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    • 1. 发明授权
    • Methods for adaptively varying gain during ultrasound agent quantification
    • 在超声波定量中自适应变化增益的方法
    • US07534210B2
    • 2009-05-19
    • US10770724
    • 2004-02-03
    • James E. ChomasRickard C. LoftmanConstantine Simopoulos
    • James E. ChomasRickard C. LoftmanConstantine Simopoulos
    • A61B8/00
    • A61B8/481G01S7/52033G01S7/52041G01S7/5205
    • Methods are provided for automatic setting of parameters for contrast agent quantification. Various processes may improve quantification. For example, for consistency in contrast agent quantification, a gain or other setting of an ultrasound system is automatically determined in response to destruction of the contrast agent or at the initiation of the contrast agent quantification procedure. Automatic setting of an adaptive gain provides equalized image intensity for each repetition of a contrast agent quantification procedure based on a same triggering event, the destruction of contrast agent. By synchronizing the adaptive setting algorithms with contrast agent destruction, similar base line information is provided for each iteration of a contrast agent quantification procedure. As another example, the contrast agent gain setting treats acoustic signals representing tissue or other non-contrast agent structure as noise, mapping the tissue values to a substantially constant low value within the dynamic range. As yet another example, by segmenting out blood pools or other areas of contrast agent likely to have contrast agents even after destruction, the resulting gain is more likely sensitive to the detection of perfused contrast agents.
    • 提供了用于自动设置造影剂定量参数的方法。 各种过程可以提高定量。 例如,为了对比剂定量的一致性,响应于造影剂的破坏或在造影剂定量程序开始时自动确定超声系统的增益或其他设置。 自适应增益的自动设置为每次重复造影剂定量过程提供均衡的图像强度,该对比剂定量过程基于相同的触发事件,破坏造影剂。 通过使自适应设置算法与造影剂破坏同步,为造影剂定量过程的每次迭代提供类似的基线信息。 作为另一示例,造影剂增益设置将表示组织或其他非造影剂结构的声学信号视为噪声,将组织值映射到动态范围内的基本上恒定的低值。 作为另一个例子,即使在破坏后,通过分割血液池或可能具有造影剂的造影剂的其它区域,所得到的增益更可能对灌注的造影剂的检测敏感。
    • 4. 发明授权
    • Contrast agent imaging with agent specific ultrasound detection
    • 对比剂成像与特异性超声检测
    • US08491483B2
    • 2013-07-23
    • US12233940
    • 2008-09-19
    • Ismayil M. GuracarJames E. ChomasPatrick J. Phillips
    • Ismayil M. GuracarJames E. ChomasPatrick J. Phillips
    • A61B8/14A61B8/00
    • A61B8/481A61B8/483
    • Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
    • 可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。 通过显示具有高度对比组织特异性的血管中的流动,基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。 与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示,例如提供由能量和速度两者分度的显示图。 结合长速度测量间隔的三次基波检测的高脉冲重复频率(PRF)可以提高低速度灵敏度和测量精度。 脉冲波(PW)多普勒可以通过使用立方基本敏感脉冲序列来改善。 使用三维基本敏感技术与其他运动估计技术(如二维速度估计或斑点跟踪)相比,使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。