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1. 发明申请

US20090155819A1 Mammalian T1R3 Sweet Taste Receptors 有权
标题翻译：哺乳动物T1R3甜味受体
公开(公告)号：US20090155819A1
公开(公告)日：2009-06-18
申请号：US12257290
申请日：2008-10-23
申请人： Isolde Erlenbach , Nicholas J.P. Ryba , Grace Zhao , Charles S. Zuker
发明人： Isolde Erlenbach , Nicholas J.P. Ryba , Grace Zhao , Charles S. Zuker
IPC分类号： G01N33/53
CPC分类号： C07K14/705 , G01N2333/726
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译：本发明提供了分离的甜味受体的核酸和氨基酸序列，所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成，对这种受体的抗体，检测此类核酸和受体的方法，以及筛选甜味和氨基酸味道受体调节剂的方法。

2. 发明授权

US07459277B2 Mammalian T1R3 sweet taste receptors 有权
标题翻译：哺乳动物T1R3甜味受体
公开(公告)号：US07459277B2
公开(公告)日：2008-12-02
申请号：US11402202
申请日：2006-04-10
申请人： Isolde Erlenbach , Nicholas J. P. Ryba , Grace Zhao , Charles S. Zuker
发明人： Isolde Erlenbach , Nicholas J. P. Ryba , Grace Zhao , Charles S. Zuker
IPC分类号： G01N33/567 , C07K14/705
CPC分类号： C07K14/705 , G01N2333/726
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译：本发明提供了分离的甜味受体的核酸和氨基酸序列，所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成，对这种受体的抗体，检测此类核酸和受体的方法，以及筛选甜味和氨基酸味道受体调节剂的方法。

3. 发明申请

US20050106571A1 Mammalian T1R3 sweet taste receptors 审中-公开
标题翻译：哺乳动物T1R3甜味受体
公开(公告)号：US20050106571A1
公开(公告)日：2005-05-19
申请号：US10679102
申请日：2003-10-02
申请人： Isolde Erlenbach , Nicholas Ryba , Grace Zhao , Charles Zuker
发明人： Isolde Erlenbach , Nicholas Ryba , Grace Zhao , Charles Zuker
IPC分类号： C07H21/04 , C07K20060101 , C07K14/705 , C12Q1/68
CPC分类号： C07K14/705 , G01N2333/726
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译：本发明提供了分离的甜味受体的核酸和氨基酸序列，所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成，对这种受体的抗体，检测此类核酸和受体的方法，以及筛选甜味和氨基酸味道受体调节剂的方法。

4. 发明申请

US20070105159A1 Mammalian T1R3 sweet taste receptors 有权
标题翻译：哺乳动物T1R3甜味受体
公开(公告)号：US20070105159A1
公开(公告)日：2007-05-10
申请号：US11402202
申请日：2006-04-10
申请人： Isolde Erlenbach , Nicholas Ryba , Grace Zhao , Charles Zuker
发明人： Isolde Erlenbach , Nicholas Ryba , Grace Zhao , Charles Zuker
IPC分类号： G01N33/567 , G01N33/53
CPC分类号： C07K14/705 , G01N2333/726
摘要： The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.
摘要翻译：本发明提供了甜味受体的分离的核酸和氨基酸序列，所述受体包括由T1R3G-蛋白偶联受体多肽的单体或同二聚体组成，对这种受体的抗体，检测此类核酸和受体的方法，以及筛选甜味和氨基酸味道受体调节剂的方法。

5. 发明授权

US08776670B2 Piston assembly 有权
标题翻译：活塞总成
公开(公告)号：US08776670B2
公开(公告)日：2014-07-15
申请号：US12706965
申请日：2010-02-17
申请人： Michael T. Lapp , Grace Zhao , Mike L. Wilder , Dieter Gabriel
发明人： Michael T. Lapp , Grace Zhao , Mike L. Wilder , Dieter Gabriel
IPC分类号： F02F3/00 , F02F3/22
CPC分类号： F02F3/003 , F02F3/22
摘要： A piston assembly and a method of making the same. Exemplary piston assemblies may include a piston crown having a ring belt portion defining a cooling gallery, and a strut extending away from the ring belt portion to define a wrist pin bore. The piston may further include a piston skirt assembly secured to the strut. The piston skirt assembly may include two separate portions that each have a closure plate formed integrally with the portion, with the closure plate generally enclosing the cooling gallery. Exemplary methods of assembling a piston may include providing a piston crown having a ring belt portion defining a cooling gallery and a strut extending away from the ring belt portion to define a wrist pin bore. The methods may further include forming a piston skirt assembly having two portions having a closure plate integrally formed therewith, and securing the skirt to the crown.
摘要翻译：活塞组件及其制造方法。示例性的活塞组件可以包括具有限定冷却库的环形带部分的活塞冠部和从环形带部分延伸的支柱，以限定腕销孔。活塞还可以包括固定到支柱的活塞裙部组件。活塞裙组件可以包括两个分开的部分，每个部分具有与该部分一体形成的封闭板，封闭板通常包围冷却库。组装活塞的示例性方法可以包括提供具有环形带部分的活塞冠部，所述环形带部分限定冷却槽和从环形带部分延伸的支柱，以限定腕销孔。所述方法可以进一步包括形成具有两个部分的活塞裙部组件，所述两个部分具有与其一体形成的封闭板，并将裙部固定到冠部。

