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1. 发明申请

US20180093009A1 Dimensionally Stable Molded Bone Replacement Element with Residual Hydraulic Activity 审中-公开
公开(公告)号：US20180093009A1
公开(公告)日：2018-04-05
申请号：US15813176
申请日：2017-11-15
申请人： Innotere GmbH
发明人： Berthold Nies
IPC分类号： A61L24/00 , A61L27/02 , A61L27/58 , A61L24/02 , A61L27/12 , A61L27/54 , A61L27/56
CPC分类号： A61L24/0036 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/02 , A61L27/12 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： Dimensionally stable molded bone replacement elements made of mineral bone cement with residual hydraulic activity that contain at least one share of hardened mineral bone cement and at least one share of unconverted or unhardened reactive mineral bone cement, wherein the share of hardened mineral bone cement is 5% to 90% by weight. The dimensionally stable molded bone replacement elements have at least 5% of the maximum value of the strength of a completely hardened bone cement comprised of the same mineral components and with the same structural characteristics and reach compressive strengths in the range of 2 to 200 MPa. They are substantially free of water and can be converted under biological conditions.

2. 发明申请

US20180161477A1 Structured Mineral Bone Replacement Element 审中-公开
公开(公告)号：US20180161477A1
公开(公告)日：2018-06-14
申请号：US15823627
申请日：2017-11-28
申请人： Innotere GmbH
发明人： Berthold Nies
IPC分类号： A61L27/02 , A61L24/00 , A61L24/02
CPC分类号： A61L27/02 , A61F2002/30985 , A61L24/0036 , A61L24/0042 , A61L24/02 , A61L27/025 , A61L27/047 , A61L27/12 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02 , C12N5/0062 , C12N5/0654 , C12N2500/14 , C12N2500/16
摘要： Structured mineral bone substitute moldings having a defined interconnecting pore system and a predetermined structure, to a method for producing structured mineral bone substitute moldings using 3D printing, and to the use thereof for producing an alloplastic implant or as a carrier material in cell culturing, tissue culturing and/or tissue engineering.

3. 发明申请

US20160220726A1 Dimensionally Stable Molded Bone Replacement Element with Residual Hydraulic Activity 有权
标题翻译：具有残余液压活动的尺寸稳定的成型骨替代元件
公开(公告)号：US20160220726A1
公开(公告)日：2016-08-04
申请号：US15021354
申请日：2014-10-23
申请人： INNOTERE GMBH
发明人： Berthold Nies
IPC分类号： A61L24/00 , A61L27/12 , A61L27/54 , A61L24/02 , A61L27/56 , A61L27/58
CPC分类号： A61L24/0036 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/02 , A61L27/12 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The invention relates to dimensionally stable molded bone replacement elements made of mineral bone cement with residual hydraulic activity that contain at least one share of hardened mineral bone cement and at least one share of unconverted or unhardened reactive mineral bone cement, wherein the share of hardened mineral bone cement is 5% to 90% by weight. The dimensionally stable molded bone replacement elements have at least 5% of the maximum value of the strength of a completely hardened bone cement comprised of the same mineral components and with the same structural characteristics and reach compressive strengths in the range of 2 to 200 MPa. They are substantially free of water and can be converted under biological conditions.
摘要翻译：本发明涉及由具有残余水力活性的矿物骨水泥制成的尺寸稳定的模制骨置换元件，其含有至少一份硬化矿物骨水泥和至少一份未转化或未硬化的活性矿物骨水泥，其中硬化矿物的份额骨水泥为5〜90重量％。尺寸稳定的成型骨置换元件具有由相同的矿物成分组成并且具有相同结构特征的完全硬化的骨水泥的强度的最大值的至少5％，并达到2至200MPa的压缩强度。它们基本上不含水，可在生物条件下转化。

4. 发明申请

US20150066144A1 Implant Made of a Fiber Composite Material 有权
标题翻译：植入物由纤维复合材料制成
公开(公告)号：US20150066144A1
公开(公告)日：2015-03-05
申请号：US14391711
申请日：2013-04-11
申请人： Innotere GmbH
发明人： Berthold Nies , Sophie Rössler , Sandra Storch , Chokri Cherif , Ezzeddine Laourine
IPC分类号： A61F2/28 , A61L31/12
CPC分类号： A61F2/28 , A61L27/427 , A61L31/124 , A61L2430/02
摘要： The invention relates to an implant and a set for producing an implant and their uses. Furthermore, the invention describes a method of making an implant as per the invention. An implant for producing bone implants with improved mechanical characteristics, especially with adjustable mechanical characteristics, is provided via the invention. The implant as per the invention made up of a fiber composite material contains resorbable mineral bone cement as the matrix material, to which reinforcing, long metal fibers and/or endless metallic fibers with an aspect ratio of at least 100:1 are added in the form of at least one fiber structure that provides a framework and that preforms the contour of the implant.
摘要翻译：本发明涉及用于生产植入物的植入物和组合及其用途。此外，本发明描述了根据本发明制造植入物的方法。通过本发明提供了用于生产具有改善的机械特性，特别是具有可调节机械特性的骨植入物的植入物。根据本发明的由纤维复合材料构成的植入物包含可再吸收的矿物骨水泥作为基质材料，在其中加入长度比为至少100:1的加强长金属纤维和/或环形金属纤维提供框架并且预制植入物轮廓的至少一个纤维结构的形式。

