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1. 发明授权

US06825200B1 Substituted dipeptides having nos inhibiting activity 失效
标题翻译：取代二肽具有抑制活性
公开(公告)号：US06825200B1
公开(公告)日：2004-11-30
申请号：US10111412
申请日：2002-05-06
申请人： Ichiro Shima , Takehiko Ohkawa , Kazuhiko Ohne , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
发明人： Ichiro Shima , Takehiko Ohkawa , Kazuhiko Ohne , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
IPC分类号： A61K31496
CPC分类号： C07K5/06191 , A61K38/05 , C07K5/06078 , C07K5/06139 , A61K2300/00
摘要： The present invention a compound represented by the formula (I): where the structural variables R1-R6 are defined herein.
摘要翻译：本发明由式（I）表示的化合物：其中结构变量R 1 -R 6在本文中定义。

2. 发明授权

US07129243B2 Peptide compounds 有权
标题翻译：肽化合物
公开(公告)号：US07129243B2
公开(公告)日：2006-10-31
申请号：US10250444
申请日：2001-12-18
申请人： Ichiro Shima , Takehiko Ohkawa , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
发明人： Ichiro Shima , Takehiko Ohkawa , Kentaro Sato , Naoki Ishibashi , Kenichiro Imamura
IPC分类号： A61K31/50
CPC分类号： C07K5/06139 , A61K38/00 , C07K5/06191
摘要： The present invention relates to a compound of the formula (I) wherein R1 is benzofuranyl substituted by halogen, or styryl substituted by halogen; R2 is substituted hydroxy, substituted mercapto or substituted sulfonyl; and X is or pharmaceutically acceptable salts thereof. The compound (1) of the present invention and pharmaceutically acceptable salts thereof possess a strong inhibitory activity on the production of nitric oxide (NO), and are useful for prevention and/or treatment of NO-mediated diseases in human being and animals
摘要翻译：本发明涉及式（I）化合物，其中R 1为被卤素取代的苯并呋喃基或被卤素取代的苯乙烯基; R2是取代的羟基，取代的巯基或取代的磺酰基; X是其药学上可接受的盐。本发明化合物（1）及其药学上可接受的盐对一氧化氮（NO）的产生具有很强的抑制活性，可用于预防和/或治疗人和动物中NO介导的疾病

3. 发明申请

US20060270678A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20060270678A1
公开(公告)日：2006-11-30
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61K31/503 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病。

4. 发明授权

US07317009B2 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US07317009B2
公开(公告)日：2008-01-08
申请号：US11500293
申请日：2006-08-08
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病

5. 发明授权

US07153854B2 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US07153854B2
公开(公告)日：2006-12-26
申请号：US10747079
申请日：2003-12-30
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： C07D487/04 , A61K31/5025
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 0 > 4 如说明书中所定义，它们作为药物的用途，其制备方法和用于治疗PDE-IV或TNF-α介导的疾病

6. 发明申请

US20050075342A1 Pyrrolopyridazine derivatives 失效
标题翻译：吡咯并哒嗪衍生物
公开(公告)号：US20050075342A1
公开(公告)日：2005-04-07
申请号：US10747079
申请日：2003-12-30
申请人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
发明人： Yoshito Abe , Makoto Inoue , Tsuyoshi Mizutani , Kozo Sawada , Kazuhiko Ohne , Mitsuaki Okumura , Yuki Sawada , Kenichiro Imamura
IPC分类号： A61P31/00 , C07D487/04 , A61K31/503
CPC分类号： C07D487/04
摘要： The invention relates to compound of the formula (I) or its salt, in which R1, R2, R3 and R4 are as defined in the description, their use of as medicament, the process for their preparation and use for the treatment of PDE-IV or TNF-α mediated diseases.
摘要翻译：本发明涉及式（I）化合物或其盐，其中R 1，R 2，R 3和R 4如说明书中所定义，它们作为药物的用途，其制备和用途用于治疗PDE-IV或TNF-α介导的疾病。

7. 发明申请

US20100256113A1 QUINOLONE DERIVATIVE 有权
标题翻译：喹诺酮衍生物
公开(公告)号：US20100256113A1
公开(公告)日：2010-10-07
申请号：US12680301
申请日：2008-09-25
申请人： Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
发明人： Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
IPC分类号： A61K31/4709 , C07D215/233 , C07D405/12 , C07D401/12 , C07D413/12 , A61K31/47 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/4725 , A61K31/55 , A61K31/553
CPC分类号： C07D401/12 , C07D215/233 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/107
摘要： As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.
摘要翻译：作为对NAD（P）H氧化酶抑制剂的广泛研究的结果，本发明人发现，在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD（P）H氧化酶抑制活性，完成了本发明。本发明的化合物具有基于NAD（P）H氧化酶抑制活性的活性氧产生抑制活性，因此可用作糖尿病预防和/或治疗药物，糖耐量异常，高脂血症，脂肪肝，糖尿病并发症等。

