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1. 发明申请

US20050274671A1 Method for preparing a compound of interaction of active substances with a porous support using supercritical fluid 有权
标题翻译：使用超临界流体制备活性物质与多孔载体相互作用的化合物的方法
公开(公告)号：US20050274671A1
公开(公告)日：2005-12-15
申请号：US10492346
申请日：2002-10-11
申请人： Jacques Fages , Bernard Freiss , Christophe Joussot-Dubien , Jean-Jacques Letourneau , Hubert Lochard , Florence Marciacq , Martial Sauceau
发明人： Jacques Fages , Bernard Freiss , Christophe Joussot-Dubien , Jean-Jacques Letourneau , Hubert Lochard , Florence Marciacq , Martial Sauceau
IPC分类号： A61J3/02 , A61K9/16 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/366 , A61K31/4439 , A61K31/445 , A61K31/5415 , A61K31/7048 , A61K47/40 , A61P1/04 , A61P3/06 , A61P29/00 , A61P35/00 , A61P37/08 , B01J3/00 , B01J13/06 , B01D11/04
CPC分类号： A61K9/1652 , A61K9/1694
摘要： The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.
摘要翻译：本发明涉及一种用于制备难溶于水性介质的活性物质与多孔载体相互作用的化合物的方法。本发明的特征在于其包括以下步骤：（a）将由超临界流体产生的活性物质与特定量的多孔载体混合; （b）通过以静态方式使超临界流体与在步骤（a）获得的混合物接触改进在步骤（a）获得的混合物的水性介质中的溶解所需的时间进行分子扩散步骤; （c）用超临界流体流洗涤在步骤（b）获得的交互化合物; （d）使由此形成的相互作用化合物的颗粒回收。本发明还涉及通过所述方法可获得的化合物。

2. 发明授权

US07390411B2 Method for preparing a compound of interaction of active substances with a porous support using supercritical fluid 有权
标题翻译：使用超临界流体制备活性物质与多孔载体相互作用的化合物的方法
公开(公告)号：US07390411B2
公开(公告)日：2008-06-24
申请号：US10492346
申请日：2002-10-11
申请人： Jacques Fages , Bernard Freiss , Christophe Joussot-Dubien , Jean-Jacques Letourneau , Hubert Lochard , Florence Marciacq , Martial Sauceau
发明人： Jacques Fages , Bernard Freiss , Christophe Joussot-Dubien , Jean-Jacques Letourneau , Hubert Lochard , Florence Marciacq , Martial Sauceau
IPC分类号： B01D61/00 , B29B9/00
CPC分类号： A61K9/1652 , A61K9/1694
摘要： The invention concerns a method for preparing compounds for interaction of an active substance hardly soluble in an aqueous medium with a porous support. The invention is characterized in that it comprises the following steps: (a) mixing the active substance generated by supercritical fluid and the specific amount of porous support; (b) carrying out a molecular diffusion step by contacting in static mode a supercritical fluid with the mixture obtained at step (a) for the time required to improve the dissolution in the aqueous medium of the mixture obtained at step (a); (c) washing the interactive compound obtained at step (b) with a supercritical fluid flow; (d) recuperating the particles of the interactive compound thus formed. The invention also concerns a compound obtainable by said method.
摘要翻译：本发明涉及一种用于制备难溶于水性介质的活性物质与多孔载体相互作用的化合物的方法。本发明的特征在于其包括以下步骤：（a）将由超临界流体产生的活性物质与特定量的多孔载体混合; （b）通过以静态方式使超临界流体与在步骤（a）获得的混合物接触改进在步骤（a）获得的混合物的水性介质中的溶解所需的时间进行分子扩散步骤; （c）用超临界流体流洗涤在步骤（b）获得的交互化合物; （d）使由此形成的相互作用化合物的颗粒回收。本发明还涉及通过所述方法可获得的化合物。

3. 发明授权

US08741346B2 Method for the preparation of molecular complexes 有权
标题翻译：分子复合物的制备方法
公开(公告)号：US08741346B2
公开(公告)日：2014-06-03
申请号：US10554058
申请日：2004-04-23
申请人： Hubert Lochard , Martial Sauceau , Bernard Freiss
发明人： Hubert Lochard , Martial Sauceau , Bernard Freiss
IPC分类号： A61K48/00
CPC分类号： B82Y5/00 , A61K47/6951
摘要： The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterized in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.
摘要翻译：本发明涉及一种制备可溶性分子复合物的方法，其包含一种或多种在水性介质中难溶性的活性物质，其包含在一个或多个宿主分子内，其特征在于包括以下步骤：（a）使一个或更多的活性物质与一种或多种宿主分子接触，（b）通过使稠密流体在压力下与静态模式中获得的混合物在（a）中获得的混合物存在下进行分子扩散步骤，一种或多种扩散剂和（c）如此形成的分子复合物的回收。

