wilsdon
发明人： James E. Hansen , Michael R. Scharnick , Thomas A. Wilsdon
IPC分类号： H04B3/14 , H04B3/28 , H02J1/02
CPC分类号： H04B3/28 , H04B3/14
摘要： A switching filter is disclosed for discriminating false control signals from actual control signals. The switching filter is particularly useful on a high impedance input, such as that of a motor controller. The filter is designed to compensate for capacitive, inductive, and/or resistive coupling between extended control lines that are run in parallel with other power lines. A low impedance is switched into the otherwise high impedance control line input for a brief instant to dissipate and phase shift false control signals to prevent the controller from interpreting the false signals as actual control signals. The filter includes a first resistor connectable to sense a presence of a possible false control signal, and a second resistor, having much lower resistance than the first resistor, connected in a path between the control line input and circuit common. A switch is provided in series with the second resistor to open and close the path between the control line input and circuit common in response to the possible false control signal. A timer is activated by a presence of a possible false control signal on the first resistor and activates the switch to provide a low shunting resistance across the control line to common for the brief period. The low shunting resistance not only dissipates the amplitude of any false signals, but also phase shifts the signals such that the controller cannot recognize multiple, successive false signals as a true control signal.
摘要翻译：公开了一种用于鉴别来自实际控制信号的假控制信号的开关滤波器。开关滤波器在诸如电动机控制器的高阻抗输入之间特别有用。滤波器设计用于补偿与其他电源线并联运行的扩展控制线之间的电容，电感和/或电阻耦合。低阻抗被切换到另外的高阻抗控制线输入以短暂瞬间消散和相移错误控制信号，以防止控制器将假信号解释为实际控制信号。滤波器包括可连接以感测可能的假控制信号的存在的第一电阻器，以及连接在控制线路输入端和电路公共端之间的路径中的电阻低于第一电阻器的第二电阻器。提供与第二电阻串联的开关，以响应于可能的假控制信号来打开和关闭控制线输入和公共电路之间的路径。通过在第一电阻器上存在可能的假控制信号来激活定时器，并激活开关以在短时间段内跨控制线提供低分流电阻以共同作用。低分流电阻不仅消耗任何假信号的幅度，而且消除信号的相移，使得控制器不能将多个连续的假信号识别为真实的控制信号。

5. 发明授权

US5934704A Vehicle steering column control system 失效
标题翻译：车辆转向柱控制系统
公开(公告)号：US5934704A
公开(公告)日：1999-08-10
申请号：US790000
申请日：1997-01-28
申请人： James E. Hansen , Ruth E. Hubbell , William J. Janutka , B. Thomas Pier , Scott A. Reid , Walter L. Rutchik
发明人： James E. Hansen , Ruth E. Hubbell , William J. Janutka , B. Thomas Pier , Scott A. Reid , Walter L. Rutchik
IPC分类号： B60R16/027 , B60R16/02 , B60R21/01 , B60R21/16 , H02J17/00 , H02P11/04 , B60R21/32
CPC分类号： B60R21/017 , B60R16/027
摘要： A control circuit is provided for transferring power and communication signals through a wireless coupling device in a vehicle steering column. The device can include a rotary transformer having a primary and secondary magnetic structure respectively associated with the wheel side and column side of the steering column. A squib power circuit transforms a high energy power signal suitable for firing an air bag from the column side to the wheel side. A low energy power circuit generates a signal from the column side to the wheel side suitable for operating isolated wheel side electronics, such as cruise control and the like. A tone encoder and decoder circuit communicates low level control signals suitable for signaling wheel side commands from the wheel side to the column side. The low energy power circuit and the tone encoder circuit operate simultaneously and continuously without signal debilitating interaction. An alternative embodiment avoids the low energy power circuit and the encoder and decoder circuit and includes a pulse circuit to impress a test signal on the wheel side to generate a ring signal representative of air bag firing operability and whether a horn switch is depressed.
摘要翻译：提供控制电路用于通过车辆转向柱中的无线联接装置传送电力和通信信号。该装置可以包括旋转变压器，其具有分别与转向柱的轮侧和列侧相关联的主磁结构和次磁结构。爆管电源电路将适合于将气囊从列侧喷射到车轮侧的高能量功率信号变换。低能量电力电路产生从列侧到车轮侧的适于操作隔离轮侧电子装置的信号，例如巡航控制等。音调编码器和解码器电路传送适合于从轮侧到列侧的信号轮侧命令的低级控制信号。低能量电源电路和色调编码器电路同时且连续工作，没有信号衰弱的相互作用。替代实施例避免了低能量电力电路和编码器和解码器电路，并且包括脉冲电路以将测试信号压在轮侧，以产生代表气囊点火可操作性的振铃信号以及喇叭开关是否被按压。

