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    • 8. 发明授权
    • Gene expressed in prostate cancer, methods and use thereof
    • 在前列腺癌中表达的基因,其方法和用途
    • US07572887B2
    • 2009-08-11
    • US10552515
    • 2004-04-05
    • Ira PastanTapan K. BeraByungkook Lee
    • Ira PastanTapan K. BeraByungkook Lee
    • C07K14/00C07H21/04C12N15/00C12Q1/68
    • A61K38/168A61K38/164A61K47/64C07K14/47C07K14/4748C12Q1/6886C12Q2600/106G01N33/57434G01N2500/00
    • A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
    • 公开了在前列腺细胞中特异性检测到的多肽,称为前列腺中表达的剪接变体 - 新型基因(SV-NGEP)。 还公开了编码SV-NGEP的多核苷酸,以及包括这些多核苷酸的载体。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合SV-NGEP的抗体和免疫结合物。 公开了使用NGEP多肽,特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。 公开了检测前列腺癌的测定。 还公开了包含SV-NGEP多肽,特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。 这些药物组合物可用于治疗前列腺癌。