5. 发明授权

US09849211B2 Dimensionally stable molded bone replacement element with residual hydraulic activity 有权
公开(公告)号：US09849211B2
公开(公告)日：2017-12-26
申请号：US15021354
申请日：2014-10-23
申请人： Innotere GmbH
发明人： Berthold Nies
IPC分类号： A61K33/42 , A61F13/00 , A61F2/28 , A61K6/08 , A61L24/00 , A61L27/02 , A61L24/02 , A61L27/56 , A61L27/12 , A61L27/54 , A61L27/58
CPC分类号： A61L24/0036 , A61L24/0015 , A61L24/0042 , A61L24/02 , A61L27/02 , A61L27/12 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2430/02
摘要： The invention relates to dimensionally stable molded bone replacement elements made of mineral bone cement with residual hydraulic activity that contain at least one share of hardened mineral bone cement and at least one share of unconverted or unhardened reactive mineral bone cement, wherein the share of hardened mineral bone cement is 5% to 90% by weight. The dimensionally stable molded bone replacement elements have at least 5% of the maximum value of the strength of a completely hardened bone cement comprised of the same mineral components and with the same structural characteristics and reach compressive strengths in the range of 2 to 200 MPa. They are substantially free of water and can be converted under biological conditions.

6. 发明授权

US09572668B2 Implant made of a fiber composite material 有权
标题翻译：植入物由纤维复合材料制成
公开(公告)号：US09572668B2
公开(公告)日：2017-02-21
申请号：US14391711
申请日：2013-04-11
申请人： Innotere GmbH
发明人： Berthold Nies , Sophie Rössler , Sandra Storch , Chokri Cherif , Ezzeddine Laourine
IPC分类号： A61F2/28 , A61L27/42 , A61L31/12
CPC分类号： A61F2/28 , A61L27/427 , A61L31/124 , A61L2430/02
摘要： The invention relates to an implant and a set for producing an implant and their uses. Furthermore, the invention describes a method of making an implant as per the invention. An implant for producing bone implants with improved mechanical characteristics, especially with adjustable mechanical characteristics, is provided via the invention. The implant as per the invention made up of a fiber composite material contains resorbable mineral bone cement as the matrix material, to which reinforcing, long metal fibers and/or endless metallic fibers with an aspect ratio of at least 100:1 are added in the form of at least one fiber structure that provides a framework and that preforms the contour of the implant.
摘要翻译：本发明涉及用于生产植入物的植入物和组合及其用途。此外，本发明描述了根据本发明制造植入物的方法。通过本发明提供了用于生产具有改善的机械特性，特别是具有可调节机械特性的骨植入物的植入物。根据本发明的由纤维复合材料构成的植入物包含可再吸收的矿物骨水泥作为基质材料，在其中加入长度比为至少100:1的加强长金属纤维和/或环形金属纤维提供框架并且预制植入物轮廓的至少一个纤维结构的形式。

7. 发明申请

US20140271769A1 Preparation for the Manufacture of an Implant 审中-公开
标题翻译：准备制造植入物
公开(公告)号：US20140271769A1
公开(公告)日：2014-09-18
申请号：US14353021
申请日：2012-10-19
申请人： InnoTERE GmbH
发明人： Berthold Nies
IPC分类号： A61L27/12 , A61L24/02
CPC分类号： A61L27/12 , A61L24/02 , A61L27/025 , A61L27/10 , A61L2430/02
摘要： The invention relates to a preparation for manufacturing an implant, preferably a bone implant, a process for said manufacture and mouldings obtainable therefrom. The preparation comprises the following components: a) mineral cement powder comprising at least one calcium-ion-containing and/or at least one magnesium-ion-containing inorganic compound as a reactive component; b) at least one organic carrier liquid; c) at least two surfactants selected from at least two of the groups of anionic, cationic, amphoteric and nonionic surfactants; d) less than 1% w/w water based on the total mass of the composition, wherein the weight ratio of the total solids present in the formulation solids to the sum of the weight of the organic carrier liquid and the at least two surfactants is more than if the cement powder contains calcium-ion-containing and no magnesium-ion-containing compounds as the reactive component, or is more than 6 if the cement powder contains magnesium-ion-containing or magnesium-ion- and calcium-ion-containing compounds as the reactive component.
摘要翻译：本发明涉及用于制造植入物，优选骨植入物的制备方法，用于所述制造的方法和可由其获得的模制品。该制剂包括以下组分：a）包含至少一种含钙离子和/或至少一种含镁离子的无机化合物作为反应性组分的矿物水泥粉末; b）至少一种有机载体液; c）至少两种表面活性剂选自阴离子，阳离子，两性和非离子表面活性剂中的至少两种; d）基于组合物的总质量小于1％w / w的水，其中制剂固体中存在的总固体与有机载体液体和至少两种表面活性剂的重量之和的重量比是超过如果水泥粉末含有含钙离子且不含有镁离子的化合物作为反应性组分，或者如果水泥粉末含有含镁离子或镁离子和钙离子的化合物，含有化合物作为反应性组分。

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