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1. 发明申请

US20170342076A1 TERTIARY ALCOHOL IMIDAZOPYRAZINE BTK INHIBITORS 审中-公开
公开(公告)号：US20170342076A1
公开(公告)日：2017-11-30
申请号：US15538910
申请日：2015-12-17
申请人： JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人： JIAN LIU , JOSEPH A. KOZLOWSKI , BRIAN M. ANDRESEN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号： C07D487/04 , A61K31/4985
CPC分类号： C07D487/04 , A61K31/4985 , A61K45/06
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I, or pharmaceutically acceptable salts thereof, Formula I or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

2. 发明申请

US20170362242A1 BENZAMIDE IMIDAZOPYRAZINE BTK INHIBITORS 审中-公开
公开(公告)号：US20170362242A1
公开(公告)日：2017-12-21
申请号：US15538902
申请日：2015-12-17
申请人： JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
发明人： JIAN LIU , JOSEPH A. KOZLOWSKI , ABDUL-BASIT ALHASSAN , SOBHANA BABU BOGA , XIAOLEI GAO , DEODIAL GUY GUIADEEN , JYHSHING WANG , WENSHENG YU , JIAQIANG CAI , SHILAN LIU , DAHAI WANG , HAO WU , CHUNDAO YANG
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , C07D519/00
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61K45/06 , A61P37/02 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated disorders.

3. 发明申请

US20180079752A1 BTK INHIBITORS 审中-公开
公开(公告)号：US20180079752A1
公开(公告)日：2018-03-22
申请号：US15578775
申请日：2016-05-31
申请人： ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
发明人： ADRIANUS PETRUS ANTONIUS DE MAN , RONALD KIM , JIAN LIU , JOSEPH A. KOZLOWSKI , SOBHANA BABU BOGA , THIERRY FISCHMANN , DEODIAL Guy GUIADEEN , ILSE HENDRICA MARIA POLS-DE ROOIJ , SHILAN LIU , HAO WU
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/5377 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds of Formula I in the treatment of Btk mediated disorders.

4. 发明申请

US20180141962A1 AZACARBAZOLE BTK INHIBITORS 审中-公开
公开(公告)号：US20180141962A1
公开(公告)日：2018-05-24
申请号：US15564349
申请日：2016-04-04
申请人： JIAN LIU , JOSEPH KOZLOWSKI , RONALD KIM , XIAOLEI GAO , SOBHANA BABU BOGA , YOUNONG YU , HAO WU , SHILAN LIU , CHUNDAO YANG , MERCK SHARP & DOHME CORP.
发明人： JIAN LIU , JOSEPH KOZLOWSKI , RONALD KIM , XIAOLEI GAO , SOBHANA BABU BOGA , YOUNONG YU , HAO WU , SHILAN LIU , CHUNDAO YANG
IPC分类号： C07D519/00 , A61P19/02
CPC分类号： C07D519/00 , A61P19/02
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula (I), or pharmaceutically acceptable salts thereof, wherein CH, R1, R1a, R1b, R2, R3, and the subscripts m1, m2, p, q, and t are as set forth herein. The present invention also provides pharmaceutical compositions comprising these compounds and their use in therapy. In Cparticular, the present invention relates to the use of Btk inhibitor compounds of Formula (I) in the treatment of Btk mediated dis orders.

