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1. 发明申请

US20170360795A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS 审中-公开
公开(公告)号：US20170360795A1
公开(公告)日：2017-12-21
申请号：US15421020
申请日：2017-01-31
申请人： INFINITY PHARMACEUTICALS, INC.
发明人： Howard M. Stern , Jeffery L. Kutok
IPC分类号： A61K31/52 , A61K39/395 , A61K45/06 , A61K31/519 , C07D473/34 , C07K16/28 , C12Q1/68
CPC分类号： A61K31/52 , A61K31/519 , A61K39/39558 , A61K45/06 , C07D473/34 , C07K16/2887 , C12Q1/6886 , C12Q2600/156 , C12Q2600/158 , A61K2300/00
摘要： Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders.

2. 发明授权

US11110096B2 Combination therapies 有权
公开(公告)号：US11110096B2
公开(公告)日：2021-09-07
申请号：US15587208
申请日：2017-05-04
申请人： Infinity Pharmaceuticals, Inc.
发明人： Jeffery L. Kutok , Howard M. Stern
IPC分类号： A61K31/52 , A61K31/5377 , A61K45/06 , A61K31/437 , A61K31/496
摘要： Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor or a pharmaceutically acceptable form thereof, and a Bcl-2 inhibitor or a pharmaceutically acceptable form thereof. Also provided herein are methods for treating cancer comprising administration the compositions, and uses of the compositions, e.g., for the treatment of cancer.

3. 发明申请

US20150320755A1 COMBINATION THERAPIES 审中-公开
标题翻译：组合治疗
公开(公告)号：US20150320755A1
公开(公告)日：2015-11-12
申请号：US14687768
申请日：2015-04-15
申请人： INFINITY PHARMACEUTICALS, INC.
发明人： Jeffery L. Kutok , Howard M. Stern
IPC分类号： A61K31/52 , A61K31/5377 , A61K45/06 , A61K31/496
CPC分类号： A61K31/52 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor or a pharmaceutically acceptable form thereof, and a Bcl-2 inhibitor or a pharmaceutically acceptable form thereof. Also provided herein are methods for treating cancer comprising administration the compositions, and uses of the compositions, e.g., for the treatment of cancer.
摘要翻译：本文提供了包含磷脂酰肌醇3-激酶抑制剂或其药学上可接受的形式和Bcl-2抑制剂或其药学上可接受的形式的药物组合物。本文还提供了治疗癌症的方法，包括给予组合物，以及组合物的用途，例如用于治疗癌症。

4. 发明申请

US20170348314A1 COMBINATION THERAPIES 审中-公开
公开(公告)号：US20170348314A1
公开(公告)日：2017-12-07
申请号：US15409912
申请日：2017-01-19
申请人： INFINITY PHARMACEUTICALS, INC.
发明人： Jeffery L. Kutok , Howard M. Stern
IPC分类号： A61K31/52 , A61K45/06 , A61K31/573
CPC分类号： A61K31/52 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor, or pharmaceutically acceptable form thereof, in combination with a second agent, or a pharmaceutically acceptable form thereof, wherein the second agent is chosen from one or more of 1) a CDK4/6 inhibitor, 2) an HDAC inhibitor, 3) a MEK inhibitor, 4) a mTOR inhibitor, 5) an AKT inhibitor, 6) a proteasome inhibitor, 7) an immunomodulator, 8) a glucocorticosteroid, 9) a BET inhibitor, 10) an epigenetic inhibitor, 11) a PI3K alpha inhibitor, 12) a topoisomerase inhibitor, or 13) an ERK inhibitor. Also provided herein are methods of treatment comprising administration of the compositions, and uses of the compositions, e.g., for treatment of cancer.

5. 发明申请

US20150320754A1 COMBINATION THERAPIES 审中-公开
标题翻译：组合治疗
公开(公告)号：US20150320754A1
公开(公告)日：2015-11-12
申请号：US14687714
申请日：2015-04-15
申请人： INFINITY PHARMACEUTICALS, INC.
发明人： Jeffery L. Kutok , Howard M. Stern
IPC分类号： A61K31/52 , A61K45/06 , A61K31/573
CPC分类号： A61K31/52 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor, or pharmaceutically acceptable form thereof, in combination with a second agent, or a pharmaceutically acceptable form thereof, wherein the second agent is chosen from one or more of 1) a CDK4/6 inhibitor, 2) an HDAC inhibitor, 3) a MEK inhibitor, 4) a mTOR inhibitor, 5) an AKT inhibitor, 6) a proteasome inhibitor, 7) an immunomodulator, 8) a glucocorticosteroid, 9) a BET inhibitor, 10) an epigenetic inhibitor, 11) a PI3K alpha inhibitor, 12) a topoisomerase inhibitor, or 13) an ERK inhibitor. Also provided herein are methods of treatment comprising administration of the compositions, and uses of the compositions, e.g., for treatment of cancer.
摘要翻译：本文提供了包含磷脂酰肌醇3-激酶抑制剂或其药学上可接受的形式与第二药剂或其药学上可接受的形式组合的药物组合物，其中第二药剂选自1）CDK4 / 6中的一种或多种抑制剂，2）HDAC抑制剂，3）MEK抑制剂，4）mTOR抑制剂，5）AKT抑制剂，6）蛋白酶体抑制剂，7）免疫调节剂，8）糖皮质激素，9）BET抑制剂，10）表观遗传抑制剂，11）PI3Kα抑制剂，12）拓扑异构酶抑制剂，或13）ERK抑制剂。本文还提供了包括施用组合物的治疗方法，以及组合物的用途，例如用于治疗癌症。

