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1. 发明授权

US06207155B1 Method of eosinophil depletion with antibody to CCR 3 receptor 失效
标题翻译：嗜酸性粒细胞消耗与CCR3受体抗体的方法
公开(公告)号：US06207155B1
公开(公告)日：2001-03-27
申请号：US09073599
申请日：1998-05-06
申请人： J. Christopher Grimaldi , Maureen C. Howard , Robert L. Coffman
发明人： J. Christopher Grimaldi , Maureen C. Howard , Robert L. Coffman
IPC分类号： A61K39395
CPC分类号： C07K16/2866 , A61K2039/505 , A61K2039/545 , Y10S514/885
摘要： Binding compositions and various methods of use of the binding compositions are provided. In particular, a method is provided which comprises administering an effective amount of the binding composition, alone or in combination with other compounds, to eosinophils, thereby reducing the level of eosinophils in an individual. Preferably, the binding composition is a monoclonal antibody specific for CCR3.
摘要翻译：提供了结合组合物和各种使用结合组合物的方法。特别地，提供了一种方法，其包括将有效量的结合组合物单独或与其它化合物组合施用于嗜酸性粒细胞，从而降低个体嗜酸性粒细胞的水平。优选地，结合组合物是CCR3特异的单克隆抗体。

2. 发明申请

US20110118341A1 LONG TERM DISEASE MODIFICATION USING IMMUNOSTIMULATORY OLIGONUCLEOTIDES 有权
标题翻译：使用免疫抑制剂寡核苷酸的长期疾病修改
公开(公告)号：US20110118341A1
公开(公告)日：2011-05-19
申请号：US12992590
申请日：2009-05-15
申请人： Edith M. Hessel , Robert L. Coffman
发明人： Edith M. Hessel , Robert L. Coffman
IPC分类号： A61K31/711 , A61P37/04 , A61P37/08 , A61P11/04
CPC分类号： A61K39/39 , A01K67/027 , A01K2207/10 , A01K2227/105 , A01K2267/0387 , A61K31/7088 , A61K39/35 , A61K39/36 , A61K2039/545 , A61K2039/55561 , A61K2039/57
摘要： The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
摘要翻译：本发明提供了通过在一段时间内使用多轮施用ISS来治疗哮喘以给予长期疾病修饰的方法。

3. 发明授权

US5676940A Method of reducing immunoglobulin E responses 失效
标题翻译：降低免疫球蛋白E反应的方法
公开(公告)号：US5676940A
公开(公告)日：1997-10-14
申请号：US210649
申请日：1994-03-17
申请人： Robert L. Coffman , Jan Egbert de Vries
发明人： Robert L. Coffman , Jan Egbert de Vries
IPC分类号： A61K38/00 , A61K39/395 , A61K45/00 , A61P37/08 , C07K16/24 , C12P21/08 , A61K45/05
CPC分类号： C07K16/247 , A61K38/00
摘要： A method of reducing immunoglobulin E responses associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-4. Preferably, the antagonist is a blocking monoclonal antibody specific for human interleukin-4, or a fragment or binding composition derived therefrom.
摘要翻译：提供了减少与某些免疫疾病相关的免疫球蛋白E反应的方法。该方法包括向人白细胞介素-4施用有效量的拮抗剂。优选地，拮抗剂是对人白细胞介素-4特异性的阻断性单克隆抗体或由其衍生的片段或结合组合物。