6. 发明授权

US5857061A Power window switch which incorporates express up/down and window motor speed control features using a force sensitive resistor or capacitor 失效
标题翻译：电动车窗开关，采用强力敏感电阻或电容，包括快速上/下和窗电机速度控制特性
公开(公告)号：US5857061A
公开(公告)日：1999-01-05
申请号：US789048
申请日：1997-01-28
申请人： Albert Y. Chang , Michael G. Taranowski , Brian T. Pier , James E. Hansen , Ruth E. Hubbell , Lewis J. Gohde , Edward J. Hummelt , Richard A. Baumann , Peter J. McGinnis , Arlene M. Klumb
发明人： Albert Y. Chang , Michael G. Taranowski , Brian T. Pier , James E. Hansen , Ruth E. Hubbell , Lewis J. Gohde , Edward J. Hummelt , Richard A. Baumann , Peter J. McGinnis , Arlene M. Klumb
IPC分类号： E05F15/16 , H01H3/02 , H03K17/96 , H02P7/29
CPC分类号： H03K17/9625 , E05F15/695 , E05F15/00 , E05Y2400/36 , E05Y2400/45 , E05Y2400/854 , E05Y2400/856 , E05Y2400/86 , E05Y2800/00 , E05Y2800/73 , E05Y2900/55 , H01H2300/01 , H01H3/0213
摘要： A system for enabling a vehicle operator to control the speed or rate of raising and lowering of a powered lift window. The actuator or switch includes a pressure responsive variable impedance device comprising a variable resistance in one embodiment and a variable capacitance in another embodiment. Increasing force directly on the variable impedance device by the user's finger or an actuator decreases the impedance which is sensed by a voltage divider which outputs a voltage which increases with increasing force. This latter voltage is compared with the output of a triangle wave oscillator and the output of the comparator is a pulse width modulated signal with pulse-width proportional to applied force. The pulses are applied to a power device (Mosfet) which modulates the duty cycle (%) of the current to the window lift mechanism drive motor to give variable motor speed.
摘要翻译：一种用于使车辆操作者能够控制动力提升窗的升降速度或速度的系统。致动器或开关包括在一个实施例中包括可变电阻的压力响应可变阻抗装置和另一实施例中的可变电容。由用户的手指或执行器直接在可变阻抗装置上增加的力减小了由输出随增加的力而增加的电压的分压器感测到的阻抗。将后一电压与三角波振荡器的输出进行比较，比较器的输出是脉冲宽度调制信号，脉冲宽度与施加的力成比例。脉冲被施加到功率器件（Mosfet）上，该功率器件将电流的占空比（％）调整到窗升降机构驱动电机以给出可变的电动机速度。

7. 发明授权

US5636863A Vehicle steering column control system 失效
标题翻译：车辆转向柱控制系统
公开(公告)号：US5636863A
公开(公告)日：1997-06-10
申请号：US233658
申请日：1994-04-26
申请人： Scott A. Reid , Paul G. Rops , James E. Hansen , Ruth E. Hubbell , Erich Rehm
发明人： Scott A. Reid , Paul G. Rops , James E. Hansen , Ruth E. Hubbell , Erich Rehm
IPC分类号： B60R16/027 , B60R16/02 , B60R21/01 , B60R21/16 , H02J17/00 , H02P11/04 , B60R21/32
CPC分类号： B60R21/017 , B60R16/027
摘要： A control circuit is provided for transferring power and communication signals through a wireless coupling device in a vehicle steering column. The device can comprise a rotary transformer having a primary and secondary magnetic structure respectfully associated with the wheel side and column side of the steering column. A squib power circuit transforms a high energy power signal suitable for firing an air bag from the column side to the wheel side. A low energy power circuit generates a signal from the column side to the wheel side suitable for operating isolated wheel side electronics, such as cruise control and the like. A tone encoder and decoder circuit communicates low level control signals suitable for signalling wheel side commands from the wheel side to the column side. The low energy power circuit and the tone encoder circuit operate simultaneously and continuously without signal debilitating interaction.
摘要翻译：提供控制电路用于通过车辆转向柱中的无线联接装置传送电力和通信信号。该装置可包括旋转变压器，其具有与转向柱的车轮侧和柱侧相关联的主和次级磁结构。爆管电源电路将适合于将气囊从列侧喷射到车轮侧的高能量功率信号变换。低能量电力电路产生从列侧到车轮侧的适于操作隔离轮侧电子装置的信号，例如巡航控制等。音调编码器和解码器电路传送适合于从轮侧到列侧的信号轮侧命令的低级控制信号。低能量电源电路和色调编码器电路同时且连续工作，没有信号衰弱的相互作用。

