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1. 发明授权

US11712416B2 Solid oral pharmaceutical compositions for isoxazoline compounds 有权
公开(公告)号：US11712416B2
公开(公告)日：2023-08-01
申请号：US17189939
申请日：2021-03-02
申请人： Intervet Inc.
发明人： Keith Freehauf , Niki Waldron , Jürgen Lutz , Frank Guerino
IPC分类号： A61K9/00 , A61K31/42 , A61K31/7048 , A61K31/35 , A61K31/422 , A61K47/38 , A61K47/22 , A61K47/16 , A61K45/06 , A61K47/18 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/51 , A61P43/00 , A61P33/14 , A61P33/00 , A61K47/12 , A61K31/365 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/44 , A61K47/36 , A61K47/42
CPC分类号： A61K9/0056 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/282 , A61K9/4858 , A61K9/5015 , A61K9/5123 , A61K31/35 , A61K31/365 , A61K31/42 , A61K31/422 , A61K31/7048 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P33/00 , A61P33/14 , A61P43/00
摘要： A solid oral pharmaceutical composition for delivery of a pharmaceutically acceptable active ingredient to an animal where the composition comprises an isoxazoline compound, a solvent and an excipient, a process for the manufacture of such solid oral pharmaceutical composition and a method of controlling a parasite infection administering such solid oral pharmaceutical composition.

2. 发明申请

US20170105972A1 SOFT CHEWABLE PHARMACEUTICAL PRODUCTS 审中-公开
公开(公告)号：US20170105972A1
公开(公告)日：2017-04-20
申请号：US15390244
申请日：2016-12-23
申请人： Intervet, Inc.
发明人： Susi Alteheld , Stefan Fuchs , Carina Hang , Jürgen Lutz
IPC分类号： A61K31/42 , A61K47/44 , A61K47/26 , A61K31/422 , A61K47/10 , A61K47/20 , A61K9/00 , A61K47/12
CPC分类号： A61K9/0056 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/282 , A61K9/4858 , A61K9/5015 , A61K9/5123 , A61K31/35 , A61K31/365 , A61K31/42 , A61K31/422 , A61K31/7048 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , B29C37/0003 , B29C43/003 , B29K2071/02 , B29K2105/0035 , B29L2031/753
摘要： A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.

3. 发明申请

US20160332975A1 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS 审中-公开
标题翻译： ISOXAZOLINE组合物及其作为抗菌剂的用途
公开(公告)号：US20160332975A1
公开(公告)日：2016-11-17
申请号：US15222171
申请日：2016-07-28
申请人： Intervet Inc.
发明人： Anja Regina Heckeroth , Jürgen Lutz , Christina Mertens , Heike Williams , Hartmut Zoller , Takeshi Mita
IPC分类号： C07D261/04 , C07D417/12 , C07D413/12 , A01N43/80
CPC分类号： C07D261/04 , A01N43/80 , A01N47/12 , A01N47/18 , A01N53/00 , A61K31/42 , C07D413/12 , C07D417/12 , Y02A50/401 , Y02A50/402
摘要： This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.
摘要翻译：本发明涉及用于控制动物及其环境的寄生虫感染的方法，更具体地，涉及使用异恶唑啉来控制动物或其环境中或动物或其环境中的寄生虫以及治疗动物寄生虫的方法。异恶唑啉包括4-（异恶唑啉基） - 苯甲酰胺（具体地，取代的4-（5-（卤代甲基）-5-苯基 - 异恶唑啉-3-基） - 苯甲酰胺）和4-（异恶唑啉基） - 苯并硫代酰胺（具体地，（5-（卤代甲基）-5-苯基 - 异恶唑啉-3-基） - 苯并硫代酰胺）。本发明还涉及包含用于此类方法的异恶唑烷的组合物，异恶唑啉用于制备用于此类方法的药物的用途，以及包含用于进行此类方法的异恶唑啉的试剂盒。本发明还涉及异恶唑啉作为药物的用途，特别是可以在上述方法中使用的药物。

4. 发明申请

US20220142984A1 Soft Chewable Pharmaceutical Products 有权
公开(公告)号：US20220142984A1
公开(公告)日：2022-05-12
申请号：US17648841
申请日：2022-01-25
申请人： Intervet Inc.
发明人： Susi Alteheld , Stefan Fuchs , Carina Hang , Jürgen Lutz
IPC分类号： A61K31/42 , A61K9/00
摘要： A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.

5. 发明申请

US20210177749A1 Solid Oral Pharmaceutical Compositions for Isoxazoline Compounds 有权
公开(公告)号：US20210177749A1
公开(公告)日：2021-06-17
申请号：US17189939
申请日：2021-03-02
申请人： Intervet Inc.
发明人： Keith Freehauf , Niki Waldron , Jürgen Lutz , Frank Guerino
IPC分类号： A61K9/00 , A61K31/42 , A61K31/7048 , A61K31/35 , A61K31/422 , A61K47/38 , A61K47/22 , A61K47/16 , A61K45/06 , A61K47/18 , A61K9/14 , A61K9/16 , A61K9/20 , A61K9/28 , A61K9/48 , A61K9/50 , A61K9/51 , A61P43/00 , A61P33/14 , A61P33/00 , A61K47/12 , A61K31/365 , A61K47/10 , A61K47/20 , A61K47/26 , A61K47/44 , A61K47/36 , A61K47/42
摘要： A solid oral pharmaceutical composition for delivery of a pharmaceutically acceptable active ingredient to an animal where the composition comprises an isoxazoline compound, a solvent and an excipient, a process for the manufacture of such solid oral pharmaceutical composition and a method of controlling a parasite infection administering such solid oral pharmaceutical composition.

