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1. 发明申请

US20090305317A1 USER INTERFACE FOR TESTING DEVICE 审中-公开
标题翻译：用于测试设备的用户界面
公开(公告)号：US20090305317A1
公开(公告)日：2009-12-10
申请号：US12468671
申请日：2009-05-19
申请人： Jacob S. Brauer , Darren Brown , Kevin Chang , Jun Chen , Richard Kates , Jennifer M. Levin , Harris Lieber , Jing Lin , Dawn Rountree , Amy Schwartz , Fred Sommer , Fu Hsiung Tsai , Huan-Ping Wu , Raymond Yao
发明人： Jacob S. Brauer , Darren Brown , Kevin Chang , Jun Chen , Richard Kates , Jennifer M. Levin , Harris Lieber , Jing Lin , Dawn Rountree , Amy Schwartz , Fred Sommer , Fu Hsiung Tsai , Huan-Ping Wu , Raymond Yao
IPC分类号： C12Q1/54 , C12M1/34
CPC分类号： G01N27/3274 , C12Q1/00 , C12Q1/004 , G01N33/96
摘要： A testing system for testing an analyte in a fluid sample includes a user interface including a display for displaying information relating to measurements of health data and an input device for receiving information from a user relating to the health data. The testing system further includes an automarking feature adapted to identify a testing result of a control solution, the testing of the control solution being distinguishable from the testing of the fluid sample. The testing result of the control solution is not included in the information relating to the measurements of health data that is displayed to a user via the user interface.
摘要翻译：用于测试流体样品中的分析物的测试系统包括用户界面，其包括用于显示关于健康数据的测量的信息的显示器和用于从用户接收关于健康数据的信息的输入设备。测试系统还包括适于识别控制解决方案的测试结果的自动识别功能，该控制解决方案的测试与流体样品的测试是可区分的。控制解决方案的测试结果不包括在与通过用户界面向用户显示的健康数据的测量相关的信息中。

2. 发明授权

US08337691B2 Control markers for auto-detection of control solution and method of use 有权
标题翻译：用于自动检测对照溶液的控制标记和使用方法
公开(公告)号：US08337691B2
公开(公告)日：2012-12-25
申请号：US12316133
申请日：2008-12-10
申请人： Jing Lin , Fu Hsiung Tsai , Huan-Ping Wu , Nicole D. Ellis , Henry C. Arndt
发明人： Jing Lin , Fu Hsiung Tsai , Huan-Ping Wu , Nicole D. Ellis , Henry C. Arndt
IPC分类号： G01N27/327 , G01N33/96
CPC分类号： G01N27/26 , C12Q1/001 , G01N27/327 , G01N27/3274 , G01N33/66 , G01N33/96 , G01N2496/00 , Y10T436/10 , Y10T436/104998 , Y10T436/13 , Y10T436/144444
摘要： A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
摘要翻译：执行在电化学测试传感器中区分对照溶液与样品的方法。该方法包括向对照溶液中加入对照标记物。对照溶液包括对照标记物和分析物。测试传感器包括工作和对电极以及试剂。对测试传感器施加电位以氧化对照标记物和分析物。测量所得的电流。将电位施加到测试传感器的低于其中电位足以氧化分析物而不是对照标记的其他电位。测量所得的电流。基于测量的电流确定是否存在对照溶液或样品。为了增加所测量的电流，与对照溶液相比，在不存在盐的情况下，盐可以以足以将电流增加至少5％的量加入到对照溶液中。

3. 发明申请

US20090148875A1 Control markers for auto-detection of control solution and method of use 有权
标题翻译：用于自动检测对照溶液的控制标记和使用方法
公开(公告)号：US20090148875A1
公开(公告)日：2009-06-11
申请号：US12316133
申请日：2008-12-10
申请人： Jing Lin , Fu Hsiung Tsai , Huan-Ping Wu , Nicole D. Ellis , Henry C. Arndt
发明人： Jing Lin , Fu Hsiung Tsai , Huan-Ping Wu , Nicole D. Ellis , Henry C. Arndt
IPC分类号： C12Q1/54
CPC分类号： G01N27/26 , C12Q1/001 , G01N27/327 , G01N27/3274 , G01N33/66 , G01N33/96 , G01N2496/00 , Y10T436/10 , Y10T436/104998 , Y10T436/13 , Y10T436/144444
摘要： A method of distinguishing a control solution from a sample in an electrochemical test sensor is performed. The method includes adding a control marker to the control solution. The control solution includes the control marker and analyte. The test sensor includes working and counter electrodes, and a reagent. A potential is applied to the test sensor to oxidize the control marker and the analyte. The resulting electrical current is measured. A potential is applied to the test sensor lower than the other potential in which the potential is sufficient to oxidize the analyte and not the control marker. The resulting electrical current is measured. Determining whether a control solution or a sample is present based on the measured electrical currents. To increase the measured current, a salt may be added to the control solution in an amount sufficient to increase the electrical current by at least 5% as compared to a control solution in the absence of a salt.
摘要翻译：执行在电化学测试传感器中区分对照溶液与样品的方法。该方法包括向对照溶液中加入对照标记物。对照溶液包括对照标记物和分析物。测试传感器包括工作和对电极以及试剂。对测试传感器施加电位以氧化对照标记物和分析物。测量所得的电流。将电位施加到测试传感器的低于其中电位足以氧化分析物而不是对照标记的其他电位。测量所得的电流。基于测量的电流确定是否存在对照溶液或样品。为了增加所测量的电流，与对照溶液相比，在不存在盐的情况下，盐可以以足以将电流增加至少5％的量加入到对照溶液中。

