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    • 10. 发明授权
    • Process for the preparation of carboxylated aromatic hydroxy compounds
    • 羧化芳族羟基化合物的制备方法
    • US5041634A
    • 1991-08-20
    • US278395
    • 1988-12-01
    • Martin ClausenPaul RysJunkuan Wang
    • Martin ClausenPaul RysJunkuan Wang
    • B01J27/053B01J27/06B01J27/08B01J27/185B01J27/187B01J27/232B01J31/04C07B61/00C07C51/265C07C51/367C07C65/03C07C65/11
    • C07C51/265
    • Process for the preparation of compounds of the formula HO-Ar-COOH in which Ar is a substituted or unsubstituted aromatic ring system, by oxidizing, by means of oxygen or compounds which donate oxygen, compounds of the formula HO-Ar-R.sub.1 in which R.sub.1 is alkyl having 1 to 5 carbon atoms and Ar is as defined above, or the O-acyl derivatives of these compounds, in an organic solvent at 80.degree. to 130.degree. C. and in the presence of an acylating agent, a cobalt and/or manganese compound and a compound which donates bromide, ions, and subsequently hydrolysing the products in a conventional manner. In the presence of the acylating agent, a selective oxidation of the hydroxyl-substituted aromatic compounds to carboxylated hydroxy compounds, which are obtained in a good state of purity and yield, is obtained without the application of pressure.The compounds obtained in accordance with the process are, for example, valuable intermediates for the preparation of dyes, plastics and pharmaceuticals.
    • 制备式HO-Ar-COOH的化合物的方法,其中Ar是取代或未取代的芳环体系,通过氧气或氧化的化合物,式HO-Ar-R1的化合物,其中 R1是具有1-5个碳原子的烷基,Ar如上所定义,或这些化合物的O-酰基衍生物在有机溶剂中在80-130℃下,在酰化剂,钴和 /或锰化合物和以常规方式提供溴化物,离子和随后水解产物的化合物。 在酰化剂的存在下,在没有施加压力的情况下获得羟基取代的芳族化合物选择性氧化成为具有良好的纯度和产率的羧化羟基化合物。 根据该方法获得的化合物是例如用于制备染料,塑料和药物的有价值的中间体。