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1. 发明申请

US20140187479A1 BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM 有权
标题翻译：抑郁症的多巴胺抑制剂及其用于治疗与异常脂肪代谢相关的肥胖，过度和/或疾病的用途
公开(公告)号：US20140187479A1
公开(公告)日：2014-07-03
申请号：US14107855
申请日：2013-12-16
申请人： Itzik Harosh , Sandrine Braud , Marco A. Ciufolini
发明人： Itzik Harosh , Sandrine Braud , Marco A. Ciufolini
IPC分类号： C07K5/08 , A61K38/06 , A61K38/05 , C07K5/06 , A61K38/00
CPC分类号： C07K5/08 , A61K38/00 , A61K38/005 , A61K38/05 , A61K38/06 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06191 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0827
摘要： Novel compounds, particularly derivatives of boroarginine, boroornithine and borolysine that selectively modulate, regulate, and/or inhibit enteropeptidase. Compositions, particularly pharmaceutical compositions, as well as methods to treat excess weight, obesity and diseases associated with an abnormal fat metabolism.
摘要翻译：选择性调节，调控和/或抑制肠肽酶的新型化合物，特别是硼精氨酸衍生物，硼代鸟氨酸和硼氢化钠。组合物，特别是药物组合物，以及治疗过量体重，肥胖和与异常脂肪代谢相关的疾病的方法。

2. 发明申请

US20100311690A1 BOROPEPTIDE INHIBITORS OF ENTEROPEPTIDASE AND THEIR USES IN TREATMENT OF OBESITY, OVERWEIGHT AND/OR DISEASES ASSOCIATED WITH AN ABNORMAL FAT METABOLISM 审中-公开
标题翻译：抑郁症的多巴胺抑制剂及其用于治疗与异常脂肪代谢相关的肥胖，过度和/或疾病的用途
公开(公告)号：US20100311690A1
公开(公告)日：2010-12-09
申请号：US12746105
申请日：2008-12-03
申请人： Itzik Harosh , Sandrine Braud
发明人： Itzik Harosh , Sandrine Braud
IPC分类号： A61K31/69 , C07F5/02 , C07K5/08 , A61P3/04
CPC分类号： C07K5/08 , A61K38/00 , A61K38/005 , A61K38/05 , A61K38/06 , C07K5/06 , C07K5/06026 , C07K5/06043 , C07K5/0606 , C07K5/06078 , C07K5/06095 , C07K5/06104 , C07K5/06191 , C07K5/0806 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0827
摘要： The present invention relates to novel compounds, particularly derivatives of boroarginine, boroornithine and borolysine that selectively modulate, regulate, and/or inhibit enteropeptidase. The invention also relates to compositions, particularly pharmaceutical compositions, as well as methods to treat excess weight, obesity and diseases associated with an abnormal fat metabolism.
摘要翻译：本发明涉及选择性调节，调控和/或抑制肠肽酶的新化合物，特别是硼精氨酸，硼氢化氨酸和硼氢化的衍生物。本发明还涉及组合物，特别是药物组合物，以及治疗过量体重，肥胖症和与异常脂肪代谢相关的疾病的方法。

3. 发明授权

US06210888B1 Technique for screening inhibitors of deamination enzyme activity 失效
标题翻译：筛选脱氨酶活性抑制剂的技术
公开(公告)号：US06210888B1
公开(公告)日：2001-04-03
申请号：US09208378
申请日：1998-12-10
申请人： Itzik Harosh
发明人： Itzik Harosh
IPC分类号： C12Q168
CPC分类号： C12Q1/52
摘要： The invention concerns a technique for the sensitive, efficient and quick screening of molecules capable of inhibiting the deaminase activity of an enzyme at a cytidine or a 5-methylated cytosine in RNA or DNA.
摘要翻译：本发明涉及用于敏感，有效和快速筛选能够抑制RNA或DNA中胞苷或5-甲基化胞嘧啶的酶的脱氨酶活性的技术。

4. 发明申请

US20070298025A1 Pharmaceutical Compositions and Methods for Reducing Body Fat 审中-公开
标题翻译：药物组合物和减少身体脂肪的方法
公开(公告)号：US20070298025A1
公开(公告)日：2007-12-27
申请号：US11748880
申请日：2007-05-15
申请人： Itzik Harosh , Benedicte Fournes , Sebastien Barradeau
发明人： Itzik Harosh , Benedicte Fournes , Sebastien Barradeau
IPC分类号： A61K38/48 , A61K36/00 , A61P3/00
CPC分类号： C12N15/1137 , C12N2310/11 , C12N2310/321 , C12Y304/21009 , C12N2310/3521
摘要： The invention concerns a method of reducing body fat content of a subject in need thereof, the method comprising administering to the subject an agent capable of down-regulating activity and/or expression of at least one component participating in protein digestion and/or absorption. Such agents may be (i) an oligonucleotide directed to an endogenous nucleic acid sequence expressing said at least one component participating in said protein digestion and/or absorption or (ii) a protease inhibitor directed to said at least one component participating in protein digestion and/or absorption. The invention is particularly directed to a method of reducing body fat content of a subject in need thereof, the method comprising administering to the subject serine protease inhibitor inhibiting both enteropeptidase and trypsin activity.
摘要翻译：本发明涉及减少有需要的受试者体内脂肪含量的方法，所述方法包括向受试者施用能够下调参与蛋白质消化和/或吸收的至少一种成分的活性和/或表达的试剂。这样的试剂可以是（i）针对参与所述蛋白质消化和/或吸收的表达所述至少一种成分的内源核酸序列的寡核苷酸或（ii）针对参与蛋白质消化的所述至少一种成分的蛋白酶抑制剂，和 /或吸收。本发明特别涉及减少有需要的受试者体内脂肪含量的方法，所述方法包括对受试者丝氨酸蛋白酶抑制剂抑制肠肽酶和胰蛋白酶活性。

5. 发明授权

US06942967B1 Target for treating athersclerosis, obesity and type II diabetes 失效
标题翻译：治疗硬化症，肥胖症和II型糖尿病的目标
公开(公告)号：US06942967B1
公开(公告)日：2005-09-13
申请号：US09607437
申请日：2000-06-29
申请人： Itzik Harosh
发明人： Itzik Harosh
IPC分类号： A61K38/00 , C12N9/78 , C12N15/12 , C12Q1/68
CPC分类号： C12Q1/68 , A61K38/00 , C12N9/78
摘要： The invention concerns the use of the apobec-1 protein or associated proteins for treating atherosclerosis and obesity, type II diabetes (non-insulin-dependent), or other diseases, characterised in particular by hyperlipidemia and/or hyperglycemia, caused for example by a level of chylomicrons and/or VLDL in the plasma above normal. The invention also concerns the cloning of the gene(s) of Anderson disease as target for treating atheroscelerosis, obesity and type II diabetes (non-insulin-dependent), or other diseases characterised in particular by hyperlipidemia and/or hyperglycermia.
摘要翻译：本发明涉及apobec-1蛋白或相关蛋白用于治疗动脉粥样硬化和肥胖症，II型糖尿病（非胰岛素依赖性）或特别是特征在于特征在于高脂血症和/或高血糖症的其它疾病的用途，其由例如由血浆中乳糜微粒和/或VLDL水平高于正常水平。本发明还涉及将安德森氏病基因克隆作为治疗动脉粥样硬化加重症，肥胖症和II型糖尿病（非胰岛素依赖型）或特别是高脂血症和/或高糖的特征的其它疾病的靶标。

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