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1. 发明申请

US20050165221A1 Methods for producing factor VIII proteins 有权
标题翻译：生产因子VIII蛋白的方法
公开(公告)号：US20050165221A1
公开(公告)日：2005-07-28
申请号：US11043784
申请日：2005-01-26
申请人： James Booth , Suresh Vunnum , Brian Kelley
发明人： James Booth , Suresh Vunnum , Brian Kelley
IPC分类号： C07K14/755
CPC分类号： C07K14/755
摘要： Methods are provided for purification of Factor VIII polypeptides by affinity chromatography and ion exchange chromatography, in which the eluate from the affinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The affinity matrix may comprise a monoclonal antibody or a peptide ligand. The methods result in improved purification without significant yield loss.
摘要翻译：提供用于通过亲和层析和离子交换层析纯化因子VIII多肽的方法，其中来自亲和柱的洗脱液用包含比洗脱溶液更高的盐浓度或更低的非极性剂浓度的溶液稀释，使稀释的溶液通过离子交换柱。亲和基质可以包含单克隆抗体或肽配体。该方法导致改进的纯化而没有显着的产率损失。

2. 发明申请

US20070060741A1 Method of weak partitioning chromatography 有权
标题翻译：弱分配色谱法
公开(公告)号：US20070060741A1
公开(公告)日：2007-03-15
申请号：US11372054
申请日：2006-03-10
申请人： Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
发明人： Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
IPC分类号： C07K16/00
CPC分类号： B01D15/30 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3828 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/065
摘要： This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid containing one or more impurities. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
摘要翻译：本发明涉及使用弱分配色谱从含有一种或多种杂质的载体流体中纯化产物的方法。此外，本发明涉及由分配系数至少为0.1的操作条件所限定的弱分配色谱法，该操作条件使培养基与每毫升培养基中的至少1mg产物结合，或者由分配系数限定。

3. 发明申请

US20070054390A1 Method of weak partitioning chromatography 审中-公开
标题翻译：弱分配色谱法
公开(公告)号：US20070054390A1
公开(公告)日：2007-03-08
申请号：US11510634
申请日：2006-08-28
申请人： Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
发明人： Brian Kelley , James Booth , Paul Brown , Jon Coffman , Ranganathan Godavarti , Tim Iskra , Shujun Sun , Mary Switzer , Suresh Vunnum , Tianning Yu
IPC分类号： C12N9/00 , C07K16/18 , C07K14/52 , C07K14/54 , C07K14/575
CPC分类号： B01D15/30 , B01D15/327 , B01D15/361 , B01D15/3804 , B01D15/3828 , C07K1/16 , C07K1/18 , C07K1/20 , C07K1/22 , C07K16/065
摘要： This invention relates to methods of using weak partitioning chromatography for the purification of a product from a load fluid. Further, the invention relates to methods of weak partitioning chromatography defined by operating conditions which cause a medium to bind least 1 mg of product per mL of medium, or alternatively, defined by a partition coefficient of at least 0.1.
摘要翻译：本发明涉及使用弱分配色谱从负载流体中纯化产物的方法。此外，本发明涉及由分配系数至少为0.1的操作条件所限定的弱分配色谱法，该操作条件使培养基与每毫升培养基中的至少1mg产物结合，或者由分配系数限定。

4. 发明授权

US07820796B2 Methods for producing Factor VIII proteins 有权
标题翻译：生产因子VIII蛋白的方法
公开(公告)号：US07820796B2
公开(公告)日：2010-10-26
申请号：US11043784
申请日：2005-01-26
申请人： James Booth , Suresh Vunnum , Brian D. Kelley
发明人： James Booth , Suresh Vunnum , Brian D. Kelley
IPC分类号： C07K14/755 , C07K1/18 , C07K1/22
CPC分类号： C07K14/755
摘要： Methods are provided for purification of Factor VIII polypeptides by affinity chromatography and ion exchange chromatography, in which the eluate from the affinity column is diluted with a solution comprising higher salt concentration, or lower non-polar agent concentration than that of the elution solution, prior to passing the diluted solution through the ion exchange column. The affinity matrix may comprise a monoclonal antibody or a peptide ligand. The methods result in improved purification without significant yield loss.
摘要翻译：提供用于通过亲和层析和离子交换层析纯化因子VIII多肽的方法，其中来自亲和柱的洗脱液用包含比洗脱溶液更高的盐浓度或更低的非极性剂浓度的溶液稀释，使稀释的溶液通过离子交换柱。亲和基质可以包含单克隆抗体或肽配体。该方法导致改进的纯化而没有显着的产率损失。

