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1. 发明申请

US20150239892A1 Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases 有权
标题翻译：吡咯并[3,2-b]嘧啶衍生物，用于治疗病毒感染和其他疾病
公开(公告)号：US20150239892A1
公开(公告)日：2015-08-27
申请号：US14434021
申请日：2013-10-09
申请人： JANSSEN R&D IRELAND
发明人： David Craig Mc Gowan , Stefaan Julien Last , Serge Maria Aloysius Pieters , Werner Embrechts , Tim Hugo Maria Jonckers , Pierre Jean-Marie Bernard Raboisson
IPC分类号： C07D487/04 , C07D519/00
CPC分类号： C07D487/04 , A61K31/407 , A61K31/519 , C07D519/00
摘要： This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
摘要翻译：本发明涉及吡咯并[3,2-d]嘧啶衍生物，其制备方法，药物组合物及其在治疗和/或治疗疾病中的用途。

2. 发明申请

US20140323441A1 Purine derivatives for the treatment of viral infections 有权
标题翻译：用于治疗病毒感染的嘌呤衍生物
公开(公告)号：US20140323441A1
公开(公告)日：2014-10-30
申请号：US14357495
申请日：2012-11-08
申请人： Janssen R&D Ireland
发明人： Jean-François Bonfanti , Frédéric Marc Maurice Doublet , Werner Embrechts , Jérôme Michel Claude Fortin , David Craig Mc Gowan , Philippe Muller , Piere Jean-Marie Bernand Raboisson
IPC分类号： C07D473/34 , C07F9/6561 , C07D473/16
CPC分类号： C07D473/34 , C07D473/16 , C07D519/00 , C07F9/65616
摘要： The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
摘要翻译：本发明涉及式（I）的嘌呤衍生物，其制备方法，药物组合物及其在治疗病毒感染中的用途。

3. 发明申请

US20140113929A1 MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS 有权
标题翻译：丙型肝炎病毒大肠杆菌抑制剂
公开(公告)号：US20140113929A1
公开(公告)日：2014-04-24
申请号：US14135826
申请日：2013-12-20
申请人： Janssen R&D Ireland (formerly Tibotec Pharmaceuticals)
发明人： Pierre Jean-Marie Raboisson , Herman Augustinus De Kock , David Craig Mc Gowan , Lili Hu , Abdellah Tahri , Sandrine Marie Helene Vendeville , Wim Van De Vreken
IPC分类号： C07D491/056 , A61K31/427 , A61K31/4741 , C07D491/048
CPC分类号： C07D491/056 , A61K31/427 , A61K31/4741 , C07D401/12 , C07D491/04 , C07D491/048 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , A61K2300/00
摘要： Inhibitors of HCV replication of formula (I) and the salts and stereoisomers thereof, wherein each dashed line (represented by - - - - -) represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; n is 3, 4, 5, or 6; R4 is C1-6alkyl or C3-7cycloalkyl; R5 is hydrogen, halo, C1-6alkyl, hydroxy, C1-6alkoxy, polyhaloC1-6alkyl; R6 is hydrogen, C1-6alkoxy, mono- or diC1-6alkylamino; or R5 and R6 may form a 5- or 6-membered unsaturated or partially unsaturated ring, optionally comprising one or two selected from O, N and S; R7 is hydrogen; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl; R8 is C3-7cycloalkyl optionally substituted with C1-6alkyl; C1-6alkyl optionally substituted with C3-7cycloalkyl; or —NR8aR8b; R8a and R8b are C1-6alkyl, or both may form a 5- or 6-membered saturated heterocyclic ring; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I).
摘要翻译：式（I）的HCV复制抑制剂及其盐和立体异构体，其中每个虚线（由 - - - - 表示）表示任选的双键; X为N，CH，X为双键，C为C; R1是-OR7，-NH-SO2R8; R2是氢，并且其中X是C或CH，R2也可以是C1-6烷基; R 3是氢，C 1-6烷基，C 1-6烷氧基C 1-6烷基，C 3-7环烷基; n为3,4,5或6; R4是C1-6烷基或C3-7环烷基; R5是氢，卤素，C1-6烷基，羟基，C1-6烷氧基，多卤代C 1-6烷基; R 6是氢，C 1-6烷氧基，单或二C 1-6烷基氨基; 或R 5和R 6可以形成5-或6-元不饱和或部分不饱和的环，任选地包含一个或两个选自O，N和S; R7是氢; 任选被C 1-6烷基取代的C 3-7环烷基; 或任选被C 3-7环烷基取代的C 1-6烷基; R8是任选被C 1-6烷基取代的C 3-7环烷基; 任选被C 3-7环烷基取代的C 1-6烷基; 或-NR8aR8b; R8a和R8b是C1-6烷基，或两者可以形成5或6元饱和杂环; 含有化合物（I）的药物组合物和制备化合物（I）的方法。

4. 发明申请

US20140350031A1 Piperidino-pyrimidine derivatives for the treatment of viral infections 有权
标题翻译：哌啶基 - 嘧啶衍生物用于治疗病毒感染
公开(公告)号：US20140350031A1
公开(公告)日：2014-11-27
申请号：US14377064
申请日：2013-02-07
申请人： Janssen R&D Ireland
发明人： David Craig Mc Gowan , Pierre Jean-Marie Bernard Raboisson , Tim Hugo Maria Jonckers , Mourad Daoubi Khamlichi
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/519
摘要： This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
摘要翻译：本发明涉及哌啶子基嘧啶衍生物，其制备方法，药物组合物及其在治疗病毒感染中的用途。

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