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1. 发明授权

US6121037A Bacterial hemoglobin receptor genes 失效
标题翻译：细菌血红蛋白受体基因
公开(公告)号：US6121037A
公开(公告)日：2000-09-19
申请号：US537361
申请日：1995-10-02
申请人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
发明人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
IPC分类号： C12N15/09 , A61K38/00 , A61K39/00 , A61K39/095 , A61K39/112 , A61K39/395 , A61P31/04 , C07K14/22 , C12N1/21 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/19 , C12R1/91 , C12N15/31 , C12N15/74
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： The present invention relates to novel bacterial hemoglobin receptor proteins and genes that encode such proteins. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of bacterial hemoglobin receptor proteins, nucleic acid encoding such proteins, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis and serotypes thereof, and N. gonorrhoeae. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effective in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.
摘要翻译：本发明涉及新型细菌血红蛋白受体蛋白和编码这些蛋白质的基因。本发明涉及细菌血红蛋白受体蛋白质的分离，表征，诊断和治疗用途，编码这些蛋白质的核酸，包含这种核酸的重组表达构建体和与其转化的细胞，以及这些血红蛋白受体蛋白质的抗体和表位。本发明特别涉及血红蛋白受体蛋白质和编码奈瑟氏菌属物种，特别是脑膜炎奈瑟氏球菌及其血清型和淋病奈瑟氏球菌的蛋白质的基因。还提供了本发明的蛋白质，表位，抗体和核酸的诊断和治疗用途的方法，包括使用本发明的蛋白质，表位，抗体和核酸来生产有效提供免疫接种的疫苗一种人抵抗奈瑟氏球菌病原菌的感染。

2. 发明授权

US07026157B1 Bacterial hemoglobin receptor genes 失效
标题翻译：细菌血红蛋白受体基因
公开(公告)号：US07026157B1
公开(公告)日：2006-04-11
申请号：US09665358
申请日：2000-09-19
申请人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
发明人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
IPC分类号： C12N1/21 , C12N15/31 , C12N15/63 , C12N15/74
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： The present invention relates to novel bacterial hemoglobin receptor proteins and genes that encode such proteins. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of bacterial hemoglobin receptor proteins, nucleic acid encoding such proteins, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis and serotypes thereof, and N. gonorrhoeae. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effectinve in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.
摘要翻译：本发明涉及新型细菌血红蛋白受体蛋白和编码这些蛋白质的基因。本发明涉及细菌血红蛋白受体蛋白质的分离，表征，诊断和治疗用途，编码这些蛋白质的核酸，包含这种核酸的重组表达构建体和与其转化的细胞，以及这些血红蛋白受体蛋白质的抗体和表位。本发明特别涉及血红蛋白受体蛋白质和编码奈瑟氏菌属物种，特别是脑膜炎奈瑟氏球菌及其血清型和淋病奈瑟氏球菌的蛋白质的基因。还提供了用于本发明的蛋白质，表位，抗体和核酸的诊断和治疗用途的方法，包括使用本发明的蛋白质，表位，抗体和核酸来生产疫苗，其用于免疫接种一种人抵抗奈瑟氏球菌病原菌的感染。

3. 发明授权

US06277382B1 Hemoglobin receptors from neisseriae 失效
标题翻译：来自奈瑟氏球菌的血红蛋白受体
公开(公告)号：US06277382B1
公开(公告)日：2001-08-21
申请号：US08817707
申请日：1997-08-19
申请人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
发明人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
IPC分类号： A61K39095
CPC分类号： C07K14/22
摘要： The present invention relates to novel bacterial hemoglobin receptor proteins and genes that encode such proteins. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of bacterial hemoglobin receptor proteins, nucleic acids encoding such proteins, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis and serotypes thereof, and N. gonorrhoeae. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effective in providing immunization of human against infection by pathogenic bacteria of Neisseria species.
摘要翻译：本发明涉及新型细菌血红蛋白受体蛋白和编码这些蛋白质的基因。本发明涉及细菌血红蛋白受体蛋白质的分离，表征，诊断和治疗用途，编码这些蛋白质的核酸，包含这种核酸的重组表达构建体和与其转化的细胞，以及这些血红蛋白受体蛋白的抗体和表位。本发明特别涉及血红蛋白受体蛋白质和编码奈瑟氏菌属物种，特别是脑膜炎奈瑟氏球菌及其血清型和淋病奈瑟氏球菌的蛋白质的基因。还提供了本发明的蛋白质，表位，抗体和核酸的诊断和治疗用途的方法，包括使用本发明的蛋白质，表位，抗体和核酸来生产有效提供人免疫的疫苗针对奈瑟氏菌属病原菌感染。