4. 发明授权

US4121983A Metal production 失效
标题翻译：金属生产
公开(公告)号：US4121983A
公开(公告)日：1978-10-24
申请号：US862829
申请日：1977-12-21
申请人： Donald L. Kinosz , Subodh K. Das , Robert L. Coffman
发明人： Donald L. Kinosz , Subodh K. Das , Robert L. Coffman
IPC分类号： C25C3/06 , C25C3/08 , C25C7/02 , C25B11/12 , C25C3/04
CPC分类号： C25C3/06 , C25C3/08 , C25C7/025
摘要： A process is provided for producing aluminum in an electrolytic cell containing aluminum chloride dissolved in a molten solvent of higher decomposition potential. The cell has a terminal anode, a terminal cathode and a bipolar electrode arranged to operate with the anode and the cathode, providing interelectrode spaces therebetween. On electrolyzing the cell chlorine is produced on each anode surface thereof and aluminum on each cathode surface, the aluminum being swept from the cathode surface by bath material. In the process, carbonaceous material is provided for use as the electrode. The direction of grain flow constituting the carbonaceous material is determined and the electrode is arranged in the cell such that the direction of electrolysis current flow through the cell is in a direction substantially perpendicular to the direction of grain flow in the electrode.
摘要翻译：提供了在含有溶解在较高分解电位的熔融溶剂中的氯化铝的电解槽中生产铝的方法。电池具有端子阳极，端子阴极和布置成与阳极和阴极一起操作的双极电极，在它们之间提供电极间空间。在电解电池时，在其每个阳极表面上产生氯，在每个阴极表面上产生铝，铝通过浴材从阴极表面扫过。在此过程中，提供碳质材料用作电极。确定构成碳质材料的晶粒流动的方向，并且将电极设置在电池中，使得电解电流流过电池的方向处于与电极中的颗粒流动方向基本垂直的方向。

5. 发明授权

US08962579B2 Methods and compositions for inhibition of immune responses and autoimmunity 有权
标题翻译：用于抑制免疫应答和自身免疫的方法和组合物
公开(公告)号：US08962579B2
公开(公告)日：2015-02-24
申请号：US12767692
申请日：2010-04-26
申请人： Franck Barrat , Robert L. Coffman , Tracy Matray , Cristiana Guiducci
发明人： Franck Barrat , Robert L. Coffman , Tracy Matray , Cristiana Guiducci
IPC分类号： A61K31/711 , C12N15/117 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/713
CPC分类号： C12N15/117 , A61K31/711 , A61K31/7115 , A61K31/712 , A61K31/7125 , A61K31/713 , A61K45/06 , C12N2310/17 , C12N2310/314 , C12N2310/315 , C12N2310/321 , C12N2310/3231 , C12N2310/331 , C12N2310/3341 , C12N2310/336 , C12N2310/345 , C12N2310/3521
摘要： The application relates to the use of immunoregulatory polynucleotides and/or immunoregulatory compounds in combination with other therapeutic agents. The application further relates to immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence. It also relates to the administration of the immunoregulatory polynucleotides and/or immunoregulatory compounds comprising a modified immunoregulatory sequence to regulate an immune response.
摘要翻译：本申请涉及免疫调节多核苷酸和/或免疫调节化合物与其它治疗剂组合的用途。本申请还涉及包含修饰的免疫调节序列的免疫调节多核苷酸和/或免疫调节化合物。它还涉及免疫调节多核苷酸和/或免疫调节化合物的施用，其包含修饰的免疫调节序列以调节免疫应答。

6. 发明申请

US20130156814A1 METHODS OF TREATMENT USING TLR7 AND/OR TLR9 INHIBITORS 有权
公开(公告)号：US20130156814A1
公开(公告)日：2013-06-20
申请号：US13704978
申请日：2011-06-16
申请人： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
发明人： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC分类号： C12N15/117 , A61K31/573 , A61K31/7125
CPC分类号： C12N15/117 , A61K31/573 , A61K31/7125 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2320/30 , C12N2320/31 , Y02A50/411 , C12N2310/3521
摘要： The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.

