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1. 发明申请

US20110129924A1 Porous Polymeric Articles 审中-公开
标题翻译：多孔聚合物
公开(公告)号：US20110129924A1
公开(公告)日：2011-06-02
申请号：US12308960
申请日：2006-09-12
申请人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy Ming Hock Loh , Karl Schumacher
发明人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy Ming Hock Loh , Karl Schumacher
IPC分类号： C12N5/071
CPC分类号： A61L27/56 , B33Y80/00
摘要： Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three-dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions.
摘要翻译：描述了多孔聚合物制品，更具体地说，用于组织工程和器官置换的多孔聚合物制品。在一些实施方案中，本文所述的方法包括使用聚合物 - 溶剂体系（例如相转化）以在结构中产生孔隙。该方法可以包括形成包含可在沉淀介质中沉淀的第一可交联组分和第二组分的结构前体材料。结构前体材料可以通过诸如三维印刷之类的合适技术成形为三维形状。在结构前体材料成型时，第一组分的至少一部分可以是交联的。然后可以将结构与沉淀介质接触以从结构中除去前体溶剂，这可使第二聚合物组分沉淀并形成含有均匀孔网络的多孔结构。在一些实施方案中，多孔结构被构造和布置为用作超滤，细胞生长和/或形成复合物，仿生性，多孔生物杂交器官的模板，其中活细胞可被固定并执行其正常的生理功能。

2. 发明申请

US20120184940A1 BIOARTIFICIAL KIDNEYS 审中-公开
标题翻译：生物科学家
公开(公告)号：US20120184940A1
公开(公告)日：2012-07-19
申请号：US13499490
申请日：2010-10-04
申请人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy C.M. Teo , Karl Schumacher , Jeremy Ming Hock Loh , Rosa Yue Qi , Qunya Ong
发明人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy C.M. Teo , Karl Schumacher , Jeremy Ming Hock Loh , Rosa Yue Qi , Qunya Ong
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： B01D63/085 , A61F2/022 , A61M1/14 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2205/3331 , A61M2209/088 , B01D61/145 , B01D69/141 , B01D2319/025 , B01D2319/06 , C12M23/54 , C12M25/02 , C12M29/04
摘要： The present invention generally relates to improved bioartificial kidneys (BAKs), and in certain embodiments to improved bioartificial kidneys that are portable and/or wearable by a user. In some embodiments, the BAKs may comprise an ultrafiltration unit and a reabsorption unit. The reabsorption unit may contain a reabsorption membrane having a layer of renal proximal tubule cells disposed thereon, where the renal proximal tubule cells selectively allow solutes to pass through the reabsorption membrane. In some embodiments, at least the reabsorption unit may be configured as a substantially flat-plate filtration device, which can impart advantageous properties such as improved maintenance of the renal proximal tubule cell layer, more facile monitoring of the renal proximal tubule cell layer as well as enhanced profile for wearability.
摘要翻译：本发明通常涉及改进的生物人造肾（BAK），并且在某些实施方案中涉及用户可携带和/或可穿戴的改进的生物人造肾。在一些实施方案中，BAK可以包括超滤单元和再吸收单元。再吸收单元可以包含其上设置有肾近端小管细胞层的再吸收膜，其中肾近端小管细胞选择性地允许溶质通过再吸收膜。在一些实施方案中，至少再吸收单元可以被配置为基本上平板的过滤装置，其可以赋予有利的性质，例如改善肾近端小管细胞层的维持性，更容易地监测肾近端小管细胞层作为耐磨性的增强型材。

3. 发明申请

US20100240117A1 THREE DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸中生物化学结构的三维制造
公开(公告)号：US20100240117A1
公开(公告)日：2010-09-23
申请号：US12749831
申请日：2010-03-30
申请人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

4. 发明授权

US08658099B2 Integrated apparatus for conducting and monitoring chemical reactions 有权
标题翻译：用于进行和监测化学反应的综合设备
公开(公告)号：US08658099B2
公开(公告)日：2014-02-25
申请号：US12746510
申请日：2008-11-06
申请人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
发明人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
IPC分类号： G05D23/00
CPC分类号： B01L3/50851 , B01J2219/00283 , B01J2219/00306 , B01J2219/00495 , B01J2219/00576 , B01J2219/00585 , B01J2219/00704 , B01J2219/00722 , B01L7/52 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , G01N21/03 , G01N2021/0346
摘要： Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
摘要翻译：用于进行和监测化学反应的装置包括安装在基座上的底座和热循环仪。多个导热容器安装在热循环仪上并与其热连通。每个容器包括限定具有开口端，第一窗口和第二窗口的孔的不透明体。容器可拆卸地安装在容器上。盒包括多个透光反应容器和连接到反应容器的管道，用于处理和传送流体。反应容器通过孔的开口端容纳在容器的孔中。光发射器安装在基座上，用于通过反应容器的第一窗口照亮反应容器。光检测器安装在基座上，用于通过容器的第二窗口选择性地接收和检测从反应容器发射的光。

