专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09333238B2 Method of immunotherapy for treament of human papillomavirus infection 有权
标题翻译：免疫治疗人乳头状瘤病毒感染的方法
公开(公告)号：US09333238B2
公开(公告)日：2016-05-10
申请号：US13514688
申请日：2010-12-08
申请人： James E. Egan , Martin Kast , Harvey Brandwein
发明人： James E. Egan , Martin Kast , Harvey Brandwein
IPC分类号： A61K38/20 , A61K38/21 , C07K14/52 , C07K14/525 , C07K14/53 , C07K14/54 , C07K14/57 , A61K38/19 , A61K31/675 , A61K45/06
CPC分类号： A61K38/217 , A61K9/0019 , A61K31/405 , A61K31/664 , A61K31/675 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2046 , A61K38/2053 , A61K38/208 , A61K38/2086 , A61K45/06 , A61K2300/00
摘要： A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.
摘要翻译：一种治疗人乳头瘤病毒（HPV）的方法，其通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物学，并诱导对HPV的免疫应答。通过对感染HPV的患者施用治疗有效量的原代细胞来源的生物学并激活LC，克服了HPV诱导的朗格汉斯细胞免疫抑制（LC）的方法。通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物体，激活LC并诱导向淋巴结的LC迁移，增加LC向淋巴结迁移的方法。通过向感染HPV的患者施用有效量的原代细胞来源的生物学，产生针对HPV的免疫并防止新的病变发展，产生针对HPV的免疫力的方法。

2. 发明申请

US20120244117A1 METHOD OF REVERSING IMMUNE SUPPRESSION OF LANGERHANS CELLS 有权
标题翻译：逆转免疫抑制兰格细胞的方法
公开(公告)号：US20120244117A1
公开(公告)日：2012-09-27
申请号：US13514688
申请日：2010-12-08
申请人： James E. Egan , Martin Kast , Diane Da Silva , Harvey Brandwein
发明人： James E. Egan , Martin Kast , Diane Da Silva , Harvey Brandwein
IPC分类号： A61K38/21 , A61P29/00 , A61P31/04 , A61P31/20 , A61P37/04
CPC分类号： A61K38/217 , A61K9/0019 , A61K31/405 , A61K31/664 , A61K31/675 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/2013 , A61K38/204 , A61K38/2046 , A61K38/2053 , A61K38/208 , A61K38/2086 , A61K45/06 , A61K2300/00
摘要： A method of treating human papillomavirus (HPV), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and inducing an immune response to HPV. A method of overcoming HPV-induced immune suppression of Langerhans cells (LC), by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, and activating LC. A method of increasing LC migration towards lymph nodes, by administering a therapeutically effective amount of a primary cell-derived biologic to a patient infected with HPV, activating LC, and inducing LC migration towards lymph nodes. A method of generating immunity against HPV, by administering an effective amount of a primary cell derived biologic to a patient infected with HPV, generating immunity against HPV, and preventing new lesions from developing.
摘要翻译：一种治疗人乳头瘤病毒（HPV）的方法，其通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物学，并诱导对HPV的免疫应答。通过对感染HPV的患者施用治疗有效量的原代细胞来源的生物学并激活LC，克服了HPV诱导的朗格汉斯细胞免疫抑制（LC）的方法。通过向感染HPV的患者施用治疗有效量的原代细胞来源的生物体，激活LC并诱导向淋巴结的LC迁移，增加LC向淋巴结迁移的方法。通过向感染HPV的患者施用有效量的原代细胞来源的生物学，产生针对HPV的免疫并防止新的病变发展，产生针对HPV的免疫力的方法。