5. 发明申请

US20060193829A1 Binding molecules for human factor VIII and factor VIII-like proteins 有权
公开(公告)号：US20060193829A1
公开(公告)日：2006-08-31
申请号：US11345031
申请日：2006-01-31
申请人： Jinan Yu , M. Potter , Brian Kelley , Jeffrey Deetz , James Booth , Marilous Potter
发明人： Jinan Yu , M. Potter , Brian Kelley , Jeffrey Deetz , James Booth , Marilous Potter
IPC分类号： C07K7/06
CPC分类号： C07K7/06 , C07K7/08 , C07K14/00 , C07K14/755
摘要： It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.

6. 发明授权

US08172134B1 Automated banking machine and system that operates to cause financial transfers responsive to data read from data bearing records 有权
标题翻译：自动银行机器和系统，用于响应于从数据记录中读取的数据进行财务转移
公开(公告)号：US08172134B1
公开(公告)日：2012-05-08
申请号：US13068890
申请日：2011-05-23
申请人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
发明人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
IPC分类号： G07F19/00
CPC分类号： G07F19/207 , G07F19/20
摘要： An automatic banking machine operates responsive to data read from data bearing records to cause financial transfers. The machine includes a card reader that reads data corresponding to financial accounts from user cards, and carries out transactions related to the accounts. The machine includes a camera, a microphone, and the card reader at a customer interface located at the front of the machine. A servicer display device is at a servicer interface located at the rear of the machine. The customer interface and servicer interface can be placed in audio/visual communication. Although a front servicer may not be directly visible to a rear servicer, they are still able to communicate with each other through the customer interface and servicer interface during machine servicing. The servicer interface can also be used to allow a lone servicer to be audibly/visually alerted to a potential customer approaching the machine.
摘要翻译：自动银行业务响应于从数据记录中读取的数据来进行资金转移。该机器包括读卡器，用于从用户卡读取对应于财务帐户的数据，并执行与该账户有关的交易。该机器在位于机器前部的客户接口处包括相机，麦克风和读卡器。服务器显示设备位于位于机器后部的服务器接口。客户接口和服务器接口可以放置在音频/视频通信中。虽然后勤服务人员可能无法直接看到前部服务人员，但是在机器维修期间，他们仍然可以通过客户界面和服务器界面进行通信。服务器接口还可用于允许单个服务器对接近机器的潜在客户进行可视地/视觉上的警报。

7. 发明授权

US07789298B1 Automated banking machine having a servicer display that allows a servicer to view a customer adjacent the customer display 有权
标题翻译：具有服务器显示器的自动银行机器允许服务者查看邻近客户显示器的客户
公开(公告)号：US07789298B1
公开(公告)日：2010-09-07
申请号：US11715010
申请日：2007-03-07
申请人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
发明人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
IPC分类号： G06K5/00
CPC分类号： G07F19/207 , G07F19/20
摘要： An automatic banking machine includes a card reader for reading user cards, and a cash dispenser. A movable camera is positionable within the ATM housing. The automated banking machine carries out transactions related to user accounts based on information read from cards. Service personnel are enabled to direct the camera toward regions of machine components while conducting service activities that are not directly visible by a servicer. A camera assembly includes a microphone to sense sounds associated with machine components during test operations. The generated data may be used by an on-site servicer, or sent to an entity at a remote location. The visual images may be used to enhance diagnostic and servicing capabilities.
摘要翻译：自动银行机包括用于读取用户卡的读卡器和自动提款机。可移动摄像机可定位在ATM外壳内。自动银行机器根据从卡读取的信息执行与用户账户有关的交易。服务人员能够进行机器组件的各个区域的引导，同时进行服务人员不能直接看到的服务活动。相机组件包括用于在测试操作期间感测与机器部件相关联的声音的麦克风。生成的数据可以由现场服务器使用，或者发送到远程位置的实体。视觉图像可用于增强诊断和维修能力。

