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    • 5. 发明申请
    • Method for determining an active agent dose
    • 确定活性剂剂量的方法
    • US20050074803A1
    • 2005-04-07
    • US10947982
    • 2004-09-23
    • Walter SchmittStefan WillmannEdgar DiesselIngmar DornJens Burmeister
    • Walter SchmittStefan WillmannEdgar DiesselIngmar DornJens Burmeister
    • G06F19/18G06Q50/24C12Q1/68G06F17/60G06F19/00G01N33/48G01N33/50
    • G06Q50/24G16B20/00
    • Method for determining the dose of at least one active agent based on a genetic analysis. The method comprises analyzing specific genes for their nucleotide sequence or their expression levels of gene-specific proteins and/or RNA molecules. The gene-specific data is assigned one or more relevant physiological functions of the human or animal body, in particular those which have an influence on the metabolism, absorption, excretion or distribution of the active agent in the body. The gene-specific data and the assigned physiological functions are then integrated into a physiology-based pharmacokinetic model (PBPK model). The PBPK model integrates pharmacokinetic data relating to one or more active agents. The PBPK model may also receive and evaluate patient-specific data directly inputted and combined with data from a knowledge database comprising known values of pharmacokinetic parameters. The PBPK's integration of these data provide a calculation of the individual dose of the active agent.
    • 基于遗传分析确定至少一种活性剂的剂量的方法。 该方法包括分析其核苷酸序列的特定基因或其基因特异性蛋白质和/或RNA分子的表达水平。 基因特异性数据被分配人或动物体的一个或多个相关的生理功能,特别是那些对体内活性剂的代谢,吸收,排泄或分布有影响的那些。 然后将基因特异性数据和分配的生理功能整合到基于生理学的药代动力学模型(PBPK模型)中。 PBPK模型整合了与一种或多种活性剂有关的药代动力学数据。 PBPK模型还可以接收和评估直接输入的患者特异性数据,并与包括已知的药代动力学参数值的知识数据库的数据组合。 PBPK对这些数据的整合提供了活性剂个体剂量的计算。
    • 6. 发明授权
    • Apparatus for automatically performing analyses
    • 用于自动执行分析的装置
    • US09128072B2
    • 2015-09-08
    • US13121581
    • 2009-09-24
    • Edgar DieβelIngmar DornMichael HabigMike KüsterKlaus Ochmann
    • Edgar DieβelIngmar DornMichael HabigMike KüsterKlaus Ochmann
    • G01N35/02G01N35/00G01N35/10
    • G01N35/028G01N2035/00306G01N2035/00326G01N2035/1051Y10T436/11
    • The present invention relates to an apparatus and a method for automatically performing chemical, biochemical and biological analyses using the apparatus. The apparatus comprises: a plurality of subsystems for each performing different operations on microtiter plates; a transporting subsystem for automated movement of microtiter plates in three directions X, Y and Z in order to transport plates from one subsystem to another subsystem within the apparatus; a liquid handler comprising at least two liquid handling probes, wherein said liquid handler is integrated in the transporting subsystem; an insertion/removal subsystem for inserting, removing and storing microtiter plates and equipment for sampling and dilution operations, wherein said insertion/removal subsystem is mechanically operated, without the need for electrical components implemented in that subsystem.
    • 本发明涉及使用该装置自动进行化学,生物化学和生物分析的装置和方法。 该装置包括:多个子系统,用于每个在微量滴定板上执行不同的操作; 运输子系统,用于在三个方向X,Y和Z上自动移动微量滴定板,以便将板从一个子系统传送到设备内的另一个子系统; 液体处理器,其包括至少两个液体处理探针,其中所述液体处理器集成在所述输送子系统中; 用于插入,移除和存储用于取样和稀释操作的微量滴定板和设备的插入/移除子系统,其中所述插入/移除子系统是机械操作的,而不需要在该子系统中实现电气部件。