3. 发明授权

US08591956B2 Method of increasing immunological effect 有权
标题翻译：增加免疫效果的方法
公开(公告)号：US08591956B2
公开(公告)日：2013-11-26
申请号：US13205229
申请日：2011-08-08
申请人： John W. Hadden , Theresa L. Whiteside-Nimick , James E. Egan , Kathy L. Signorelli-Petrat , Harvey Brandwein
发明人： John W. Hadden , Theresa L. Whiteside-Nimick , James E. Egan , Kathy L. Signorelli-Petrat , Harvey Brandwein
IPC分类号： A61K35/26 , C12N5/00 , C12N5/02
CPC分类号： A61K45/06 , A61K31/4439 , A61K33/00 , Y10S514/885 , A61K2300/00
摘要： A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.
摘要翻译：通过向患者施用有效量的原代细胞来源的生物学，诱导免疫产生，阻断免疫破坏和增加患者的免疫学作用，增加患者免疫学效果的方法。治疗免疫靶标，治疗肿瘤，免疫预防和预防肿瘤逃逸的方法。

4. 发明申请

US20090155291A1 METHOD OF INCREASING IMMUNOLOGICAL EFFECT 有权
标题翻译：增加免疫力的方法
公开(公告)号：US20090155291A1
公开(公告)日：2009-06-18
申请号：US12323595
申请日：2008-11-26
申请人： John W. Hadden , Theresa L. Whiteside , Margareta Czystowska , James E. Egan , Kathy L. Signorelli , Harvey Brandwein
发明人： John W. Hadden , Theresa L. Whiteside , Margareta Czystowska , James E. Egan , Kathy L. Signorelli , Harvey Brandwein
IPC分类号： A61K39/00 , A61P37/04
CPC分类号： A61K45/06 , A61K31/4439 , A61K33/00 , Y10S514/885 , A61K2300/00
摘要： A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.
摘要翻译：通过向患者施用有效量的原代细胞来源的生物学，诱导免疫产生，阻断免疫破坏和增加患者的免疫学作用，增加患者免疫学效果的方法。治疗免疫靶标，治疗肿瘤，免疫预防和预防肿瘤逃逸的方法。

5. 发明申请

US20120141512A1 METHOD OF INCREASING IMMUNOLOGICAL EFFECT 有权
标题翻译：增加免疫力的方法
公开(公告)号：US20120141512A1
公开(公告)日：2012-06-07
申请号：US13205229
申请日：2011-08-08
申请人： John W. Hadden , Theresa L. Whiteside , Margareta Czytowska , James E. Egan , Kathy L. Signorelli , Harvey Brandwein
发明人： John W. Hadden , Theresa L. Whiteside , Margareta Czytowska , James E. Egan , Kathy L. Signorelli , Harvey Brandwein
IPC分类号： A61K39/00 , A61P35/00 , A61P37/04
CPC分类号： A61K45/06 , A61K31/4439 , A61K33/00 , Y10S514/885 , A61K2300/00
摘要： A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.
摘要翻译：通过向患者施用有效量的原代细胞来源的生物学，诱导免疫产生，阻断免疫破坏和增加患者的免疫学作用，增加患者免疫学效果的方法。治疗免疫靶标，治疗肿瘤，免疫预防和预防肿瘤逃逸的方法。

6. 发明授权

US07993660B2 Method of increasing immunological effect 有权
标题翻译：增加免疫效果的方法
公开(公告)号：US07993660B2
公开(公告)日：2011-08-09
申请号：US12323595
申请日：2008-11-26
申请人： John W. Hadden , Theresa L. Whiteside , Margareta Czystowska , James E. Egan , Kathy L. Signorelli , Harvey Brandwein
发明人： John W. Hadden , Theresa L. Whiteside , Margareta Czystowska , James E. Egan , Kathy L. Signorelli , Harvey Brandwein
IPC分类号： A61K45/00 , A01N25/00
CPC分类号： A61K45/06 , A61K31/4439 , A61K33/00 , Y10S514/885 , A61K2300/00
摘要： A method of increasing immunological effect in a patient by administering an effective amount of a primary cell derived biologic to the patient, inducing immune production, blocking immune destruction, and increasing immunological effect in the patient. Methods of treating an immune target, treating a tumor, immune prophylaxis, and preventing tumor escape.
摘要翻译：通过向患者施用有效量的原代细胞来源的生物学，诱导免疫产生，阻断免疫破坏和增加患者的免疫学作用，增加患者免疫学效果的方法。治疗免疫靶标，治疗肿瘤，免疫预防和预防肿瘤逃逸的方法。