8. 发明授权

US07950574B1 ATM that places front customer interface in communication with rear servicer interface 有权
标题翻译：前端客户端口与后端服务器接口通信的ATM
公开(公告)号：US07950574B1
公开(公告)日：2011-05-31
申请号：US12657687
申请日：2010-01-26
申请人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
发明人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
IPC分类号： G07F19/00
CPC分类号： G07F19/207 , G07F19/20
摘要： An automatic banking machine operates responsive to data read from data bearing records to cause financial transfers. The machine includes a card reader that reads data corresponding to financial accounts from user cards and carries out transactions related to the accounts. The machine includes a camera, a microphone, and the card reader at a customer interface located at the front of the machine. A servicer display device is at a servicer interface located at the rear of the machine. The customer interface and the servicer interface can be placed in audio/visual communication. Although a first servicer located at the customer interface may not be directly visible to a second servicer located at the servicer interface, they are still able to communicate through the customer interface and servicer interface during machine servicing.
摘要翻译：自动银行业务响应于从数据记录中读取的数据来进行资金转移。该机器包括读卡器，用于从用户卡读取对应于财务帐户的数据，并执行与该帐户有关的交易。该机器在位于机器前部的客户接口处包括相机，麦克风和读卡器。服务器显示设备位于位于机器后部的服务器接口。客户界面和服务器接口可以放置在音频/视频通信中。虽然位于客户界面的第一个服务器可能不是位于服务器接口的第二个服务器直接可见，但是在机器服务期间，它们仍然能够通过客户界面和服务器接口进行通信。

9. 发明授权

US07793828B2 Cash dispensing automated banking machine with leveling legs 有权
标题翻译：自动点钞自动银行机配平整腿
公开(公告)号：US07793828B2
公开(公告)日：2010-09-14
申请号：US11787430
申请日：2007-04-16
申请人： James Booth , Natarajan Ramachandran , Richard Lute, Jr. , Zachary Utz
发明人： James Booth , Natarajan Ramachandran , Richard Lute, Jr. , Zachary Utz
IPC分类号： B65D19/44 , E05G1/04
CPC分类号： G07F19/201 , G07F19/20 , G07F19/205
摘要： A cash dispensing automated banking machine, such as an ATM, has leveling legs. The legs are also used to fasten the ATM to a shipping pallet. Each leg has a support foot and an opposite free end. The free end is inserted through an opening in an intermediate shipping plate. With the shipping plate situated between the foot and the ATM underside, the free end is screwed into an underside opening. The leg is rotated until the plate is raised to be secure against the underside. The plate is then set on the pallet and fastened thereto by lag screws. The pallet includes horizontally adjustable stabilizing feet at sides thereof. The pallet feet can be extended outward to decrease the ability of a supported ATM to tip over. When not needed, such as during pallet storage, the feet can be retracted inward to reduce pallet size.
摘要翻译：自动付款自动银行机，如ATM，具有调平的腿。腿也用于将ATM紧固到运输托盘。每条腿都有支撑脚和相对的自由端。自由端通过中间运输板中的开口插入。随着运输板位于脚和ATM下侧之间，自由端拧入下侧开口。旋转腿直到板升起以固定在下侧。然后将板放在托盘上并用拉力螺钉固定。托盘在其侧面包括水平调节的稳定脚。托盘脚可以向外延伸，以降低支撑的自动柜员机翻倒的能力。当不需要时，例如在托盘存放期间，脚可以向内缩回以减小托盘尺寸。

10. 发明授权

US07789299B1 Automated banking machine that allows servicer to use customer display to view images from a camera located inside the machine 有权
标题翻译：自动银行机器，允许服务人员使用客户显示来查看机器内部相机的图像
公开(公告)号：US07789299B1
公开(公告)日：2010-09-07
申请号：US11715011
申请日：2007-03-07
申请人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
发明人： Natarajan Ramachandran , Jeffrey A. Hill , James Booth , Pedro Tula , Paul Mercina
IPC分类号： G06K5/00
CPC分类号： G07F19/207 , G07F19/20
摘要： An automatic banking machine includes a card reader for reading user cards, and a cash dispenser. A movable camera is positionable within the ATM housing. The automated banking machine carries out transactions related to user accounts based on information read from cards. Service personnel are enabled to direct the camera toward regions of machine components while conducting service activities that are not directly visible by a servicer. A camera assembly includes a microphone to sense sounds associated with machine components during test operations. The generated data may be used by an on-site servicer, or sent to an entity at a remote location. The visual images may be used to enhance diagnostic and servicing capabilities.
摘要翻译：自动银行机包括用于读取用户卡的读卡器和自动提款机。可移动摄像机可定位在ATM外壳内。自动银行机器根据从卡读取的信息执行与用户账户有关的交易。服务人员能够进行机器组件的各个区域的引导，同时进行服务人员不能直接看到的服务活动。相机组件包括用于在测试操作期间感测与机器部件相关联的声音的麦克风。生成的数据可以由现场服务器使用，或者发送到远程位置的实体。视觉图像可用于增强诊断和维修能力。

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