5. 发明申请

US20150353570A1 BTK INHIBITORS 有权
标题翻译： BTK抑制剂
公开(公告)号：US20150353570A1
公开(公告)日：2015-12-10
申请号：US14762954
申请日：2014-01-22
申请人： Hao WU , Ronald M. KIM , Jian LIU , Xiaolei GAO , Sobhana Babu BOGA , Deodialsingh GUIADEEN , Joseph KOZLOWSKI , Wensheng YU , Rajan ANAND , Younong YU , Oleg B. Selyutin , Ying-Duo GAO , Shilan LIU , Chundao YANG , Hongjian WANG , MERCK SHARP & DOHME CORP.
发明人： RONALD M. KIM , JIAN LIU , XIAOLEI GAO , SOBHANA BABU BOGA , DEODIALSINGH GUIADEEN , JOSEPH A. KOZLOWSKI , WENSHENG WU , RAJAN ANAND , YOUNONG YU , OLEG B. SELYUTIN , YING-DUO GAO , HAO WU , SHILAN LIU , CHUNDAO YANG , HONGJIAN WANG
IPC分类号： C07D491/048 , C07D471/04 , A61K45/06 , A61K31/5383 , C07D455/02 , A61K31/5365 , A61K31/497 , C07D498/04
CPC分类号： C07D491/048 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K31/5365 , A61K31/5383 , A61K45/06 , C07D455/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D519/00 , Y02A50/411 , Y02A50/463
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译：本发明提供了根据式I的Bruton's酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

6. 发明申请

US20150353565A1 BTK INHIBITORS 有权
标题翻译： BTK抑制剂
公开(公告)号：US20150353565A1
公开(公告)日：2015-12-10
申请号：US14762929
申请日：2014-01-17
申请人： Hao WU , Ronald M. KIM , Jian LIU , Shilan LIU , Chundao YANG , Shuling ZHENG , MERCK SHARP & DOHME CORP.
发明人： RONALD M. KIM , JIAN LIU , HAO WU , SHILAN LIU , CHUNDAO YANG , SHULING ZHENG
IPC分类号： C07D487/04 , A61K31/519 , A61K31/4985
CPC分类号： A61K45/06 , A61K31/4985 , A61K31/519 , C07D473/34 , C07D487/04 , C07D519/00
摘要： The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or pharmaceutically acceptable salts thereof. Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要翻译：本发明提供了根据式I的Bruton的酪氨酸激酶（Btk）抑制剂化合物或其药学上可接受的盐。式I或其药学上可接受的盐或包含这些化合物的药物组合物及其在治疗中的用途。特别地，本发明涉及Btk抑制剂化合物在治疗Btk介导的病症中的用途。

7. 发明申请

US20150320114A1 TOUCH CONTROL ELECTRONIC CIGARETTE 审中-公开
标题翻译：触控电子香烟
公开(公告)号：US20150320114A1
公开(公告)日：2015-11-12
申请号：US14274840
申请日：2014-05-12
申请人： HAO WU
发明人： HAO WU
IPC分类号： A24F47/00
CPC分类号： A24F47/008 , A24F47/002
摘要： A touch control electronic cigarette comprises a casing containing a fragrance; a cigarette filter arranged at the rear end of the casing; a smoke generator arranged inside the casing and atomizing the fragrance into gas; a capacitive sensor module arranged inside the cigarette filter, and generating capacitance variation functioning as a triggering signal while the user is touching the cigarette filter; and a control chip arranged inside the casing, controlling the smoke generator according to the triggering signal to atomize the fragrance into gas, which is to be inhaled by the user, and stopping controlling the smoke generator to atomize the fragrance while the user does not touch the cigarette filter. The present invention is not turned on by push button but triggered by lips of the user lest the user turn on the electronic cigarette imprudently. Besides, the present invention conforms to the usage habit of users.
摘要翻译：触摸控制电子香烟包括含有香料的外壳; 布置在所述壳体的后端的香烟过滤嘴; 烟雾发生器布置在壳体内并将香料雾化成气体; 布置在所述香烟过滤嘴内部的电容传感器模块，并且在使用者接触所述香烟过滤器时产生用作触发信号的电容变化; 以及设置在壳体内的控制芯片，根据触发信号控制烟雾发生器，以将香料雾化成由用户吸入的气体，并且在用户不接触时停止控制烟雾发生器来雾化香料香烟过滤嘴。本发明不是由按钮打开而是由用户的嘴唇触发，以免用户轻率地打开电子烟。此外，本发明符合用户的使用习惯。

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