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1. 发明授权

US11369498B2 Stent and stent delivery system with improved deliverability 有权
公开(公告)号：US11369498B2
公开(公告)日：2022-06-28
申请号：US13014632
申请日：2011-01-26
申请人： James B. McClain , Douglas Taylor , David Enscore
发明人： James B. McClain , Douglas Taylor , David Enscore
IPC分类号： A61F2/958 , A61F2/00 , A61F2/82
摘要： Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.

2. 发明授权

US09789233B2 Stents having bioabsorbable layers 有权
公开(公告)号：US09789233B2
公开(公告)日：2017-10-17
申请号：US12426198
申请日：2009-04-17
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/06 , A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61F2/91 , A61F2210/0004 , A61F2250/0035 , A61F2250/0067 , A61L31/16 , A61L2300/216 , A61L2300/604 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/08
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

3. 发明申请

US20110190864A1 STENT AND STENT DELIVERY SYSTEM WITH IMPROVED DELIVERABILITY 审中-公开
标题翻译：具有改进的可交付性的STENT和STENT交付系统
公开(公告)号：US20110190864A1
公开(公告)日：2011-08-04
申请号：US13014632
申请日：2011-01-26
申请人： James B. McClain , Douglas Taylor , David Enscore
发明人： James B. McClain , Douglas Taylor , David Enscore
IPC分类号： A61F2/84 , A61F2/82
CPC分类号： A61F2/958 , A61F2/0077 , A61F2002/826 , A61F2250/003
摘要： Stent delivery systems having improved deliverability comprising an elongate member having an inflation lumen and a guidewire lumen therein; a balloon having an interior that is in fluid communication with the inflation lumen; and a stent comprising a coating mounted on the balloon. Methods for making stent delivery systems having improved deliverability. Methods for delivering two stent delivery systems concurrently through a guiding catheter, each stent delivery system comprising elongate member having an inflation lumen and a guidewire lumen therein, a balloon having an interior that is in fluid communication with the inflation lumen, and a stent comprising a coating mounted on the balloon. Stent coatings may comprise a pharmaceutical agent at least a portion of which is in crystalline form.
摘要翻译：具有改善的输送能力的支架输送系统包括具有充气腔和其中的导丝腔的细长构件; 具有与膨胀腔流体连通的内部的气囊; 以及支架，其包括安装在气囊上的涂层。用于制备具有改善的输送性的支架输送系统的方法。用于通过引导导管同时递送两个支架输送系统的方法，每个支架输送系统包括具有充气腔和其中的导丝腔的细长构件，具有与充气腔流体连通的内部的球囊，以及支架，涂层安装在气球上。支架涂层可以包含至少一部分为结晶形式的药剂。

4. 发明申请

US20100272778A1 STENTS HAVING CONTROLLED ELUTION 有权
标题翻译：具有控制力的手柄
公开(公告)号：US20100272778A1
公开(公告)日：2010-10-28
申请号：US12762007
申请日：2010-04-16
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/00 , A61K31/436 , A61P7/00
CPC分类号： A61F2/86 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61K31/436 , A61L31/022 , A61L31/06 , A61L31/08 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/204 , A61L2300/416 , A61L2300/426 , A61L2300/602 , A61L2300/604 , A61L2300/608 , A61L2300/63 , A61L2420/08 , C08L67/04
摘要： Provided herein is a device comprising: a. stent; b. a plurality of layers on said stent framework to form said device; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供的装置包括：a。支架; b。在所述支架框架上的多个层以形成所述装置; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

5. 发明申请

US20100211164A1 STENTS HAVING BIODEGRADABLE LAYERS 审中-公开
标题翻译：具有生物可降解层的手套
公开(公告)号：US20100211164A1
公开(公告)日：2010-08-19
申请号：US12595848
申请日：2008-04-17
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/82 , B05D1/34
CPC分类号： A61L31/10 , A61F2/82 , A61F2230/0069 , A61F2250/0067 , A61L31/148 , A61L31/16 , A61L2300/416 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/08 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising: a. stent framework; b. a plurality of layers deposited on said stent framework to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：a。支架框架; b。沉积在所述支架框架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

6. 发明授权

US09981072B2 Coated stents 有权
公开(公告)号：US09981072B2
公开(公告)日：2018-05-29
申请号：US12751902
申请日：2010-03-31
申请人： Douglas Taylor , James B. McClain
发明人： Douglas Taylor , James B. McClain
IPC分类号： A61F2/82 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/16 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.

