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1. 发明授权

US4521344A Cyano-dicarboxylate 失效
标题翻译：氰基二羧酸酯
公开(公告)号：US4521344A
公开(公告)日：1985-06-04
申请号：US531095
申请日：1983-09-12
申请人： Jacob S. Tou , Alfred A. Schleppnik
发明人： Jacob S. Tou , Alfred A. Schleppnik
IPC分类号： C07C51/56 , C07C57/34 , C07D307/60
CPC分类号： C07C57/34 , C07C51/56
摘要： A phenylethyl substituted dimer of ethylene and maleic anhydride, named 7-phenyloctane-(1,2),(5,6)-dianhydride, is chemically synthesized by(a) alkylating alkyl 2,4-dihalobutyrate with alkyl 2-cyano-3-phenylbutyrate,(b) alkylating the resulting halide condensation product with a carboxylate selected from the group consisting of trialkyl ethane-1,1,2-tricarboxylate and dimethyl cyanoethane-1,2-dicarboxylate,(c) acid hydrolyzing the resulting tetra or pentaester accompanied by decarboxylating, and(d) dehydrating the resulting tetra-acid to yield the desired phenylethyl substituted dimer of ethylene and maleic anhydride,wherein the alkyls in the butyrate and carboxylate ester groups each contain from one to about four carbon atoms and halo is selected from the group consisting of bromo, chloro and iodo.
摘要翻译：乙烯和马来酸酐的苯基乙基取代二聚体，命名为7-苯辛基 - （1,2），（5,6） - 二氢化钠，是通过（a）使2,4-二卤代烷基烷基化与2-氰基-3- - 苯基丁酸酯，（b）将所得的卤化物缩合产物与选自三烷基乙烷-1,1,2-三羧酸三乙酯和二甲基氰基乙烷-1,2-二羧酸酯的羧酸烷基化，（c）酸水解所得四五酸酯伴随着脱羧，和（d）使得到的四酸脱水得到乙烯和马来酸酐所需的苯基乙基取代的二聚体，其中丁酸酯和羧酸酯基团中的烷基各自含有1个至约4个碳原子，卤素是选自溴，氯和碘。

2. 发明授权

US4428887A Method of producing mono-substituted terminal diesters 失效
标题翻译：单取代的末端二酯的制备方法
公开(公告)号：US4428887A
公开(公告)日：1984-01-31
申请号：US398060
申请日：1982-07-14
申请人： Jacob S. Tou , Alfred A. Schleppnik
发明人： Jacob S. Tou , Alfred A. Schleppnik
IPC分类号： C07C67/34 , C07C69/34 , C07C69/38 , C07C69/602 , C07C69/612 , C07C120/00
CPC分类号： C07C255/00
摘要： Mono-substituted terminal diesters of malonic acid are prepared by reaction of the corresponding substituted 1,2-diesters with alkali metal hydride in the presence of organic solvent medium.
摘要翻译：丙二酸的单取代的末端二酯通过相应的取代的1,2-二酯与碱金属氢化物在有机溶剂介质的存在下反应来制备。