6. 发明申请

US20110197845A1 PISTON ASSEMBLY 审中-公开
标题翻译：活塞装配
公开(公告)号：US20110197845A1
公开(公告)日：2011-08-18
申请号：US12898300
申请日：2010-10-05
申请人： William Flowers , Dieter Gabriel , Grace Zhao , Ralph Klein
发明人： William Flowers , Dieter Gabriel , Grace Zhao , Ralph Klein
IPC分类号： F02F3/16 , F16J1/04 , B23P15/10
CPC分类号： F02F3/003 , F02F3/22 , Y10T29/49254
摘要： An exemplary piston assembly and method of making the same are disclosed. A piston assembly may include a piston crown and piston skirt. The crown may include a ring belt portion defining at least in part a cooling gallery, as well as radially inner and outer crown mating surfaces. The skirt may be received in a central opening of the crown such that the crown and skirt cooperate to form an upper combustion bowl surface. The skirt also may include radially inner and outer skirt mating surfaces that are abutted with the inner and outer crown mating surfaces, respectively, such that the cooling gallery is generally enclosed by the skirt.
摘要翻译：公开了一种示例性活塞组件及其制造方法。活塞组件可以包括活塞冠和活塞裙。冠部可以包括至少部分地限定冷却槽的环形带部分，以及径向内部和外部冠部配合表面。裙部可以被容纳在冠的中央开口中，使得冠和裙部协作以形成上燃烧碗表面。裙部还可以包括径向内部和外部裙部配合表面，其分别与内部和外部冠部配合表面邻接，使得冷却库通常由裙部包围。

7. 发明申请

US20070283917A1 Piston for a combustion engine 审中-公开
标题翻译：内燃机活塞
公开(公告)号：US20070283917A1
公开(公告)日：2007-12-13
申请号：US11451257
申请日：2006-06-12
申请人： Michael T. Lapp , Valerian Ioja , Grace Zhao
发明人： Michael T. Lapp , Valerian Ioja , Grace Zhao
IPC分类号： F02F3/00 , F16J9/00
CPC分类号： F02F3/003 , F02F3/10 , F02F3/22
摘要： The present invention relates to a piston (10, 110) for a combustion engine having a basic element (11, 111) and a ring carrier element (12, 112) held on the basic element (11, 111) with a top land (25, 125) all around its circumference and ring belt (26, 126) all around its circumference. It is provided in accordance with the invention that the ring carrier element (12, 112) grips around the basic element (11, 111) at least partially and is held on the basic element (11, 111) by means of a press fit.
摘要翻译：本发明涉及一种用于内燃机的活塞（10,110），所述活塞具有基本元件（11,111）和保持在具有顶部平台的基本元件（11,111）上的环形载体元件（12,112） 25,125）围绕其圆周和环带（26,126）围绕其圆周。根据本发明，根据本发明提供环形载体元件（12,112）至少部分地夹在基本元件（11,111）周围，并通过压配合保持在基本元件（11,111）上。

8. 发明申请

US20110197758A1 PISTON ASSEMBLY 有权
标题翻译：活塞装配
公开(公告)号：US20110197758A1
公开(公告)日：2011-08-18
申请号：US12706965
申请日：2010-02-17
申请人： Michael T. Lapp , Grace Zhao , Mike L. Wilder , Dieter Gabriel
发明人： Michael T. Lapp , Grace Zhao , Mike L. Wilder , Dieter Gabriel
IPC分类号： F01B31/08 , B21D39/03
CPC分类号： F02F3/003 , F02F3/22
摘要： A piston assembly and a method of making the same. Exemplary piston assemblies may include a piston crown having a ring belt portion defining a cooling gallery, and a strut extending away from the ring belt portion to define a wrist pin bore. The piston may further include a piston skirt assembly secured to the strut. The piston skirt assembly may include two separate portions that each have a closure plate formed integrally with the portion, with the closure plate generally enclosing the cooling gallery. Exemplary methods of assembling a piston may include providing a piston crown having a ring belt portion defining a cooling gallery and a strut extending away from the ring belt portion to define a wrist pin bore. The methods may further include forming a piston skirt assembly having two portions having a closure plate integrally formed therewith, and securing the skirt to the crown.
摘要翻译：活塞组件及其制造方法。示例性的活塞组件可以包括具有限定冷却库的环形带部分的活塞冠部和从环形带部分延伸的支柱，以限定腕销孔。活塞还可以包括固定到支柱的活塞裙部组件。活塞裙组件可以包括两个分开的部分，每个部分具有与该部分一体形成的封闭板，封闭板通常包围冷却库。组装活塞的示例性方法可以包括提供具有环形带部分的活塞冠部，所述环形带部分限定冷却槽和从环形带部分延伸的支柱，以限定腕销孔。所述方法可以进一步包括形成具有两个部分的活塞裙部组件，所述两个部分具有与其一体形成的封闭板，并将裙部固定到冠部。

9. 发明申请

US20070295299A1 Piston for a combustion engine 审中-公开
标题翻译：内燃机活塞
公开(公告)号：US20070295299A1
公开(公告)日：2007-12-27
申请号：US11803941
申请日：2007-05-16
申请人： Michael Lapp , Valerian Ioja , Grace Zhao
发明人： Michael Lapp , Valerian Ioja , Grace Zhao
IPC分类号： F02F3/00
CPC分类号： F02F3/0023 , F02F3/003 , F02F3/22
摘要： A piston for a combustion engine has a basic element and a ring carrier element held on the basic element with a top land all around its circumference and a ring belt all around its circumference. The ring carrier element grips around the basic element at least partially and is held on the basic element by a press fit.
摘要翻译：用于内燃机的活塞具有基本元件和保持在基本元件上的环形载体元件，其顶部平台遍及其周边，环形带围绕其圆周。环形载体元件至少部分地夹在基本元件周围，并通过压配合保持在基本元件上。

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