5. 发明申请

US20100248245A1 INTEGRATED APPARATUS FOR CONDUCTING AND MONITORING CHEMICAL REACTIONS 有权
标题翻译：用于导电和监测化学反应的综合装置
公开(公告)号：US20100248245A1
公开(公告)日：2010-09-30
申请号：US12746510
申请日：2008-11-06
申请人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
发明人： Jackie Y. Ying , Tseng-Ming Hsieh , Jeremy Ming Hock Loh , Chunyan Zhang
IPC分类号： C12Q1/68 , C12M1/34 , C12M1/38
CPC分类号： B01L3/50851 , B01J2219/00283 , B01J2219/00306 , B01J2219/00495 , B01J2219/00576 , B01J2219/00585 , B01J2219/00704 , B01J2219/00722 , B01L7/52 , B01L2300/0654 , B01L2300/1822 , B01L2300/1827 , G01N21/03 , G01N2021/0346
摘要： Apparatus for conducting and monitoring chemical reactions comprises a base and a thermal cycler mounted on the base. A plurality of heat-conducting receptacles are mounted on the thermal cycler and in heat-communication therewith. Each receptacle comprises an opaque body defining a bore having an open end, a first window, and a second window. A cartridge is removably mounted on the receptacles. The cartridge comprises a plurality of light-transmitting reaction vessels, and conduits connected to the reaction vessels for processing and transferring fluid. The reaction vessels are received in the bores of the receptacles through the open ends of the bores. A light emitter is mounted on the base for illuminating the reaction vessels through the first windows of the reaction vessels. A light detector is mounted on the base for selectively receiving and detecting light emitted from the reaction vessels through the second windows of the receptacles.
摘要翻译：用于进行和监测化学反应的装置包括安装在基座上的底座和热循环仪。多个导热容器安装在热循环仪上并与其热连通。每个容器包括限定具有开口端，第一窗口和第二窗口的孔的不透明体。容器可拆卸地安装在容器上。盒包括多个透光反应容器和连接到反应容器的管道，用于处理和传送流体。反应容器通过孔的开口端容纳在容器的孔中。光发射器安装在基座上，用于通过反应容器的第一窗口照亮反应容器。光检测器安装在基座上，用于通过容器的第二窗口选择性地接收和检测从反应容器发射的光。

6. 发明申请

US20120035288A1 FORMING COPOLYMER FROM BICONTINUOUS MICROEMULSION COMPRISING MONOMERS OF DIFFERENT HYDROPHILICITY 失效
标题翻译：由包含不同亲水单体的双酚微胶囊形成共聚物
公开(公告)号：US20120035288A1
公开(公告)日：2012-02-09
申请号：US13257570
申请日：2009-03-19
申请人： Edwin Pei Yong Chow , Jackie Y. Ying
发明人： Edwin Pei Yong Chow , Jackie Y. Ying
IPC分类号： C08J9/04 , G02C7/04 , A61F2/14 , C08F20/28 , C08F2/24
CPC分类号： C08F220/18 , C08F2/22 , C08F226/10 , C08J9/283 , C08J2207/10 , C08J2333/06
摘要： A copolymer defines interconnected pores and comprises polymerized monomers. The monomers comprise a first monomer more hydrophilic than 2-hydroxyethyl methacrylate (HEMA), and a second monomer as hydrophilic as, or less hydrophilic than, HEMA. In a method of forming a polymer, a bicontinuous microemulsion comprising water, a surfactant, and a combination of monomers copolymerizable for forming a porous copolymer is provided. The combination of monomers comprises the first and second monomers. The monomers in the bicontinuous microemulsion are polymerized to form the porous copolymer. The first monomer may comprise N-vinylpyrrolidone (NVP) or methacrylic acid (MAA). The second monomer may comprise HEMA or methyl methacrylate (MMA).
摘要翻译：共聚物定义相互连通的孔并且包含聚合的单体。所述单体包含比甲基丙烯酸羟乙酯（HEMA）更亲水的第一单体，以及与HEMA亲水或亲水性低的HEMA的第二单体。在形成聚合物的方法中，提供了包含水，表面活性剂和可共聚形成多孔共聚物的单体的组合的双连续微乳液。单体的组合包括第一和第二单体。将双连续微乳液中的单体聚合形成多孔共聚物。第一单体可以包含N-乙烯基吡咯烷酮（NVP）或甲基丙烯酸（MAA）。第二单体可以包含HEMA或甲基丙烯酸甲酯（MMA）。

