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1. 发明授权

US5492914A 2-(1-azabicyclo[2.2.2]oct-3 s-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[DE]i s [2.2.2]oct-3's-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1h-benz [DE]isoquinolin-1-one and individual stereoisomers thereof 失效
标题翻译： 2-（1-氮杂双环[2.2.2]辛-3-基）-6-羟基-2,4,5,6-四氢-1H-苯并[DE]异喹啉-1-酮和2-（1- 氮杂双环[2.2.2]辛-3'-基）-6-羟基-2,3,3a，4,5,6-六氢-1H-苯并[DE]异喹啉-1-酮及其各自的立体异构体
公开(公告)号：US5492914A
公开(公告)日：1996-02-20
申请号：US282110
申请日：1994-07-28
申请人： Jacob Berger , Robin D. Clark , Paul E. Weller , Douglas L. Wren
发明人： Jacob Berger , Robin D. Clark , Paul E. Weller , Douglas L. Wren
IPC分类号： A61K31/435 , A61P1/00 , A61P1/08 , A61P9/00 , A61P25/00 , A61P25/04 , A61P43/00 , C07D453/02 , A61K31/485 , C07D401/08
CPC分类号： C07D453/02
摘要： This invention relates to 2-(1'-azabicyclo[2.2.2]oct-3'S-yl)-6-hydroxy-2,4,5,6-tetrahydro-1H-benz[de]isoquinolin-1-one and 2-(1'-azabicyclo[2.2.2]oct-3'S-yl)-6-hydroxy-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one and their individual stereoisomers and uses and the processes for their making.
摘要翻译：本发明涉及2-（1'-氮杂双环[2.2.2]辛-3'-基）-6-羟基-2,4,5,6-四氢-1H-苯并[de]异喹啉-1-酮和 2-（1'-氮杂双环[2.2.2]辛-3'-基）-6-羟基-2,3,3a，4,5,6-六氢-1H-苯并[de]异喹啉-1-酮及其个体立体异构体和用途及其制备方法。

2. 发明授权

US4780281A Method for assay of peroxidase enzyme or reducing substrate activity 失效
标题翻译：测定过氧化物酶或降低底物活性的方法
公开(公告)号：US4780281A
公开(公告)日：1988-10-25
申请号：US744673
申请日：1985-06-14
申请人： Lawrence J. Marnett , Paul E. Weller
发明人： Lawrence J. Marnett , Paul E. Weller
IPC分类号： C12Q1/28
CPC分类号： C12Q1/28 , C12Q2326/00 , Y10S435/803 , Y10S435/81
摘要： A preferred method wherein 5-phenyl-4-pentenyl-hydroperoxide (PPHP) is reduced to 5-phenyl-4-pentenyl-alcohol (PPA) by plant and animal peroxidases in the presence of reducing substrates is described. The method also uses related homologs containing 3 to 8 carbon atoms. PHP and PPA are rapidly isolated with solid phase extraction, separated by isocrated reverse phase high performance liquid chromatography, and quantitated with a fixed-wavelength ultraviolet detector. The procedure described in suitable for detecting peroxide reducing enzymes, determining the kinetic properties of heme- and non-heme-containing peroxidases, and evaluating oxidizable compounds as reducing substrates for peroxidases. The method identifies compounds which are reducing substrates and also ranks them for relative activity. The method can be used to identify active antithrombotic, antimetastatic, or anti-inflammatory drugs as substrates as well as detect and characterize mammalian peroxidases.
摘要翻译：描述了在还原底物存在下，通过植物和动物过氧化物酶将5-苯基-4-戊烯基 - 过氧化氢（PPHP）还原为5-苯基-4-戊烯醇（PPA）的优选方法。该方法还使用含有3至8个碳原子的相关同系物。通过固相萃取快速分离出PHP和PPA，用反相高效液相色谱法分离，用固定波长紫外检测器定量。适用于检测过氧化物还原酶，确定含血红素和非含血红素的过氧化物酶的动力学性质以及评价可氧化化合物作为过氧化物酶底物的方法。该方法鉴定了减少底物的化合物，并将它们排列成相对活性。该方法可用于鉴定活性抗血栓形成，抗转移或抗炎药物作为底物，以及检测和表征哺乳动物过氧化物酶。

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