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1. 发明申请

US20070150006A1 Neural stimulator to treat sleep disordered breathing 有权
标题翻译：神经刺激剂治疗睡眠呼吸紊乱
公开(公告)号：US20070150006A1
公开(公告)日：2007-06-28
申请号：US11320500
申请日：2005-12-28
申请人： Imad Libbus , Anthony Caparso , M. Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人： Imad Libbus , Anthony Caparso , M. Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号： A61N1/32
CPC分类号： A61N1/36185 , A61N1/3611
摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.
摘要翻译：各种方面涉及可植入装置。各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和与脉冲发生器。所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。本文提供了其它方面和实施例。

2. 发明申请

US20060282131A1 System for neural control of respiration 有权
公开(公告)号：US20060282131A1
公开(公告)日：2006-12-14
申请号：US11151122
申请日：2005-06-13
申请人： Anthony Caparso , Imad Libbus , M. Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony Caparso , Imad Libbus , M. Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/00
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

3. 发明申请

US20110319959A1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 有权
标题翻译：神经控制系统
公开(公告)号：US20110319959A1
公开(公告)日：2011-12-29
申请号：US13229211
申请日：2011-09-09
申请人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

4. 发明授权

US07672728B2 Neural stimulator to treat sleep disordered breathing 有权
公开(公告)号：US07672728B2
公开(公告)日：2010-03-02
申请号：US11320500
申请日：2005-12-28
申请人： Imad Libbus , Anthony Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人： Imad Libbus , Anthony Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号： A61N1/00
CPC分类号： A61N1/36185 , A61N1/3611
摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.

5. 发明申请

US20120323292A1 SYSTEM FOR NEURAL CONTROL OF RESPIRATION 有权
标题翻译：神经控制系统
公开(公告)号：US20120323292A1
公开(公告)日：2012-12-20
申请号：US13596595
申请日：2012-08-28
申请人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

6. 发明申请

US20100121406A1 NEURAL STIMULATOR TO TREAT SLEEP DISORDERED BREATHING 有权
标题翻译：神经刺激器治疗睡眠障碍性呼吸
公开(公告)号：US20100121406A1
公开(公告)日：2010-05-13
申请号：US12691392
申请日：2010-01-21
申请人： Imad Libbus , Anthony Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
发明人： Imad Libbus , Anthony Caparso , M. Jason Brooke , Jonathan Kwok , Kent Lee , Yachuan Pu
IPC分类号： A61N1/36
CPC分类号： A61N1/36185 , A61N1/3611
摘要： Various aspects relate to an implantable device. Various device embodiments include at least one sensor for use in detecting sleep disordered breathing, a pulse generator adapted to deliver a first electrical signal through at least one electrode to stimulate a neural target, and a controller adapted to communicate with the at least one sensor and with the pulse generator. The controller is adapted to detect sleep disordered breathing using the at least one sensor and provide a therapy for sleep disordered breathing in response to a detected apneic event. The therapy for sleep disordered breathing is adapted to deliver the first electrical signal through the at least one electrode to induce a cough reflex to terminate the apneic event. Various embodiments stimulate a superior laryngeal nerve, various embodiments stimulate a recurrent laryngeal nerve, and various embodiments stimulate a vagus nerve. Other aspects and embodiments are provided herein.
摘要翻译：各种方面涉及可植入装置。各种装置实施例包括用于检测睡眠无序呼吸的至少一个传感器，适于通过至少一个电极传递第一电信号以刺激神经靶的脉冲发生器，以及适于与至少一个传感器和与脉冲发生器。所述控制器适于使用所述至少一个传感器检测睡眠呼吸障碍，并响应于检测到的呼吸暂停事件提供针对睡眠呼吸障碍的治疗。用于睡眠呼吸紊乱的治疗适于通过至少一个电极传递第一电信号以引起咳嗽反射以终止呼吸暂停事件。各种实施方案刺激上喉神经，各种实施方案刺激复发性喉神经，并且各种实施方案刺激迷走神经。本文提供了其它方面和实施例。

7. 发明授权

US08036750B2 System for neural control of respiration 有权
标题翻译：呼吸神经控制系统
公开(公告)号：US08036750B2
公开(公告)日：2011-10-11
申请号：US11151122
申请日：2005-06-13
申请人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/18
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.
摘要翻译：提供了一种用于呼吸神经控制的系统，装置和方法。本公开的一个方面涉及用于在中枢呼吸系统疾病发作期间感测和控制呼吸的可植入医疗装置。根据各种实施例，该装置包括感测电路，用于接收代表中枢呼吸系统疾病发生率的感测信号。该装置还包括适于产生神经刺激信号的神经刺激器，以及响应于检测到中枢性呼吸系统疾病发生率而控制器与感测电路通信并控制神经刺激器以刺激所需神经靶标。在一个实施例中，该装置包括多个传感器，其适于监测生理参数以检测中枢性呼吸系统疾病的发生并向感测电路发送信号。本文提供了其它方面和实施例。

8. 发明授权

US08050765B2 Method and apparatus for controlling neural stimulation during disordered breathing 有权
标题翻译：在无序呼吸期间控制神经刺激的方法和装置
公开(公告)号：US08050765B2
公开(公告)日：2011-11-01
申请号：US11468603
申请日：2006-08-30
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/08
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

9. 发明授权

US08401651B2 System for neural control of respiration 有权
公开(公告)号：US08401651B2
公开(公告)日：2013-03-19
申请号：US13229211
申请日：2011-09-09
申请人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
发明人： Anthony V. Caparso , Imad Libbus , M. Jason Brooke , Kent Lee , Jonathan Kwok , Yachuan Pu
IPC分类号： A61N1/18
CPC分类号： A61N1/3601 , A61N1/36114
摘要： A system, device and method for neural control of respiration are provided. One aspect of this disclosure relates to an implantable medical device for sensing and controlling respiration during incidence of central respiratory diseases. According to various embodiments, the device includes a sensing circuit to receive sensed signals representative of an incidence of a central respiratory disease. The device also includes a neural stimulator adapted to generate neural stimulation signals, and a controller to communicate with the sensing circuit and to control the neural stimulator to stimulate a desired neural target in response to the detection of the incidence of a central respiratory disease. In an embodiment, the device includes a plurality of sensors which are adapted to monitor physiological parameters to detect the incidence of a central respiratory disease and to send signals to the sensing circuit. Other aspects and embodiments are provided herein.

10. 发明申请

US20120046709A1 METHOD AND APPARATUS FOR CONTROLLING NEURAL STIMULATION DURING DISORDERED BREATHING 有权
标题翻译：用于控制异常呼吸期间神经刺激的方法和装置
公开(公告)号：US20120046709A1
公开(公告)日：2012-02-23
申请号：US13285457
申请日：2011-10-31
申请人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
发明人： Kent Lee , Imad Libbus , Anthony V. Caparso , Jonathan Kwok , Yachuan Pu , Paul A. Haefner , Kristofer J. James
IPC分类号： A61N1/365 , A61N1/36
CPC分类号： A61N1/36135 , A61B5/0215 , A61B5/08 , A61B5/0816 , A61B5/4035 , A61B5/4818 , A61N1/3601
摘要： A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.
摘要翻译：神经刺激系统使用呼吸信号作为治疗反馈输入来控制神经刺激的传递。呼吸信号用于增加神经刺激的有效性，例如迷走神经刺激，同时减少呼吸功能的潜在不利副作用。在一个实施例中，神经刺激系统检测呼吸暂停，并且作为响应调整神经刺激脉冲的传递和/或递送治疗所检测的呼吸暂停的呼吸治疗。

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