7. 发明申请

US20100298928A1 Drug Coated Stents 审中-公开
标题翻译：药物涂层支架
公开(公告)号：US20100298928A1
公开(公告)日：2010-11-25
申请号：US12738411
申请日：2008-10-17
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/82 , B05D3/00
CPC分类号： A61L31/16 , A61L31/022 , A61L31/042 , A61L31/10 , A61L31/148 , A61L2300/236 , A61L2300/416 , A61L2300/42 , A61L2300/426 , A61L2300/602 , A61L2300/63 , A61L2420/02 , A61L2420/06 , A61L2420/08 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising: a stent framework; heparin molecules attached to the stent framework; and a rapamycin-polymer coating wherein at least part of rapamycin is in crystalline form. In one embodiment, the rapamycin-polymer coating comprises one or more resorbable polymers.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：支架框架; 肝素分子附着在支架框架上; 和雷帕霉素聚合物涂层，其中至少部分雷帕霉素是结晶形式。在一个实施方案中，雷帕霉素聚合物涂层包含一种或多种可再吸收的聚合物。

8. 发明申请

US20100256748A1 COATED STENTS 有权
标题翻译：涂层手套
公开(公告)号：US20100256748A1
公开(公告)日：2010-10-07
申请号：US12751902
申请日：2010-03-31
申请人： Douglas Taylor , James B. McClain
发明人： Douglas Taylor , James B. McClain
IPC分类号： A61F2/82 , B05D3/00
CPC分类号： A61L31/10 , A61F2/82 , A61F2210/0004 , A61F2250/0067 , A61L31/16 , C08L67/04
摘要： Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：a。支架; b。沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

9. 发明申请

US20100241220A1 Peripheral Stents Having Layers 审中-公开
标题翻译：具有层的外围支架
公开(公告)号：US20100241220A1
公开(公告)日：2010-09-23
申请号：US12729156
申请日：2010-03-22
申请人： James B. McClain , Douglas Taylor
发明人： James B. McClain , Douglas Taylor
IPC分类号： A61F2/06 , B05D7/00
CPC分类号： A61L31/10 , A61F2/86 , A61F2240/001 , A61F2250/001 , A61L31/16 , A61L2300/216 , A61L2300/416 , A61L2300/606 , A61L2300/608 , A61L2300/63 , A61L2420/02 , A61L2420/06 , A61L2420/08
摘要： Provided herein is a coated coronary stent, comprising: a. stent; b. a plurality of layers deposited on said stent to form said coronary stent; wherein at least one of said layers comprises a bioabsorbable polymer and at least one of said layers comprises one or more active agents; wherein at least part of the active agent is in crystalline form.
摘要翻译：本文提供了一种涂覆的冠状动脉支架，包括：a。支架; b。沉积在所述支架上以形成所述冠状动脉支架的多个层; 其中所述层中的至少一层包含生物可吸收聚合物，并且所述层中的至少一层包含一种或多种活性剂; 其中至少部分活性剂为结晶形式。

10. 发明申请

US20100239635A1 DRUG DELIVERY MEDICAL DEVICE 审中-公开
标题翻译：药物递送医疗设备
公开(公告)号：US20100239635A1
公开(公告)日：2010-09-23
申请号：US12729580
申请日：2010-03-23
申请人： James B. McClain , Douglas Taylor , John Neet
发明人： James B. McClain , Douglas Taylor , John Neet
IPC分类号： A61K9/00 , A61K38/22 , A61P43/00
CPC分类号： A61L31/16 , A61L27/16 , A61L27/34 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/602 , A61L2300/608 , A61L2300/63 , A61L2420/08 , A61M25/0045
摘要： Provided is a coated implantable medical device, comprising: a substrate; and a coating disposed on said substrate, wherein said coating comprises at least one polymer and at least one pharmaceutical agent in a therapeutically desirable morphology and/or at least one active biological agent and optionally, one or more pharmaceutical carrying agents; wherein substantially all of pharmaceutical agent and/or active biological agent remains within said coating and on said substrate until the implantable device is deployed at an intervention site inside the body of a subject and wherein upon deployment of said medical device in the body of said subject a portion of said pharmaceutical agent and/or active biological agent is delivered at said intervention site along with at least a portion of said polymer and/or a at least a portion of said pharmaceutical carrying agents.
摘要翻译：提供一种涂覆的可植入医疗装置，包括：基底; 以及设置在所述基底上的涂层，其中所述涂层包含至少一种聚合物和至少一种治疗上需要的形态和/或至少一种活性生物试剂和任选的一种或多种药物载体的药剂; 其中基本上所有的药剂和/或活性生物制剂都保留在所述涂层内和所述衬底上，直到可植入装置部署在受试者身体内部的介入部位，并且其中在将所述医疗装置部署在所述受试者的身体中时所述药剂和/或活性生物剂的一部分与所述聚合物的至少一部分和/或所述药物载体的至少一部分在所述介入部位递送。

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