7. 发明授权

US08940310B2 Methods of treatment using TLR7 and/or TLR9 inhibitors 有权
标题翻译：使用TLR7和/或TLR9抑制剂的治疗方法
公开(公告)号：US08940310B2
公开(公告)日：2015-01-27
申请号：US13704978
申请日：2011-06-16
申请人： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
发明人： Franck Barrat , Robert L. Coffman , Cristiana Guiducci
IPC分类号： A61K31/7125 , A01N43/04 , C12N15/117
CPC分类号： C12N15/117 , A61K31/573 , A61K31/7125 , C12N2310/17 , C12N2310/315 , C12N2310/321 , C12N2320/30 , C12N2320/31 , Y02A50/411 , C12N2310/3521
摘要： The application relates to compositions and methods of regulating an immune response comprising inhibitors of TLR7 and/or TLR9, such as immunoregulatory polynucleotides and/or immunoregulatory compounds. The application also relates to compositions and methods for predicting and/or determining responsiveness of a disease to treatment comprising inhibitors of TLR7 and/or TLR9.
摘要翻译：本申请涉及调节包含TLR7和/或TLR9抑制剂的免疫应答的组合物和方法，例如免疫调节多核苷酸和/或免疫调节化合物。本申请还涉及用于预测和/或确定疾病对包括TLR7和/或TLR9抑制剂的治疗反应性的组合物和方法。

8. 发明授权

US08815817B2 Long term disease modification using immunostimulatory oligonucleotides 有权
标题翻译：使用免疫刺激性寡核苷酸进行长期疾病修饰
公开(公告)号：US08815817B2
公开(公告)日：2014-08-26
申请号：US12992590
申请日：2009-05-15
申请人： Edith M. Hessel , Robert L. Coffman
发明人： Edith M. Hessel , Robert L. Coffman
IPC分类号： A01N43/04 , C07H21/02 , C12P19/34 , C12N15/63
CPC分类号： A61K39/39 , A01K67/027 , A01K2207/10 , A01K2227/105 , A01K2267/0387 , A61K31/7088 , A61K39/35 , A61K39/36 , A61K2039/545 , A61K2039/55561 , A61K2039/57
摘要： The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
摘要翻译：本发明提供了通过在一段时间内使用多轮施用ISS来治疗哮喘以给予长期疾病修饰的方法。

9. 发明授权

US08252757B2 Long term disease modification using immunostimulatory oligonucleotides 有权
标题翻译：使用免疫刺激性寡核苷酸进行长期疾病修饰
公开(公告)号：US08252757B2
公开(公告)日：2012-08-28
申请号：US11938192
申请日：2007-11-09
申请人： Edith M. Hessel , Robert L. Coffman
发明人： Edith M. Hessel , Robert L. Coffman
IPC分类号： C12N15/11 , C07H21/02
CPC分类号： C12N15/117 , C12N2310/17 , C12N2310/315 , C12N2320/35
摘要： The invention provides methods for treating asthma by using multiple rounds of administration of ISS over a period of time to confer long term disease modification.
摘要翻译：本发明提供了通过在一段时间内使用多轮施用ISS来治疗哮喘以给予长期疾病修饰的方法。

10. 发明授权

US5096704A Method of treating eosinophilia 失效
标题翻译：嗜酸性粒细胞增多症的治疗方法
公开(公告)号：US5096704A
公开(公告)日：1992-03-17
申请号：US556757
申请日：1990-07-23
申请人： Robert L. Coffman , Donna M. Rennick
发明人： Robert L. Coffman , Donna M. Rennick
IPC分类号： A61K38/00 , C07K16/24
CPC分类号： C07K16/244 , A61K38/00 , Y10S424/81 , Y10S530/866
摘要： A method of preventing eosinophilia associated with certain immune disorders is provided. The method comprises administering an effective amount of an antagonist to human interleukin-5. Preferably, the antagonist is a blocking monoclonal antibody specific for human interleukin-5, or a fragment or binding composition derived therefrom.
摘要翻译：提供了预防与某些免疫疾病相关的嗜酸粒细胞增多症的方法。该方法包括向人白介素-5施用有效量的拮抗剂。优选地，拮抗剂是对人白细胞介素-5特异的阻断性单克隆抗体或由其衍生的片段或结合组合物。

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