6. 发明申请

US20150283142A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS 审中-公开
标题翻译：使用PI3激动剂ISOFORM调节器治疗癌症
公开(公告)号：US20150283142A1
公开(公告)日：2015-10-08
申请号：US14439965
申请日：2013-11-01
申请人： INFINITY PHARMACEUTICALS, INC.
发明人： Howard M. Stern , Jeffery L. Kutok
IPC分类号： A61K31/52 , A61K31/519 , A61K31/704 , G01N15/10 , A61K31/505 , G01N33/574 , G01N33/50 , C07D473/34 , A61K45/06
CPC分类号： A61K31/52 , A61K31/505 , A61K31/519 , A61K31/704 , A61K45/06 , C07D401/12 , C07D471/04 , C07D473/00 , C07D473/34 , G01N33/5011 , G01N33/574 , G01N2333/521 , G01N2333/525 , G01N2333/53 , G01N2333/5434 , G01N2333/9121 , G01N2333/96494 , A61K2300/00
摘要： Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders.
摘要翻译：本文提供了包括用于治疗癌症或血液学障碍的PI3激酶抑制剂的方法，试剂盒和药物组合物。

7. 发明授权

US11944631B2 Combination therapies 有权
公开(公告)号：US11944631B2
公开(公告)日：2024-04-02
申请号：US17391869
申请日：2021-08-02
申请人： Infinity Pharmaceuticals, Inc.
发明人： Jeffery L Kutok , Howard M. Stern
IPC分类号： A61K31/52 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06
CPC分类号： A61K31/52 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K31/52 , A61K2300/00 , A61K31/437 , A61K2300/00 , A61K31/496 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor or a pharmaceutically acceptable form thereof, and a Bcl-2 inhibitor or a pharmaceutically acceptable form thereof. Also provided herein are methods for treating cancer comprising administration the compositions, and uses of the compositions, e.g., for the treatment of cancer.

8. 发明申请

US20210060022A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS 有权
公开(公告)号：US20210060022A1
公开(公告)日：2021-03-04
申请号：US16848485
申请日：2020-04-14
申请人： Infinity Pharmaceuticals, Inc.
发明人： Howard M. Stern , Jeffrey L. Kutok
IPC分类号： A61K31/52 , C07D473/34 , A61K31/519 , A61K31/704 , A61K45/06 , A61K31/505 , G01N33/574 , G01N33/50 , C07D401/12 , C07D471/04 , C07D473/00
摘要： Provided herein are methods, kits, and pharmaceutical compositions that include a P13 kinase inhibitor for treating cancers or hematologic disorders.

9. 发明申请

US20180055847A1 COMBINATION THERAPIES 审中-公开
公开(公告)号：US20180055847A1
公开(公告)日：2018-03-01
申请号：US15587208
申请日：2017-05-04
申请人： Infinity Pharmaceuticals, Inc.
发明人： Jeffery L. Kutok , Howard M. Stern
IPC分类号： A61K31/52 , A61K45/06 , A61K31/437 , A61K31/496 , A61K31/5377
CPC分类号： A61K31/52 , A61K31/437 , A61K31/496 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： Provided herein are pharmaceutical compositions comprising a phosphatidylinositol 3-kinase inhibitor or a pharmaceutically acceptable form thereof, and a Bcl-2 inhibitor or a pharmaceutically acceptable form thereof. Also provided herein are methods for treating cancer comprising administration the compositions, and uses of the compositions, e.g., for the treatment of cancer.

10. 发明申请

US20180015093A1 TREATMENT OF CANCERS USING PI3 KINASE ISOFORM MODULATORS 审中-公开
公开(公告)号：US20180015093A1
公开(公告)日：2018-01-18
申请号：US15581414
申请日：2017-04-28
申请人： Infinity Pharmaceuticals, Inc.
发明人： Howard M. Stern , Jeffrey L. Kutok
IPC分类号： A61K31/52 , A61K31/519 , A61K31/704 , A61K45/06 , C07D401/12 , C07D473/00 , C07D473/34 , G01N33/574 , A61K31/505 , G01N15/10 , G01N33/50 , C07D471/04 , G01N15/00
CPC分类号： A61K31/52 , A61K31/505 , A61K31/519 , A61K31/704 , A61K45/06 , C07D401/12 , C07D471/04 , C07D473/00 , C07D473/34 , G01N33/5011 , G01N33/574 , G01N2333/521 , G01N2333/525 , G01N2333/53 , G01N2333/5434 , G01N2333/9121 , G01N2333/96494 , A61K2300/00
摘要： Provided herein are methods, kits, and pharmaceutical compositions that include a PI3 kinase inhibitor for treating cancers or hematologic disorders.

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