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1. 发明申请

US20210268141A1 SUPERABSORBENT, FREEZE DRIED HYDROGELS FOR MEDICAL APPLICATIONS 有权
公开(公告)号：US20210268141A1
公开(公告)日：2021-09-02
申请号：US17174476
申请日：2021-02-12
申请人： Incept, LLC
发明人： Amarpreet S. Sawhney , Steven L. Bennett , Suresh S. Pai , Scott R. Sershen , Fred H. Co
IPC分类号： A61L24/00 , A61L24/04 , A61L24/10
摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

2. 发明授权

US10940231B2 Superabsorbent, freeze dried hydrogels for medical applications 有权
公开(公告)号：US10940231B2
公开(公告)日：2021-03-09
申请号：US14327245
申请日：2014-07-09
申请人： Incept, LLC
发明人： Amarpreet S. Sawhney , Steven L. Bennett , Suresh S. Pai , Scott R. Sershen , Fred H. Co
IPC分类号： A61L24/00 , A61L24/04 , A61L24/10 , A61B17/00
摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

3. 发明申请

US20140341836A1 SUPERABSORBENT, FREEZE DRIED HYDROGELS FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：用于医疗应用的冷冻干燥水凝胶
公开(公告)号：US20140341836A1
公开(公告)日：2014-11-20
申请号：US14327245
申请日：2014-07-09
申请人： Incept, LLC
发明人： Amarpreet S. Sawhney , Steven L. Bennett , Suresh S. Pai , Scott R. Sershen , Fred H. Co
IPC分类号： A61L24/00 , A61L24/10 , A61L24/04
CPC分类号： A61L24/0031 , A61B2017/0065 , A61L24/046 , A61L24/10 , C08L71/02
摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.
摘要翻译：提供了用于制备冻干的水凝胶和其结构的方法，其可以被引入患者体内用于医疗应用。组合前体组分以引发交联。将组合的前体组分置于冷藏的托盘中，并在放置在托盘上之前和/或之后使其交联至所需水平的完全交联。将部分交联的水凝胶冷冻并冷冻干燥。冷冻干燥后，将水凝胶调节至基本上完全交联，并形成一种或多种结构，例如塞子，止血剂或其他医疗装置。例如，水凝胶可以被切割，机加工，滚压，折叠，压缩和/或加工成可以被加载到可被引入到体内的输送装置中以将结构植入或以其他方式将结构输送到体内，例如密封穿刺或穿过组织的其他通道。

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