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1. 发明授权

US06338949B1 Nucleic acids encoding receptor recognition factor stat4 and methods of use thereof 失效
标题翻译：编码受体识别因子stat4的核酸及其使用方法
公开(公告)号：US06338949B1
公开(公告)日：2002-01-15
申请号：US08956653
申请日：1997-10-23
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： C07H2104
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705 , A61K2300/00
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN&agr; and IFN&ggr;. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFNγ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

2. 发明授权

US07060682B2 Receptor recognition factors, protein sequences and methods of use thereof 失效
标题翻译：受体识别因子，蛋白质序列及其使用方法
公开(公告)号：US07060682B2
公开(公告)日：2006-06-13
申请号：US10639617
申请日：2003-08-12
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/17 , C07K14/46
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705 , Y02A50/473 , A61K2300/00
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFNγ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

3. 发明授权

US5976835A Nucleic acids encoding receptor recognition factor Stat1.alpha. and Stat1.beta., and methods of use thereof 失效
标题翻译：编码受体识别因子Stat1a和Stat1β的核酸及其使用方法
公开(公告)号：US5976835A
公开(公告)日：1999-11-02
申请号：US820754
申请日：1997-03-19
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/00 , A61K38/21 , C07K14/47 , C07K16/28 , C12N15/113 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567 , C07H21/00
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN.alpha. and IFN-.gamma.. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFN-γ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

4. 发明授权

US6124118A Receptor recognition factors, protein sequences and methods of use thereof 失效
标题翻译：受体识别因子，蛋白质序列及其使用方法
公开(公告)号：US6124118A
公开(公告)日：2000-09-26
申请号：US948547
申请日：1997-10-10
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/00 , A61K38/21 , C07K14/47 , C07K16/28 , C12N15/113 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567 , C12P21/06 , C07H21/04
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN.alpha. and IFN.gamma.. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录，特别是由IFNα和IFNγ引起的活化的研究结果说明了本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

5. 发明授权

US06605442B1 Methods of testing drugs or agents that modulate the activity of receptor recognition factors 失效
标题翻译：测试调节受体识别因子活性的药物或药剂的方法
公开(公告)号：US06605442B1
公开(公告)日：2003-08-12
申请号：US08212185
申请日：1994-03-11
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： G01N3353
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705 , Y02A50/473 , A61K2300/00
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN&agr; and IFN&ggr;. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFNγ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

6. 发明授权

US6013475A Nucleic acids encoding receptor recognition factors and methods of use thereof 失效
标题翻译：编码受体识别因子的核酸及其使用方法
公开(公告)号：US6013475A
公开(公告)日：2000-01-11
申请号：US956652
申请日：1997-10-23
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/00 , A61K38/21 , C07K14/47 , C07K16/28 , C12N15/113 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN.alpha. and IFN.gamma.. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFNγ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

7. 发明授权

US07339039B2 Nucleic acids encoding receptor recognition factors, and methods of use thereof 失效
标题翻译：编码受体识别因子的核酸及其使用方法
公开(公告)号：US07339039B2
公开(公告)日：2008-03-04
申请号：US09876773
申请日：2001-06-07
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： C07H21/04 , C12P21/06 , C07K14/00
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705 , Y02A50/473 , A61K2300/00
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted With interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFNα and IFNγ. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录，特别是由IFNα和IFNγ引起的活化的研究结果说明了本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

8. 发明授权

US6030808A Nucleic acids encoding receptor recognition factor stat 3 and methods of use thereof 失效
标题翻译：编码受体识别因子stat 3的核酸及其使用方法
公开(公告)号：US6030808A
公开(公告)日：2000-02-29
申请号：US956869
申请日：1997-10-23
申请人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
发明人： James E. Darnell, Jr. , Christian W. Schindler , Xin-Yuan Fu , Zilong Wen , Zhong Zhong
IPC分类号： A61K38/00 , A61K38/21 , C07K14/47 , C07K16/28 , C12N15/113 , C12N15/12 , C12P21/08 , C12Q1/68 , G01N33/53 , G01N33/567 , C07H21/04 , C12N15/63
CPC分类号： C12N15/113 , A61K38/21 , C07K14/4705
摘要： Receptor recognition factors exist that recognizes the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN.alpha. and IFN-.gamma.. Specific DNA and amino acid sequences for various human and murine receptor recognition factors are provided, as are polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
摘要翻译：存在识别特异性配体已被结合的特异性细胞受体的受体识别因子，从而可以将转录因子与DNA位点的结合信号和/或启动。受体识别因子在一个例子中是转录因子的一部分，并且还可以与其他转录因子相互作用，以使其激活并前往细胞核进行DNA结合。受体识别因子似乎在其活动中是与第二信使无关的，因为第二信使浓度的明显的扰动是无效的。通过用干扰素（IFN）刺激的基因转录进行的研究结果，特别是由IFNα和IFN-γ引起的活化来说明本发明的概念。提供了各种人和鼠受体识别因子的特异性DNA和氨基酸序列，两种ISGF-3基因的多肽片段也已经被制备和测试。这些多肽证实了酪氨酸激酶在细胞内消息传播中的直接参与。还公开了许多诊断和治疗材料和效用。