7. 发明申请

US20100048755A1 POROUS POLYMERIC MATERIAL WITH CROSS-LINKABLE WETTING AGENT 审中-公开
标题翻译：具有交联润湿剂的多孔聚合材料
公开(公告)号：US20100048755A1
公开(公告)日：2010-02-25
申请号：US12515264
申请日：2007-11-17
申请人： Edwin Pei Yong Chow , Jackie Y. Ying
发明人： Edwin Pei Yong Chow , Jackie Y. Ying
IPC分类号： C08G63/00 , C08J9/00 , C08G73/06
CPC分类号： C08J9/283 , A61F9/0008 , A61L27/16 , A61L27/50 , A61L27/56 , C08B37/0021 , C08B37/0072 , C08F290/10 , C08J2207/10 , C08J2333/06 , C08L51/02 , G02B1/043 , C08L2666/02
摘要： A porous material is provided which comprises a transparent polymer matrix defining interconnected pores and a wetting agent. At least a portion of the wetting agent is cross-linked with the polymer matrix. A process for forming a porous polymeric material is also provided. A bicontinuous microemulsion comprising water, a wetting agent, a monomer, and a surfactant copolymerizable with the monomer is polymerized, to form a polymer defining interconnected pores. The wetting agent comprises a cross-linkable wetting agent such that after polymerization, at least a portion of the cross-linkable wetting agent is cross-linked with the polymer. The wetting agent may comprise acrylated hyaluronic acid (AHA) such as methacrylated hyaluronic acid (MeHA). The wetting agent may also comprise a hyaluronic acid (HA). The wetting agent may include an unbonded portion that this releasable from the material. A contact lens may be made from the porous material.
摘要翻译：提供一种多孔材料，其包括限定互连孔的透明聚合物基质和润湿剂。润湿剂的至少一部分与聚合物基质交联。还提供了一种形成多孔聚合物材料的方法。将包含水，润湿剂，单体和可与单体共聚的表面活性剂的双连续微乳液聚合，形成限定互连孔的聚合物。润湿剂包括可交联的润湿剂，使得在聚合后，至少一部分可交联润湿剂与聚合物交联。润湿剂可以包括丙烯酸酯化透明质酸（AHA），例如甲基丙烯酸酯化透明质酸（MeHA）。润湿剂还可以包含透明质酸（HA）。润湿剂可以包括可从材料中释放的未粘合部分。隐形眼镜可以由多孔材料制成。

8. 发明申请

US20120309761A1 FAST-RESPONSE PHOTOCHROMIC NANOSTRUCTURED CONTACT LENSES 审中-公开
标题翻译：快速响应光致变色纳米结构的接触镜
公开(公告)号：US20120309761A1
公开(公告)日：2012-12-06
申请号：US13387014
申请日：2010-10-27
申请人： Edwin Pei Yong Chow , Jackie Y. Ying , Yuri Shona Pek
发明人： Edwin Pei Yong Chow , Jackie Y. Ying , Yuri Shona Pek
IPC分类号： G02B5/23 , A61K31/5377 , A61P27/02 , A61K47/32
CPC分类号： G02B1/043 , B82Y20/00 , C08F299/065 , C08J9/283 , C08J2207/10 , C08J2333/10 , C08K5/0041 , C08K5/3412 , C08K5/357 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1029 , C08L71/02 , C08L33/10
摘要： A bicontinuous microemulsion of water, a monomer, and a surfactant copolymerizable with the monomer is polymerized to form a polymeric material, the polymeric material comprising a polymer matrix defining interconnected pores. The polymeric material may additional comprise at least one photochromic agent. The photochromic agent may be dispersed in one or both of the polymer matrix or the interconnected pores. The polymeric material may be used to form photochromic articles including ophthalmic articles such as contact lenses.
摘要翻译：水，单体和可与单体共聚的表面活性剂的双连续微乳液被聚合以形成聚合材料，聚合物材料包含限定互连孔的聚合物基质。聚合物材料可另外包含至少一种光致变色剂。光致变色剂可以分散在聚合物基质或互连孔中的一个或两个中。聚合物材料可用于形成光致变色制品，包括眼用制品如隐形眼镜。

