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1. 发明授权

US07517705B2 Phosphorus-containing polymers for optical signal transducers 失效
公开(公告)号：US07517705B2
公开(公告)日：2009-04-14
申请号：US11507329
申请日：2006-08-21
申请人： Ingmar Dorn , Burkhard Kohler
发明人： Ingmar Dorn , Burkhard Kohler
IPC分类号： H01L21/02 , C08F130/02
CPC分类号： G02B6/1221 , C08F8/40 , C08F230/02 , C08F251/02 , C08F275/00 , C09D151/003 , C09D151/02 , C09D153/00 , Y10T428/29 , C08L2666/02
摘要： The invention relates to a phosphorus-containing polymer for coating dielectric materials, to processes for its preparation and to its use, as well as to an optical signal transducer having a coating of the polymer and to its use.

2. 发明申请

US20060287453A1 Phosphorus-containing polymers for optical signal transducers 失效
公开(公告)号：US20060287453A1
公开(公告)日：2006-12-21
申请号：US11507329
申请日：2006-08-21
申请人： Ingmar Dorn , Burkhard Kohler
发明人： Ingmar Dorn , Burkhard Kohler
IPC分类号： C08F30/02
CPC分类号： G02B6/1221 , C08F8/40 , C08F230/02 , C08F251/02 , C08F275/00 , C09D151/003 , C09D151/02 , C09D153/00 , Y10T428/29 , C08L2666/02
摘要： The invention relates to a phosphorus-containing polymer for coating dielectric materials, to processes for its preparation and to its use, as well as to an optical signal transducer having a coating of the polymer and to its use.

3. 发明申请

US20050064604A1 Assay based on doped nanoparticles 失效
标题翻译：基于掺杂纳米粒子的测定
公开(公告)号：US20050064604A1
公开(公告)日：2005-03-24
申请号：US10494390
申请日：2002-11-04
申请人： Kerstin Bohmann , Werner Hoheisel , Burkhard Kohler , Ingmar Dorn
发明人： Kerstin Bohmann , Werner Hoheisel , Burkhard Kohler , Ingmar Dorn
IPC分类号： G01N33/543 , B82B20060101 , B82B1/00 , C12Q1/34 , C12Q1/37 , C12Q1/42 , C12Q1/48 , C12Q1/68 , C40B40/06 , C40B40/10 , G01N21/64 , G01N21/78 , G01N33/52 , G01N33/53 , G01N33/542 , G01N33/553 , G01N33/566 , G01N33/58 , G01N33/60
CPC分类号： B82Y30/00 , B01J2219/005 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00722 , B01J2219/00725 , C12Q1/6818 , C40B40/06 , C40B40/10 , G01N33/542 , C12Q2563/155 , C12Q2545/101
摘要： The invention relates to an assay based on resonance energy transfer (RET), comprising a first molecule grope A, which is marked with at least one energy donor, and at least one second molecule group B which is marked with at least one energy acceptor, the donor comprising a molecule or particle which can be energetically excited by an external radiation source and which is fluorescence enabled and the acceptor comprising a molecule or particle which can be excited by energy transfer via the donor with partial or complete quenching of the donor fluorescence, and the donor and/or acceptor comprise luminescing inorganic dope nanoparticles having an expansion of ≦50 nanometers, emitting electromagnetic radiation with stokes or anti-stokes scattering after energetic excitation.
摘要翻译：本发明涉及基于共振能量转移（RET）的测定法，其包括用至少一个能量给体标记的第一分子曲线A和至少一个第二分子组B，其被至少一个能量受体标记，所述供体包含能够被外部辐射源能量激发并且是荧光使能的分子或颗粒，并且所述受体包含分子或颗粒，所述分子或颗粒可以通过供体荧光的部分或完全猝灭通过供体通过能量转移而被激发，供体和/或受体包括具有<= 50纳米的扩张的发射无机掺杂纳米颗粒，在激发激发后发射具有斯托克斯或反斯托克斯散射的电磁辐射。

4. 发明申请

US20090075273A1 Planar Waveguide Detection Chips and Chambers for Performing Multiple PCR Assays 审中-公开
标题翻译：用于执行多个PCR测定的平面波导检测芯片和室
公开(公告)号：US20090075273A1
公开(公告)日：2009-03-19
申请号：US12092280
申请日：2006-11-09
申请人： Ingmar Dorn , John J. Quinn , Brian D. Warner
发明人： Ingmar Dorn , John J. Quinn , Brian D. Warner
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： G01N21/6428 , G01N21/648 , G01N21/7703
摘要： Provided are planar waveguide (“PWG”) detection chips that are used to perform multiplex PCR and kinetic PCR assays with a single fluorescent dye. The PWG detection chips are housed in PWG detection chambers that house at least one PWG chip. The PWG detection chambers may be in a single chamber or a dual chamber configuration. Also provided are methods for analyzing amplification products using the PWG detection chambers of the present invention.
摘要翻译：提供了用于使用单个荧光染料进行多重PCR和动力学PCR测定的平面波导（“PWG”）检测芯片。 PWG检测芯片安装在容纳至少一个PWG芯片的PWG检测室中。 PWG检测室可以在单室或双室配置中。还提供了使用本发明的PWG检测室分析扩增产物的方法。

