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1. 发明授权

US08012982B2 Modulators of HCV replication 失效
标题翻译： HCV复制的调节剂
公开(公告)号：US08012982B2
公开(公告)日：2011-09-06
申请号：US11664580
申请日：2005-09-29
申请人： Immacolata Conte , Caterina Ercolani , Claudio Giuliano , Giovanni Migliaccio , Gessica Filocamo, legal representative , Veronica Suriano, legal representative , Ian Stansfield
发明人： Immacolata Conte , Caterina Ercolani , Claudio Giuliano , Giovanni Migliaccio , Ian Stansfield
IPC分类号： A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号： C07D295/185 , C07D277/62 , C07D295/155
摘要： The present invention is directed to compounds of formula (I): where X, Y, R1, R2 and R3 are defined therein, which can act as modulators of viral replication and/or virus production, especially of the hepatitis C virus (HCV).
摘要翻译：本发明涉及式（I）化合物：其中X，Y，R 1，R 2和R 3在其中定义，其可以作为病毒复制和/或病毒产生的调节剂，特别是丙型肝炎病毒（HCV）。

2. 发明申请

US20090069344A1 Modulators of hcv replication 失效
标题翻译： hcv复制调制器
公开(公告)号：US20090069344A1
公开(公告)日：2009-03-12
申请号：US11664580
申请日：2005-09-29
申请人： Immacolata Conte , Caterina Ercolani , Claudio Giuliano , Giovanni Migliaccio , Ian Stansfield , Gessica Filocamo , Veronica Suriano
发明人： Immacolata Conte , Caterina Ercolani , Claudio Giuliano , Giovanni Migliaccio , Ian Stansfield , Gessica Filocamo , Veronica Suriano
IPC分类号： A61K31/4965 , C07D241/04 , C12Q1/70 , A61P31/12 , C12N5/08 , C07D241/18
CPC分类号： C07D295/185 , C07D277/62 , C07D295/155
摘要： The present invention is directed to compounds of formula (I): where X, Y, R1, R2 and R3 are defined therein, which can act as modulators of viral replication and/or virus production, especially of the hepatitis C virus (HCV).
摘要翻译：本发明涉及式（I）化合物：其中X，Y，R 1，R 2和R 3在其中定义，其可以作为病毒复制和/或病毒产生的调节剂，特别是丙型肝炎病毒（HCV）。

3. 发明授权

US07091209B2 Dihydroxypyridmidine carboxylic acids as viral polymerase inhibitors 失效
标题翻译：二羟基吡啶并咪唑羧酸作为病毒聚合酶抑制剂
公开(公告)号：US07091209B2
公开(公告)日：2006-08-15
申请号：US10333431
申请日：2001-07-11
申请人： Cristina Gardelli , Claudio Giuliano , Steven Harper , Uwe Koch , Frank Narjes , Jesus Maria Ontoria Ontoria , Marco Poma , Simona Ponzi , Ian Stansfield , Vincenzo Summa
发明人： Cristina Gardelli , Claudio Giuliano , Steven Harper , Uwe Koch , Frank Narjes , Jesus Maria Ontoria Ontoria , Marco Poma , Simona Ponzi , Ian Stansfield , Vincenzo Summa
IPC分类号： C07D239/557 , C07D409/04 , C07D409/12 , C07D417/14 , C07D401/12
CPC分类号： C07D239/557 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： A class of 2-aryl-4,5-dihydroxy-6-carboxypyrimidines of formula (I): wherein Ar is an optionally substituted aryl or heterocyclicgroup; as well as compounds of formula (I) which are derivatized at one or more of the 4-hydroxy, 5-hydroxy or 6-carboxy groups; and tautomers thereof, and pharmaceutically acceptable salts or esters thereof; and inhibitors of viral polymerases, especially the hepatitis C virus (HCV) polymerase enzyme
摘要翻译：一类式（I）的2-芳基-4,5-二羟基-6-羧基嘧啶：其中Ar是任选取代的芳基或杂环基; 以及在一个或多个4-羟基，5-羟基或6-羧基衍生化的式（I）化合物; 及其互变异构体及其药学上可接受的盐或酯; 和病毒聚合酶抑制剂，特别是丙型肝炎病毒（HCV）聚合酶

4. 发明授权

US08895586B2 Methods of treating emesis 有权
标题翻译：治疗呕吐的方法
公开(公告)号：US08895586B2
公开(公告)日：2014-11-25
申请号：US13864381
申请日：2013-04-17
申请人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： A61K31/444 , A61K31/497 , C07D213/02 , C07D401/04 , A61K31/44 , C07D213/89 , A61K31/496 , A61K31/56 , C07D213/74 , A61K45/06
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
摘要翻译：公开了用于预防和/或治疗由神经激肽（NK1）受体病理生理介导的疾病的化合物，组合物和方法。该化合物具有通式（I）：

5. 发明授权

US08658797B2 Asymmetric ureas and medical uses thereof 有权
标题翻译：不对称尿素及其医疗用途
公开(公告)号：US08658797B2
公开(公告)日：2014-02-25
申请号：US13404165
申请日：2012-02-24
申请人： Silvina Garcia Rubio , Claudio Giuliano , Claudio Pietra , Zhigang Li
发明人： Silvina Garcia Rubio , Claudio Giuliano , Claudio Pietra , Zhigang Li
IPC分类号： C07D211/56 , A61K31/445
CPC分类号： C07D211/58 , A61K31/4468 , A61K31/4525 , A61K31/4545 , A61K31/5375 , C07D211/60 , C07D211/94 , C07D211/96 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I):
摘要翻译：公开了用于预防和/或治疗由生长素释放肽受体病理生理介导的疾病的化合物，组合物和方法。该化合物具有通式（I）：