9. 发明申请

US20120202741A1 DELIVERY OF BMP-7 AND METHODS OF USE THEREOF 审中-公开
标题翻译： BMP-7的递送及其使用方法
公开(公告)号：US20120202741A1
公开(公告)日：2012-08-09
申请号：US13500563
申请日：2010-10-06
申请人： Daniele Zink , Jackie Y. Ying , Edwin Pei Yong Chow , Farah Tasnim
发明人： Daniele Zink , Jackie Y. Ying , Edwin Pei Yong Chow , Farah Tasnim
IPC分类号： A61K38/18 , C12M3/00 , A61M1/14 , C12M3/06 , B01D63/02 , B01D61/24 , C12N5/071 , C12N5/10
CPC分类号： A61K38/1875 , A61M1/3489 , C12N5/0686 , C12N2501/155
摘要： The present invention generally relates to delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist and methods of use thereof. In some embodiments, methods and devices are provided for delivery of BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist to a patient. In some cases, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be released in controlled fashion from a device in fluid communication with a patient. In some embodiments, the BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be expressed by cells within a device. In other embodiments, methods are provided for improving the function of devices containing renal proximal tubule cells. For example, in some embodiments, exposure of renal proximal tubule cells to BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be used to inhibit disruption of cell layers comprising renal proximal tubule cells. In another embodiment, exposure of renal proximal tubule cells to BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be used to inhibit trans- and de-differentiation of renal proximal tubule cells. In another embodiment, exposure of renal proximal tubule cells to BMP-7 or functional variants or functional fragments thereof and/or a BMP-7 agonist may be used to improve renal proximal tubule cell functions.
摘要翻译：本发明一般涉及BMP-7或功能变体或其功能片段和/或BMP-7激动剂的递送及其使用方法。在一些实施方案中，提供方法和装置用于向患者递送BMP-7或功能变体或其功能性片段和/或BMP-7激动剂。在一些情况下，BMP-7或其功能变体或功能片段和/或BMP-7激动剂可以以受控的方式从与患者流体连通的装置释放。在一些实施方案中，BMP-7或其功能变体或功能片段和/或BMP-7激动剂可以由器件内的细胞表达。在其他实施方案中，提供了用于改善含有肾近端小管细胞的装置功能的方法。例如，在一些实施方案中，肾近端小管细胞暴露于BMP-7或功能变体或其功能性片段和/或BMP-7激动剂可用于抑制包含肾近端小管细胞的细胞层的破坏。在另一个实施方案中，肾近端小管细胞暴露于BMP-7或功能变体或其功能片段和/或BMP-7激动剂可用于抑制肾近端小管细胞的反式和去分化。在另一个实施方案中，肾近端小管细胞暴露于BMP-7或功能变体或其功能片段和/或BMP-7激动剂可用于改善肾近端小管细胞功能。

10. 发明授权

US08513353B2 Forming copolymer from bicontinuous microemulsion comprising monomers of different hydrophilicity 失效
标题翻译：由包含不同亲水性的单体的双连续微乳液形成共聚物
公开(公告)号：US08513353B2
公开(公告)日：2013-08-20
申请号：US13257570
申请日：2009-03-19
申请人： Edwin Pei Yong Chow , Jackie Y. Ying
发明人： Edwin Pei Yong Chow , Jackie Y. Ying
IPC分类号： C08F2/24
CPC分类号： C08F220/18 , C08F2/22 , C08F226/10 , C08J9/283 , C08J2207/10 , C08J2333/06
摘要： A copolymer defines interconnected pores and comprises polymerized monomers. The monomers comprise a first monomer more hydrophilic than 2-hydroxyethyl methacrylate (HEMA), and a second monomer as hydrophilic as, or less hydrophilic than, HEMA. In a method of forming a polymer, a bicontinuous microemulsion comprising water, a surfactant, and a combination of monomers copolymerizable for forming a porous copolymer is provided. The combination of monomers comprises the first and second monomers. The monomers in the bicontinuous microemulsion are polymerized to form the porous copolymer. The first monomer may comprise N-vinylpyrrolidone (NVP) or methacrylic acid (MAA). The second monomer may comprise HEMA or methyl methacrylate (MMA).
摘要翻译：共聚物定义相互连通的孔并且包含聚合的单体。所述单体包含比甲基丙烯酸羟乙酯（HEMA）更亲水的第一单体，以及与HEMA亲水或亲水性低的HEMA的第二单体。在形成聚合物的方法中，提供了包含水，表面活性剂和可共聚形成多孔共聚物的单体的组合的双连续微乳液。单体的组合包括第一和第二单体。将双连续微乳液中的单体聚合形成多孔共聚物。第一单体可以包含N-乙烯基吡咯烷酮（NVP）或甲基丙烯酸（MAA）。第二单体可以包含HEMA或甲基丙烯酸甲酯（MMA）。

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