5. 发明申请

US20050074803A1 Method for determining an active agent dose 审中-公开
标题翻译：确定活性剂剂量的方法
公开(公告)号：US20050074803A1
公开(公告)日：2005-04-07
申请号：US10947982
申请日：2004-09-23
申请人： Walter Schmitt , Stefan Willmann , Edgar Diessel , Ingmar Dorn , Jens Burmeister
发明人： Walter Schmitt , Stefan Willmann , Edgar Diessel , Ingmar Dorn , Jens Burmeister
IPC分类号： G06F19/18 , G06Q50/24 , C12Q1/68 , G06F17/60 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G06Q50/24 , G16B20/00
摘要： Method for determining the dose of at least one active agent based on a genetic analysis. The method comprises analyzing specific genes for their nucleotide sequence or their expression levels of gene-specific proteins and/or RNA molecules. The gene-specific data is assigned one or more relevant physiological functions of the human or animal body, in particular those which have an influence on the metabolism, absorption, excretion or distribution of the active agent in the body. The gene-specific data and the assigned physiological functions are then integrated into a physiology-based pharmacokinetic model (PBPK model). The PBPK model integrates pharmacokinetic data relating to one or more active agents. The PBPK model may also receive and evaluate patient-specific data directly inputted and combined with data from a knowledge database comprising known values of pharmacokinetic parameters. The PBPK's integration of these data provide a calculation of the individual dose of the active agent.
摘要翻译：基于遗传分析确定至少一种活性剂的剂量的方法。该方法包括分析其核苷酸序列的特定基因或其基因特异性蛋白质和/或RNA分子的表达水平。基因特异性数据被分配人或动物体的一个或多个相关的生理功能，特别是那些对体内活性剂的代谢，吸收，排泄或分布有影响的那些。然后将基因特异性数据和分配的生理功能整合到基于生理学的药代动力学模型（PBPK模型）中。 PBPK模型整合了与一种或多种活性剂有关的药代动力学数据。 PBPK模型还可以接收和评估直接输入的患者特异性数据，并与包括已知的药代动力学参数值的知识数据库的数据组合。 PBPK对这些数据的整合提供了活性剂个体剂量的计算。

6. 发明授权

US09128072B2 Apparatus for automatically performing analyses 有权
标题翻译：用于自动执行分析的装置
公开(公告)号：US09128072B2
公开(公告)日：2015-09-08
申请号：US13121581
申请日：2009-09-24
申请人： Edgar Dieβel , Ingmar Dorn , Michael Habig , Mike Küster , Klaus Ochmann
发明人： Edgar Dieβel , Ingmar Dorn , Michael Habig , Mike Küster , Klaus Ochmann
IPC分类号： G01N35/02 , G01N35/00 , G01N35/10
CPC分类号： G01N35/028 , G01N2035/00306 , G01N2035/00326 , G01N2035/1051 , Y10T436/11
摘要： The present invention relates to an apparatus and a method for automatically performing chemical, biochemical and biological analyses using the apparatus. The apparatus comprises: a plurality of subsystems for each performing different operations on microtiter plates; a transporting subsystem for automated movement of microtiter plates in three directions X, Y and Z in order to transport plates from one subsystem to another subsystem within the apparatus; a liquid handler comprising at least two liquid handling probes, wherein said liquid handler is integrated in the transporting subsystem; an insertion/removal subsystem for inserting, removing and storing microtiter plates and equipment for sampling and dilution operations, wherein said insertion/removal subsystem is mechanically operated, without the need for electrical components implemented in that subsystem.
摘要翻译：本发明涉及使用该装置自动进行化学，生物化学和生物分析的装置和方法。该装置包括：多个子系统，用于每个在微量滴定板上执行不同的操作; 运输子系统，用于在三个方向X，Y和Z上自动移动微量滴定板，以便将板从一个子系统传送到设备内的另一个子系统; 液体处理器，其包括至少两个液体处理探针，其中所述液体处理器集成在所述输送子系统中; 用于插入，移除和存储用于取样和稀释操作的微量滴定板和设备的插入/移除子系统，其中所述插入/移除子系统是机械操作的，而不需要在该子系统中实现电气部件。