6. 发明申请

US20210061775A1 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS 有权
公开(公告)号：US20210061775A1
公开(公告)日：2021-03-04
申请号：US17021698
申请日：2020-09-15
申请人： Intervet Inc.
发明人： Anja Regina Heckeroth , Jürgen Lutz , Christina Mertens , Heike Williams , Hartmut Zoller , Takeshi Mita
IPC分类号： C07D261/04 , A01N43/80 , A01N47/12 , A01N47/18 , A01N53/00 , A61K31/42 , C07D413/12 , C07D417/12
摘要： This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.

7. 发明申请

US20180155301A1 ISOXAZOLINE COMPOSITIONS AND THEIR USE AS ANTIPARASITICS 审中-公开
公开(公告)号：US20180155301A1
公开(公告)日：2018-06-07
申请号：US15880770
申请日：2018-01-26
申请人： Intervet Inc.
发明人： Anja Regina Heckeroth , Jürgen Lutz , Christina Mertens , Heike Williams , Hartmut Zoller , Takeshi Mita
IPC分类号： C07D261/04 , C07D417/12 , C07D413/12 , A01N43/80 , A01N53/00 , A01N47/18 , A01N47/12 , A61K31/42
CPC分类号： C07D261/04 , A01N43/80 , A01N47/12 , A01N47/18 , A01N53/00 , A61K31/42 , C07D413/12 , C07D417/12 , Y02A50/401 , Y02A50/402
摘要： This invention relates to methods for controlling parasitic infestations of animals and their environments, and, more particularly, to methods using isoxazolines to control parasites in or on animals or in their environments, as well as treat parasitoses of animals. The isoxazolines include 4-(isoxazolinyl)-benzamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzamides) and 4-(isoxazolinyl)-benzothioamides (specifically, substituted 4-(5-(halomethyl)-5-phenyl-isoxazolin-3-yl)-benzothioamides). This invention also relates to compositions comprising the isoxazolines for use in such methods, the use of the isoxazolines to make medicaments for use in such methods, and kits comprising the isoxazolines for carrying out such methods. This invention further relates to the use of the isoxazolines as medicaments, particularly medicaments that can be used in the above-referenced method.

8. 发明申请

US20170100377A1 Solid Oral Pharmaceutical Compositions for Isoxazoline Compounds 审中-公开
公开(公告)号：US20170100377A1
公开(公告)日：2017-04-13
申请号：US15386100
申请日：2016-12-21
申请人： Intervet Inc.
发明人： Keith Freehauf , Niki Waldron , Jürgen Lutz , Frank Guerino
IPC分类号： A61K31/42 , A61K31/365 , A61K45/06 , A61K31/7048 , A61K9/00 , A61K9/20
CPC分类号： A61K9/0056 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/282 , A61K9/4858 , A61K9/5015 , A61K9/5123 , A61K31/35 , A61K31/365 , A61K31/42 , A61K31/422 , A61K31/7048 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , B29C37/0003 , B29C43/003 , B29K2071/02 , B29K2105/0035 , B29L2031/753
摘要： A solid oral pharmaceutical composition for delivery of a pharmaceutically acceptable active ingredient to an animal where the composition comprises an isoxazoline compound, a solvent and an excipient, a process for the manufacture of such solid oral pharmaceutical composition and a method of controlling a parasite infection administering such solid oral pharmaceutical composition.

9. 发明授权

US11285101B2 Soft chewable pharmaceutical products 有权
公开(公告)号：US11285101B2
公开(公告)日：2022-03-29
申请号：US16296490
申请日：2019-03-08
申请人： Intervet Inc.
发明人： Susi Alteheld , Stefan Fuchs , Carina Hang , Jürgen Lutz
IPC分类号： A61K9/00 , A61K31/42 , A61K47/16 , A61K47/22 , A61K47/38 , A61K31/422 , A61K31/35 , A61K31/7048 , A61K47/42 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/36 , A61K47/44 , A61K47/20 , A61K47/26 , A61K47/10 , A61K31/365 , A61K9/20 , A61K9/51 , A61K9/50 , A61K9/48 , A61K9/28 , A61K9/16 , A61K9/14 , B29C37/00 , B29C43/00 , A61P43/00 , A61P33/14 , A61P33/00
摘要： A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.

10. 发明申请

US20190201332A1 Soft Chewable Pharmaceutical Products 审中-公开
公开(公告)号：US20190201332A1
公开(公告)日：2019-07-04
申请号：US16296490
申请日：2019-03-08
申请人： Intervet Inc.
发明人： Susi Alteheld , Stefan Fuchs , Carina Hang , Jürgen Lutz
IPC分类号： A61K9/00 , A61K31/42 , B29C37/00 , A61K47/16 , A61K47/22 , A61K47/38 , A61K31/422 , A61K31/35 , A61K31/7048 , A61K47/42 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/36 , B29C43/00 , A61K47/44 , A61K47/20 , A61K47/26 , A61K47/10 , A61K31/365 , A61K9/20 , A61K9/51 , A61K9/50 , A61K9/48 , A61K9/28 , A61K9/16 , A61K9/14
CPC分类号： A61K9/0056 , A61K9/145 , A61K9/1617 , A61K9/2013 , A61K9/2031 , A61K9/2054 , A61K9/2068 , A61K9/2095 , A61K9/282 , A61K9/4858 , A61K9/5015 , A61K9/5123 , A61K31/35 , A61K31/365 , A61K31/42 , A61K31/422 , A61K31/7048 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , B29C37/0003 , B29C43/003 , B29K2071/02 , B29K2105/0035 , B29L2031/753
摘要： A soft chewable pharmaceutical product for delivery of a pharmaceutically acceptable active ingredient to an animal comprising pamoic acid or a pharmaceutically acceptable salt and a process for the manufacture of such soft chewable pharmaceutical product.

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