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1. 发明申请

US20110319372A1 METHOD OF DIAGNOSING AND THERAPEUTICALLY TREATING A PATIENT FOR A TRAUMATIC BRAIN INJURY 失效
标题翻译：诊断和治疗TRAUMATIC脑损伤的患者的方法
公开(公告)号：US20110319372A1
公开(公告)日：2011-12-29
申请号：US13160735
申请日：2011-06-15
申请人： JULES B. PUSCHETT , LEE SHAPIRO
发明人： JULES B. PUSCHETT , LEE SHAPIRO
IPC分类号： A61K31/58 , A61P25/00 , G01N33/566
CPC分类号： G01N33/53 , A61K31/585 , G01N33/743 , G01N2800/28 , G01N2800/40
摘要： Known or suspected traumatic brain injuries may be treated therapeutically by administering a therapeutically effective dose of resibufogenin. A preferred method for determining if a patient has a traumatic brain injury includes obtaining a body specimen from the patient, determining the concentration of marinobufagenin in the body specimen, comparing the concentration of marinobufagenin to the concentration in such body specimens in normal patients, and if the marinobufagenin concentration is substantially above the concentration of a normal patient, concluding traumatic brain injury exists. In a preferred embodiment, a substantial elevation is deemed to be an increase of about 30 percent above the marinobufagenin concentration of a normal patient. The body specimen may be blood, urine, or cerebrospinal fluid. If a substantial elevation is deemed to exist, the magnitude of the departure from the concentration of a normal patient may be employed in determining the timing and nature of treatment provided to the patient. The method may be repeated at predetermined intervals to monitor changes in the marinobufagenin with time.
摘要翻译：可以通过施用治疗有效剂量的抗纤维蛋白原治疗来治疗已知或怀疑的创伤性脑损伤。用于确定患者是否具有创伤性脑损伤的优选方法包括从患者获得身体标本，确定身体标本中海马素原基因的浓度，将正常患者中的马氏原虫基因的浓度与这些身体标本中的浓度进行比较，以及如果造血干细胞因子浓度明显高于正常患者的浓度，结论存在创伤性脑损伤。在优选的实施方案中，认为实质高程比普通患者的海因素原基因浓度高出约30％。身体标本可能是血液，尿液或脑脊液。如果认为存在实质性高程，则在确定提供给患者的治疗的时间和性质时可以采用偏离正常患者浓度的大小。可以以预定的间隔重复该方法以随时间监测马铃薯白蛋白原的变化。

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