6. 发明授权

US08426450B1 Substituted 4-phenyl pyridines having anti-emetic effect 有权
标题翻译：取代的具有抗呕吐作用的4-苯基吡啶
公开(公告)号：US08426450B1
公开(公告)日：2013-04-23
申请号：US13478361
申请日：2012-05-23
申请人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stella
IPC分类号： A61K31/44
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
摘要翻译：公开了用于预防和/或治疗由神经激肽（NK1）受体病理生理介导的疾病的化合物，组合物和方法。该化合物具有通式（I）：

7. 发明申请

US20130231315A1 MODIFIED 4-PHENYL-PYRIDINE DERIVATIVES 有权
标题翻译：改性的4-苯基 - 吡啶衍生物
公开(公告)号：US20130231315A1
公开(公告)日：2013-09-05
申请号：US13864381
申请日：2013-04-17
申请人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stell
发明人： Luca Fadini , Peter Manini , Claudio Pietra , Claudio Giuliano , Emanuela Lovati , Roberta Cannella , Alessio Venturini , Valentino J. Stell
IPC分类号： C07D213/74 , A61K45/06 , A61K31/56 , C07D213/89 , A61K31/496
CPC分类号： C07F9/650952 , A61K31/44 , A61K31/473 , A61K31/496 , A61K31/56 , A61K31/675 , A61K45/06 , C07D213/74 , C07D213/89 , C07D401/04
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the neurokinin (NK1) receptor. The compounds have the general formula (I):
摘要翻译：公开了用于预防和/或治疗由神经激肽（NK1）受体病理生理介导的疾病的化合物，组合物和方法。该化合物具有通式（I）：

8. 发明申请

US20120220629A1 ASYMMETRIC UREAS AND MEDICAL USES THEREOF 有权
标题翻译：非对称性尿路及其医疗用途
公开(公告)号：US20120220629A1
公开(公告)日：2012-08-30
申请号：US13404165
申请日：2012-02-24
申请人： Silvina GARCIA RUBIO , Claudio Pietra , Claudio Giuliano , Zhigang Li
发明人： Silvina GARCIA RUBIO , Claudio Pietra , Claudio Giuliano , Zhigang Li
IPC分类号： A61K31/4468 , A61P3/04 , A61P3/10 , A61P3/00 , A61P9/04 , A61P21/00 , A61P1/16 , A61P11/00 , A61P1/00 , A61P25/30 , A61P3/08 , A61P5/48 , A61P3/06 , A61P9/10 , A61P9/00 , A61P25/00 , A61P9/12 , A61P7/00 , A61P1/04 , A61P25/32 , A61P25/36 , C07D211/58
CPC分类号： C07D211/58 , A61K31/4468 , A61K31/4525 , A61K31/4545 , A61K31/5375 , C07D211/60 , C07D211/94 , C07D211/96 , C07D401/06 , C07D401/12 , C07D405/12 , C07D413/12
摘要： Disclosed are compounds, compositions and methods for the prevention and/or treatment of diseases which are pathophysiologically mediated by the ghrelin receptor. The compounds have the general formula (I):
摘要翻译：公开了用于预防和/或治疗由生长素释放肽受体病理生理介导的疾病的化合物，组合物和方法。该化合物具有通式（I）：

9. 发明授权

US4923354A Magazine with movable shelves, for the maturation of cakes of synthetic foam material 失效
标题翻译：具有可移动货架的杂志，用于成熟合成泡沫材料的蛋糕
公开(公告)号：US4923354A
公开(公告)日：1990-05-08
申请号：US267164
申请日：1988-10-24
申请人： Claudio Giuliano , Pier E. Gilardi
发明人： Claudio Giuliano , Pier E. Gilardi
IPC分类号： B29C67/20 , B65G1/02 , B65G49/08
CPC分类号： B65G49/085 , B65G1/026
摘要： A magazine for the maturation of cakes of synthetic foam material, for a plant served by a conveyor belt bringing the cakes for distribution in the magazine, and by an overhead crane with a gripper intended for lifting a cake from the belt conveyor, for shifting it laterally and for depositing the same into a maturation space, which comprises stands arranged parallel to and at the side of the belt conveyor; each stand comprises a frame which supports a fixed lower shelf whose width and length are adapted to the width and length of the cakes to be received, and above the fixed shelf, at vertical mutual distances somewhat greater than the height of the cakes to be received, a plurality of movable shelves for receiving the cakes; each movable shelf is shiftable between a working position, in which it constitutes a surface whose width and length are adapted to the width and length of the cakes to be received, and a rest position, in which it leaves free the access from above to the shelf lying below. The rest position of the movable shelves is preferably arranged below the fixed shelf.
摘要翻译：一种用于合成泡沫材料的蛋糕成熟的杂志，用于将输送带带入蛋糕以供分配到杂志的工厂所用的工厂，以及用于将带状输送机上的蛋糕从其上移动的具有夹持器的高架起重机横向地并用于将其沉积到成熟空间中，该成熟空间包括平行于带式输送机并在其侧面设置的台架; 每个支架包括框架，其支撑固定的下搁架，其宽度和长度适应于待接收的蛋糕的宽度和长度，并且在固定搁架上方，在垂直相互距离处稍大于待接收的蛋糕的高度，多个用于接收蛋糕的活动搁架; 每个可移动搁架可在工作位置之间移动，在该工作位置，工作位置构成其宽度和长度适应于待接收的蛋糕的宽度和长度的表面，以及静止位置，其中从上方到达架子躺在下面。可动搁架的静止位置优选地设置在固定架的下方。

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