4. 发明授权

US09164076B2 Slope-based compensation including secondary output signals 有权
标题翻译：基于斜率的补偿，包括二次输出信号
公开(公告)号：US09164076B2
公开(公告)日：2015-10-20
申请号：US13117872
申请日：2011-05-27
申请人： Dijia Huang , Huan-Ping Wu
发明人： Dijia Huang , Huan-Ping Wu
IPC分类号： G01N33/48 , G01N33/487
CPC分类号： G01N27/3274 , G01N33/48714
摘要： A biosensor system determines analyte concentration from analytic and/or secondary output signals. The biosensor system adjusts a correlation for determining analyte concentrations from output signals with one or more index functions extracted from the output signals. The index functions determine at least one slope deviation or normalized slope deviation from one or more error parameters. The slope-adjusted correlation between analyte concentrations and output signals may be used to determine analyte concentrations having improved accuracy and/or precision from output signals including components attributable to bias.
摘要翻译：生物传感器系统从分析和/或次要输出信号确定分析物浓度。生物传感器系统通过从输出信号提取的一个或多个指数函数来调整从输出信号确定分析物浓度的相关性。索引函数确定与一个或多个错误参数的至少一个斜率偏差或归一化斜率偏差。可以使用分析物浓度和输出信号之间的斜率调整的相关性来确定包括归因于偏压的成分的输出信号具有改进的精度和/或精度的分析物浓度。

5. 发明授权

US09034160B2 Rapid-read gated amperometry devices 有权
标题翻译：快速读门控电流分析仪
公开(公告)号：US09034160B2
公开(公告)日：2015-05-19
申请号：US13401222
申请日：2012-02-21
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： G01N27/26 , G01N33/487 , G01N33/50 , C12Q1/00 , G01N27/327 , G01N27/406 , G01N35/00
CPC分类号： G01N27/327 , G01N27/3273 , G01N27/4065 , G01N35/0092
摘要： A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Input signals including multiple duty cycles of sequential excitation pulses and relaxations are input to the sample. One or more signals output from the sample within 300 ms of the input of an excitation pulse may be correlated with the analyte concentration of the sample to improve the accuracy and/or precision of the analysis. Determining the analyte concentration of the sample from these rapidly measured output values may reduce analysis errors arising from the hematocrit effect, mediator background, and other error sources.
摘要翻译：描述了用于确定样品中分析物浓度的传感器系统，装置和方法。包括连续激励脉冲和松弛的多个占空比的输入信号被输入到样品。在激励脉冲的输入的300ms内从样品输出的一个或多个信号可以与样品的分析物浓度相关联，以提高分析的精度和/或精度。从这些快速测量的输出值确定样品的分析物浓度可能会降低由血细胞比容影响，介质背景和其他误差源引起的分析误差。

6. 发明授权

US08973422B2 Underfill detection system for a biosensor 有权
标题翻译：用于生物传感器的底部填充检测系统
公开(公告)号：US08973422B2
公开(公告)日：2015-03-10
申请号：US13107363
申请日：2011-05-13
申请人： Huan-Ping Wu , Christine D. Nelson
发明人： Huan-Ping Wu , Christine D. Nelson
IPC分类号： G01N27/327 , G01N27/26 , G01N35/00 , G01N35/10
CPC分类号： G01N27/4163 , G01N27/327 , G01N27/3274 , G01N35/00029 , G01N35/1016 , G01N2035/00108 , Y10T436/10
摘要： A biosensor has an underfill detection system that determines whether a sample of a biological fluid is large enough for an analysis of one or more analytes. The underfill detection system applies an excitation signal to the sample, which generates an output signal in response to the excitation signal. The underfill detection system switches the amplitude of the excitation signal. The transition of the excitation signal to a different amplitude changes the output signal when the sample is not large enough for an accurate and/or precise analysis. The underfill detection system measures and compares the output signal with one or more underfill thresholds to determine whether an underfill condition exists.
摘要翻译：生物传感器具有底部填充检测系统，其确定生物流体的样品是否足够大以分析一种或多种分析物。底部填充检测系统向样品施加激励信号，其产生响应于激发信号的输出信号。底部填充检测系统切换激励信号的幅度。当样品不够大以进行准确和/或精确的分析时，激发信号向不同幅度的转变会改变输出信号。底部填充检测系统测量并比较输出信号与一个或多个底部填充阈值，以确定是否存在底部填充条件。