4. 发明申请

US20060246140A1 Method for the preparation of molecular complexes 有权
标题翻译：分子复合物的制备方法
公开(公告)号：US20060246140A1
公开(公告)日：2006-11-02
申请号：US10554058
申请日：2004-04-23
申请人： Hubert Lochard , Martial Sauceau , Bernard Freiss
发明人： Hubert Lochard , Martial Sauceau , Bernard Freiss
IPC分类号： A61K48/00 , A61K31/724 , A61K9/14
CPC分类号： B82Y5/00 , A61K47/6951
摘要： The invention relates to a method for the preparation of soluble molecular complexes, comprising one or more active substances which are poorly-soluble in an aqueous medium, included within one or more host molecules, characterised in comprising the following steps: (a) bringing one or more active substances into contact with one or more host molecules, (b) carrying out a molecular diffusion step by bringing a dense fluid into contact, under pressure, with the mixture obtained in (a), in static mode, in the presence of one or more diffusion agents and (c) recovery of the molecular complex thus formed.
摘要翻译：本发明涉及一种制备可溶性分子复合物的方法，其包含一种或多种在水性介质中难溶性的活性物质，其包含在一个或多个宿主分子内，其特征在于包括以下步骤：（a）使一个或更多的活性物质与一种或多种宿主分子接触，（b）通过使稠密流体在压力下与静态模式中获得的混合物在（a）中获得的混合物存在下进行分子扩散步骤，一种或多种扩散剂和（c）如此形成的分子复合物的回收。

5. 发明申请

US20070270379A1 Inclusion Complexes Containing Piroxicam, a Cyclodextrin and Arginine 有权
标题翻译：包含吡罗昔康，环糊精和精氨酸的复合物
公开(公告)号：US20070270379A1
公开(公告)日：2007-11-22
申请号：US10594740
申请日：2005-03-29
申请人： Bernard Freiss , Florence Marciacq , Hubert Lochard
发明人： Bernard Freiss , Florence Marciacq , Hubert Lochard
IPC分类号： A61K31/54 , A61K31/195 , A61K31/724 , C07C257/00 , C07D279/16 , C08B37/16
CPC分类号： C08B37/0015 , A61K31/5415 , A61K47/6951 , B82Y5/00
摘要： The invention relates to a method for preparing a soluble inclusion complex comprising one or several active substances which are hardly soluble in an aqueous medium and are included in one or several host molecules, characterised in that it comprises the following succesive stages: (a) one or several active substances are brought into contact with one or several host molecules; (b) initiation of a molecular diffusion stage by bringing a dense pressurized fluid into contact with the mixture obtained in stage (a) in a static mode in the presence of one or several diffusing agents; (c) recovery of the active substance- host molecule molecular complex thus formed; (d) initiation of a stage wherein an interaction agent is added to and mixed with the active substance host molecule molecular complex; (e) recovery of the soluble inclusion compound thus formed. The invention also relates to the soluble inclusion compound which can be obtained by said method, particularly a piroxicam-cyclodextrin-arginine compound
摘要翻译：本发明涉及一种制备可溶性包合络合物的方法，其包含难溶于水性介质并包含在一个或多个宿主分子中的一种或几种活性物质，其特征在于其包含以下成功阶段：（a）一种或几种活性物质与一种或多种宿主分子接触; （b）通过在一种或几种扩散剂的存在下使致密的加压流体以静态方式与阶段（a）中获得的混合物接触来引发分子扩散阶段; （c）如此形成的活性物质 - 宿主分子分子复合物的回收; （d）开始其中将相互作用剂加入并与活性物质宿主分子分子复合物混合的阶段; （e）如此形成的可溶性夹杂物的回收。本发明还涉及可通过所述方法获得的可溶性包合物，特别是吡罗昔康 - 环糊精 - 精氨酸化合物

6. 发明申请

US20110124728A1 DHA ENRICHMENT PROCESS 审中-公开
标题翻译： DHA充实过程
公开(公告)号：US20110124728A1
公开(公告)日：2011-05-26
申请号：US12950723
申请日：2010-11-19
申请人： Florence MARCIACQ , Mathieu Soulayres , Bernard Freiss
发明人： Florence MARCIACQ , Mathieu Soulayres , Bernard Freiss
IPC分类号： A61K31/225 , A61P43/00
CPC分类号： C11B1/104 , A23D9/007 , C11B7/005 , C11C1/005 , C11C1/08 , C11C3/003 , Y02P20/544
摘要： The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.
摘要翻译：本发明涉及DHA富集脂肪酸或其衍生物的方法的连续方法，其包含相对于溶液的总脂肪酸或其衍生物的小于50％的DHA，其中该方法包括以下步骤：（a ）在小于或等于70℃的温度和在100℃之间的压力下同时逆流注入脂肪酸或其衍生物和超临界CO 2流的流动的分馏塔中 ×105Pa和160×105Pa，其中超临界CO 2的水平在30和70之间，和（b）相对于残基或其衍生物的总脂肪酸，回收包含至少50％的DHA的残余物，其中DHA产率大于或等于60％。