7. 发明申请

US20070196479A1 Method For The Timed Dosage Of Medicaments 有权
标题翻译：药物定时剂量的方法
公开(公告)号：US20070196479A1
公开(公告)日：2007-08-23
申请号：US10598416
申请日：2005-02-19
申请人： Stefan Willmann , Walter Schmitt , Jorg Lippert , Ingmar Dorn
发明人： Stefan Willmann , Walter Schmitt , Jorg Lippert , Ingmar Dorn
IPC分类号： A61K9/22 , G06F19/00
CPC分类号： A61M5/1723 , A61M15/00 , A61M15/0083 , A61M16/01 , A61M2005/14208 , G06F19/00 , G06F19/12 , G06F19/26 , G06F19/3468 , G16H50/50 , G16H50/70
摘要： The invention relates to a method for the controlled dosage of a medicament as a function of time by means of a method for the determination of a corresponding dosage profile and corresponding control of a dosage instrument.
摘要翻译：本发明涉及通过用于确定相应剂量分布和剂量仪器的对应控制的方法来控制药物剂量随时间变化的方法。

8. 发明授权

US07046893B2 Layer structure and optical waveguide sensor based on photoaddressable polymers 失效
标题翻译：基于光可寻址聚合物的层结构和光波导传感器
公开(公告)号：US07046893B2
公开(公告)日：2006-05-16
申请号：US10969814
申请日：2004-10-20
申请人： Ingmar Dorn , Thomas Bieringer , Rainer Hagen , Serguei Kostromine , Rino E. Kunz
发明人： Ingmar Dorn , Thomas Bieringer , Rainer Hagen , Serguei Kostromine , Rino E. Kunz
IPC分类号： G02B6/10
CPC分类号： G01N21/7703 , G01N21/648 , G02B1/045
摘要： An optical layer structure having at least two layers and also a sensor based on this layer structure are described. The layer structure comprises at least a substrate layer and at least one (light) waveguide layer and a coupling element for the coupling of the optical beam, the layer adjacent to the waveguide layer having a smaller refractive index than the waveguide layer, and at least one layer consisting of a photoaddressable polymer.
摘要翻译：描述了具有至少两层的光学层结构以及基于该层结构的传感器。该层结构包括至少一个衬底层和至少一个（光）波导层和用于耦合光束的耦合元件，与波导层相邻的具有比波导层更小的折射率的层，并且至少一层由可光寻址聚合物组成。

9. 发明申请

US20060105337A1 Solid phase based nucleic acid assays combining high affinity and high specificity 审中-公开
标题翻译：结合高亲和力和高特异性的基于固相的核酸测定
公开(公告)号：US20060105337A1
公开(公告)日：2006-05-18
申请号：US10525479
申请日：2003-08-29
申请人： Brian Warner , Jack Quinn , Jens Burmeister , Ingmar Dorn , Edgar Diessel
发明人： Brian Warner , Jack Quinn , Jens Burmeister , Ingmar Dorn , Edgar Diessel
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6827 , C12Q1/6834 , C12Q2565/543 , C12Q2561/125 , C12Q2537/143 , C12Q2535/125 , C12Q2565/537 , C12Q2565/519 , C12Q2535/131 , C12Q2525/186
摘要： The invention relates to methods for detection of nucleic acids on a solid phase, combining high affinity and high specificity. More particularly, the invention relates to methods combining high-affinity hybridization with highly specific enzymatic discrimination in solid phase based nucleic acid assays. This invention further relates to kits containing the reagents necessary for carrying out the disclosed assays.
摘要翻译：本发明涉及用于检测固相上核酸的方法，结合高亲和力和高特异性。更具体地，本发明涉及在基于固相的核酸测定中将高亲和力杂交与高度特异性酶鉴别相结合的方法。本发明还涉及包含用于进行所公开的测定所必需的试剂的试剂盒。

10. 发明申请

US20050094958A1 Layer structure and optical waveguide sensor based on photoaddressable polymers 失效
标题翻译：基于光可寻址聚合物的层结构和光波导传感器
公开(公告)号：US20050094958A1
公开(公告)日：2005-05-05
申请号：US10969814
申请日：2004-10-20
申请人： Ingmar Dorn , Thomas Bieringer , Rainer Hagen , Serguei Kostromine , Rino Kunz
发明人： Ingmar Dorn , Thomas Bieringer , Rainer Hagen , Serguei Kostromine , Rino Kunz
IPC分类号： G01N21/77 , G02B1/04 , G02B6/10
CPC分类号： G01N21/7703 , G01N21/648 , G02B1/045
摘要： An optical layer structure having at least two layers and also a sensor based on this layer structure are described. The layer structure comprises at least a substrate layer and at least one (light) waveguide layer and a coupling element for the coupling of the optical beam, the layer adjacent to the waveguide layer having a smaller refractive index than the waveguide layer, and at least one layer consisting of a photoaddressable polymer.
摘要翻译：描述了具有至少两层的光学层结构以及基于该层结构的传感器。该层结构包括至少一个衬底层和至少一个（光）波导层和用于耦合光束的耦合元件，与波导层相邻的具有比波导层更小的折射率的层，并且至少一层由可光寻址聚合物组成。

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