3. 发明授权

US4514340A Cyano-polycarboxylates 失效
标题翻译：氰基 - 多羧酸盐
公开(公告)号：US4514340A
公开(公告)日：1985-04-30
申请号：US531104
申请日：1983-09-12
申请人： Jacob S. Tou , Alfred A. Schleppnik
发明人： Jacob S. Tou , Alfred A. Schleppnik
IPC分类号： C07C51/56 , C07C57/34 , C07C121/66
CPC分类号： C07C57/34 , C07C51/56
摘要： A phenylethyl substituted dimer of ethylene and maleic anhydride, named 7-phenyloctane-(1,2),(5,6)-dianhydride, is chemically synthesized by(a) alkylating alkyl 2,4-dihalobutyrate with alkyl 2-cyano-3-phenylbutyrate,(b) alkylating the resulting halide condensation product with a carboxylate selected from the group consisting of trialkyl ethane-1,1,2-tricarboxylate and dimethyl cyanoethane-1,2-dicarboxylate,(c) acid hydrolyzing the resulting tetra or pentaester accompanied by decarboxylating, and(d) dehydrating the resulting tetra-acid to yield the desired phenylethyl substituted dimer of ethylene and maleic anhydride,wherein the alkyls in the butyrate and carboxylate ester groups each contain from one to about four carbon atoms and halo is selected from the group consisting of bromo, chloro and iodo.
摘要翻译：乙烯和马来酸酐的苯基乙基取代二聚体，命名为7-苯辛基 - （1,2），（5,6） - 二氢化钠，是通过（a）使2,4-二卤代烷基烷基化与2-氰基-3- - 苯基丁酸酯，（b）将所得的卤化物缩合产物与选自三烷基乙烷-1,1,2-三羧酸三乙酯和二甲基氰基乙烷-1,2-二羧酸酯的羧酸烷基化，（c）酸水解所得四五酸酯伴随着脱羧，和（d）使得到的四酸脱水得到乙烯和马来酸酐所需的苯基乙基取代的二聚体，其中丁酸酯和羧酸酯基团中的烷基各自含有1个至约4个碳原子，卤素是选自溴，氯和碘。

4. 发明授权

US4442298A Chemical synthesis of ethylene/maleic anhydride dimer with phenylethyl end group 失效
标题翻译：乙烯/马来酸酐二聚体与苯基乙基端基的化学合成
公开(公告)号：US4442298A
公开(公告)日：1984-04-10
申请号：US413009
申请日：1982-08-30
申请人： Jacob S. Tou , Alfred A. Schleppnik
发明人： Jacob S. Tou , Alfred A. Schleppnik
IPC分类号： C07C51/56 , C07C57/34 , C07D307/60
CPC分类号： C07C57/34 , C07C51/56
摘要： A phenylethyl substituted dimer of ethylene and maleic anhydride, names 7-phenyloctane-(1,2),(5,6)-dianhydride, is chemically synthesized by(a) alkylating alkyl 2,4-dihalobutyrate with alkyl 2-cyano-3-phenylbutyrate,(b) alkylating the resulting halide condensation product with a carboxylate selected from the group consisting of trialkyl ethane-1,1,2-tricarboxylate and dimethyl cyanoethane-1,2-dicarboxylate,(c) acid hydrolyzing the resulting tetra or pentaester accompanied by decarboxylating, and(d) dehydrating the resulting tetra-acid to yield the desired phenylethyl substituted dimer of ethylene and maleic anhydride,wherein the alkyls in the butyrate and carboxylate ester groups each contain from one to about four carbon atoms and halo is selected from the group consisting of bromo, chloro and iodo.The dimer has anti-tumor and anti-viral properties and can be used in silver halide emulsions.
摘要翻译：乙烯和马来酸酐的苯基乙基取代的二聚体名称为7-苯辛基 - （1,2），（5,6） - 二氢化物，是通过（a）使2,4-二卤代烷基烷基化与2-氰基-3- - 苯基丁酸酯，（b）将所得的卤化物缩合产物与选自三烷基乙烷-1,1,2-三羧酸三乙酯和二甲基氰基乙烷-1,2-二羧酸酯的羧酸烷基化，（c）酸水解所得四五酸酯伴随着脱羧，和（d）使得到的四酸脱水得到乙烯和马来酸酐所需的苯基乙基取代的二聚体，其中丁酸酯和羧酸酯基团中的烷基各自含有1个至约4个碳原子，而卤素是选自溴，氯和碘。二聚体具有抗肿瘤和抗病毒性质，可用于卤化银乳剂。