9. 发明授权

US5716622A Functionally active regions of signal transducer and activators of transcription 失效
标题翻译：信号传感器和转录激活子的功能活跃区域
公开(公告)号：US5716622A
公开(公告)日：1998-02-10
申请号：US369796
申请日：1995-01-06
申请人： James E. Darnell, Jr. , Zilong Wen , Curt M. Horvath , Zhong Zhong
发明人： James E. Darnell, Jr. , Zilong Wen , Curt M. Horvath , Zhong Zhong
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , A61K39/385 , C07K14/715 , C07K17/02
CPC分类号： C07K14/4718 , C07K14/4705 , A61K38/00 , A61K48/00 , Y10S530/81 , Y10S530/827
摘要： The present invention relates generally to intracellular receptor recognition proteins or factors, termed Signal Transducers and Activators of Transcription (STAT), to methods and compositions utilizing such factors, and to the antibodies reactive toward them, in assays and for diagnosing, preventing and/or treating cellular debilitation, derangement or dysfunction. More particularly, the present invention relates to particular functional domains of molecules that exhibit both receptor recognition and message delivery via DNA binding in receptor-ligand specific manner, i.e., that directly participate both in the interaction with the ligand-bound receptor at the cell surface and in the activity of transcription in the nucleus as a DNA binding protein. The invention likewise relates to the antibodies and other entities that are specific to the functional domain of a STAT protein and that would thereby selectively modulate its activity.
摘要翻译：本发明一般涉及称为信号转导和转录激活因子（STAT）的细胞内受体识别蛋白或因子，涉及利用这些因子的方法和组合物，以及在测定中用于诊断，预防和/或治疗细胞衰弱，紊乱或功能障碍。更具体地说，本发明涉及通过受体 - 配体特异性方式的DNA结合表现出受体识别和消息传递的分子的特定功能结构域，即直接参与与细胞表面的配体结合受体的相互作用并且在细胞核中作为DNA结合蛋白的转录活性。本发明同样涉及对STAT蛋白的功能结构域特异的抗体和其它实体，从而选择性调节其活性。

10. 发明授权

US5883228A Functionally active regions of signal transducer and activator of transcription 失效
标题翻译：信号传感器和转录激活子的功能活跃区域
公开(公告)号：US5883228A
公开(公告)日：1999-03-16
申请号：US852091
申请日：1997-05-06
申请人： James E. Darnell, Jr. , Zilong Wen , Curt M. Horvath , Zhong Zhong
发明人： James E. Darnell, Jr. , Zilong Wen , Curt M. Horvath , Zhong Zhong
IPC分类号： A61K38/00 , A61K48/00 , C07K14/47 , C07K1/00 , A61K38/17
CPC分类号： C07K14/4718 , C07K14/4705 , A61K38/00 , A61K48/00 , Y10S530/81 , Y10S530/827
摘要： The present invention relates generally to intracellular receptor recognition proteins or factors, termed Signal Transducers and Activators of Transcription (STAT), to methods and compositions utilizing such factors, and to the antibodies reactive toward them, in assays and for diagnosing, preventing and/or treating cellular debilitation, derangement or dysfunction. More particularly, the present invention relates to particular functional domains of molecules that exhibit both receptor recognition and message delivery via DNA binding in receptor-ligand specific manner, i.e., that directly participate both in the interaction with the ligand-bound receptor at the cell surface and in the activity of transcription in the nucleus as a DNA binding protein. The invention likewise relates to the antibodies and other entities that are specific to the functional domain of a STAT protein and that would thereby selectively modulate its activity.
摘要翻译：本发明一般涉及称为信号转导和转录激活因子（STAT）的细胞内受体识别蛋白或因子，涉及利用这些因子的方法和组合物，以及在测定中用于诊断，预防和/或治疗细胞衰弱，紊乱或功能障碍。更具体地说，本发明涉及通过受体 - 配体特异性方式的DNA结合表现出受体识别和消息传递的分子的特定功能结构域，即直接参与与细胞表面的配体结合受体的相互作用并且在细胞核中作为DNA结合蛋白的转录活性。本发明同样涉及对STAT蛋白的功能结构域特异的抗体和其它实体，从而选择性调节其活性。

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