8. 发明授权

US08367702B2 Quinolone derivative 有权
标题翻译：喹诺酮衍生物
公开(公告)号：US08367702B2
公开(公告)日：2013-02-05
申请号：US12680301
申请日：2008-09-25
申请人： Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
发明人： Kenichi Onda , Kenichiro Imamura , Fumie Sato , Hiroyuki Moritomo , Yasuharu Urano , Yuki Sawada , Naoki Ishibashi , Keita Nakanishi , Kazuhiro Yokoyama , Shigetada Furukawa , Kazuhiro Momose
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D401/12 , C07D215/233 , C07D401/06 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/107
摘要： As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.
摘要翻译：作为对NAD（P）H氧化酶抑制剂的广泛研究的结果，本发明人发现，在2位具有被杂原子等取代的烷基的喹诺酮衍生物具有优异的NAD（P）H氧化酶抑制活性，完成了本发明。本发明的化合物具有基于NAD（P）H氧化酶抑制活性的活性氧产生抑制活性，因此可用作糖尿病预防和/或治疗药物，糖耐量异常，高脂血症，脂肪肝，糖尿病并发症等。

9. 发明授权

US07887313B2 Mold apparatus for resin encapsulation and resin encapsulation method 有权
标题翻译：树脂封装模塑装置和树脂封装方法
公开(公告)号：US07887313B2
公开(公告)日：2011-02-15
申请号：US12094010
申请日：2006-11-24
申请人： Kenji Ogata , Masashi Nishiguchi , Kenichiro Imamura
发明人： Kenji Ogata , Masashi Nishiguchi , Kenichiro Imamura
IPC分类号： B29C45/14
CPC分类号： H01L21/565 , B29C45/02 , B29C45/021 , B29C45/14655 , H01L24/97 , H01L2924/181 , H01L2924/00
摘要： To provide a mold apparatus for resin encapsulation, which is small in number of components, has a simple driving mechanism, is easy in assembly or disassembly work, requires no labor for maintenance and has good workability; and a resin encapsulation method. Therefore, of a lower cavity bar 51 and an upper cavity bar 26, a plurality of groove-shaped pots 52 are provided in parallel at a predetermined pitch in a region where a substrate board is disposed, and each groove-shaped pot 52 is individually provided with a plurality of cavities 54 in parallel through runners. Then, a plunger plate 60 inserted in the grooved-shaped pot 52 in a manner so as to be able to move up and down is driven by a plunger 76, whereby a resin for encapsulation inserted into the pot 52 is melted with the plunger plate 60, and the melted resin is filled in the cavities 54 through the runners.
摘要翻译：为了提供组件数量少的树脂封装用模具装置，具有简单的驱动机构，易于组装或拆卸工作，不需要维护劳动并具有良好的可加工性; 和树脂封装方法。因此，在下腔体棒51和上腔棒26中，在设置衬底板的区域中以预定间距平行设置多个槽形罐52，并且每个槽形罐52分别设置有通过跑道平行的多个空腔54。然后，通过柱塞76驱动以能够上下移动的方式插入槽状罐52中的柱塞板60，由此插入到罐52中的用于封装的用于封装的树脂用柱塞板 60，并且熔融的树脂通过流道填充在空腔54中。

10. 发明申请

US20080308969A1 Mold Apparatus for Resin Encapsulation and Resin Encapsulation Method 有权
标题翻译：树脂封装模塑装置和树脂封装方法
公开(公告)号：US20080308969A1
公开(公告)日：2008-12-18
申请号：US12094010
申请日：2006-11-24
申请人： Kenji Ogata , Masashi Nishiguchi , Kenichiro Imamura
发明人： Kenji Ogata , Masashi Nishiguchi , Kenichiro Imamura
IPC分类号： B29C45/14
CPC分类号： H01L21/565 , B29C45/02 , B29C45/021 , B29C45/14655 , H01L24/97 , H01L2924/181 , H01L2924/00
摘要： To provide a mold apparatus for resin encapsulation, which is small in number of components, has a simple driving mechanism, is easy in assembly or disassembly work, requires no labor for maintenance and has good workability; and a resin encapsulation method. Therefore, of a lower cavity bar 51 and an upper cavity bar 26, a plurality of groove-shaped pots 52 are provided in parallel at a predetermined pitch in a region where a substrate board is disposed, and each groove-shaped pot 52 is individually provided with a plurality of cavities 54 in parallel through runners. Then, a plunger plate 60 inserted in the grooved-shaped pot 52 in a manner so as to be able to move up and down is driven by a plunger 76, whereby a resin for encapsulation inserted into the pot 52 is melted with the plunger plate 60, and the melted resin is filled in the cavities 54 through the runners.
摘要翻译：为了提供组件数量少的树脂封装用模具装置，具有简单的驱动机构，易于组装或拆卸工作，不需要维护劳动并具有良好的可加工性; 和树脂封装方法。因此，在下腔体棒51和上腔棒26中，在设置衬底板的区域中以预定间距平行设置多个槽形罐52，并且每个槽形罐52分别设置有通过跑道平行的多个空腔54。然后，通过柱塞76驱动以能够上下移动的方式插入槽状罐52中的柱塞板60，由此插入到罐52中的用于封装的用于封装的树脂用柱塞板 60，并且熔融的树脂通过流道填充在空腔54中。

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