5. 发明授权

US06794159B1 Method of removing n-terminal alanine residues from polypeptides with aeromonas aminopeptidase 失效
标题翻译：从氨基肽酶气单胞菌多肽中除去N-末端丙氨酸残基的方法
公开(公告)号：US06794159B1
公开(公告)日：2004-09-21
申请号：US09541844
申请日：2000-04-03
申请人： Jacob S. Tou , Douglas W. Taylor
发明人： Jacob S. Tou , Douglas W. Taylor
IPC分类号： C12P2106
CPC分类号： C12N9/48 , C07K14/61
摘要： This invention describes a method of removing N-terminal alanine residues from polypeptides, preferably recombinant proteins, using an aminopeptidase derived from the marine bacterium Aeromonas proteolytica. Accordingly, Aeromonas aminopeptidase (AAP; E.C. 3.4.11.10) can be used to remove N-terminal alanyl residues from derivatives of human somatotropin (hST, human growth hormone, or hGH), porcine somatotropin (pST), and bovine somatotropin (bST), for example, to yield proteins having their native amino acid sequences. The enzyme reactions can be carried out in free solution, or the AAP can be immobilized on a solid support, for reactions carried out in vitro. An efficient method for converting Ala-hGH to hGH, for example, comprises expression of Ala-hGH in E. coli, recovery of inclusion bodies, solubilization and refolding in detergent, detergent removal by ultrafiltration, selective precipitation, enzyme cleavage, followed by two column chromatography steps.
摘要翻译：本发明描述了使用衍生自海洋细菌嗜水气单胞菌的氨基肽酶从多肽，优选重组蛋白中除去N-末端丙氨酸残基的方法。因此，气单胞菌氨基肽酶（AAP; EC 3.4.11.10）可用于从人类生长激素（hST，人生长激素或hGH），猪生长激素（pST）和牛生长激素（bST）的衍生物中除去N-末端丙氨酰残基，例如，产生具有其天然氨基酸序列的蛋白质。酶反应可以在游离溶液中进行，或者AAP可以固定在固体支持物上，用于在体外进行的反应。例如，将Ala-hGH转化为hGH的有效方法包括在大肠杆菌中表达Ala-hGH，回收包涵体，在洗涤剂中溶解和重折叠，通过超滤去除洗涤剂，选择性沉淀，酶切，然后是两个柱色谱步骤。

6. 发明授权

US06410694B1 Method for solubilization and naturation of somatotropins 有权
公开(公告)号：US06410694B1
公开(公告)日：2002-06-25
申请号：US09461784
申请日：1999-12-15
申请人： S. Bradley Storrs , Jacob S. Tou , Jessica Marie Ballinger
发明人： S. Bradley Storrs , Jacob S. Tou , Jessica Marie Ballinger
IPC分类号： C07K102
CPC分类号： C07K14/61
摘要： A method for the solubilization and/or naturation of a somatotropin involves contacting a somatotropin with a detergent composition and water under conditions effective to obtain a naturated somatotropin, wherein the detergent composition may be a C10, C12, C16 or C18 acyl glutamate, a C10, C14 or C18 alkyl sulfate, an alcohol ethoxy sulfate, lauroyl ethylenediamine-triacetic acid (LEDA), a C10 to C18 linear alkyl benzene sulfonate, diphenyl disulfonate or an acyl amino acid.

7. 发明授权

US06743600B1 Method of removing N-terminal alanine residues from polypeptides with Aeromonas aminopeptidase 失效
标题翻译：用气单胞菌氨肽酶从多肽中除去N-末端丙氨酸残基的方法
公开(公告)号：US06743600B1
公开(公告)日：2004-06-01
申请号：US10018304
申请日：2002-09-16
申请人： Jacob S. Tou , Douglas W. Taylor
发明人： Jacob S. Tou , Douglas W. Taylor
IPC分类号： C12Q137
CPC分类号： C12P21/06 , C07K14/61
摘要： This invention describes a method of removing N-terminal alanine residues from polypeptides, preferably recombinant proteins, using an aminopeptidase derived from the marine bacterium Aeromonas proteolytica. Accordingly, Aeromonas aminopeptidase (AAP; E.C. 3.4.11.10) can be used to remove N-terminal alanyl residues from derivatives of human somatotropin (hST, human growth hormone, or hGH), porcine somatotropin (pST), and bovine somtotropin (bST), for example, to yield proteins having their native amino acid sequences. The enzyme reactions can be carried out in free solution, or the AAP can be immobilized on a solid support, for reactions carried out in vitro. An efficient method for converting Ala-hGH to hGH, for example, comprises expression of Ala-hGH in E. coli, recovery of inclusion bodies, solubilization and refolding in detergent, detergent removal by ultrafiltration, selective precipitation, enzyme cleavage, followed by two column chromatography steps.
摘要翻译：本发明描述了使用衍生自海洋细菌嗜水气单胞菌的氨基肽酶从多肽，优选重组蛋白中除去N-末端丙氨酸残基的方法。因此，气单胞菌氨基肽酶（AAP; EC 3.4.11.10）可用于从人类生长激素（hST，人生长激素或hGH），猪生长激素（pST）和牛嗜马逊托品（bST）的衍生物中除去N-末端丙氨酰残基，例如，产生具有其天然氨基酸序列的蛋白质。酶反应可以在游离溶液中进行，或者AAP可以固定在固体支持物上，用于在体外进行的反应。例如，将Ala-hGH转化为hGH的有效方法包括在大肠杆菌中表达Ala-hGH，回收包涵体，在洗涤剂中溶解和重折叠，通过超滤去除洗涤剂，选择性沉淀，酶切，然后是两个柱色谱步骤。