7. 发明授权

US4606855A Monoclonal antibody to digoxin 失效
标题翻译：地高辛单克隆抗体
公开(公告)号：US4606855A
公开(公告)日：1986-08-19
申请号：US516483
申请日：1983-07-22
申请人： Alice Deutsch , Harvey Brandwein , Herbert Platt , Dianne M. Hunter , Andrew Dubitsky , Susan M. Durham
发明人： Alice Deutsch , Harvey Brandwein , Herbert Platt , Dianne M. Hunter , Andrew Dubitsky , Susan M. Durham
IPC分类号： G01N33/543 , G01N33/74 , G01N33/94 , G01N33/53 , G01N33/531 , G01N33/577
CPC分类号： G01N33/543 , G01N33/54366 , G01N33/743 , G01N33/9453 , Y10S435/948
摘要： A method of determining the concentration of an antigen in a sample solution comprising(a) coating an antigen-protein conjugate onto a solid matrix,(b) conjugating an enzyme to an antibody specific for said antigen,(c) to a known quantity of a solution containing the antibody-enzyme conjugate of (b) adding a specified quantity of a sample containing an unknown amount of the antigen whose content is to be determined,(d) contacting the coated solid matrix of (a) with the solution (c) and incubate so as to effect binding between the antibody and antigen, some of the antigen being that from the sample and some being that on the solid matrix,(e) removing the solid matrix from the solution and washing,(f) immersing the solid matrix in a solution containing a known amount of an enzyme-substrate which is acted upon by the enzyme so as to effect reaction between the enzyme and enzyme-substrate to produce a product, and then separating the solid matrix form the solution of enzyme-substrate, and(g) then measuring the solid matrix and/or the solution of enzyme-substrate with a pre-established standard to indicate the amount of antigen which was in the sample added in (c).
摘要翻译：一种确定样品溶液中抗原浓度的方法，包括（a）将抗原蛋白缀合物涂覆在固体基质上，（b）将酶与所述抗原特异性抗体结合，（c）与已知量的含有抗体 - 酶结合物的溶液（b）加入规定量的含有未确定含量的抗原的样品，（d）使（a）的涂覆的固体基质与溶液（c）接触）并孵育以实现抗体和抗原之间的结合，一些抗原来自样品，一些抗原是固体基质上的抗原，（e）从溶液中除去固体基质并洗涤，（f）将在含有已知量的酶底物的溶液中的固体基质，其被酶作用，以便实现酶和酶底物之间的反应以产生产物，然后将固体基质分离成酶 - 基质，和（g）然后用预先建立的标准测量固体基质和/或酶底物溶液以指示在（c）中加入的样品中的抗原量。

8. 发明授权

US06544751B1 Methods of harvesting rare cells from blood products 有权
标题翻译：从血液制品中收获稀有细胞的方法
公开(公告)号：US06544751B1
公开(公告)日：2003-04-08
申请号：US09402158
申请日：1999-09-30
申请人： Harvey Brandwein , Samuel Coker
发明人： Harvey Brandwein , Samuel Coker
IPC分类号： G01N3353
CPC分类号： C12N5/0634
摘要： The present invention provides methods of harvesting rare cells from blood products and/or obtaining products of the rare cells. The method includes contacting a blood product containing rare cells with a porous medium, and selectively retaining rare cells of interest on the porous medium. The porous medium can be contacted with an elution fluid wherein a population of the rare cells is eluted from the porous medium. Rare cells selectively retained on the porous medium can be cultured on the porous medium, and products of the rare cells can be obtained.
摘要翻译：本发明提供从血液制品中收获稀有细胞和/或获得稀有细胞的产物的方法。该方法包括使含有稀有细胞的血液制品与多孔介质接触，并在多孔介质上选择性地保留目标稀有细胞。多孔介质可与洗脱流体接触，其中罕见细胞群从多孔介质中洗脱出来。选择性地保留在多孔介质上的稀释细胞可以在多孔介质上培养，并且可以获得稀有细胞的产物。