7. 发明授权

US08702926B2 Oxidizable species as an internal reference in control solutions for biosensors 有权
标题翻译：可氧化物种作为生物传感器控制解决方案的内部参考
公开(公告)号：US08702926B2
公开(公告)日：2014-04-22
申请号：US13180214
申请日：2011-07-11
申请人： Greg P. Beer , Huan-Ping Wu
发明人： Greg P. Beer , Huan-Ping Wu
IPC分类号： C12Q1/54 , G01N27/327 , G01N33/96 , G01N27/26
CPC分类号： G01N27/3274 , C12Q1/004 , G01N33/48707 , G01N33/49 , G01N33/66 , G01N33/96 , Y10T436/104998
摘要： Testing of the performance of an electrochemical meter used to measure the presence of an analyte in a biological sample, particularly glucose in whole blood, includes introducing a control solution containing a predetermined amount of the analyte and a predetermined amount of an internal reference compound. The internal reference compound is selected such that it is oxidized at a potential greater than that used to oxidize the analyte, thereby making it possible to distinguish the control solution from a biological sample.
摘要翻译：用于测量生物样品中特别是葡萄糖的分析物存在的电化学仪表的性能的测试包括引入含有预定量的分析物和预定量的内部参考化合物的对照溶液。选择内部参考化合物使得其以比用于氧化分析物的电位大的电位被氧化，从而使得可以将对照溶液与生物样品区分开。

8. 发明授权

US08647489B2 Gated voltammetry devices 有权
标题翻译：门控伏安法器件
公开(公告)号：US08647489B2
公开(公告)日：2014-02-11
申请号：US13780589
申请日：2013-02-28
申请人： Huan-Ping Wu
发明人： Huan-Ping Wu
IPC分类号： G01N27/327
CPC分类号： G01N27/413 , A61B5/14532 , A61B5/1486 , C12Q1/001 , G01N27/3273 , G01N27/3274 , G01N33/5438
摘要： A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.
摘要翻译：描述了用于确定样品中分析物浓度的传感器系统，装置和方法。包括顺序激发和松弛的多个占空比的门控伏安脉冲序列可以提供较短的分析时间和/或提高分析的精度和/或精度。所公开的脉冲序列可以减少由血细胞比容效应，帽间隙体积变化，非稳态条件，介体背景，单组校准常数，欠补充以及活性电离剂含量变化引起的分析误差的传感器条。

9. 发明授权

US08470604B2 Transient decay amperometry 有权
标题翻译：瞬态衰变电流分析法
公开(公告)号：US08470604B2
公开(公告)日：2013-06-25
申请号：US13210738
申请日：2011-08-16
申请人： Huan-Ping Wu , Steven C. Charlton , Amy H. Chu , Andrew J. Edelbrock , Sung-Kwon Jung , Dijia Huang
发明人： Huan-Ping Wu , Steven C. Charlton , Amy H. Chu , Andrew J. Edelbrock , Sung-Kwon Jung , Dijia Huang
IPC分类号： G01N27/333 , G01N33/66
CPC分类号： C12Q1/54 , A61B5/14532 , A61B5/1455 , A61B5/1486 , A61B5/1495 , C12Q1/004 , G01N27/3271 , G01N27/3272
摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.
摘要翻译：生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

10. 发明授权

US08445290B2 Temperature-adjusted analyte determination for biosensor systems 有权
标题翻译：生物传感器系统的温度调节分析物测定
公开(公告)号：US08445290B2
公开(公告)日：2013-05-21
申请号：US13413028
申请日：2012-03-06
申请人： Huan-Ping Wu , Christine D. Nelson
发明人： Huan-Ping Wu , Christine D. Nelson
IPC分类号： G01N33/66 , G01N25/00 , G01N33/50 , C12Q1/54
CPC分类号： G01N27/26 , A61B5/14532 , A61B5/1486 , A61B2560/0252 , G01N27/3274 , G06F19/10 , Y10T436/10 , Y10T436/104998 , Y10T436/12 , Y10T436/144444
摘要： A biosensor system determines analyte concentration from an output signal generated by an oxidation/reduction reaction of the analyte. The biosensor system adjusts a correlation for determining analyte concentrations from output signals at one temperature to determining analyte concentrations from output signals at other temperatures. The temperature-adjusted correlation between analyte concentrations and output signals at a reference temperature may be used to determine analyte concentrations from output signals at a sample temperature.
摘要翻译：生物传感器系统通过分析物的氧化/还原反应产生的输出信号来确定分析物浓度。生物传感器系统调整相关性，以确定在一个温度下的输出信号的分析物浓度，以便在其它温度下从输出信号确定分析物浓度。在参考温度下，分析物浓度和输出信号之间的温度调节相关性可用于在样品温度下从输出信号确定分析物浓度。

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