8. 发明授权

US6034224A Method for solubilization and naturation of somatotropins 失效
公开(公告)号：US6034224A
公开(公告)日：2000-03-07
申请号：US2565
申请日：1997-12-31
申请人： S. Bradley Storrs , Jacob S. Tou , Jessica Marie Ballinger
发明人： S. Bradley Storrs , Jacob S. Tou , Jessica Marie Ballinger
IPC分类号： C12N15/09 , C07K1/14 , C07K14/61 , C12P21/02 , C07K1/00
CPC分类号： C07K14/61
摘要： A method for the solubilization and/or naturation of a somatotropin involves contacting a somatotropin with a detergent composition and water under conditions effective to obtain a naturated somatotropin, wherein the detergent composition may be a C.sub.10, C.sub.12, C.sub.16 or C.sub.18 acyl glutamate, a C.sub.10, C.sub.14 or C.sub.18 alkyl sulfate, an alcohol ethoxy sulfate, lauroyl ethylenediamine-triacetic acid (LEDA), a C.sub.10 to C.sub.18 linear alkyl benzene sulfonate, diphenyl disulfonate or an acyl amino acid.

9. 发明授权

US06562951B2 Method of solubilization and naturation of somatotropins 有权
标题翻译：生长激素的溶解和生成方法
公开(公告)号：US06562951B2
公开(公告)日：2003-05-13
申请号：US10002084
申请日：2001-11-02
申请人： S. Bradley Storrs , Jacob S. Tou , Jessica Marie Ballinger
发明人： S. Bradley Storrs , Jacob S. Tou , Jessica Marie Ballinger
IPC分类号： C07K102
CPC分类号： C07K14/61
摘要： A method for the solubilization and/or naturation of a somatotropin involves contacting a somatotropin with a detergent composition and water under conditions effective to obtain a naturated somatotropin, wherein the detergent composition may be a C10, C12, C16 or C18 acyl glutamate, a C10, C14 or C18 alkyl sulfate, an alcohol ethoxy sulfate, lauroyl ethylenediamine-triacetic acid (LEDA), a C10 to C18 linear alkyl benzene sulfonate, diphenyl disulfonate or an acyl amino acid.
摘要翻译：促生长激素的增溶和/或释放的方法包括使生长激素与洗涤剂组合物和水在有效获得生理素生长激素的条件下接触，其中洗涤剂组合物可以是C10，C12，C16或C18酰基谷氨酸，C10 ，C14或C18烷基硫酸盐，醇乙氧基硫酸盐，月桂酰乙二胺 - 三乙酸（LEDA），C10至C18直链烷基苯磺酸盐，二苯基二磺酸盐或酰基氨基酸。

