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1. 发明申请

US20040039414A1 Methods for manufacturing a clip and clip 有权
标题翻译：制造夹子和夹子的方法
公开(公告)号：US20040039414A1
公开(公告)日：2004-02-26
申请号：US10335075
申请日：2002-12-31
申请人： Integrated Vascular Systems, Inc.
发明人： Michael T. Carley , Richard S. Ginn
IPC分类号： A61B017/08
CPC分类号： A61B17/068 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00867 , C22C19/007 , C22F1/00 , C22F1/10 , C22F1/16
摘要： The present invention relates to a method of making clips which can be used to engage body tissue for the purpose of closing wounds. Such clips are generally annular in shape and have radially inwardly extending tines. It is often desirable for such clips to have a small lateral dimension, but manufacturing difficulty has been encountered in making small clips because of the difficulty in cutting materials accurately when attempting to produce a clip with closely packed elements. The present invention avoids these difficulties by first forming a precursor which, in one embodiment, has the tines extending radially outwardly from the annular body and then forms the clip by inverting the precursor such that the tines extend radially inwardly. In an alternate embodiment, the precursor is formed with an over-sized lateral dimension and then compressed inwardly to bring the tines closer together and to reduce the lateral dimension of the precursor. It is preferred to manufacture such clips from a superelastic alloy such as nickel-titanium, in which case the inverted or compressed precursor must be heated and quenched to heat set the clip in its final shape.
摘要翻译：本发明涉及一种制造夹子的方法，该夹具可用于接合身体组织以便关闭伤口。这种夹子通常是环形的并且具有径向向内延伸的尖齿。通常希望这样的夹具具有小的横向尺寸，但是制造小夹子时遇到制造困难，因为当试图制造具有紧密堆积元件的夹子时，难以准确地切割材料。本发明通过首先形成前体避免了这些困难，在一个实施方案中，前体具有从环形体径向向外延伸的齿，然后通过倒转前体形成夹子，使得尖齿径向向内延伸。在替代实施例中，前体形成为具有超大尺寸的侧向尺寸，然后被向内压缩以使尖齿更靠近在一起并减小前体的横向尺寸。优选从诸如镍钛的超弹性合金制造这种夹子，在这种情况下，必须加热和淬火反转或压缩的前体以将夹子热定型成其最终形状。

2. 发明申请

US20040153123A1 Clip applier and methods of use 有权
标题翻译：夹子施放器和使用方法
公开(公告)号：US20040153123A1
公开(公告)日：2004-08-05
申请号：US10638115
申请日：2003-08-08
申请人： Integrated Vascular Systems, Inc.
发明人： Thomas J. Palermo , William M. Belef , Michael T. Carley , Richard S. Ginn , Ronald J. Jabba , Anthony Pantages
IPC分类号： A61D001/00
CPC分类号： A61B17/064 , A61B17/0057 , A61B17/0643 , A61B17/0644 , A61B17/068 , A61B17/1227 , A61B17/1285 , A61B2017/00637 , A61B2017/00672
摘要： An apparatus for delivering a closure element into an opening formed in a blood vessel or other body lumen and methods for manufacturing and using same. The apparatus is configured to retain the closure element such that the closure element is disposed substantially within the apparatus. The apparatus also can engage, and position the closure element substantially adjacent to, the blood vessel wall adjacent to the opening. During deployment of the closure element, the apparatus expands the closure element beyond a natural cross-section of the closure element such that the closure element, when deployed, is configured to engage a significant amount of the blood vessel wall and/or tissue. Engaging the blood vessel wall and/or tissue, the closure element is further configured to return to the natural cross-section, thereby drawing the engaged blood vessel wall and/or tissue substantially closed and/or sealed, such that hemostasis within the opening is enhanced.
摘要翻译：一种用于将闭合元件输送到形成在血管或其他体腔中的开口中的装置及其制造和使用方法。该装置构造成保持封闭元件，使得封闭元件基本上设置在该装置内。该装置还可以将封闭件基本上邻近开口附近的血管壁接合并定位。在封闭元件的展开过程中，该装置将闭合元件膨胀超过封闭元件的自然横截面，使得封闭元件在展开时构造成与大量的血管壁和/或组织接合。接合血管壁和/或组织，闭合元件进一步构造成返回到自然横截面，从而将所接合的血管壁和/或组织基本上闭合和/或密封，使得开口内止血增强。

3. 发明申请

US20040073236A1 Closure device and methods for making and using them 有权
公开(公告)号：US20040073236A1
公开(公告)日：2004-04-15
申请号：US10667144
申请日：2003-09-19
申请人： Integrated Vascular Systems, Inc.
发明人： Michael T. Carley , Richard S. Ginn , Javier Sagastegui , Ronald J. Jabba , William N. Aldrich , W. Martin Belef
IPC分类号： A61B017/08
CPC分类号： A61B17/08 , A61B17/0057 , A61B17/064 , A61B17/0644 , A61B17/068 , A61B17/083 , A61B90/39 , A61B2017/00004 , A61B2017/00637 , A61B2017/00668 , A61B2017/00672 , A61B2017/00867 , A61B2017/0641 , A61B2017/081 , H03K3/356139 , H03K3/356156
摘要： A clip for engaging tissue includes a generally annular-shaped body defining a plane and disposed about a central axis extending normal to the plane. The body includes alternating inner and outer curved regions, defining a zigzag pattern about a periphery of the clip. The body is biased towards a planar configuration lying in the plane and deflectable towards a transverse configuration extending out of the plane. Tines extend from the inner curved regions, the tines being oriented towards the central axis in the planar configuration, and parallel to the central axis in the transverse configuration. The tines may include primary tines and secondary tines that are shorter than the primary tines. The primary tines may be disposed on opposing inner curved regions and oriented towards one another such that they overlap in the planar configuration.

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