9. 发明授权

US5266219A Device and method for separating plasma from blood 失效
标题翻译：血液分离装置及方法
公开(公告)号：US5266219A
公开(公告)日：1993-11-30
申请号：US745166
申请日：1991-08-15
申请人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Harvey Brandwein
发明人： David B. Pall , Thomas C. Gsell , Vlado I. Matkovich , Harvey Brandwein
IPC分类号： B01D39/16 , G01N33/49 , B01D37/00
CPC分类号： B01D39/163 , G01N33/491 , Y10T436/25375
摘要： A device for separating plasma from blood is provided comprising a synthetic polymeric fibrous structure having a CWST in excess of 65 dynes/cm, the structure having a first region for receiving a blood sample and a second region for accumulating plasma.
摘要翻译：提供了一种用于从血液中分离血浆的装置，其包括具有超过65达因/厘米的CWST的合成聚合物纤维结构，所述结构具有用于接收血液样品的第一区域和用于积聚血浆的第二区域。

10. 发明授权

US4477576A Antigen assay method and kit 失效
标题翻译：抗原测定方法和试剂盒
公开(公告)号：US4477576A
公开(公告)日：1984-10-16
申请号：US401460
申请日：1982-07-26
申请人： Alice Deutsch , Harvey Brandwein , Herbert Platt , Dianne M. Hunter , Andrew Dubitsky , Susan M. Durham
发明人： Alice Deutsch , Harvey Brandwein , Herbert Platt , Dianne M. Hunter , Andrew Dubitsky , Susan M. Durham
IPC分类号： C07K1/22 , C07K14/575 , C07K14/76 , C07K16/00 , C07K17/00 , C07K19/00 , C12N15/02 , C12P21/08 , C12Q1/28 , C12Q1/32 , C12Q1/42 , C12Q1/44 , G01N33/543 , G01N33/547 , G01N33/74 , G01N33/94 , G01N33/54
CPC分类号： G01N33/9453 , G01N33/543 , G01N33/54366 , G01N33/743 , Y10S435/81 , Y10S435/964 , Y10S435/975 , Y10S436/807 , Y10S436/808 , Y10S436/81 , Y10S436/815 , Y10S436/817 , Y10S436/823
摘要： A method of determining the concentration of an antigen in a sample solution comprising(a) coating an antigen-protein conjugate onto a solid matrix,(b) conjugating an enzyme to an antibody specific for said antigen,(c) to a known quantity of a solution containing the antibody-enzyme conjugate of (b) adding a specified quantity of a sample containing an unknown amount of the antigen whose content is to be determined,(d) contacting the coated solid matrix of (a) with the solution (c) and incubate so as to effect binding between the antibody and antigen, some of the antigen being that from the sample and some being that on the solid matrix,(e) removing the solid matrix from the solution and washing,(f) immersing the solid matrix in a solution containing a known amount of an enzyme-substrate which is acted upon by the enzyme so as to effect reaction between the enzyme and enzyme-substrate to produce a product, and then separating the solid matrix from the solution of enzyme-substrate, and(g) then measuring the solid matrix and/or the solution of enzyme-substrate with a pre-established standard to indicate the amount of antigen which was in the sample added in (c).
摘要翻译：一种确定样品溶液中抗原浓度的方法，包括（a）将抗原蛋白缀合物涂覆在固体基质上，（b）将酶与所述抗原特异性抗体结合，（c）与已知量的含有抗体 - 酶结合物的溶液（b）加入规定量的含有未确定含量的抗原的样品，（d）使（a）的涂覆的固体基质与溶液（c）接触）并孵育以实现抗体和抗原之间的结合，一些抗原来自样品，一些抗原是固体基质上的抗原，（e）从溶液中除去固体基质并洗涤，（f）将在含有已知量的酶底物的溶液中的固体基质，其被酶作用，以便实现酶和酶底物之间的反应以产生产物，然后将固体基质与酶 - 基质，和（g）然后用预先建立的标准测量固体基质和/或酶底物溶液以指示在（c）中加入的样品中的抗原量。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式