4. 发明授权

US6123942A Bacterial hemoglobin receptor gene 失效
标题翻译：细菌血红蛋白受体基因
公开(公告)号：US6123942A
公开(公告)日：2000-09-26
申请号：US990470
申请日：1997-12-15
申请人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
发明人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
IPC分类号： A61K38/00 , A61K39/00 , C07K14/22 , C12N1/21 , A61K39/02 , A61K39/095 , C07K1/00
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： The present invention relates to a novel bacterial hemoglobin receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of a bacterial hemoglobin receptor protein, nucleic acid encoding such a protein, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effectinve in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.
摘要翻译：本发明涉及一种新的细菌性血红蛋白受体蛋白质和编码这种蛋白质的基因。本发明涉及细菌血红蛋白受体蛋白的分离，表征，诊断和治疗用途，编码这种蛋白质的核酸，包含这种核酸的重组表达构建体和与其转化的细胞，以及这些血红蛋白受体蛋白的抗体和表位。本发明特别涉及血红蛋白受体蛋白和编码奈瑟氏球菌（Neisseria），特别是脑膜炎奈瑟氏菌（N脑膜炎奈瑟氏球菌）的蛋白质的基因。还提供了用于本发明的蛋白质，表位，抗体和核酸的诊断和治疗用途的方法，包括使用本发明的蛋白质，表位，抗体和核酸来生产疫苗，其用于免疫接种一种人抵抗奈瑟氏球菌病原菌的感染。

5. 发明授权

US5698438A Bacterial hemoglobin receptor gene 失效
标题翻译：细菌血红蛋白受体基因
公开(公告)号：US5698438A
公开(公告)日：1997-12-16
申请号：US326670
申请日：1994-10-18
申请人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
发明人： Igor Stojiljkovic , Magdalene So , Vivian Hwa , Fred Heffron , Xavier Nassif
IPC分类号： A61K38/00 , A61K39/00 , C07K14/22 , C12N1/21 , C12N15/31 , C12N15/74
CPC分类号： C07K14/22 , A61K38/00 , A61K39/00 , Y10S530/825
摘要： The present invention relates to a novel bacterial hemoglobin receptor protein and genes that encode such a protein. The invention is directed toward the isolation, characterization, diagnostic and therapeutic use of a bacterial hemoglobin receptor protein, nucleic acid encoding such a protein, recombinant expression constructs comprising such nucleic acids and cells transformed therewith, and antibodies and epitopes of such hemoglobin receptor proteins. The invention relates particularly to hemoglobin receptor proteins and genes encoding such proteins from Neisseria species, especially N. meningitidis. Methods for the diagnostic and therapeutic use of the proteins, epitopes, antibodies and nucleic acids of the invention are also provided, including the use of the proteins, epitopes, antibodies and nucleic acids of the invention for the production of vaccines effective in providing immunization of a human against infection by pathogenic bacteria of Neisseria species.
摘要翻译：本发明涉及一种新的细菌性血红蛋白受体蛋白质和编码这种蛋白质的基因。本发明涉及细菌血红蛋白受体蛋白的分离，表征，诊断和治疗用途，编码这种蛋白质的核酸，包含这种核酸的重组表达构建体和与其转化的细胞，以及这些血红蛋白受体蛋白的抗体和表位。本发明特别涉及血红蛋白受体蛋白和编码奈瑟氏球菌（Neisseria），特别是脑膜炎奈瑟氏菌（N脑膜炎奈瑟氏球菌）的蛋白质的基因。还提供了本发明的蛋白质，表位，抗体和核酸的诊断和治疗用途的方法，包括使用本发明的蛋白质，表位，抗体和核酸来生产有效提供免疫的疫苗一种人抵抗奈瑟氏球菌病原菌的感染。

6. 发明授权

US6066628A Non-iron metalloporphyrins and methods of use 失效
标题翻译：非铁金属卟啉及其使用方法
公开(公告)号：US6066628A
公开(公告)日：2000-05-23
申请号：US5373
申请日：1998-01-09
申请人： Igor Stojiljkovic , Gordon G. Churchward
发明人： Igor Stojiljkovic , Gordon G. Churchward
IPC分类号： A01N55/02 , A61K31/555 , A61K31/40 , C07D487/22
CPC分类号： A01N55/02 , A61K31/555
摘要： The present disclosure provides novel non-iron metalloporphyrins, especially those porphyrin complexes containing gallium or indium as the metal ion, and antibacterial compositions comprising artificial metalloporphyrins (such as protoporphyrin IX) completed with a metal ion selected from metal ions including, but not limited to, gadolinium, ruthenium copper, gallium, indium and manganese, and methods for inhibiting or killing bacteria and other microorganisms and for treating infections caused by microorganisms using the artificial metalloporphyrin of the present invention.
摘要翻译：本公开提供了新的非铁金属卟啉，特别是包含镓或铟作为金属离子的卟啉络合物，以及包含人造金属卟啉（例如原卟啉IX）的抗菌组合物，其中金属离子选自金属离子，金属离子包括但不限于钆，钌铜，镓，铟和锰，以及用于本发明的人造金属卟啉抑制或杀死细菌和其它微生物以及治疗由微生物引起的感染的方法。

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