8. 发明授权

US5622244A Torque converter clutch having a parallel viscous drive 失效
标题翻译：扭矩转换离合器具有平行粘性驱动
公开(公告)号：US5622244A
公开(公告)日：1997-04-22
申请号：US537993
申请日：1995-10-02
申请人： James E. Hansen
发明人： James E. Hansen
IPC分类号： F16D35/00 , F16D47/06 , F16H45/02
CPC分类号： F16D35/00 , F16D47/06 , F16H45/02 , F16H2045/0278
摘要： A bypass clutch for use in an hydrodynamic torque converter (10) includes a viscous coupling (30) driveably engaged with the torque converter input shell (12) and turbine (18), and a friction clutch (24) driveably engaged with said input shell (12) and turbine (18) in parallel to the viscous coupling (30).
摘要翻译：用于液力变矩器转换器（10）的旁路离合器包括与变矩器输入壳体（12）和涡轮机（18）可驱动接合的粘性联轴器（30）和与所述输入壳体驱动地接合的摩擦离合器（24）（12）和涡轮（18）平行于粘性联轴器（30）。

9. 发明授权

US4851743A DC motor speed controller having protection 失效
标题翻译：直流电机转速控制器有保护
公开(公告)号：US4851743A
公开(公告)日：1989-07-25
申请号：US114348
申请日：1987-10-27
申请人： Richard F. Schmerda , James E. Hansen
发明人： Richard F. Schmerda , James E. Hansen
IPC分类号： H02H7/08 , H02J7/00 , H02P7/288
CPC分类号： H02H7/0833 , H02J7/0063 , H02P7/288 , Y10S388/90 , Y10S388/903 , Y10S388/91 , Y10S388/937
摘要： A controller for a battery-driven DC motor controls the average motor current by switching a series-connected FET on and off with a pulse-width-modulated gate signal. Motor speed is changed by changing the duty cycle of the signal, which is generated by an oscillator. An undervoltage protection circuit senses the battery voltage and compares it with a reference system that has hysteresis. An overload protection circuit senses the motor current, integrates the sensed signal, and compares the result with a Zener reference diode that is connected in an amplifier circuit for positive feedback. The oscillator's pulse-width-modulated output, the undervoltage protection circuit's output, and the overload protection circuit's output are input to a "NOR" logic gate, whose output drives the gate of the FET.
摘要翻译：用于电池驱动的直流电动机的控制器通过用脉冲宽度调制的栅极信号切换串联连接的FET来控制平均电动机电流。通过改变由振荡器产生的信号的占空比来改变电机速度。欠压保护电路检测电池电压，并将其与具有迟滞的参考系进行比较。过载保护电路检测电动机电流，对感测信号进行积分，并将结果与连接在放大器电路中用于正反馈的齐纳二极管进行比较。振荡器的脉冲宽度调制输出，欠压保护电路的输出和过载保护电路的输出输入到“NOR”逻辑门，其输出驱动FET的栅极。

10. 发明授权

US4591006A Well servicing rig 失效
标题翻译：井服务台
公开(公告)号：US4591006A
公开(公告)日：1986-05-27
申请号：US427096
申请日：1982-09-29
申请人： Stanley O. Hutchison , Paul V. Oldershaw , James E. Hansen
发明人： Stanley O. Hutchison , Paul V. Oldershaw , James E. Hansen
IPC分类号： E21B19/20
CPC分类号： E21B19/20
摘要： A fully mobil and totally contained well servicing and drilling rig is disclosed having equipment on the rig for automatically handling well elements (pipe, tubing and rods) going into and coming out of a well. The rig provides well element storage racks, cranes for moving well elements onto and off the tracks, transfer means for moving well elements from horizontal to vertical position, well element conveying means for moving elements to and from the transfer means, an automatic manipulator for moving elements into alignment with the well being serviced, automatic hoisting means, means for connecting and disconnecting elements from the element string within the well, driving means for all of the equipment, and control means for sequencing and operating all of the means so that the entire well servicing or drilling can be accomplished without human handling of well elements in the vicinity of the well head and rig.
摘要翻译：公开了一种完全移动和完全包含的井服务和钻机，其具有用于自动处理进入和流出井的井元件（管，管和杆）的钻机上的设备。该钻机提供了良好的元件存储架，用于将井元件移动到轨道上和从轨道移动的起重机，用于将井元件从水平位置移动到垂直位置的传送装置，用于将元件移动到传送装置和从传送装置移动元件的传送装置，用于移动的自动操纵器元件与被维护的井对齐，自动提升装置，用于将元件与井内的元件串连接和断开的装置，用于所有设备的驱动装置，以及用于对所有装置进行排序和操作的控制装置，可以在井口和钻机附近不需要人工处理井元件的情况下完成维修或钻井。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式