10. 发明授权

US06706670B2 Water soluble metal working fluids 失效
标题翻译：水溶性金属加工液
公开(公告)号：US06706670B2
公开(公告)日：2004-03-16
申请号：US09242821
申请日：1999-02-24
申请人： Dennis J. Kalota , Yueting Chou , Timothy K. Hirzel , David C. Silverman , Jacob S. Tou , Winsor R. Cho
发明人： Dennis J. Kalota , Yueting Chou , Timothy K. Hirzel , David C. Silverman , Jacob S. Tou , Winsor R. Cho
IPC分类号： C10M14102
CPC分类号： C10M173/02 , C10M125/22 , C10M125/24 , C10M125/26 , C10M129/24 , C10M129/34 , C10M129/36 , C10M129/40 , C10M129/42 , C10M129/44 , C10M129/72 , C10M131/10 , C10M133/06 , C10M133/08 , C10M133/16 , C10M133/20 , C10M133/22 , C10M133/44 , C10M133/46 , C10M135/08 , C10M135/10 , C10M135/20 , C10M135/26 , C10M137/02 , C10M137/04 , C10M137/06 , C10M137/08 , C10M137/12 , C10M137/16 , C10M145/12 , C10M145/22 , C10M149/18 , C10M149/20 , C10M149/22 , C10M2201/065 , C10M2201/066 , C10M2201/084 , C10M2201/085 , C10M2201/087 , C10M2201/10 , C10M2201/102 , C10M2201/105 , C10M2207/08 , C10M2207/122 , C10M2207/123 , C10M2207/124 , C10M2207/126 , C10M2207/127 , C10M2207/128 , C10M2207/282 , C10M2207/285 , C10M2207/286 , C10M2209/082 , C10M2209/102 , C10M2215/04 , C10M2215/042 , C10M2215/08 , C10M2215/082 , C10M2215/086 , C10M2215/10 , C10M2215/102 , C10M2215/12 , C10M2215/122 , C10M2215/14 , C10M2215/223 , C10M2215/224 , C10M2217/024 , C10M2217/028 , C10M2217/044 , C10M2217/045 , C10M2217/046 , C10M2219/04 , C10M2219/042 , C10M2219/044 , C10M2219/08 , C10M2219/085 , C10M2223/02 , C10M2223/04 , C10M2223/041 , C10M2223/043 , C10M2223/049 , C10M2223/06 , C10M2223/061 , C10M2223/08 , C10M2223/10 , C10N2230/06 , C10N2230/30 , C10N2230/70 , C10N2240/40 , C10N2240/401 , C10N2240/402 , C10N2270/02
摘要： This invention relates to novel water soluble metal working fluid compositions, their use to work metal, a process for working metal using such compositions and the metal worked article of manufacture. More particularly, this invention relates to fluid compositions useful in cutting, grinding, shaping and other metal working operations which require a lubricant. The terms “first Group A” and “second Group B” are used herein to denote different groups and not to indicate any sequence of use or selection as any possible combination or sequence of use of a component(s) is envisioned without limit of any kind. The disclosed fluid compositions are also anticorrosive and environmentally more acceptable than current oil based fluids. There has now been discovered an essentially odorless, substantially non-oil misting, water-soluble metal working fluid comprising at least one component selected from a first Group A herein and optionally one or more components selected from a second Group B herein preferably with the balance of the composition being water and other (optional) minor ingredients. When a component is employed from Group A and a component is employed from Group B the action of the combination generally enhances performance of the resulting combination with contain moieties from both Group A and Group B.
摘要翻译：本发明涉及新型水溶性金属工作流体组合物，它们用于加工金属的方法，使用这种组合物加工金属的方法和金属加工制品。更具体地说，本发明涉及可用于切割，研磨，成形和其它需要润滑剂的金属加工操作的流体组合物。术语“第一组A”和“第二组B”在本文中用于表示不同的组，并且不表示任何使用或选择的任何序列，作为组分的任何可能的组合或使用顺序被设想为没有任何限制类。所公开的流体组合物也比目前的油基流体具有防腐蚀性和环境性更好的可接受性。现在已经发现了基本上无臭的基本上非油雾的水溶性金属工作流体，其包含至少一种选自本文的第一组A和任选的一种或多种选自第二组B的组分，优选与余量的组合物是水和其他（任选的）次要成分。当从A组中使用组分并且从B组中使用组分时，组合的作用通常增强了所得组合的性能，其含有来自A组和B组的含有部分。

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