7. 发明授权

US07906666B2 DHA enrichment process 有权
标题翻译： DHA浓缩过程
公开(公告)号：US07906666B2
公开(公告)日：2011-03-15
申请号：US12086771
申请日：2006-12-19
申请人： Florence Marciacq , Mathieu Soulayres , Bernard Freiss
发明人： Florence Marciacq , Mathieu Soulayres , Bernard Freiss
IPC分类号： C11B3/00
CPC分类号： C11B1/104 , A23D9/007 , C11B7/005 , C11C1/005 , C11C1/08 , C11C3/003 , Y02P20/544
摘要： The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.
摘要翻译：本发明涉及DHA富集脂肪酸或其衍生物的方法的连续方法，其包含相对于溶液的总脂肪酸或其衍生物的小于50％的DHA，其中该方法包括以下步骤：（a ）在小于或等于70℃的温度和在100℃之间的压力下同时逆流注入脂肪酸或其衍生物和超临界CO 2流的流动的分馏塔中 ×105Pa和160×105Pa，其中超临界CO 2的水平在30和70之间，和（b）相对于残基或其衍生物的总脂肪酸，回收包含至少50％的DHA的残余物，其中DHA产率大于或等于60％。

8. 发明申请

US20090036532A1 DHA Enrichment Process 有权
标题翻译： DHA浓缩过程
公开(公告)号：US20090036532A1
公开(公告)日：2009-02-05
申请号：US12086771
申请日：2006-12-19
申请人： Florence Marciacq , Mathieu Soulayres , Bernard Freiss
发明人： Florence Marciacq , Mathieu Soulayres , Bernard Freiss
IPC分类号： A61K31/202 , A61P25/00 , A61P25/28
CPC分类号： C11B1/104 , A23D9/007 , C11B7/005 , C11C1/005 , C11C1/08 , C11C3/003 , Y02P20/544
摘要： The present invention relates to a continuous process of DHA enrichment of a solution of fatty acids or derivatives thereof comprising less than 50% of DHA relative to the total fatty acids of the solution or to derivatives thereof, wherein the process comprises the steps of (a) simultaneous countercurrent injection, into a fractionation column, of the flow of the solution of fatty acids or of derivatives thereof and of a flow of supercritical CO2 at a temperature of less than or equal to 70° C. and at a pressure of between 100×105 Pa and 160×105 Pa, wherein the level of supercritical CO2 is between 30 and 70, and (b) recovery of the residue comprising at least 50% of DHA relative to the total fatty acids of the residue or to derivatives thereof, wherein the DHA yield is greater than or equal to 60%.
摘要翻译：本发明涉及DHA富集脂肪酸或其衍生物的方法的连续方法，其包含相对于溶液的总脂肪酸或其衍生物的小于50％的DHA，其中该方法包括以下步骤：（a ）在小于或等于70℃的温度和在100×10 5的压力下同时逆流注入脂肪酸或其衍生物和超临界CO 2流的流动的分馏塔中 Pa和160×10 5 Pa，其中超临界CO 2的水平在30和70之间，和（b）相对于残基或其衍生物的总脂肪酸，包含至少50％的DHA的残余物的回收，其中DHA产率大于或等于60％。

9. 发明授权

US08716342B2 Method for preparing molecular complexes between adapalene and cyclodextrins 有权
标题翻译：在阿达帕林与环糊精之间制备分子复合物的方法
公开(公告)号：US08716342B2
公开(公告)日：2014-05-06
申请号：US13259945
申请日：2010-04-09
申请人： Hubert Lochard , Bernard Freiss
发明人： Hubert Lochard , Bernard Freiss
IPC分类号： A61K31/192 , A61K47/40
CPC分类号： C07C65/26 , A61K47/6951 , B82Y5/00 , C07C2603/74
摘要： A method for preparing molecular complexes between Adapalene and cyclodextrins using the technology of dense fluids under pressure, especially that of CO2 is described.
摘要翻译：描述了使用压力下的致密流体，特别是二氧化碳的技术，在阿达帕林和环糊精之间制备分子复合物的方法。

10. 发明申请

US20070293454A1 Complex Containing Mequitazine, a Cyclodextrin and an Interaction Agent 失效
标题翻译：含有美沙醌，环糊精和相互作用剂的复合物
公开(公告)号：US20070293454A1
公开(公告)日：2007-12-20
申请号：US11665839
申请日：2005-10-19
申请人： Bernard Freiss , Hubert Lochard
发明人： Bernard Freiss , Hubert Lochard
IPC分类号： A61K31/5415 , A61P27/14 , A61P37/08 , C08B37/16
CPC分类号： B82Y5/00 , A61K47/6951
摘要： The present invention relates to a complex that includes mequitazine, a cyclodextrin, and an interaction agent wherein the rate of solubilization in water of complexed mequitazine, measured for a 2 g/l mixture of mequitazine in water at 35° C. after 15 minutes of stirring, is greater than 50% at pH 9. The present invention also relates to a method of preparing the aforementioned complex and a pharmaceutical composition of which the complex is a part.
摘要翻译：本发明涉及一种复合物，其包括甲基it嗪，环糊精和相互作用剂，其中在35℃下，在35℃下测定2g / l甲基azine嗪在水中的复合度的喹喔啉的溶解速率，15分钟后搅拌，在pH9时大于50％。本发明还涉及一种制备上述络合物的方法和该复合物是其一部分的药物组合物。

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